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Volumn 40, Issue 3, 2010, Pages 237-247

The importance of steatosis in chronic hepatitis C infection and its management: A review

Author keywords

Genotype; Hepatitis C virus; Steatosis; Sustained virological response

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FATTY ACID; HEPCIDIN; INSULIN; INSULIN RECEPTOR SUBSTRATE; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; METFORMIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PEGINTERFERON ALPHA2A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIOGLITAZONE; PLACEBO; RIBAVIRIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 77954378905     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2010.00626.x     Document Type: Review
Times cited : (20)

References (93)
  • 1
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004, 126:586-97.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.E.2    Loria, P.3    Carulli, N.4    Ruggiero, G.5    Day, C.P.6
  • 2
    • 37849038662 scopus 로고    scopus 로고
    • Combination of oxidative stress and steatosis is a risk factor for fibrosis in alcohol-drinking patients with chronic hepatitis C
    • Vidali M, Occhino G, Ivaldi A, Rigamonti C, Sartori M, Albano E. Combination of oxidative stress and steatosis is a risk factor for fibrosis in alcohol-drinking patients with chronic hepatitis C. Am J Gastroenterol 2008, 103:147-53.
    • (2008) Am J Gastroenterol , vol.103 , pp. 147-153
    • Vidali, M.1    Occhino, G.2    Ivaldi, A.3    Rigamonti, C.4    Sartori, M.5    Albano, E.6
  • 3
    • 0034997875 scopus 로고    scopus 로고
    • Outcome of liver disease in a large cohort of histologically proven chronic hepatitis C: influence of HCV genotype
    • Roffi L, Redaelli A, Colloredo G. Outcome of liver disease in a large cohort of histologically proven chronic hepatitis C: influence of HCV genotype. Eur J Gastroenterol Hepatol 2001, 13:501-6.
    • (2001) Eur J Gastroenterol Hepatol , vol.13 , pp. 501-506
    • Roffi, L.1    Redaelli, A.2    Colloredo, G.3
  • 4
    • 0036727323 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol
    • Monto A, Alonzo J, Watson JJ, Grunfeld C, Wright TL. Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology 2002, 36:729-36.
    • (2002) Hepatology , vol.36 , pp. 729-736
    • Monto, A.1    Alonzo, J.2    Watson, J.J.3    Grunfeld, C.4    Wright, T.L.5
  • 5
    • 0345017776 scopus 로고    scopus 로고
    • Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes
    • Aytug S, Reich D, Sapiro LE, Bernstein D, Begum N. Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes. Hepatology 2003, 38:1384-92.
    • (2003) Hepatology , vol.38 , pp. 1384-1392
    • Aytug, S.1    Reich, D.2    Sapiro, L.E.3    Bernstein, D.4    Begum, N.5
  • 6
    • 7244243810 scopus 로고    scopus 로고
    • Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3
    • Kawaguchi T, Yoshida T, Harada M. Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. Am J Pathol 2004, 165:1499-508.
    • (2004) Am J Pathol , vol.165 , pp. 1499-1508
    • Kawaguchi, T.1    Yoshida, T.2    Harada, M.3
  • 7
    • 21044456174 scopus 로고    scopus 로고
    • Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C
    • Fartoux L, Poujol-Robert A, Guechot J, Wendum D, Poupon R, Serfaty L. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut 2005, 54:1003-8.
    • (2005) Gut , vol.54 , pp. 1003-1008
    • Fartoux, L.1    Poujol-Robert, A.2    Guechot, J.3    Wendum, D.4    Poupon, R.5    Serfaty, L.6
  • 8
    • 0346874154 scopus 로고    scopus 로고
    • In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy
    • Hickman IJ, Powell EE, Prins JB. In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy. J Hepatol 2003, 39:1042-8.
    • (2003) J Hepatol , vol.39 , pp. 1042-1048
    • Hickman, I.J.1    Powell, E.E.2    Prins, J.B.3
  • 9
    • 33845990292 scopus 로고    scopus 로고
    • Lipocalins and insulin resistance: etiological role of retinol-binding protein 4 and lipocalin-2?
    • van Dam RM, Hu FB. Lipocalins and insulin resistance: etiological role of retinol-binding protein 4 and lipocalin-2? Clin Chem 2007, 53:5-7.
    • (2007) Clin Chem , vol.53 , pp. 5-7
    • van Dam, R.M.1    Hu, F.B.2
  • 10
    • 30444461216 scopus 로고    scopus 로고
    • Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
    • Larter CZ, Farrell GC. Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat? J Hepatol 2006, 44:253-61.
