Osteoarthritis in women: Effects of estrogen, obesity and physical activity

Women's Health

Volumn 6, Issue 4, 2010, Pages 601-615

  Stevens Lapsley, Jennifer E ^a   Kohrt, Wendy M ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

estrogen; hormone; obesity; osteoarthritis; physical activity; sex; women

Indexed keywords

ESTROGEN; GESTAGEN; ORAL CONTRACEPTIVE AGENT; PLACEBO; SEX HORMONE;

ARTHROPLASTY; BODY MASS; DISEASE COURSE; HORMONAL THERAPY; HUMAN; INCIDENCE; KINESIOTHERAPY; MENARCHE; MENOPAUSE; OBESITY; OSTEOARTHRITIS; PARITY; PHYSICAL ACTIVITY; PREVALENCE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; WALKING; WEIGHT REDUCTION; WOMEN'S HEALTH;

AGE FACTORS; BODY MASS INDEX; DISEASE PROGRESSION; ESTROGENS; FEMALE; GONADAL STEROID HORMONES; HORMONE REPLACEMENT THERAPY; HUMANS; INCIDENCE; MALE; MOTOR ACTIVITY; OBESITY; OSTEOARTHRITIS; PARITY; PREGNANCY; RISK FACTORS; UNITED STATES;

EID: 77954439908     PISSN: 17455057     EISSN: 17455065     Source Type: Journal    
DOI: 10.2217/whe.10.38     Document Type: Review

References (103)

