In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament

Biomaterials

Volumn 29, Issue 7, 2008, Pages 904-916

  Steinert, Andre F ^a,b   Weber, Meike ^a   Kunz, Manuela ^a   Palmer, Glyn D ^b   Nöth, Ulrich ^a   Evans, Christopher H ^b   Murray, Martha M ^c  

^a Orthopedic Clinic   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Adenovirus; Anterior cruciate ligament; Collagen hydrogel; Gene transfer; IGF 1

Indexed keywords

CELL CULTURE; COLLAGEN; FIBROBLASTS; HYDROGELS; INSULIN; LIGAMENTS; MONOLAYERS;

ADENOVIRUS; ANTERIOR CRUCIATE LIGAMENTS; COLLAGEN HYDROGELS; GROWTH FACTORS; LESIONS;

GENE TRANSFER;

ADENOVIRUS VECTOR; COLLAGEN TYPE 1; COLLAGEN TYPE 3; ELASTIN; SOMATOMEDIN; TENASCIN; VIMENTIN;

ADULT; ANTERIOR CRUCIATE LIGAMENT INJURY; ARTICLE; CELL REGENERATION; CELL VIABILITY; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEL; MALE; PRIORITY JOURNAL; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS LOAD;

ADENOVIRIDAE; ANTERIOR CRUCIATE LIGAMENT; BIOLOGICAL MARKERS; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; HYDROGELS; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; TRANSGENES;

ADENOVIRIDAE;

EID: 37249065744     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2007.10.054     Document Type: Article

References (50)