    • (2006) J Hepatol , vol.44 , pp. 253-261
    • Larter, C.Z.1    Farrell, G.C.2
  • 11
    • 33745095399 scopus 로고    scopus 로고
    • Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
    • Graham TE, Yang Q, Bluher M. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006, 354:2552-63.
    • (2006) N Engl J Med , vol.354 , pp. 2552-2563
    • Graham, T.E.1    Yang, Q.2    Bluher, M.3
  • 12
    • 84984586017 scopus 로고    scopus 로고
    • Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C
    • Liu CJ, Chen PJ, Jeng YM. Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C. J Hepatol 2005, 43:235-42.
    • (2005) J Hepatol , vol.43 , pp. 235-242
    • Liu, C.J.1    Chen, P.J.2    Jeng, Y.M.3
  • 13
    • 47149104844 scopus 로고    scopus 로고
    • Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1
    • Petta S, Camma C, Di Marco V. Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1. Hepatology 2008, 48:28-37.
    • (2008) Hepatology , vol.48 , pp. 28-37
    • Petta, S.1    Camma, C.2    Di Marco, V.3
  • 14
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003, 125:437-43.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 16
    • 12144289459 scopus 로고    scopus 로고
    • Early HCV dynamics on Peg-interferon and ribavirin in HIV/HCV co-infection: indications for the investigation of new treatment approaches
    • Ballesteros AL, Franco S, Fuster D. Early HCV dynamics on Peg-interferon and ribavirin in HIV/HCV co-infection: indications for the investigation of new treatment approaches. Aids 2004, 18:59-66.
    • (2004) Aids , vol.18 , pp. 59-66
    • Ballesteros, A.L.1    Franco, S.2    Fuster, D.3
  • 17
    • 17844385292 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients
    • Adinolfi LE, Ingrosso D, Cesaro G. Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology 2005, 41:995-1003.
    • (2005) Hepatology , vol.41 , pp. 995-1003
    • Adinolfi, L.E.1    Ingrosso, D.2    Cesaro, G.3
  • 18
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001, 33:1358-64.
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 19
    • 0033933140 scopus 로고    scopus 로고
    • Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3
    • Rubbia-Brandt L, Quadri R, Abid K. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J Hepatol 2000, 33:106-15.
    • (2000) J Hepatol , vol.33 , pp. 106-115
    • Rubbia-Brandt, L.1    Quadri, R.2    Abid, K.3
  • 20
    • 0035572430 scopus 로고    scopus 로고
    • Liver steatosis in chronic hepatitis C: a morphological sign suggesting infection with HCV genotype 3
    • Rubbia-Brandt L, Leandro G, Spahr L. Liver steatosis in chronic hepatitis C: a morphological sign suggesting infection with HCV genotype 3. Histopathology 2001, 39:119-24.
    • (2001) Histopathology , vol.39 , pp. 119-124
    • Rubbia-Brandt, L.1    Leandro, G.2    Spahr, L.3
  • 21
    • 0030859121 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces hepatic steatosis in transgenic mice
    • Moriya K, Yotsuyanagi H, Shintani Y. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol 1997, 78:1527-31.
    • (1997) J Gen Virol , vol.78 , pp. 1527-1531
    • Moriya, K.1    Yotsuyanagi, H.2    Shintani, Y.3
  • 22
    • 0036830436 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response
    • Kumar D, Farrell GC, Fung C, George J. Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response. Hepatology 2002, 36:1266-72.
    • (2002) Hepatology , vol.36 , pp. 1266-1272
    • Kumar, D.1    Farrell, G.C.2    Fung, C.3    George, J.4
  • 23
    • 37649012154 scopus 로고    scopus 로고
    • Hepatic steatosis in chronic hepatitis C: baseline host and viral characteristics and influence on response to therapy with peginterferon alpha-2a plus ribavirin
    • Reddy KR, Govindarajan S, Marcellin P. Hepatic steatosis in chronic hepatitis C: baseline host and viral characteristics and influence on response to therapy with peginterferon alpha-2a plus ribavirin. J Viral Hepat 2008, 15:129-36.
    • (2008) J Viral Hepat , vol.15 , pp. 129-136
    • Reddy, K.R.1    Govindarajan, S.2    Marcellin, P.3
  • 24
    • 10744224572 scopus 로고    scopus 로고
    • Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis
    • Castera L, Hezode C, Roudot-Thoraval F. Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis. Gut 2004, 53:420-4.