1. Lawrence RC, Felson DT, Helmick CG et al.: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 58, 26-35 (2008).
2. Hutton CW: Osteoarthritis: the cause not result of joint failure? Ann. Rheum. Dis. 48, 958-961 (1989).
3. Arden N, Nevitt MC: Osteoarthritis: epidemiology. Best Pract. Res. Clin. Rheumatol. 20, 3-25 (2006). (Pubitemid 43230460)
4. Hunter DJ: Imaging insights on the epidemiology and pathophysiology of osteoarthritis. Rheum. Dis. Clin. North Am. 35, 447-463 (2009).
5. Ai F, Yu C, Zhang W, Morelli JN, Kacher D, Li X: MR imaging of knee osteoarthritis and correlation of fndings with reported patient pain. J. Huazhong Univ. Sci. Technolog. Med. Sci. 30(2), 248-524 (2010).
6. Hannan MT, Anderson JJ, Pincus T, Felson DT: Educational attainment and osteoarthritis: differential associations with radiographic changes and symptom reporting. J. Clin. Epidemiol. 45, 139-147 (1992).
7. Felson DT: An update on the pathogenesis and epidemiology of osteoarthritis. Radiol. Clin. North Am. 42, 1-9 (2004).
8. Anderson JJ, Felson DT: Factors associated with osteoarthritis of the knee in the frst national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am. J. Epidemiol. 128, 179-189 (1988).
9. Felson DT: Risk factors for osteoarthritis: understanding joint vulnerability. Clin. Orthop. Relat. Res. S16-21 (2004).
10. Felson DT: Developments in the clinical understanding of osteoarthritis. Arthritis Res. Ther. 11, 203 (2009).
11. Felson DT, Lawrence RC, Dieppe PA et al.: Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann. Intern. Med. 133, 635-646. (2000).
12. Blagojevic M, Jinks C, Jeffery A, Jordan KP: Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage 18(1), 24-33 (2010).
13. Physical Activity Guidelines Advisory Committee. Physical Activity Guidelines Advisory Committee Report, 2008. US Department of Health and Human Services, Washington, DC, USA (2008).
14. de Klerk BM, Schiphof D, Groeneveld FP et al.: No clear association between female hormonal aspects and osteoarthritis of the hand, hip and knee: a systematic review. Rheumatology (Oxford) 48, 1160-1165 (2009).
15. Sharma L, Lou C, Felson DT et al.: Laxity in healthy and osteoarthritic knees. Arthritis Rheum. 42, 861-870 (1999). (Pubitemid 29214996)
16. Sharma L, Dunlop DD, Cahue S, Song J, Hayes KW: Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Ann. Intern. Med. 138, 613-619 (2003). (Pubitemid 38124651)
17. Cooper C, Snow S, McAlindon TE et al.: Ris factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum. 43, 995-1000 (2000). (Pubitemid 30368175)
18. Doherty M: Risk factors for progression of kne osteoarthritis. Lancet 358, 775-776 (2001). (Pubitemid 32868721)
19. Belo JN, Berger MY, Reijman M, Koes BW, Bierma-Zeinstra SM: Prognostic factors of progression of osteoarthritis of the knee: a systematic review of observational studies. Arthritis Rheum. 57, 13-26 (2007). (Pubitemid 46256720)
20. Dillon CF, Rasch EK, Gu Q, Hirsch R: Prevalence of knee osteoarthritis in the Unite States: arthritis data from the Third Nationa Health and Nutrition Examination Survey 1991-1994. J. Rheumatol. 33, 2271-2279 (200
21. Felson DT, Zhang Y, Hannan MT et al.: The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 38, 1500-1505 (1995).
22. Brooks PM: The burden of musculoskeletal disease-a global perspective. Clin. Rheumato 25, 778-781 (2006).
23. Cho HJ, Chang CB, Yoo JH, Kim SJ, Kim TK: Gender differences in the correlatio between symptom and radiographic severity i patients with knee osteoarthritis. Clin. Ortho Relat. Res. DOI:10.1007/s11999-010-1282-z (2010) (Epub ahead of print).
24. Hannan MT: Epidemiologic perspectives on women and arthritis: an overview. Arthritis Care Res. 9, 424-434 (1996).
25. Kapstad H, Rustoen T, Hanestad BR et al.: Changes in pain, stiffness and physical function in patients with osteoarthritis waitin for hip or knee joint replacement surgery. Osteoarthritis Cartilage 15, 837-843 (2007). (Pubitemid 46900085)
26. Kelly KD, Voaklander DC, Johnston DWC, Newman SC, Suarez-Almazor ME: Change i pain and function while waiting for major join arthroplasty. J. Arthroplasty 16, 351-359 (2001
27. Srikanth VK, Fryer JL, Zhai G et al.: A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage 13, 769-781 (2005). (Pubitemid 41263935)
28. de Klerk BM, Schiphof D, Groeneveld FP et al.: Limited evidence for a protective effect of unopposed oestrogen therapy for osteoarthritis of the hip: a systematic review. Rheumatology (Oxford) 48, 104-112 (2009).
