HIF-1α accumulation upregulates MICA and MICB expression on human cardiomyocytes and enhances NK cell cytotoxicity during hypoxia-reoxygenation

Life Sciences

Volumn 87, Issue 3-4, 2010, Pages 111-119

  Wei, Liang ^a   Lu, Jun ^a   Feng, Li ^a   Long, Dan ^a   Shan, Juan ^a   Li, Shengfu ^a   Li, Youping ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Cyclosporin A; HIF 1 ; Human cardiomyocytes; Hypoxia reoxygenation; Ischemia reperfusion injury; MICA; MICB; NK cell cytotoxicity

Indexed keywords

CYCLOSPORIN A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SMALL INTERFERING RNA; CYCLOSPORIN; HLA ANTIGEN CLASS 1; IMMUNOSUPPRESSIVE AGENT; MHC CLASS I RELATED CHAIN A; MHC CLASS I-RELATED CHAIN A; MICB ANTIGEN; OXYGEN;

ADENOVIRUS; ALLOGRAFT; ANTIGEN RECOGNITION; ARTICLE; CELL CULTURE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GRAFT SURVIVAL; HEART MUSCLE CELL; HEART TRANSPLANTATION; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOSTIMULATION; MULTIGENE FAMILY; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REOXYGENATION; RNA INTERFERENCE; VIRUS RECOMBINANT; CELL HYPOXIA; DRUG EFFECT; GENETICS; METABOLISM; PATHOPHYSIOLOGY; REPERFUSION INJURY; TIME; TUMOR CELL LINE; UPREGULATION;

ADENOVIRIDAE;

ADENOVIRIDAE; CELL HYPOXIA; CELL LINE, TUMOR; CYCLOSPORINE; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOSUPPRESSIVE AGENTS; KILLER CELLS, NATURAL; MYOCYTES, CARDIAC; OXYGEN; REPERFUSION INJURY; RNA INTERFERENCE; TIME FACTORS; UP-REGULATION;

EID: 77954310163     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.05.012     Document Type: Article

References (32)