    • (2004) Gut , vol.53 , pp. 420-424
    • Castera, L.1    Hezode, C.2    Roudot-Thoraval, F.3
  • 25
    • 11144357274 scopus 로고    scopus 로고
    • Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
    • Barba G, Harper F, Harada T. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc Natl Acad Sci USA 1997, 94:1200-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1200-1205
    • Barba, G.1    Harper, F.2    Harada, T.3
  • 26
    • 0031712813 scopus 로고    scopus 로고
    • The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
    • Moriya K, Fujie H, Shintani Y. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998, 4:1065-7.
    • (1998) Nat Med , vol.4 , pp. 1065-1067
    • Moriya, K.1    Fujie, H.2    Shintani, Y.3
  • 27
    • 18244365866 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis
    • Perlemuter G, Sabile A, Letteron P. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. Faseb J 2002, 16:185-94.
    • (2002) Faseb J , vol.16 , pp. 185-194
    • Perlemuter, G.1    Sabile, A.2    Letteron, P.3
  • 28
    • 47149095922 scopus 로고    scopus 로고
    • Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis
    • Piodi A, Chouteau P, Lerat H, Hezode C, Pawlotsky JM. Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis. Hepatology 2008, 48:16-27.
    • (2008) Hepatology , vol.48 , pp. 16-27
    • Piodi, A.1    Chouteau, P.2    Lerat, H.3    Hezode, C.4    Pawlotsky, J.M.5
  • 29
    • 0035068318 scopus 로고    scopus 로고
    • Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C
    • Serfaty L, Andreani T, Giral P, Carbonell N, Chazouilleres O, Poupon R. Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C. J Hepatol 2001, 34:428-34.
    • (2001) J Hepatol , vol.34 , pp. 428-434
    • Serfaty, L.1    Andreani, T.2    Giral, P.3    Carbonell, N.4    Chazouilleres, O.5    Poupon, R.6
  • 30
    • 0026470990 scopus 로고
    • Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
    • Wetterau JR, Aggerbeck LP, Bouma ME. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science 1992, 258:999-1001.
    • (1992) Science , vol.258 , pp. 999-1001
    • Wetterau, J.R.1    Aggerbeck, L.P.2    Bouma, M.E.3
  • 31
    • 18344370950 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity
    • Tsutsumi T, Suzuki T, Shimoike T. Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity. Hepatology 2002, 35:937-46.
    • (2002) Hepatology , vol.35 , pp. 937-946
    • Tsutsumi, T.1    Suzuki, T.2    Shimoike, T.3
  • 32
    • 23044450214 scopus 로고    scopus 로고
    • Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver
    • Yamaguchi A, Tazuma S, Nishioka T. Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver. Dig Dis Sci 2005, 50:1361-71.
    • (2005) Dig Dis Sci , vol.50 , pp. 1361-1371
    • Yamaguchi, A.1    Tazuma, S.2    Nishioka, T.3
  • 33
    • 33644882808 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection
    • de Gottardi A, Pazienza V, Pugnale P. Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection. Aliment Pharmacol Ther 2006, 23:107-14.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 107-114
    • de Gottardi, A.1    Pazienza, V.2    Pugnale, P.3
  • 34
    • 31644451456 scopus 로고    scopus 로고
    • Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A
    • Cheng Y, Dharancy S, Malapel M, Desreumaux P. Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A. World J Gastroenterol 2005, 11:7591-6.
    • (2005) World J Gastroenterol , vol.11 , pp. 7591-7596
    • Cheng, Y.1    Dharancy, S.2    Malapel, M.3    Desreumaux, P.4
  • 35
    • 77954360765 scopus 로고    scopus 로고
    • Steatosis and intrahepatic expression levels of genes regulating lipid metabolism in Japanese patients with chronic hepatitis C
    • Yasui KHY, Mitsuyoshi H, Tsuji K. Steatosis and intrahepatic expression levels of genes regulating lipid metabolism in Japanese patients with chronic hepatitis C. Hepatology 2008, 48(4):775A. Suppl
    • (2008) Hepatology , vol.48 , Issue.4 SUPPL
    • Yasui, K.H.Y.1    Mitsuyoshi, H.2    Tsuji, K.3
  • 36
    • 0028618516 scopus 로고
    • Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population
    • Allison ME, Wreghitt T, Palmer CR, Alexander GJ. Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population. J Hepatol 1994, 21:1135-9.
