Antibiotic-impregnated PMMA hip spacers: Current status

Acta Orthopaedica

Volumn 77, Issue 4, 2006, Pages 628-637

  Anagnostakos, Konstantinos ^a   Fürst, Oliver ^a   Kelm, Jens ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZTREONAM; CEFAMANDOLE; CEFOTAXIME; CEFTAZIDIME; CEFTIZOXIME; CEPHALOSPORIN; CIPROFLOXACIN; CLINDAMYCIN; CLOXACILLIN; DALFOPRISTIN PLUS QUINUPRISTIN; GENTAMICIN; NAFCILLIN; PENICILLIN DERIVATIVE; PENICILLIN G; PIPERACILLIN; POLY(METHYL METHACRYLATE); RIFAMPICIN; STREPTOMYCIN; TEICOPLANIN; TOBRAMYCIN; VANCOMYCIN;

ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; COXITIS; ELUTION; HIP ARTHROPLASTY; HUMAN; INFECTION PREVENTION; MATERIALS TESTING; MECHANICS; POSTOPERATIVE INFECTION; REVIEW;

ANTI-BACTERIAL AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BIOMECHANICS; BONE CEMENTS; DRUG COMBINATIONS; HIP PROSTHESIS; HUMANS; POLYMETHYL METHACRYLATE; PROSTHESIS-RELATED INFECTIONS; TREATMENT OUTCOME;

EID: 33747693240     PISSN: 17453674     EISSN: 17453682     Source Type: Journal    
DOI: 10.1080/17453670610012719     Document Type: Review

References (54)

