Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea-pigs

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 11, 2005, Pages 1415-1420

  Calasans Maia, Jorge A ^a   Zapata Sudo, Gisele ^a   Sudo, Roberto T ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; DEXMEDETOMIDINE; LEVOBUPIVACAINE; YOHIMBINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BUPIVACAINE; DRUG DERIVATIVE; LOCAL ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; GUINEA PIG; MALE; MOTOR NERVE BLOCK; NONHUMAN; SPINAL ANESTHESIA; ANIMAL; DRUG INTERACTION; DRUG POTENTIATION; INTRASPINAL DRUG ADMINISTRATION; MOTONEURON; MOTOR ACTIVITY; NERVE BLOCK; TIME;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANESTHESIA, SPINAL; ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GUINEA PIGS; INJECTIONS, SPINAL; MALE; MOTOR ACTIVITY; MOTOR NEURONS; NERVE BLOCK; RECEPTORS, ADRENERGIC, ALPHA-2; TIME FACTORS; YOHIMBINE;

EID: 34548093199     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.57.11.0006     Document Type: Article

References (30)

1. Ackerman, L. L., Follett, K. A., Rosenquist, R. W. (2003) Long-term outcomes during treatment of chronic pain with intrathecal clonidine or clonidine / opioid combinations. J. Pain Symptom Manage. 26: 668-677
2. Bhana, N., Goa, K. L., McClellan, K. J. (2000) Dexmedetomidine. Drugs 59: 263-268
3. Bonnet, F., Brun-Buisson, V., Saada, M., Boico, O., Rostaing, S., Touboul, C. (1989) Dose-related prolongation of hyperbaric tetracaine spinal anesthesia by clonidine in humans. Anesth. Analg. 68: 619-622
4. Butterworth, J. F., Strichartz, G. R. (1993) The α2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers. Anesth. Analg. 76: 295-301
5. Correa-Sales, C., Rabin, B. C., Maze, M. (1992) A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology 76: 948-952
6. Dobrydnjov, I., Axelsson, K., Thörn, S. E., Matthiesen P., Klockhoff, H., Holmstrom, B., Gupta, A. (2003) Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blind study. Anesth. Analg. 96: 1496-1503
7. Drew, G. M., Gower, A., Marriot, A. S. (1979) Alpha-2 adrenoceptors mediate clonidine-induced sedation in the rat. Br. J. Pharmacol. 67: 133-141
8. Eisenach, J. C., Shafer, S. L., Bucklin, B. A., Jackson, C., Kallio, A. (1994) Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep. Anesthesiology 80: 1349-1359
9. Eisenach, J. C., Kock, M. D., Klimscha, W. (1996) α2-adrenergic agonists for regional anesthesia. Anesthesiology 85: 655-674
10. Erne-Brand, F., Jirounek, P., Drewe, J., Hampl, K., Schneider, M. C. (1999) Mechanism of antinociceptive action of clonidine in nonmyelinated nerve fibres. Eur. J. Pharmacol. 383: 1-8
11. Filos, K. S., Goudas, L. C., Patroni, O., Polyzou, V. (1994) Hemodynamic and analgesic profile after intrathecal clonidine in humans. A dose-response study. Anesthesiology 81: 591-601
12. Gaumann, D. M., Brunet, P. C., Jirounek, P. (1992) Clonidine enhances the effects of lidocaine on C-fiber action potential. Anesth. Analg. 74: 719-725
13. Grace, D., Bunting, H., Milligan, K. R., Fee, J. P. (1995) Postoperative analgesia after co-administration of clonidine and morphine by the intrathecal route in patients undergoing hip replacement. Anesth. Analg. 80: 86-91
14. Guthrie, S. K., Hariharan, M., Grunhaus, L. J. (1990) Yohimbine bioavailability in humans. Eur. J. Clin. Pharmacol. 39: 409-411
15. Jaakola, M. L., Salonen, M., Lehtinen, R., Scheinin, H. (1991) The analgesic action of dexmedetomidine - a novel alpha 2 adrenoceptor agonist in healthy volunteers. Pain 46: 281-285
16. Jones, D. J., Kendall, D. E., Enna, S. J. (1982) Adrenergic receptors in rat spinal cord. Neuropharmacology 21: 191-195
17. Liu, S., Chiu, A., Neal, J. M., Carpenter, R. I., Bainton, B. G., Gerancher, J. C. (1995) Oral clonidine prolongs spinal anesthesia in humans volunteers. Anesthesiology 82: 1353-1359
18. Malinovsky, J. M., Bernard, J. M. (1996) Spinal clonidine fails to provide surgical anesthesia for transurethral resection of prostate. Reg. Anesth. 21: 419-423
19. Nishiyama, T., Hanaoka, K. (2004) Intrathecal clonidine and bupivacaine have synergistic analgesia for acute thermally or inflammatory-induced pain in rats. Anesth. Analg. 98: 1056-1061
20. Ono, H., Fukuda, H. (1995) Pharmacology of descending noradrenergic systems in relation to motor function. Pharmacol. Ther. 68: 105-112
21. Owen, J. Á., Nakatsu, S. L., Fenemore, J., Condra, M., Surridge, D. H., Morales, A. (1987) The pharmacokinetics of yohimbine in man. Eur. J. Clin. Pharmacol. 32: 577-582
22. 5] enkephalin: a synergistic interaction. Eur. J. Pharmacol. 179: 463-468
23. Raffa, R. B., Stone, D. J., Tallarida, R. J. (2001) Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine. Eur. J. Pharmacol. 412: R1-R2
24. Rochette, A., Raux, O., Troncin, R., Dadure, C., Verdier, R., Capdevila, X. (2004) Clonidine prolongs spinal anesthesia in newborns: a prospective dose-ranging study. Anesth. Analg. 98: 56-59
25. Roudet, C., Mouchet, P., Feuerstein, C., Savasta, M. (1994) Normal distribution of alpha 2-adrenoceptors in the rat spinal cord and its modification after noradrenergic denervation: a quantitative autoradiographic study. J. Neurosci. Res. 39: 319-329
26. Shahbaz, R. A., Ruehlow, R. M., Uhrich, T. D., Ebert, T. J. (2004) The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth. Analg. 98: 153-158
27. Siddall, P. J., Molloy, A. R., Walker, S., Rutkowski, S. B. (2000) The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury. Anesth. Analg. 91: 493-498
28. Strahlendorf, J. C., Strahlendorf, H. K., Kingsley, R. E., Gintautas, J., Barnes, C. D. (1980) Facilitation of lumbar monosynaptic reflexes by locus coeruleus stimulation. Neuropharmacology 19: 225-230
29. Talke, P., Caldwell, J. E., Richardson, C. A., Kirkegaard-Nielsen, H., Stafford, M. (1999) The effects of dexmedetomidine on neuromuscular blockade in human volunteers. Anesth. Analg. 88: 633-639
30. Talke, P., Xu, M., Paloheimo, M., Kalso, E. (2003) Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats. Acta Anaesthesiol. Scand. 47: 347-354