    • (1994) J Hepatol , vol.21 , pp. 1135-1139
    • Allison, M.E.1    Wreghitt, T.2    Palmer, C.R.3    Alexander, G.J.4
  • 37
    • 0034032877 scopus 로고    scopus 로고
    • Increased risk of type 2 diabetes in noncirrhotic patients with chronic hepatitis C virus infection
    • Knobler H, Schihmanter R, Zifroni A, Fenakel G, Schattner A. Increased risk of type 2 diabetes in noncirrhotic patients with chronic hepatitis C virus infection. Mayo Clin Proc 2000, 75:355-9.
    • (2000) Mayo Clin Proc , vol.75 , pp. 355-359
    • Knobler, H.1    Schihmanter, R.2    Zifroni, A.3    Fenakel, G.4    Schattner, A.5
  • 38
    • 0033779703 scopus 로고    scopus 로고
    • Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States
    • Mehta SH, Brancati FL, Sulkowski MS, Strathdee SA, Szklo M, Thomas DL. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med 2000, 133:592-9.
    • (2000) Ann Intern Med , vol.133 , pp. 592-599
    • Mehta, S.H.1    Brancati, F.L.2    Sulkowski, M.S.3    Strathdee, S.A.4    Szklo, M.5    Thomas, D.L.6
  • 39
    • 13744254182 scopus 로고    scopus 로고
    • Chronic hepatitis C and type II diabetes mellitus: a prospective cross-sectional study
    • Zein CO, Levy C, Basu A, Zein NN. Chronic hepatitis C and type II diabetes mellitus: a prospective cross-sectional study. Am J Gastroenterol 2005, 100:48-55.
    • (2005) Am J Gastroenterol , vol.100 , pp. 48-55
    • Zein, C.O.1    Levy, C.2    Basu, A.3    Zein, N.N.4
  • 40
    • 0037282977 scopus 로고    scopus 로고
    • Association between hepatitis C, diabetes mellitus, and race. a case-control study
    • Thuluvath PJ, John PR. Association between hepatitis C, diabetes mellitus, and race. a case-control study. Am J Gastroenterol 2003, 98:438-41.
    • (2003) Am J Gastroenterol , vol.98 , pp. 438-441
    • Thuluvath, P.J.1    John, P.R.2
  • 41
    • 53249121480 scopus 로고    scopus 로고
    • Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis
    • White DL, Ratziu V, El-Serag HB. Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis. J Hepatol 2008, 49:831-44.
    • (2008) J Hepatol , vol.49 , pp. 831-844
    • White, D.L.1    Ratziu, V.2    El-Serag, H.B.3
  • 42
    • 0345655291 scopus 로고    scopus 로고
    • Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected
    • Hui JM, Sud A, Farrell GC. Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected. Gastroenterology 2003, 125:1695-704.
    • (2003) Gastroenterology , vol.125 , pp. 1695-1704
    • Hui, J.M.1    Sud, A.2    Farrell, G.C.3
  • 43
    • 77954358029 scopus 로고    scopus 로고
    • Serum hepcidin levels are related to viral load and to histological severity of liver lesions in chronic hepatitis C
    • Tsochatzis EPG, Koliaraki V, Manesis EK, Mamalaki A, Archimandritis AJ. Serum hepcidin levels are related to viral load and to histological severity of liver lesions in chronic hepatitis C. Hepatology 2008, 48:774A.
    • (2008) Hepatology , vol.48
    • Tsochatzis, E.P.G.1    Koliaraki, V.2    Manesis, E.K.3    Mamalaki, A.4    Archimandritis, A.J.5
  • 44
    • 0031055840 scopus 로고    scopus 로고
    • Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype
    • Mihm S, Fayyazi A, Hartmann H, Ramadori G. Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype. Hepatology 1997, 25:735-9.
    • (1997) Hepatology , vol.25 , pp. 735-739
    • Mihm, S.1    Fayyazi, A.2    Hartmann, H.3    Ramadori, G.4
  • 45
    • 10744220759 scopus 로고    scopus 로고
    • Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C
    • Asselah T, Boyer N, Guimont MC. Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C. Gut 2003, 52:1638-43.
    • (2003) Gut , vol.52 , pp. 1638-1643
    • Asselah, T.1    Boyer, N.2    Guimont, M.C.3
  • 46
    • 0141757418 scopus 로고    scopus 로고
    • Worsening of steatosis and fibrosis progression in hepatitis C
    • Castera L, Pawlotsky JM, Dhumeaux D. Worsening of steatosis and fibrosis progression in hepatitis C. Gut 2003, 52:1531.