1. Abendschein W. Salvage of infected total hip replacement: use of antibiotic/PMMA-Spacer. Orthopedics 1992; 15 (2): 228-9.
2. Affatato S, Mattarozi A, Taddei P, Robotti P, Soffiatti R, Sudanese A, Toni A. Investigations on the wear behaviour of the temporary PMMA-based hip Spacer-G. Proc Inst Mech Eng (H) 2003; 217 (1): 1-8.
3. Anagnostakos K, Kelm J, Regitz T, Schmitt E, Jung W. In vitro evaluation of antibiotic release from and bacteria growth inhibition by antibiotic-loaded acrylic bone cement spacers. J Biomed Mater Res B Appl Biomater 2005; 72 (2): 373-8.
4. Armstrong M S, Spencer R F, Cunningham J L, Gheduzzi S, Miles A W, Learmonth I D. Mechanical characteristics of antibiotic-laden bone cement. Acta Orthop Scand 2002; 73 (6): 688-90.
5. Askew M J, Kufel M F, Fleissner P R, Gradisar I A, Salstrom S-J, Tan J S. Effect of vacuum mixing on the mechanocal properties of antibiotic- impregnatized polymethylmethacrylat bone cement. J Biomed Mater Res 1990; 24 (5): 573-80.
6. Barrack R L. Rush pin technique for temporary antibiotic-impregnated cement prosthesis for infected total hip arthroplasty. J Arthroplasty 2002; 17 (5): 600-3.
7. Bertazzoni Minelli E, Benini A, Magnan B, Bartolozzi P. Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty. J Antimicrob Chemother 2004; 53 (2): 329-34.
8. Buchholz H W, Engelbrecht E. Über die Depotwirkung einiger Antibiotika bei Vermischung mit dem Kunstharz Palacos. Chirurg 1970; 41: 511-5.
9. Cercenado E, Garcia Leoni M E, Diaz M D, Sanchez-Carrillo C, Catalan P, De Quiros J C, Bouza E. Emergence of teicoplanin-resistant coagulase-negative staphylococci. J Clin Microbiol 1996; 34 (7):1 765-8.
10. Deshmukh R G, Thevarajan K, Kok C S, Sivapathasundaram N, George S V N. An intramedullary cement spacer in total hip arthroplasty. J Arthroplasty 1998; 13 (2): 197-9.
11. Duncan C P, Beauchamp C. A temporary antibiotic-loaded joint replacement system for management of complex infections involving the hip. Orthop Clin North Am 1993; 24 (4): 751-9.
12. Duncan C P, Masri B A. The role of antibiotic-loaded cement in the treatment of an infection after a hip replacement. J Bone Joint Surg (Am) 1994; 76 (11): 1742-51.
13. Durbhakula S M, Czajka J, Fuchs M D, Uhl R L. Spacer endoprosthesis for the treatment of infected total hip arthoplasty. J Arthoplasty 2004; 19 (6): 760-7.
14. Ger E, Dall D, Miles T, Forder A. Bone cement and antibiotics. S Afr Med J 1977; 51 (9): 276-9.
15. Greene N, Holtom P D, Warren C A, Ressler R L, Shepherd L, McPherson E J, Patzakis M J. In vitro elution of tobramycin and vancomycin polymethylmethacrylat beads and spacers from Palacos and Simplex. Am J Orthop 1998; 27 (3): 201-5.
16. Haaker R, Senge A, Kramer J, Rubenthaler F. Osteomyelitis after endoprostheses. Orthopäde 2004; 33: 431-8.
17. Haddad F S, Masri B A, Garbuz D S, Duncan C P. The treatment of the infected hip replacement: the complex case. Clin Orthop 1999; (369): 144-56.
18. Holtom P D, Warren C A, Greene N W, Bravos P D, Ressler R L, Shepherd L, McPherson E J, Patzakis M J. Relation of surface area to in vitro elution characteristics of vancomycin-impregnated polymethylmethylacrylate spacers. Am J Orthop 1998; 27 (3): 207-10.
19. Hsieh P-H, Shih C-H, Chang Y-H, Lee MS, Shih H-N, Yang W-E. Two-stage revision hip arthroplasty for infection: comparison between the interim use of antibiotic-loaded cement beads and a spacer prosthesis. J Bone Joint Surg (Am) 2004; 86 (9): 1989-97.
20. Hsieh P-H, Shih C-H, Chang Y-H, Lee MS, Yanh W-E, Shih H-N. Treatment of deep infection of the hip associated with massive bone loss. Two-stage revision with an antibiotic-loaded interim cement prosthesis followed by reconstruction with allograft. J Bone Joint Surg (Br) 2005; 87 (6): 770-5.
21. Isiklar Z U, Demirörs H, Akpinar S, Tandogan R N, Alparslan M. Two-stage treatment of chronic staphylococcal implant-related infections using Vancomycin-impregnated PMMA-Spacer and rifampicin containing antibiotic protocol. Bull Hosp Jt Dis 1999; 58 (2): 79-85.
22. Ivarsson I, Wahlström O, Djerf K, Jacobsson S-A. Revision of infected hip replacement. Two-stage procedure with a temporary gentamicin spacer. Acta Orthop Scand 1994; 65 (1): 7-8.
23. Jahoda D, Sosna A, Landor I, Vavrik P, Pokorny D. Canulated spacer in the treatment of deep infection of total hip arthroplasty using a two-stage reimplantation. Oper Orthop Traumatol 2003; 1: 57-69.
24. Joseph T N, Chen A L, Di Cesare P E. Use of antibiotic-impregnated cement in total joint arthroplasty. J Am Acad of Orthop Surg 2003; 11 (1): 38-47.
25. Kelm J, Regitz T, Schmitt E. Infektsanierung durch resistenzgerechte Hüftinterimsprothese und Antibiotikakette. J DGPW 2001; 23: 61-2.
26. Koo K-H, Yang J-W, Cho S-H, Song H-R, Park H-B, Ha YC, Chang J-D, Kim S-Y, Kim Y-H. Impregnation of vancomycin, gentamicin and cefotaxime in a cement spacer for two-stage cementless reconstruction in infected total hip arthroplasty. J Arthroplasty 2001; 16 (7): 882-92.