1. Ameri K., Lewis C.E., Raida M., Sowter H., Hai T., Harris A.L. Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. Blood 2004, 103:1876-1882.
2. Bahram S., Bresnahan M., Geraghty D.E., Spies T. A second lineage of mammalian major histocompatibility complex class I genes. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:6259-6263.
3. Bahram S., Spies T. Nucleotide sequence of a human MHC class I MICB cDNA. Immunogenetics 1996, 43:230-233.
4. Baird N.A., Turnbull D.W., Johnson E.A. Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. The Journal of Biological Chemistry 2006, 281:38675-38681.
5. Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999, 285:727-729.
6. Cheng F., Feng L., Li S., Tan J., Cao L., He Y., Ye Z., Li Y. Yisheng injection decreases the expression of H60 and RAE-1 genes in ischemic mice liver. Transplantation Proceedings 2006, 38:2210-2213.
7. Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., Bukowski J.F. MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function. Immunity 2001, 15:83-93.
8. Date T., Mochizuki S., Belanger A.J., Yamakawa M., Luo Z., Vincent K.A., Cheng S.H., Gregory R.J., Jiang C. Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury. American Journal of Physiology. Cell Physiology 2005, 288:314-320.
9. Feng L., Cheng F., Ye Z., Li S., He Y., Yao X., Tang Q., Li Y. The effect of renal ischemia-reperfusion injury on expression of RAE-1 and H60 in mice kidney. Transplantation Proceedings 2006, 38:2195-2198.
10. Gong J.H., Maki G., Klingemann H.G. Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells. Leukemia 1994, 8:652-658.
11. Haddad J.J., Harb H.L. Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha. International Immunopharmacology 2005, 5:461-483.
12. Hellwig-Bürgel T., Stiehl D.P., Wagner A.E., Metzen E., Jelkmann W. Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions. Journal of Interferon & Cytokine Research 2005, 25:297-310.
13. Hirota K., Semenza G.L. Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochemical and Biophysical Research Communications 2005, 338:610-616.
14. Huang Y., Hickey R.P., Yeh J.L., Liu D., Dadak A., Young L.H., Johnson R.S., Giordano F.J. Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. The FASEBJ Journal 2004, 18:1138-1140.
15. Hung T.H., Skepper J.N., Burton G.J. In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. The American Journal of Pathology 2001, 159:1031-1043.
16. Jaakkola P., Mole D.R., Tian Y.M., Wilson M.I., Gielbert J., Gaskell S.J., Kriegsheim A.V., Hebestreit H.F., Mukherji M., Schofield C.J., Maxwell P.H., Pugh C.W., Ratcliffe P.J. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001, 292:468-472.
17. Joosten S.A., van Kooten C., Sijpkens Y.W., de Fijter J.W., Paul L.C. The pathobiology of chronic allograft nephropathy: immune-mediated damage and accelerated aging. Kidney International 2004, 65:1556-1559.
18. Kong X., Lin Z., Caro J. Immunophilin-ligands FK506 and CsA inhibit HIF1alpha expression by a VHL- and ubiquitin-independent mechanism. FEBS Letters 2006, 580:6182-6186.
19. Lei L., Mason S., Liu D., Huang Y., Marks C., Hickey R., Jovin I.S., Pypaert M., Johnson R.S., Giordano F.J. Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Molecular and Cellular Biology 2008, 28:3790-3803.
20. Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399:271-275.
21. Nishiyama S., Manabe N., Kubota Y., Ohnishi H., Kitanaka A., Tokuda M., Taminato T., Ishida T., Takahara J., Tanaka T. Cyclosporin A inhibits the early phase of NF-kappaB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells. International Immunopharmacology 2005, 5:699-710.
22. Salih H.R., Goehlsdorf D., Steinle A. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients. Human Immunology 2006, 67:188-195.
23. Senmaza G.L. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends in Molecular Medicine 2001, 7:345-350.
24. Suárez-Alvarez B., López-Vázquez A., Gonzalez M.Z., Fdez-Morera J.L., Díaz-Molina B., Blanco-Gelaz M.A., Pascual D., Martínez-Borra J., Muro M., Alvarez-López M.R., López-Larrea C. The relationship of anti-MICA antibodies and MICA expression with heart allograft rejection. American Journal of Transplantation 2007, 7:1842-1848.
25. Tan S., Yokoyama Y., Wang Z., Zhou F., Nielsen V., Murdoch A.D., Adams C., Parks D.A. Hypoxia-reoxygenation is as damaging as ischemia-reperfusion in the rat liver. Critical Care Medicine 1998, 26:995-996.
26. Tomasec P., Wang E., Groh V., Spies T., McSharry B., Aicheler R., Stanton R., Wilkinson G. Adenovirus vector delivery stimulates natural killer cell recognition. The Journal of General Virology 2007, 88:1103-1108.
27. Tullius S.G., Reutzel-Selke A., Egermann F., Nieminen-Kelhä M., Jonas S., Bechstein W.O. Contribution of prolonged ischemia and donor age to chronic renal allograft dysfunction. Journal of the American Society of Nephrology 2000, 11:1317-1324.
28. Tullius S.G., Tilney N.L. Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation 1995, 59:313-318.
29. Venkataraman G.M., Suciu D., Groh V., Boss J.M., Spies T. Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D. Journal of Immunology 2007, 178:961-969.
30. Wang G.L., Jiang B.H., Rue E.A., Semenza G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proceedings of the National Academy of Sciences of the United States of America 1995, 92:5510-5514.
31. Wei L., Lu J., Feng L., Li S., Shan J., Li Y. Construction of recombinant adenovirus vector containing a modified gene that codes for human hypoxia-inducible factor-1α without oxygen-dependent degradation domain. Plasmid 2010, 63:20-26.
32. Ye Z., Feng L., Huang S., Li S., He Y., Li Y. Expression of H60 on mice heart graft and influence of cyclosporine. Transplantation Proceedings 2006, 38:2168-2171.