    • (2003) Gut , vol.52 , pp. 1531
    • Castera, L.1    Pawlotsky, J.M.2    Dhumeaux, D.3
  • 47
    • 0038122773 scopus 로고    scopus 로고
    • Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C
    • Poynard T, Ratziu V, McHutchison J. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology 2003, 38:75-85.
    • (2003) Hepatology , vol.38 , pp. 75-85
    • Poynard, T.1    Ratziu, V.2    McHutchison, J.3
  • 48
    • 10744227418 scopus 로고    scopus 로고
    • The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients
    • Patton HM, Patel K, Behling C. The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients. J Hepatol 2004, 40:484-90.
    • (2004) J Hepatol , vol.40 , pp. 484-490
    • Patton, H.M.1    Patel, K.2    Behling, C.3
  • 49
    • 10744224920 scopus 로고    scopus 로고
    • Steatosis affects chronic hepatitis C progression in a genotype specific way
    • Rubbia-Brandt L, Fabris P, Paganin S. Steatosis affects chronic hepatitis C progression in a genotype specific way. Gut 2004, 53:406-12.
    • (2004) Gut , vol.53 , pp. 406-412
    • Rubbia-Brandt, L.1    Fabris, P.2    Paganin, S.3
  • 50
    • 77953987260 scopus 로고    scopus 로고
    • Prospective Comparison of Fibroscan, King's Score and Liver Biopsy for the Assessment of Cirrhosis in Chronic Hepatitis C infection
    • Cross TJ, Calvaruso V, Maimone S. Prospective Comparison of Fibroscan, King's Score and Liver Biopsy for the Assessment of Cirrhosis in Chronic Hepatitis C infection. J Viral Hepat 2009
    • (2009) J Viral Hepat
    • Cross, T.J.1    Calvaruso, V.2    Maimone, S.3
  • 51
    • 67651139900 scopus 로고    scopus 로고
    • Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial
    • Lok AS, Everhart JE, Chung RT. Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial. Hepatology 2009, 49:1828-37.
    • (2009) Hepatology , vol.49 , pp. 1828-1837
    • Lok, A.S.1    Everhart, J.E.2    Chung, R.T.3
  • 52
    • 0032146915 scopus 로고    scopus 로고
    • Host- and disease-specific factors affecting steatosis in chronic hepatitis C
    • Czaja AJ, Carpenter HA, Santrach PJ, Moore SB. Host- and disease-specific factors affecting steatosis in chronic hepatitis C. J Hepatol 1998, 29:198-206.
    • (1998) J Hepatol , vol.29 , pp. 198-206
    • Czaja, A.J.1    Carpenter, H.A.2    Santrach, P.J.3    Moore, S.B.4
  • 53
    • 0036381117 scopus 로고    scopus 로고
    • Genotype-specific mechanisms for hepatic steatosis in chronic hepatitis C infection
    • Hui JM, Kench J, Farrell GC. Genotype-specific mechanisms for hepatic steatosis in chronic hepatitis C infection. J Gastroenterol Hepatol 2002, 17:873-81.
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 873-881
    • Hui, J.M.1    Kench, J.2    Farrell, G.C.3
  • 54
    • 29244484291 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: why does it really matter?
    • Asselah T, Rubbia-Brandt L, Marcellin P, Negro F. Steatosis in chronic hepatitis C: why does it really matter? Gut 2006, 55:123-30.
    • (2006) Gut , vol.55 , pp. 123-130
    • Asselah, T.1    Rubbia-Brandt, L.2    Marcellin, P.3    Negro, F.4
  • 55
    • 38649120719 scopus 로고    scopus 로고
    • Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis
    • Moucari R, Asselah T, Cazals-Hatem D. Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. Gastroenterology 2008, 134:416-23.
    • (2008) Gastroenterology , vol.134 , pp. 416-423
    • Moucari, R.1    Asselah, T.2    Cazals-Hatem, D.3
  • 56
    • 33646529840 scopus 로고    scopus 로고
    • Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data
    • Leandro G, Mangia A, Hui J. Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data. Gastroenterology 2006, 130:1636-42.
    • (2006) Gastroenterology , vol.130 , pp. 1636-1642
    • Leandro, G.1    Mangia, A.2    Hui, J.3
  • 57
    • 0036294003 scopus 로고    scopus 로고
    • Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C
    • Hickman IJ, Clouston AD, Macdonald GA. Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C. Gut 2002, 51:89-94.
