Effect of diplacone on lps-induced inflammatory gene expression in macrophages

Folia Biologica

Volumn 56, Issue 3, 2010, Pages 124-130

  Hošek, Jan ^a   Zavalova V ^a   Smejkal K ^a   Bartos M ^a,b  

^a UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^b Genex CZ   (Czech Republic)

Author keywords

Geranyl flavanone; Inflammation; MCP 1; mRNA; TNF ; ZFP36

Indexed keywords

DIPLACONE; FLAVONOID; INDOMETACIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRISTETRAPROLIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PROPOLIN C;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL LINE; MACROPHAGE; UPREGULATION; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM;

CELL LINE; CHEMOKINE CCL2; FLAVONOIDS; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MOLECULAR STRUCTURE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954391863     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Assreuy, A. M. S., Alencar, N. M. N., Cavada, B. S., Rocha, D. R., Feitosa, R. F. G., Cunha, F. Q., Calvete, J. J., Ribeiro, R. A. (2003) Porcine spermadhesin PSP-I/PSP-II stimulates macrophages to release a neutrophil chemotactic substance: Modulation by mast cells. Biol. Reprod. 68, 1836-1841.
2. Auwerx, J. (1991) The human leukemia-cell line, Thp-1 - a multifaceted model for the study of monocyte-macrophage differentiation. Experientia 47, 22-31.
3. Bodet, C., La, V. D., Epifano, F., Grenier, D. (2008) Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models. J. Periodont. Res. 43, 400-407.
4. Chen, C. N., Wu, C. L., Lin, J. K. (2004) Propolin C from propolis induces apoptosis through activating caspases, Bid and cytochrome c release in human melanoma cells. Biochem. Pharmacol. 67, 53-66.
5. Deleault, K. M., Skinner, S. J., Brooks, S. A. (2008) Tristetraprolin regulates TNF TNF-α mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways. Mol. Immunol. 45, 13-24.
6. Dixon, R. A. (2004) Phytoestrogens. Annu. Rev. Plant. Biol. 55, 225-261.
7. Geraets, L., Haegens, A., Brauers, K., Haydock, J. A., Vernooy, J. H., Wouters, E. F., Bast, A., Hageman, G. J. (2009) Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. Biochem. Biophys. Res. Commun. 382, 598-603.
8. Guardia, T., Rotelli, A. E., Juarez, A. O., Pelzer, L. E. (2001) Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 56, 683-687.
9. Hämäläinen, M., Nieminen, R., Vuorela, P., Heinonen, M., Moilanen, E. (2007) Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediat. Inflamm. 2007, 45673.
10. Havsteen, B. H. (2002) The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 96, 67-202.
11. Lin, N., Sato, T., Takayama, Y., Mimaki, Y., Sashida, Y., Yano, M., Ito, A. (2003) Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem. Pharmacol. 65, 2065-2071.
12. Manna, S. K., Aggarwal, R. S., Sethi, G., Aggarwal, B. B., Ramesh, G. T. (2007) Morin (3,5,7,2′,4′-Pentahydroxyflavone) abolishes nuclear factor-κB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-κB-regulated gene expression and up-regulation of apoptosis. Clin. Cancer Res. 13, 2290-2297.
13. Matsuda, H., Wang, Q., Matsuhira, K., Nakamura, S., Yuan, D., Yoshikawa, M. (2008) Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells. Phytomedicine 15, 177-184.
14. Murphy, B. T., Cao, S., Norris, A., Miller, J. S., Ratovoson, F., Andriantsiferana, R., Rasamison, V. E., Kingston, D. G. (2005) Cytotoxic flavanones of Schizolaena hystrix from the Madagascar rainforest. J. Nat. Prod. 68, 417-419.