29. Liu B, Balkwill A, Cooper C et al.: Reproductive history, hormonal factors and t incidence of hip and knee replacement for osteoarthritis in middle-aged women. Ann. Rheum. Dis. 68, 1165-1170 (2009).
30. Richmond RS, Carlson CS, Register TC, Shanker G, Loeser RF: Functional estrogen receptors in adult articular cartilage: estrogen replacement therapy increases chondrocyte synthesis of proteoglycans and insulin-like growth factor binding protein 2. Arthritis Rheum. 43, 2081-2090 (2000).
31. Roman-Blas JA, Castaneda S, Largo R, Herrero-Beaumont G: Osteoarthritis associated with estrogen defciency. Arthritis Res. Ther. 11, 241 (2009).
32. Reginster JY, Kvasz A, Bruyere O, Henrotin Y: Is there any rationale for prescribing hormone replacement therapy (HRT) to prevent or to treat osteoarthritis? Osteoarthritis Cartilage 11, 87-91 (2003). (Pubitemid 36221644)
33. Hannan MT, Felson DT, Anderson JJ, Naimark A, Kannel WB: Estrogen use and radiographic osteoarthritis of the knee in women. The Framingham Osteoarthritis Study. Arthritis Rheum. 33, 525-532 (1990). (Pubitemid 20151239)
34. Hart DJ, Doyle DV, Spector TD: Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum. 42, 17-24 (1999).
35. Nevitt MC, Felson DT: Sex hormones and the risk of osteoarthritis in women: epidemiological evidence. Ann. Rheum. Dis. 55, 673-676 (1996).
36. Samanta A, Jones A, Regan M, Wilson S, Doherty M: Is osteoarthritis in women affected by hormonal changes or smoking? Br. J. Rheumatol. 32, 366-370 (1993). (Pubitemid 23181987)
37. Spector TD, Nandra D, Hart DJ, Doyle DV: Is hormone replacement therapy protective for hand and knee osteoarthritis in women? The Chingford Study. Ann. Rheum. Dis. 56, 432-434 (1997). (Pubitemid 27345263)
38. Zhang Y, McAlindon TE, Hannan MT et al.: Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: the Framingham Study. Arthritis Rheum. 41, 1867-1873 (1998).
39. Parazzini F: Menopausal status, hormone replacement therapy use and risk of self-reported physician-diagnosed osteoarthritis in women attending menopause clinics in Italy. Maturitas 46, 207-212 (2003). (Pubitemid 37338408)
40. Karlson EW, Mandl LA, Aweh GN et al.: Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifable risk factors. Am. J. Med. 114, 93-98 (2003).
41. Cirillo DJ, Wallace RB, Wu L, Yood RA: Effect of hormone therapy on risk of hip and knee joint replacement in the Women's Health Initiative. Arthritis Rheum. 54, 3194-3204 (2006). (Pubitemid 44622090)
42. Nevitt MC, Felson DT, Williams EN, Grady D: The effect of estrogen plus progestin on knee symptoms and related disability in postmenopausal women: The Heart and Estrogen/Progestin Replacement Study, a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 44, 811-818 (2001). (Pubitemid 32319773)
43. Tepper S, Hochberg MC: Factors associated with hip osteoarthritis: data from the First National Health and Nutrition Examination Survey (NHANES-I). Am. J. Epidemiol. 137, 1081-1088 (1993). (Pubitemid 23191075)
44. Spector TD, Campion GD: Generalised osteoarthritis: a hormonally mediated disease. Ann. Rheum. Dis. 48, 523-527 (1989).
45. Liu B, Balkwill A, Banks E et al.: Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women. Rheumatology (Oxford) 46, 861-867 (2007). (Pubitemid 47061722)
46. Kalichman L, Kobyliansky E: Age, body composition, and reproductive indices as predictors of radiographic hand osteoarthritis in Chuvashian women. Scand J. Rheumatol. 36, 53-57 (2007). (Pubitemid 46572909)
47. Cooley HM, Stankovich J, Jones G: The association between hormonal and reproductive factors and hand osteoarthritis. Maturitas 45, 257-265 (2003). (Pubitemid 36966738)
48. Remsberg KE, Demerath EW, Schubert CM et al.: Early menarche and the development of cardiovascular disease risk factors in adolescent girls: the Fels Longitudinal Study. J. Clin. Endocrinol. Metab. 90, 2718-2724 (2005). (Pubitemid 40686315)
49. Dawson J, Juszczak E, Thorogood M et al.: An investigation of risk factors for symptomatic osteoarthritis of the knee in women using a life course approach. J. Epidemiol. Community Health 57, 823-830 (2003). (Pubitemid 37260323)
50. Dennison EM, Arden NK, Kellingray S et al.: Hormone replacement therapy, other reproductive variables and symptomatic hip osteoarthritis in elderly white women: a case-control study. Br. J. Rheumatol. 37, 1198-1202 (1998). (Pubitemid 28526077)