    • (2002) Gut , vol.51 , pp. 89-94
    • Hickman, I.J.1    Clouston, A.D.2    Macdonald, G.A.3
  • 58
    • 0035117297 scopus 로고    scopus 로고
    • Steatosis and chronic hepatitis C: analysis of fibrosis and stellate cell activation
    • Clouston AD, Jonsson JR, Purdie DM. Steatosis and chronic hepatitis C: analysis of fibrosis and stellate cell activation. J Hepatol 2001, 34:314-20.
    • (2001) J Hepatol , vol.34 , pp. 314-320
    • Clouston, A.D.1    Jonsson, J.R.2    Purdie, D.M.3
  • 59
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis
    • Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 1997, 94:2557-62.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 60
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, Li K, Beard MR. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002, 122:366-75.
    • (2002) Gastroenterology , vol.122 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3
  • 61
    • 8544254757 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features
    • Paradis V, Mathurin P, Kollinger M. In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features. J Clin Pathol 1997, 50:401-6.
    • (1997) J Clin Pathol , vol.50 , pp. 401-406
    • Paradis, V.1    Mathurin, P.2    Kollinger, M.3
  • 62
    • 0030854425 scopus 로고    scopus 로고
    • A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C
    • Houglum K, Venkataramani A, Lyche K, Chojkier M. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 1997, 113:1069-73.
    • (1997) Gastroenterology , vol.113 , pp. 1069-1073
    • Houglum, K.1    Venkataramani, A.2    Lyche, K.3    Chojkier, M.4
  • 63
    • 0029165057 scopus 로고
    • Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver
    • Teli MR, Day CP, Burt AD, Bennett MK, James OF. Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 1995, 346:987-90.
    • (1995) Lancet , vol.346 , pp. 987-990
    • Teli, M.R.1    Day, C.P.2    Burt, A.D.3    Bennett, M.K.4    James, O.F.5
  • 66
    • 0036185832 scopus 로고    scopus 로고
    • Risk factors of fibrosis in alcohol-induced liver disease
    • Raynard B, Balian A, Fallik D. Risk factors of fibrosis in alcohol-induced liver disease. Hepatology 2002, 35:635-8.
    • (2002) Hepatology , vol.35 , pp. 635-638
    • Raynard, B.1    Balian, A.2    Fallik, D.3
  • 67
    • 1542287381 scopus 로고    scopus 로고
    • Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
    • Shintani Y, Fujie H, Miyoshi H. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004, 126:840-8.
    • (2004) Gastroenterology , vol.126 , pp. 840-848
    • Shintani, Y.1    Fujie, H.2    Miyoshi, H.3
  • 68
    • 0030052322 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C
    • Larrea E, Garcia N, Qian C, Civeira MP, Prieto J. Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C. Hepatology 1996, 23:210-17.
    • (1996) Hepatology , vol.23 , pp. 210-217
    • Larrea, E.1    Garcia, N.2    Qian, C.3    Civeira, M.P.4    Prieto, J.5
  • 69
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389:610-14.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 70
    • 0035034309 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor-alpha on insulin action in cultured human muscle cells
    • Halse R, Pearson SL, McCormack JG, Yeaman SJ, Taylor R. Effects of tumor necrosis factor-alpha on insulin action in cultured human muscle cells. Diabetes 2001, 50:1102-9.
    • (2001) Diabetes , vol.50 , pp. 1102-1109
    • Halse, R.1    Pearson, S.L.2    McCormack, J.G.3    Yeaman, S.J.4    Taylor, R.5
  • 71
    • 0034802171 scopus 로고    scopus 로고
    • High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
    • Paradis V, Perlemuter G, Bonvoust F. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology 2001, 34:738-44.
    • (2001) Hepatology , vol.34 , pp. 738-744
    • Paradis, V.1    Perlemuter, G.2    Bonvoust, F.3
  • 72
    • 0033950690 scopus 로고    scopus 로고
    • Evaluation of factors controlling glucose tolerance in patients with HCV infection before and after 4 months therapy with interferon-alpha
    • Konrad T, Zeuzem S, Vicini P. Evaluation of factors controlling glucose tolerance in patients with HCV infection before and after 4 months therapy with interferon-alpha. Eur J Clin Invest 2000, 30:111-21.
    • (2000) Eur J Clin Invest , vol.30 , pp. 111-121
    • Konrad, T.1    Zeuzem, S.2    Vicini, P.3
  • 73
    • 0031448152 scopus 로고    scopus 로고
    • Changes in glucose tolerance after interferon-alpha therapy in patients with chronic hepatitis C
    • Tanaka H, Shiota G, Kawasaki H. Changes in glucose tolerance after interferon-alpha therapy in patients with chronic hepatitis C. J Med 1997, 28:335-46.