1. In: Praemer A., Furner S., and Rice D.P. (Eds). Musculoskeletal conditions in the United States (1999), AAOS, Rosemont
2. Owings M.F., and Kozak L.J. Ambulatory and inpatient procedures in the United States, 1996. Vital Health Stat 13 139 (1998) 1-119
3. Frank C.B., and Jackson D.W. The science of reconstruction of the anterior cruciate ligament. J Bone Jt Surg Am 79 10 (1997) 1556-1576
4. Caborn D.N., and Johnson B.M. The natural history of the anterior cruciate ligament-deficient knee. A review. Clin Sports Med 12 4 (1993) 625-636
5. Feagin Jr. J.A., and Curl W.W. Isolated tear of the anterior cruciate ligament: 5-year follow-up study. Am J Sports Med 4 3 (1976) 95-100
6. West R.V., and Harner C.D. Graft selection in anterior cruciate ligament reconstruction. J Am Acad Orthop Surg 13 3 (2005) 197-207
7. Freedman K.B., D'Amato M.J., Nedeff D.D., Kaz A., and Bach Jr. B.R. Arthroscopic anterior cruciate ligament reconstruction: a metaanalysis comparing patellar tendon and hamstring tendon autografts. Am J Sports Med 31 1 (2003) 2-11
8. Aglietti P., Buzzi R., D'Andria S., and Zaccherotti G. Long-term study of anterior cruciate ligament reconstruction for chronic instability using the central one-third patellar tendon and a lateral extraarticular tenodesis. Am J Sports Med 20 1 (1992) 38-45
9. Anderson A.F., Snyder R.B., and Lipscomb Sr. A.B. Anterior cruciate ligament reconstruction using the semitendinosus and gracilis tendons augmented by the losee iliotibial band tenodesis. A long-term study. Am J Sports Med 22 5 (1994) 620-626
10. Ge Z., Yang F., Goh J.C., Ramakrishna S., and Lee E.H. Biomaterials and scaffolds for ligament tissue engineering. J Biomed Mater Res A 77 3 (2006) 639-652
11. Petrigliano F.A., McAllister D.R., and Wu B.M. Tissue engineering for anterior cruciate ligament reconstruction: a review of current strategies. Arthroscopy 22 4 (2006) 441-451
12. Hutmacher D.W., Sittinger M., and Risbud M.V. Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. Trends Biotechnol 22 7 (2004) 354-362
13. Vunjak-Novakovic G., Altman G., Horan R., and Kaplan D.L. Tissue engineering of ligaments. Annu Rev Biomed Eng 6 (2004) 131-156
14. Murray M.M., Martin S.D., and Spector M. Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds. J Orthop Res 18 4 (2000) 557-564
15. Murray M.M., and Spector M. The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. Biomaterials 22 17 (2001) 2393-2402
16. Murray M.M., Spindler K.P., Abreu E., Muller J.A., Nedder A., Kelly M., et al. Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res 25 1 (2007) 81-91
17. Spindler K.P., Murray M.M., Devin C., Nanney L.B., and Davidson J.M. The central ACL defect as a model for failure of intra-articular healing. J Orthop Res 24 3 (2006) 401-406
18. Murray M.M., Spindler K.P., Devin C., Snyder B.S., Muller J., Takahashi M., et al. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res 24 4 (2006) 820-830
19. Evans C.H. Cytokines and the role they play in the healing of ligaments and tendons. Sports Med 28 2 (1999) 71-76
20. Gerich T.G., Kang R., Fu F.H., Robbins P.D., and Evans C.H. Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing. Gene Ther 3 12 (1996) 1089-1093
21. Gerich T.G., Kang R., Fu F.H., Robbins P.D., and Evans C.H. Gene transfer to the patellar tendon. Knee Surg Sports Traumatol Arthrosc 5 2 (1997) 118-123
22. Hildebrand K.A., Deie M., Allen C.R., Smith D.W., Georgescu H.I., Evans C.H., et al. Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury. J Orthop Res 17 1 (1999) 37-42
23. Scherping Jr. S.C., Schmidt C.C., Georgescu H.I., Kwoh C.K., Evans C.H., and Woo S.L. Effect of growth factors on the proliferation of ligament fibroblasts from skeletally mature rabbits. Connect Tissue Res 36 1 (1997) 1-8
24. Schmidt C.C., Georgescu H.I., Kwoh C.K., Blomstrom G.L., Engle C.P., Larkin L.A., et al. Effect of growth factors on the proliferation of fibroblasts from the medial collateral and anterior cruciate ligaments. J Orthop Res 13 2 (1995) 184-190
25. Evans C.H., Bandara G., Robbins P.D., Mueller G.M., Georgescu H.I., and Glorioso J.C. Gene therapy for ligament healing. In: Jackson D.W. (Ed). In the anterior cruciate ligament: current and future concepts (1993), Raven Press, New York, NY 419-422
26. Evans C.H., Ghivizzani S.C., Herndon J.H., and Robbins P.D. Gene therapy for the treatment of musculoskeletal diseases. J Am Acad Orthop Surg 13 4 (2005) 230-242
27. Pascher A., Steinert A.F., Palmer G.D., Betz O., Gouze J.N., Gouze E., et al. Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. Mol Ther 10 2 (2004) 327-336
28. Evans C.H., Palmer G.D., Pascher A., Porter R., Kwong F.N., Gouze E., et al. Facilitated endogenous repair: making tissue engineering simple, practical, and economical. Tissue Eng 13 9 (2007) 2227-2237
29. Provenzano P.P., Alejandro-Osorio A.L., Grorud K.W., Martinez D.A., Vailas A.C., Grindeland R.E., et al. Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: evaluation of loaded and unloaded ligaments. BMC Physiol 7 (2007) 2
30. Hardy S., Kitamura M., Harris-Stansil T., Dai Y., and Phipps M.L. Construction of adenovirus vectors through Cre-lox recombination. J Virol 71 3 (1997) 1842-1849
31. Palmer G., Gouze E., Gouze J.N., Betz O., Evans C.H., and Ghivizzani S.C. Gene transfer to articular chondrocytes with recombinant adenovirus. Methods Mol Biol 215 (2003) 235-246
32. Marui T., Niyibizi C., Georgescu H.I., Cao M., Kavalkovich K.W., Levine R.E., et al. Effect of growth factors on matrix synthesis by ligament fibroblasts. J Orthop Res 15 1 (1997) 18-23
33. Peterkofsky B., and Diegelmann R. Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins. Biochemistry 10 6 (1971) 988-994
34. Meaney Murray M., Rice K., Wright R.J., and Spector M. The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three-dimensional collagen-GAG scaffold. J Orthop Res 21 2 (2003) 238-244
35. Murray M.M., Forsythe B., Chen F., Lee S.J., Yoo J.J., Atala A., et al. The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. J Orthop Res 24 3 (2006) 508-515
36. Noth U., Schupp K., Heymer A., Kall S., Jakob F., Schutze N., et al. Anterior cruciate ligament constructs fabricated from human mesenchymal stem cells in a collagen type I hydrogel. Cytotherapy 7 5 (2005) 447-455
37. Doroski D.M., Brink K.S., and Temenoff J.S. Techniques for biological characterization of tissue-engineered tendon and ligament. Biomaterials 28 2 (2007) 187-202
38. Molloy T., Wang Y., and Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med 33 5 (2003) 381-394
39. Hildebrand K.A., Frank C.B., and Hart D.A. Gene intervention in ligament and tendon: current status, challenges, future directions. Gene Ther 11 4 (2004) 368-378
40. DesRosiers E.A., Yahia L., and Rivard C.H. Proliferative and matrix synthesis response of canine anterior cruciate ligament fibroblasts submitted to combined growth factors. J Orthop Res 14 2 (1996) 200-208
41. Schek R.M., Hollister S.J., and Krebsbach P.H. Delivery and protection of adenoviruses using biocompatible hydrogels for localized gene therapy. Mol Ther 9 1 (2004) 130-138
42. Dai Q., Manfield L., Wang Y., and Murrel G.A.C. Adenovirus-mediated gene transfer to healing tendon-enhanced efficiency using a gelatin sponge. J Orthop Res 21 (2003) 604-609
43. Cooper J.A., Lu H.H., Ko F.K., Freeman J.W., and Laurencin C.T. Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation. Biomaterials 26 13 (2005) 1523-1532
44. Altman G.H., Diaz F., Jakuba C., Calabro T., Horan R.L., Chen J., et al. Silk-based biomaterials. Biomaterials 24 3 (2003) 401-416
45. Bonadio J. Tissue engineering via local gene delivery: update and future prospects for enhancing the technology. Adv Drug Deliv Rev 44 2-3 (2000) 185-194
46. Hu W.W., Wang Z., Hollister S.J., and Krebsbach P.H. Localized viral vector delivery to enhance in situ regenerative gene therapy. Gene Ther 14 11 (2007) 891-901
47. Park H., Temenoff J.S., Tabata Y., Caplan A.I., and Mikos A.G. Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials 28 21 (2007) 3217-3227
48. Schek R.M., Wilke E.N., Hollister S.J., and Krebsbach P.H. Combined use of designed scaffolds and adenoviral gene therapy for skeletal tissue engineering. Biomaterials 27 7 (2006) 1160-1166
49. Lehrman S. Virus treatment questioned after gene therapy death. Nature 401 6753 (1999) 517-518
50. Marshall E. Gene therapy death prompts review of adenovirus vector. Science 286 5448 (1999) 2244-2245