27. Kraay M J, Goldberg V M, Figgie H E III. Use of an antibiotic impregnated polymethyl methylacrylate intramedullary spacer for complicated revision total hip arthroplasty. J Arthroplasty (Suppl) 1992; 7: 397-402.
28. Krcmery V, Trupl J, Dragona L, Lacka J, Kukuckova E, Oravcova E. Nosocomial bacteremia due to vancomycin-resistant Staphylococcus epidermidis in four patients with cancer, neutropenia, and previous treatment with vancomycin. Eur J Clin Microbiol Infect Dis 1996; 15 (3): 259-61.
29. Lautenschlager E P, Jacobs J J, Marshall G W, Meyer P R Jr. Mechanical properties of bone cements containing large doses of antibiotic powders. J Biomedical Mater Res 1976; 10 (6): 929-38.
30. Leunig M, Chosa E, Speck M, Ganz R. A cement spacer for two-stage revision of infected implants of the hip-joint. Int Orthop 1998; 22 (4): 209-14.
31. Levin P D. The effectiveness of various antibiotics in methylmethacrylat. J Bone Joint Surg (Br) 1975; 57 (2): 234-7.
32. Lewis G. Fatigue testing and performance of acrylic bonecement materials: State-of-the-art review. J Biomed Mater Res 2003; 66 (1): 457-86.
33. Lidgren L, Bodelind B, Moller J. Bone cement improved by vacuum mixing and chilling. Acta Orthop Scand 1987; 58 (1): 27-32.
34. Magnan B, Regis D, Biscaglia R, Bartolozzi P. Preformed acrylic bone cement spacer loaded with antibiotics. Use of two-stage procedure in 10 patients because of infected hips after total replacement. Acta Orthop Scand 2001; 72 (6): 591-4.
35. Masri B A, Duncan C P, Beauchamp C P, Paris N J, Arntorp J. Tobramycin and Vancomycin elution from bone cement. An in vivo and in vitro study. Orthop Trans 1994; 18:130.
36. Masri B A, Duncan C P, Beauchamp C P. Long-term elution of antibiotics from bone-cement. J Arthroplasty 1998; 13 (3): 331-8.
37. McGrory B J, Shinnick J, Ruterbories J. A simple method of intra-articular antibiotic delivery in infected hip arthroplasty. Am J Orthop 2002; 31 (5): 250-1.
38. Morimoto S, Futani H, Ogura H, Okayama A, Maruo S. Successful reimplantation of total femoral prosthesis after deep infection. J Arthroplasty 2003; 18 (2): 216-20.
39. Murray W R. Use of antibiotic-containing bone cement. Clin Orthop 1984; (190): 89-95.
40. Neu H C. The crisis in antibiotic resistance. Science 1992; 257 (5073): 1064-72.
41. Pearle A D, Sculco T P. Technique for fabrication of an antibiotic-loaded cement hemiarthroplasty (ANTILOCH) prosthesis for infected total hip arthroplasty. Am J Orthop 2002; 31 (7): 425-7.
42. Ries M D, Jergesen H. An inexpensive molding method for antibiotic-impregnated cement spacers in infected total hip arthroplasty. J Arthroplasty 1999; 14 (6): 764-5.
43. Schöllner C, Fürderer S, Rompe J-D, Eckardt A. Individual bone cement spacers (IBCS) for septic hip revision - preliminary report. Arch Orthop Traum Surg 2003; 123 (5): 254-9.
44. Shin S S, Della Valle C J, Ong B C, Meere P A. A simple method for construction of an articulating antibiotic-loaded cement spacer. J Arthroplasty 2002; 17 (6): 785-7.
45. Takahira N, Itoman M, Higashi K, Utsiyama K, Miyabe M, Naruse K. Treatment outcome of two-stage revision total hip arthroplasty for infected hip arthroplasty using antibiotic-impregnated cement spacer. J Orthopedic Sci 2003; 8 (1): 26-31.
46. Thomes B, Murray P, Bouchier-Hayes D. Development of resistant strains of Staphylococcus epidermidis on gentamicin-loaded bone cement in vivo. J Bone Joint Surg (Br) 2002; 84 (5): 758-60.
47. Ure K J, Amstutz H C, Nasser S, Schmalzried T P. Directexchange for the arthroplasty treatment of infection after total hip arthroplasty. J Bone Joint Surg (Am) 1998; 80 (7): 961-8.
48. Wagner H, Wagner M. Infizierte Hüftgelenksprothesen. Gesichtspunkte für den einzeitigen und zweizeitigen Prothesenwechsel. Orthopäde 1995: 24 (4): 314-8.
49. Wahlig H. Über die Freisetzungskinetik von Antibiotika aus Knochenzementen - Ergebnisse vergleichender Untersuchungen in vitro und in vivo. Aktuelle Probl Chir Orthop 1987; 31: 221-6.
50. Wendt C, Rüden H, Edmond M. Vancomycin-resistente Enterokokken. Dtsch Ärzteblatt 1998; 95: 1284-91.
51. Yamamoto K, Miyagawa N, Masaoka T, Katori Y, Shishido T, Imakiire A. Clinical effectiveness of antibiotic-impregnated cement spacers for the treatment of infected implants of the hip joint. J Orthop Sci 2003; 8 (6): 823-8.
52. Younger A S E, Duncan C P, Masri B A, McGraw R W. The outcome of two-stage arthroplasty using a custom-made interval spacer to treat the infected hip. J Arthroplasty 1997; 12 (6): 615-23.
53. Younger A S, Duncan C P, Masri B A. Treatment of infection associated with segmental bone loss in the proximal part of the femur in two stages with use of an antibiotic-loaded interval prosthesis. J Bone Joint Surg (Am) 1998; 80 (1): 60-9.
54. Zilkens K-W, Casser H-R, Ohnsorge J. Treatment of an old infection in a total hip replacement with an interim spacer prosthesis. Arch Orthop Trauma Surg 1990; 109 (2): 94-6.