BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells

Cytotherapy

Volumn 12, Issue 4, 2010, Pages 505-513

  Haddad Weber, Meike ^a   Prager, Patrick ^a   Kunz, Manuela ^a   Seefried, Lothar ^a   Jakob, Franz ^a   Murray, Martha M ^b   Evans, Christopher H ^c   Nöth, Ulrich ^a   Steinert, Andre F ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adenovirus; Anterior cruciate ligament; BMP12; BMP13; Collagen hydrogel; Fibroblasts; Gene transfer; Mesenchymal stromal cells

Indexed keywords

ADENOVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN 12; COLLAGEN TYPE 1; COMPLEMENTARY DNA; DECORIN; ELASTIN; FIBRONECTIN; GROWTH DIFFERENTIATION FACTOR 6; HEMATOXYLIN; TENASCIN; VIMENTIN;

ADULT; AGED; ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CELL VIABILITY; FIBROBLAST; GENE EXPRESSION; GENE TRANSFER; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MESENCHYMAL STEM CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 77954449625     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653241003709652     Document Type: Article

References (41)

1. Schoderbek RJ Jr, Treme GP, Miller MD. Bone-patella tendon-bone autograft anterior cruciate ligament reconstruction. Clin Sports Med. 2007;26:525-547
2. Lawhorn KW, Howell SM. Principles for using hamstring tendons for anterior cruciate ligament reconstruction. Clin Sports Med. 2007;26:567-585
3. Anderson AF. Transepiphyseal replacement of the anterior cruciate ligament using quadruple hamstring grafts in skeletally immature patients. J Bone Joint Surg Am. 2004;86A (Suppl 1):201-209
4. Cooper JA Jr, Bailey LO, Carter JN, Castiglioni CE, Kofron MD, Ko FK, et al. Evaluation of the anterior cruciate ligament, medial collateral ligament, Achilles tendon and patellar tendon as cell sources for tissue-engineered ligament. Biomaterials. 2006;27:2747-2754
5. Gentleman E, Livesay GA, Dee KC, Nauman EA. Development of ligament-like structural organization and properties in cell-seeded collagen scaffolds in vitro. Ann Biomed Eng. 2006;34:726-736
6. Hairfield-Stein M, England C, Paek HJ, Gilbraith KB, Dennis R, Boland E, et al. Development of self-assembled, tissue-engineered ligament from bone marrow stromal cells. Tissue Eng. 2007;13:703-710
7. Heckmann L, Fiedler J, Mattes T, Brenner RE. Mesenchymal progenitor cells communicate via alpha and beta integrins with a three-dimensional collagen type I matrix. Cells Tissues Organs. 2006;182:143-154
8. Laurencin CT, Freeman JW. Ligament tissue engineering: an evolutionary materials science approach. Biomaterials. 2005;26:7530-7536
9. Liu H, Fan H, Toh SL, Goh JC. A comparison of rabbit mesenchymal stem cells and anterior cruciate ligament fibroblasts responses on combined silk scaffolds. Biomaterials. 2008;29:1443-1453
10. Noth U, Schupp K, Heymer A, Kall S, Jakob F, Schutze N, et al. Anterior cruciate ligament constructs fabricated from human mesenchymal stem cells in a collagen type I hydrogel. Cytotherapy. 2005;7:447-455
11. Murray MM, Forsythe B, Chen F, Lee SJ, Yoo JJ, Atala A, et al. The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. J Orthop Res. 2006;24:508-515
12. Kuo CK, Tuan RS. Mechanoactive tenogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A. 2008; 14:1615-1627
13. Altman GH, Horan RL, Martin I, Farhadi J, Stark PR, Volloch V, et al. Cell differentiation by mechanical stress. FASEB J. 2002;16:270-272
14. Redden RA, Doolin EJ. Collagen crosslinking and cell density have distinct effects on fibroblast-mediated contraction of collagen gels. Skin Res Technol. 2003;9:290-293
15. Evans CH. Cytokines and the role they play in the healing of ligaments and tendons. Sports Med. 1999;28:71-76
16. Fu SC, Wong YP, Chan BP, Pau HM, Cheuk YC, Lee KM, et al. The roles of bone morphogenetic protein (BMP) 12 in stimulating the proliferation and matrix production of human patellar tendon fibroblasts. Life Sci. 2003;72:2965-2974
17. Heckmann L, Schlenker HJ, Fiedler J, Brenner R, Dauner M, Bergenthal G, et al. Human mesenchymal progenitor cell responses to a novel textured poly(L-lactide) scaffold for ligament tissue engineering. J Biomed Mater Res B Appl Biomater. 2007;81:82-90.