15. Njamen, D., Mbafor, J. T., Fomum, Z. T., Kamanyi, A., Mbanya, J. C., Recio, M. C., Giner, R. M., Manez, S., Rios, J. L. (2004) Anti-inflammatory activities of two flavanones, sigmoidin A and sigmoidin B, from Erythrina sigmoidea. Planta Med. 70, 104-107.
16. O'Shea, J. J., Ma, A., Lipsky, P. (2002) Cytokines and autoimmunity. Nat. Rev. Immunol. 2, 37-45.
17. Pahl, H. L. (1999) Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853-6866.
18. Park, J. S., Woo, M. S., Kim, D. H., Hyun, J. W., Kim, W. K., Lee, J. C., Kim, H. S. (2007) Anti-inflammatory mechanisms of isoflavone metabolites in lipopolysaccharidestimulated microglial cells. J. Pharmacol. Exp. Ther. 320, 1237-1245.
19. Phillips, W. R., Baj, N. J., Gunatilaka, A. A., Kingston, D. G. (1996) C-geranyl compounds from Mimulus clevelandii. J. Nat. Prod. 59, 495-497.
20. Phommart, S., Sutthivaiyakit, P., Chimnoi, N., Ruchirawat, S., Sutthivaiyakit, S. (2005) Constituents of the leaves of Macaranga tanarius. J. Nat. Prod. 68, 927-930.
21. Plaeger, S. F. (2003) Clinical immunology and traditional herbal medicines. Clin. Diagn. Lab. Immunol. 10, 337-338.
22. Sauer, I., Schaljo, B., Vogl, C., Gattermeier, I., Kolbe, T., Muller, M., Blackshear, P. J., Kovarik, P. (2006) Interferons limit inflammatory responses by induction of tristetraprolin. Blood 107, 4790-4797.
23. Sharif, O., Bolshakov, V. N., Raines, S., Newham, P., Perkins, N. D. (2007) Transcriptional profiling of the LPS induced NF-κB response in macrophages. BMC Immunol. 8, 1.
24. Shin, E. K., Kwon, H. S., Kim, Y. H., Shin, H. K., Kim, J. K. (2009) Chrysin, a natural flavone, improves murine inflammatory bowel diseases. Biochem. Biophys. Res. Commun. 381, 502-507.
25. Smejkal, K., Grycova, L., Marek, R., Lemiere, F., Jankovska, D., Forejtnikova, H., Vanco, J., Suchy, V. (2007) C-Geranyl compounds from Paulownia tomentosa fruits. J. Nat. Prod. 70, 1244-1248.
26. Smejkal, K., Babula, P., Slapetova, T., Brognara, E., Dall'acqua, S., Zemlicka, M., Innocenti, G., Cvacka, J. (2008a) Cytotoxic activity of C-geranyl compounds from Paulownia tomentosa fruits. Planta Med. 74, 1488-1491.
27. Smejkal, K., Chudik, S., Kloucek, P., Marek, R., Cvacka, J., Urbanova, M., Julinek, O., Kokoska, L., Slapetova, T., Holubova, P., Zima, A., Dvorska, M. (2008b) Antibacterial C-geranylflavonoids from Paulownia tomentosa fruits. J. Nat. Prod. 71, 706-709.
28. Vafeiadou, K., Vauzour, D., Lee, H. Y., Rodriguez-Mateos, A., Williams, R. J., Spencer, J. P. (2009) The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch. Biochem. Biophys. 484, 100-109.
29. Weseler, A. R., Geraets, L., Moonen, H. J. J., Manders, R. J. F., van Loon, L. J. C., Pennings, H. J., Wouters, E. E. M., Bast, A., Hageman, G. J. (2009) Poly (ADP-ribose) polymerase1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes. J. Nutr. 139, 952-957.
30. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., Chen, C. H. (2008) Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. J. Agric. Food Chem. 56, 838-2845.
31. Yoder, B. J., Cao, S., Norris, A., Miller, J. S., Ratovoson, F., Razafitsalama, J., Andriantsiferana, R., Rasamison, V. E., Kingston, D. G. (2007) Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. J. Nat. Prod. 70, 342-346.