51. Spector TD, Roman E, Silman AJ: The pill, parity, and rheumatoid arthritis. Arthritis Rheum. 33, 782-789 (1990). (Pubitemid 20205757)
52. Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ: Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann. Intern. Med. 116, 535-539 (1992).
53. Felson DT: The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Semin. Arthritis Rheum. 20, 42-50 (1990).
54. Gillespie GN, Porteous AJ: Obesity and knee arthroplasty. Knee 14, 81-86 (2007). (Pubitemid 46298812)
55. Sturmer T, Gunther K P, Brenner H: Obesity, overweight and patterns of osteoarthritis: the Ulm Osteoarthritis Study. J. Clin. Epidemiol. 53, 307-313 (2000). (Pubitemid 30173251)
56. Bourne R, Mukhi S, Zhu N, Keresteci M, Marin M: Role of obesity on the risk for total hip or knee arthroplasty. Clin. Orthop. Relat. Res. 465, 185-188 (2007). (Pubitemid 350306514)
57. Sowers MF, Hochberg M, Crabbe JP et al.: Association of bone mineral density and sex hormone levels with osteoarthritis of the hand and knee in premenopausal women. Am. J. Epidemiol. 143, 38-47 (1996). (Pubitemid 26011653)
58. Miyazaki T, Wada M, Kawahara H et al.: Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis. Ann. Rheum. Dis. 61, 617-622 (2002). (Pubitemid 34717773)
59. Dumond H, Presle N, Terlain B et al.: Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 48, 3118-3129 (2003). (Pubitemid 37409323)
60. Abramson SB, Attur M: Developments in the scientifc understanding of osteoarthritis. Arthritis Res. Ther. 11, 227 (2009).
61. Kohrt WM, Malley MT, Dalsky GP, Holloszy JO: Body composition of healthy sedentary and trained, young and older men and women. Med. Sci. Sports Exerc. 24, 832-837 (1992).
62. Bullough PG: The geometry of diarthrodial joints, its physiologic maintenance, and the possible signifcance of age-related changes in geometry-to-load distribution and the development of osteoarthritis. Clin. Orthop. Relat. Res.61-66 (1981).
63. Felson DT, Naimark A, Anderson J et al.: The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 30, 914-918 (1987). (Pubitemid 17140857)
64. Felson DT, Zhang Y, Hannan MT et al.: Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum. 40, 728-733 (1997). (Pubitemid 27157580)
65. Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF: Obesity and knee osteoarthritis. The Framingham Study. Ann. Intern. Med. 109, 18-24 (1988).
66. Spector TD, Hart DJ, Doyle DV: Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population: the effect of obesity. Ann. Rheum. Dis. 53, 565-568 (1994)
67. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 43, 1905-1915 (2000).
68. Pendleton A, Arden N, Dougados M et al.: EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann. Rheum. Dis. 59, 936-944 (2000). (Pubitemid 32464004)
69. Miller GD, Rejeski WJ, Williamson JD et al.: The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results. Control Clin. Trials 24, 462-480 (2003).
70. Miller GD, Nicklas BJ, Davis C et al.: Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity (Silver Spring) 14, 1219-1230 (2006). (Pubitemid 46219688)
71. Messier SP, Gutekunst DJ, Davis C, DeVita P: Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum. 52, 2026-2032 (2005). (Pubitemid 40994325)
72. Felson DT, Goggins J, Niu J, Zhang Y, Hunter DJ: The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum. 50, 3904-3909 (2004). (Pubitemid 39643937)
73. Nguyen AD, Shultz SJ: Sex differences in clinical measures of lower extremity alignment. J. Orthop. Sports Phys. Ther. 37, 389-398 (2007).
74. Sharma L, Song J, Felson DT et al.: The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA 286, 188-195 (2001). (Pubitemid 32640850)
75. Felson DT, McLaughlin S, Goggins J et al.: Bone marrow edema and its relation to progression of knee osteoarthritis. Ann. Intern. Med. 139, 330-336 (2003). (Pubitemid 38124588)
76. Toda Y, Toda T, Takemura S et al.: Change in body fat, but not body weight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after a weigh tcontrol program. J. Rheumatol. 25, 2181-2186 (1998). (Pubitemid 28505866)
77. Otterness IG, Eskra JD, Bliven ML et al.: Exercise protects against articular cartilage degeneration in the hamster. Arthritis Rheum. 41, 2068-2076 (1998).
78. Galois L, Etienne S, Grossin L et al.: Moderate-impact exercise is associated with decreased severity of experimental osteoarthritis in rats. Rheumatology (Oxford) 42, 692-693; author reply 693-694 (2003). (Pubitemid 37220881)
79. Lane NE, Buckwalter JA: Exercise and osteoarthritis. Curr. Opin. Rheumatol. 11, 413-416 (1999).