18. Jenner JM, van Eijk F, Saris DB, Willems WJ, Dhert WJ, Creemers LB. Effect of transforming growth factor-beta and growth differentiation factor-5 on proliferation and matrix production by human bone marrow stromal cells cultured on braided poly lactic-co-glycolic acid scaffolds for ligament tissue engineering. Tissue Eng. 2007;13:1573-1582
19. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003;33:381-394
20. Tsai AD, Yeh LC, Lee JC. Effects of osteogenic protein-1 (OP-1, BMP-7) on gene expression in cultured medial collateral ligament cells. J Cell Biochem. 2003;90:777-791
21. Helm GA, Li JZ, Alden TD, Hudson SB, Beres EJ, Cunningham M, et al. A light and electron microscopic study of ectopic tendon and ligament formation induced by bone morphogenetic protein-13 adenoviral gene therapy. J Neurosurg. 2001;95:298-307.
22. Wolfman NM, Hattersley G, Cox K, Celeste AJ, Nelson R, Yamaji N, et al. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest. 1997; 100:321-330
23. Aspenberg P, Forslund C. Enhanced tendon healing with GDF 5 and 6. Acta Orthop Scand. 1999;70:51-54
24. Lou J, Tu Y, Burns M, Silva MJ, Manske P. BMP-12 gene transfer augmentation of lacerated tendon repair. J Orthop Res. 2001;19:1199-1202
25. Rickert M, Jung M, Adiyaman M, Richter W, Simank HG. A growth and differentiation factor-5 (GDF-5)-coated suture stimulates tendon healing in an Achilles tendon model in rats. Growth Factors. 2001;19:115-126
26. Majewski M, Betz O, Ochsner PE, Liu F, Porter RM, Evans CH. Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model. Gene Ther. 2008;15:1139-1146
27. Palmer G, Gouze E, Gouze JN, Betz O, Evans CH, Ghivizzani SC. Gene transfer to articular chondrocytes with recombinant adenovirus. Methods Mol Biol. 2003;215: 235-246
28. Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone. 1992;13:81-88
29. Noth U, Osyczka AM, Tuli R, Hickok NJ, Danielson KG, Tuan RS. Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. J Orthop Res. 2002;20:1060-1069
30. Chen G, Sato T, Sakane M, Ohgushi H, Ushida T, Tanaka J, et al. Application of PLGA-collagen hybrid mesh for threedimensional culture of canine anterior cruciate ligament cells. Mat Sci Engineer C. 2004;24:861-866
31. Steinert AF, Weber M, Kunz M, Palmer GD, Noth U, Evans CH, et al. In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament. Biomaterials. 2008; 29:904-916
32. Martin SJ, Reutelingsperger CP, McGahon AJ, Rader JA, van Schie RC, LaFace DM, et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med. 1995;182:1545-1556
33. Pascher A, Steinert AF, Palmer GD, Betz O, Gouze JN, Gouze E, et al. Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. Mol Ther. 2004;10:327-336
34. Murray MM, Spindler KP, Ballard P, Welch TP, Zurakowski D, Nanney LB. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res. 2007;25:1007-1017
35. Heckmann L, Fiedler J, Mattes T, Dauner M, Brenner RE. Interactive effects of growth factors and three-dimensional scaffolds on multipotent mesenchymal stromal cells. Biotechnol Appl Biochem. 2008;49:185-194
36. Forslund C, Aspenberg P. Tendon healing stimulated by injected CDMP-2. Med Sci Sports Exerc. 2001;33:685-687
37. Hoffmann A, Gross G. Tendon and ligament engineering: from cell biology to in vivo application. Regen Med. 2006; 1:563-574
38. Hoffmann A, Pelled G, Turgeman G, Eberle P, Zilberman Y, Shinar H, et al. Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. J Clin Invest. 2006;116:940-952
39. Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, et al. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscleanchoring tendons. Development. 2007;134:2697-2708
40. Schweitzer R, Chyung JH, Murtaugh LC, Brent AE, Rosen V, Olson EN, et al. Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development. 2001;128:3855-3866
41. Docheva D, Hunziker EB, Fassler R, Brandau O. Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol. 2005;25:699-705.