Synthesis of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-β- carbolinesas antileishmanial agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 8, 2010, Pages 3274-3280

  Kumar, Ravi ^a   Khan, Shahnawaz ^a   Verma, Aditya ^a   Srivastava, Saumya ^a   Viswakarma, Preeti ^a   Gupta, Suman ^a   Meena, Sanjeev ^a   Singh, Neetu ^a   Sarkar, Jayanta ^a   Chauhan, Prem M S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

2,4,6 Triaminopyrimidine; 2 Amino 4,6 dichloropyrimidine; Antileishmanial; Tetrahydro carboline

Indexed keywords

(4,6 DIMORPHOLIN 4 YL PYRIMIDIN 2 YL) [2 (1H INDOL 3 YL)ETHYL]AMINE; 1 (3 BROMOPHENYL) 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 1 (BENZO[D][1,3]DIOXOL 5 YL) 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 1 (BENZO[D][1,3]DIOXOL 5 YL) 2 [4,6 BIS(4 ETHYLPIPERAZIN 1 YL)PYRIMIDIN 2 YL] 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 1 (BENZO[D][1,3]DIOXOL 5 YL) 2 [4,6 BIS(4 METHYLPIPERAZIN 1 YL)PYRIMIDIN 2 YL] 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 1 [4 (BENZYLOXY)PHENYL] 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (2 METHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (2,4 DIMETHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (2,5 DIMETHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (3 METHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (3,4 DIMETHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (3,4,5 TRIMETHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (3,5 DIMETHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (4 ETHYLPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 (4 METHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DICHLOROPYRIMIDIN 2 YL) 1 4 TOLYL 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DIMORPHOLIN 4 YL PYRIMIDIN 2 YL) 1 (3,4 DIMETHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (4,6 DIMORPHOLIN 4 YL PYRIMIDIN 2 YL) 1 (4 METHOXYPHENYL) 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE; 2 (PYRIMIDIN 2 YL) 1 PHENYL 2,3,4,9 TETRAHYDRO 1H BETA CARBOLINE DERIVATIVE; ANTILEISHMANIAL AGENT; CARBOLINE DERIVATIVE; N (2 (1H INDOL 3 YL)ETHYL) 4,6 DICHLOROPYRIMIDIN 2 AMINE; PENTAMIDINE; SODIUM STILBOGLUCONATE; UNCLASSIFIED DRUG; [4,6 BIS(4 METHYLPIPERAZIN 1 YL)PYRIMIDIN 2 YL][2 (1H INDOL 3 YL)ETHYL]AMINE;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LEISHMANIA DONOVANI; NONHUMAN;

EID: 77954311384     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.04.004     Document Type: Article

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