80. Spector TD, Harris PA, Hart DJ et al.: Risk of osteoarthritis associated with long-term weight-bearing sports: a radiologic survey of the hips and knees in female ex-athletes and population controls. Arthritis Rheum. 39, 988-995 (1996).
81. Kiviranta I, Tammi M, Jurvelin J et al.: Articular cartilage thickness and glycosaminoglycan distribution in the young canine knee joint after remobilization of the immobilized limb. J. Orthop. Res. 12, 161-167 (1994). (Pubitemid 24146879)
82. Felson DT, Niu J, Clancy M et al.: Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study. Arthritis Rheum. 57, 6-12 (2007). (Pubitemid 46256719)
83. Rogers LQ, Macera CA, Hootman JM, Ainsworth BE, Blairi SN: The association between joint stress from physical activity and self-reported osteoarthritis: an analysis of the Cooper Clinic data. Osteoarthritis Cartilage 10, 617-622 (2002).
84. Manninen P, Riihimaki H, Heliovaara M, Suomalainen O: Physical exercise and risk of severe knee osteoarthritis requiring arthroplasty. Rheumatology (Oxford) 40, 432-437 (2001). (Pubitemid 32409557)
85. Felson DT, Zhang Y: An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 41, 1343-1355 (1998). (Pubitemid 28373113)
86. Gwinn DE, Wilckens JH, McDevitt ER, Ross G, Kao TC: The relative incidence of anterior cruciate ligament injury in men and women at the United States Naval Academy. Am. J. Sports Med. 28, 98-102 (2000). (Pubitemid 30056337)
87. Hutchinson MR, Ireland ML: Knee injuries in female athletes. Sports Med. 19, 288-302 (1995).
88. McAlindon TE, Wilson PW, Aliabadi P, Weissman B, Felson DT: Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study. Am. J. Med. 106, 151-157 (1999). (Pubitemid 29115954)
89. Vingard E, Alfredsson L, Malchau H: Osteoarthrosis of the hip in women and its relationship to physical load from sports activities. Am. J. Sports Med. 26, 78-82 (1998). (Pubitemid 28086407)
90. Felson DT, Hannan MT, Naimark A et al.: Occupational physical demands, knee bending, and knee osteoarthritis: results from the Framingham Study. J. Rheumatol. 18, 1587-1592 (1991).
91. Ettinger WH Jr, Burns R, Messier SP et al.: A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). JAMA 277, 25-31 (1997). (Pubitemid 27009037)
92. Lange AK, Vanwanseele B, Fiatarone Singh MA: Strength training for treatment of osteoarthritis of the knee: a systematic review. Arthritis Rheum. 59, 1488-1494 (2008).
93. Urquhart DM, Soufan C, Teichtahl AJ et al.: Factors that may mediate the relationship between physical activity and the risk for developing knee osteoarthritis. Arthritis Res. Ther. 10, 203 (2008). (Pubitemid 351659659)
94. Bosomworth NJ: Exercise and knee osteoarthritis: beneft or hazard? Can. Fam. Physician 55, 871-878 (2009).
95. Zhang W, Moskowitz RW, Nuki G et al.: OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16, 137-162 (2008) (Pubitemid 351222155)
96. Exercise prescription for older adults with osteoarthritis pain: consensus practice recommendations. A supplement to the AGS Clinical Practice Guidelines on the management of chronic pain in older adults. J. Am. Geriatr. Soc. 49, 808-823 (2001).
97. Vignon E, Valat JP, Rossignol M et al.: Osteoarthritis of the knee and hip and activity: a systematic international review and synthesis (OASIS). Joint Bone Spine 73, 442-455 (2006).
98. Roddy E, Zhang W, Doherty M et al.: Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee-the MOVE consensus. Rheumatology (Oxford) 44, 67-73 (2005). (Pubitemid 40124334)
99. Jordan KM, Arden NK, Doherty M et al.: EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann. Rheum. Dis. 62, 1145-1155 (2003). (Pubitemid 37500619)
100. Zhang W, Doherty M, Arden N et al.: EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann. Rheum. Dis. 64, 669-681 (2005). (Pubitemid 40559291)
101. Manninen P, Heliovaara M, Riihimaki H, Suoma-Iainen O: Physical workload and the risk of severe knee osteoarthritis. Scand. J. Work Environ. Health 28, 25-32 (2002). (Pubitemid 34591149)
102. Hootman JM, Macera CA, Helmick CG, Blair SN: Infuence of physical activity-related joint stress on the risk of self-reported hip/knee osteoarthritis: a new method to quantify physical activity. Prev. Med. 36, 636-644 (2003).
103. Cheng Y, Macera CA, Davis DR et al.: Physical activity and self-reported, physician-diagnosed osteoarthritis: is physical activity a risk factor? J. Clin. Epidemiol. 53, 315-322 (2000). (Pubitemid 30173252)