    • (1997) J Med , vol.28 , pp. 335-346
    • Tanaka, H.1    Shiota, G.2    Kawasaki, H.3
  • 74
    • 15744381704 scopus 로고    scopus 로고
    • Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients
    • Romero-Gomez M, Del Mar Viloria M, Andrade RJ. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology 2005, 128:636-41.
    • (2005) Gastroenterology , vol.128 , pp. 636-641
    • Romero-Gomez, M.1    Del Mar Viloria, M.2    Andrade, R.J.3
  • 75
    • 0031800754 scopus 로고    scopus 로고
    • Liver biopsy is a useful predictor of response to interferon therapy in chronic hepatitis C
    • Kaserer K, Fiedler R, Steindl P, Muller CH, Wrba F, Ferenci P. Liver biopsy is a useful predictor of response to interferon therapy in chronic hepatitis C. Histopathology 1998, 32:454-61.
    • (1998) Histopathology , vol.32 , pp. 454-461
    • Kaserer, K.1    Fiedler, R.2    Steindl, P.3    Muller, C.H.4    Wrba, F.5    Ferenci, P.6
  • 76
    • 17944392178 scopus 로고    scopus 로고
    • Effect of combined interferon-alpha induction therapy and ribavirin on chronic hepatitis C virus infection: a randomized multicentre study
    • Bjoro K, Bell H, Hellum KB. Effect of combined interferon-alpha induction therapy and ribavirin on chronic hepatitis C virus infection: a randomized multicentre study. Scand J Gastroenterol 2002, 37:226-32.
    • (2002) Scand J Gastroenterol , vol.37 , pp. 226-232
    • Bjoro, K.1    Bell, H.2    Hellum, K.B.3
  • 77
    • 0036892371 scopus 로고    scopus 로고
    • Efficacy of interferon monotherapy to 394 consecutive naive cases infected with hepatitis C virus genotype 2a in Japan: therapy efficacy as consequence of tripartite interaction of viral, host and interferon treatment-related factors
    • Akuta N, Suzuki F, Tsubota A. Efficacy of interferon monotherapy to 394 consecutive naive cases infected with hepatitis C virus genotype 2a in Japan: therapy efficacy as consequence of tripartite interaction of viral, host and interferon treatment-related factors. J Hepatol 2002, 37:831-6.
    • (2002) J Hepatol , vol.37 , pp. 831-836
    • Akuta, N.1    Suzuki, F.2    Tsubota, A.3
  • 78
    • 33749589381 scopus 로고    scopus 로고
    • Impact of liver steatosis on the antiviral response in the hepatitis C virus-associated chronic hepatitis
    • Soresi M, Tripi S, Franco V. Impact of liver steatosis on the antiviral response in the hepatitis C virus-associated chronic hepatitis. Liver Int 2006, 26:1119-25.
    • (2006) Liver Int , vol.26 , pp. 1119-1125
    • Soresi, M.1    Tripi, S.2    Franco, V.3
  • 79
    • 0043037223 scopus 로고    scopus 로고
    • High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    • Bressler BL, Guindi M, Tomlinson G, Heathcote J. High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C. Hepatology 2003, 38:639-44.
    • (2003) Hepatology , vol.38 , pp. 639-644
    • Bressler, B.L.1    Guindi, M.2    Tomlinson, G.3    Heathcote, J.4
  • 80
    • 36349022057 scopus 로고    scopus 로고
    • Impact of weight-based ribavirin with peginterferon alfa-2b in African Americans with hepatitis C virus genotype 1
    • Jacobson IM, Brown RS, McCone J. Impact of weight-based ribavirin with peginterferon alfa-2b in African Americans with hepatitis C virus genotype 1. Hepatology 2007, 46:982-90.
    • (2007) Hepatology , vol.46 , pp. 982-990
    • Jacobson, I.M.1    Brown, R.S.2    McCone, J.3
  • 81
    • 0037406263 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase pathway and its role in interferon signaling
    • Platanias LC. The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacol Ther 2003, 98:129-42.
    • (2003) Pharmacol Ther , vol.98 , pp. 129-142
    • Platanias, L.C.1
  • 82
    • 0034857085 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: can weight reduction improve therapeutic efficacy?
    • Giannini E, Ceppa P, Testa R. Steatosis in chronic hepatitis C: can weight reduction improve therapeutic efficacy? J Hepatol 2001, 35:432-3.
    • (2001) J Hepatol , vol.35 , pp. 432-433
    • Giannini, E.1    Ceppa, P.2    Testa, R.3
  • 83
    • 60049094719 scopus 로고    scopus 로고
    • Pioglitazone improves early virologic kinetic response to PEG IFN/RBV combination therapy in hepatitis C genotype 1 naive pts
    • Elgouhari HCK, Lopez R, Zein NM. Pioglitazone improves early virologic kinetic response to PEG IFN/RBV combination therapy in hepatitis C genotype 1 naive pts. Hepatology 2008, 48(4):383A. Suppl
    • (2008) Hepatology , vol.48 , Issue.4 SUPPL
    • Elgouhari, H.C.K.1    Lopez, R.2    Zein, N.M.3
  • 84
    • 60049101298 scopus 로고    scopus 로고
    • A randomized, double blind, placebo-controlled study of PPAR-gamma agonist pioglitazone given in combination with peginterferon and ribavirin in patients with genotype-1 chronic hepatitis C.
    • Conjeevaram HBC, McKenna B, Harsh D. A randomized, double blind, placebo-controlled study of PPAR-gamma agonist pioglitazone given in combination with peginterferon and ribavirin in patients with genotype-1 chronic hepatitis C. Hepatology 2008, 48(4):384A. Suppl
    • (2008) Hepatology , vol.48 , Issue.4 SUPPL
    • Conjeevaram, H.B.C.1    McKenna, B.2    Harsh, D.3
  • 85
    • 33645114359 scopus 로고    scopus 로고
    • Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1
    • Walsh MJ, Jonsson JR, Richardson MM. Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. Gut 2006, 55:529-35.
    • (2006) Gut , vol.55 , pp. 529-535
    • Walsh, M.J.1    Jonsson, J.R.2    Richardson, M.M.3
  • 86
    • 36349030379 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy
    • Persico M, Capasso M, Persico E. Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy. Hepatology 2007, 46:1009-15.
    • (2007) Hepatology , vol.46 , pp. 1009-1015
    • Persico, M.1    Capasso, M.2    Persico, E.3
  • 87
    • 72549104493 scopus 로고    scopus 로고
    • Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin
    • Romero-Gomez M, Diago M, Andrade RJ. Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin. Hepatology 2009, 50:1702-8.
    • (2009) Hepatology , vol.50 , pp. 1702-1708
    • Romero-Gomez, M.1    Diago, M.2    Andrade, R.J.3
  • 88
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • Lerat H, Honda M, Beard MR. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002, 122:352-65.
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1    Honda, M.2    Beard, M.R.3
  • 89
    • 0037714524 scopus 로고    scopus 로고
    • Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection
    • Ohata K, Hamasaki K, Toriyama K. Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer 2003, 97:3036-43.
    • (2003) Cancer , vol.97 , pp. 3036-3043
    • Ohata, K.1    Hamasaki, K.2    Toriyama, K.3
  • 90
    • 33846850496 scopus 로고    scopus 로고
    • Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis
    • Moriishi K, Mochizuki R, Moriya K. Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis. Proc Natl Acad Sci USA 2007, 104:1661-6.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1661-1666
    • Moriishi, K.1    Mochizuki, R.2    Moriya, K.3
  • 91
    • 33846849610 scopus 로고    scopus 로고
    • Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein
    • Miyamoto H, Moriishi K, Moriya K. Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein. J Virol 2007, 81:1727-35.
    • (2007) J Virol , vol.81 , pp. 1727-1735
    • Miyamoto, H.1    Moriishi, K.2    Moriya, K.3
  • 92
    • 33644660193 scopus 로고    scopus 로고
    • Hepatic steatosis and the risk of hepatocellular carcinoma in chronic hepatitis C
    • Kumar D, Farrell GC, Kench J, George J. Hepatic steatosis and the risk of hepatocellular carcinoma in chronic hepatitis C. J Gastroenterol Hepatol 2005, 20:1395-400.
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 1395-1400
    • Kumar, D.1    Farrell, G.C.2    Kench, J.3    George, J.4
  • 93
    • 34250339305 scopus 로고    scopus 로고
    • Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis
    • Pekow JR, Bhan AK, Zheng H, Chung RT. Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. Cancer 2007, 109:2490-6.
    • (2007) Cancer , vol.109 , pp. 2490-2496
    • Pekow, J.R.1    Bhan, A.K.2    Zheng, H.3    Chung, R.T.4


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