Controlled release of antibiotics from biomedical polyurethanes: Morphological and structural features

Biomaterials

Volumn 18, Issue 12, 1997, Pages 839-844

  Schierholz, Jörg M ^a   Steinhauser, H ^b   Rump, A F E ^b   Berkels, R ^b   Pulverer, G ^b  

^a B Braun Melsungen AG   (Germany)

^b NONE

Author keywords

Antibiotics; Controlled release; Drug polymer compatibility; Polyurethanes

Indexed keywords

BACTERIA; BIOASSAY; BIOCOMPATIBILITY; BIOMATERIALS; CONTROLLED DRUG DELIVERY; GRANULAR MATERIALS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MORPHOLOGY; PHARMACOKINETICS; PHYSICAL CHEMISTRY; POLYURETHANES; SCANNING ELECTRON MICROSCOPY;

CIPROFLOXACIN; FLUCLOXACILLIN; FOSFOMYCIN; GENTAMYCIN; SOLVENT CASTING;

ANTIBIOTICS;

ANTIBIOTIC AGENT; CIPROFLOXACIN; FLUCLOXACILLIN; FOSFOMYCIN; GENTAMICIN; POLYURETHAN; SOLVENT;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; BIOASSAY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS EPIDERMIDIS;

ANTI-BACTERIAL AGENTS; BACTERIAL ADHESION; BIOCOMPATIBLE MATERIALS; BIOFILMS; CIPROFLOXACIN; DRUG IMPLANTS; FLOXACILLIN; FOSFOMYCIN; GENTAMICINS; HUMANS; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; POLYURETHANES; PROSTHESES AND IMPLANTS; PROSTHESIS-RELATED INFECTIONS; STAPHYLOCOCCAL INFECTIONS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS EPIDERMIDIS;

EID: 0031172321     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(96)00199-8     Document Type: Article

References (25)

1. 1. Sugarman, B. and Young, Y., Infections associated with prosthetic devices. Magnitude of the problem. Inf. Dis. Clin. North Am., 1989, 3(2), 187-198.
2. 2. Maki, D.G., Infections due to infusion therapy. In Hospital Infections, ed. J.V. Bennett and P.S. Brachmann. Little, Brown and Co, Boston, 1992, pp. 849-858.
3. 3. Maki, D.G., Infections associated with infusion therapy. In Infections Associated with Indwelling Devices, ed. A.L. Bisno and F.A. Waldvogel. ASM, Washington, DC, 1989, pp. 161-177.
4. 4. Bayston, R., Grove, N., Siegel, J., Lawellin, D. and Barshan, S., Prevention of hydrocephalus shunt catheter colonization in vitro by impregnation with antimicrobials. J. Neurolog. Neuros. Psych., 1989, 52, 605-609.
5. 5. Schierholz, J. and Pulverer, G., Kontrollierte Freisetzung einer antimikrobiellen Dreifachkombination von CSF-Shuntsystemen zur effizienten Prevention von 'Fremdkörperinfektionen'. Hyg. Med., 1996, 21(Suppl. 1).
6. 6. Schierholz, J.M., Rump, A.F.E, and Pulverer, G., Drug delivery concepts for efficacious prevention of foreign-body infections. Zbl. Bakt., 1996, 284, 390-401.
7. 7. Hampl, J., Schierholz, J.M., Jansen, B. and Aschoff, A., In vitro and in vivo efficacy of a rifampin loaded silicone catheter in prevention of CSF-shunt infections. Acta Neurochirurg., 1995, 133, 147-152.
8. 8. Schierholz, J., Jansen, B., Steinhauser, H., Schumacher-Perdreau, F. and Pulverer, G., Drug release from antibiotic containing polyurethanes. New. Pol. Mat., 1991, 3(1), 61-72.
9. 9. Schierholz, J., Kontrollierte Antibiotikafreisetzung aus Biomaterialien - ein rationaler Lösungsansatz zur Prävention von Fremdkörperinfektionen. Hospitalis, 1995, 65(9), 1-7.
10. 10. Schierholz, J., Jansen, B., Jaenicke, L. and Pulverer, G., In vitro efficacy of an antibiotic releasing silicone ventricle catheter to prevent shunt infection. Biomaterials, 1995, 15(12), 996-1000.
11. 11. Bach, A., Böhrer, H., Motsch, J., Martin, E., Geiss, H.K. and Sonntag, H.G., Prevention of bacterial colonization of intravenous catheters by antiseptic impregnation of polyurethane polymers. J. Antimicrob. Chem., 1994, 33, 969-978.
12. 12. Raad, I., Darouiche, R., Hachem, R., Mansouri, M. and Bodey, G.P., The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J. Inf. Dis., 1996, 173(2), 418-424.
13. 13. Benvenisti, A.I., Tannenbaum, G., Ahlborn, T.N. et al., Control of prosthetic bacterial infection: evaluation of an easily incorporated, tightly bound silver-antibiotic PTFE-graft. J. Surg. Res., 1988, 44, 1-7.
14. 14. McDougal, E.G., Burnham, S.J. and Johnson, G., Rifampin protection against experimental graft sepsis. J. Vasc. Surg., 1986, 4, 5-7.
15. 15. Solomon, D.D. and Sherertz, R.J., Antibiotic releasing polymers. Contr. Rel., 1987, 343-352.
16. 16. Sampath, L.A., Chowdhury, N., Caraos, L. and Modak, S.M., Infection resistance of surface modified catheters with either short-lived or prolonged activity. J. Hosp. Inf., 1995, 30, 201-210.
17. 17. Peppas, N.A. and Lustig, S.R., The role of cross-links, entanglements and relaxations of the macromolecular barrier in the diffusional release of biological active materials. Ann. New York Acad. Sci., 1984, 5, 26-41.
18. 18. Ritger, P.L. and Peppas, N.A., A simple equation for description of solute release Fickian and non-Fickian release from swellable devices in the form of slabs, spheres, cylinders or discs. J. Contr. Rel., 1987, 5, 23-26.
19. 19. Brown, M.R.W. and Williams, P., Influence of substrate limitation and growth phase on sensitivity to antimicrobial agents. JAC, 1985, 15(Suppl. A), 7-14.
20. 20. Chien, Y.W. and Lambert, H.J., Controlled drug release from polymeric delivery devices. V. Hydroxy-group-effects on drug release kinetics and thermodynamics. J. Pharm. Sci., 1985, 68(6), 689-693.
21. 21. Chien, Y.W. and Lau, E.P.K., Controlled drug release from polymeric delivery devices. IV. In vitro-in vivo correlation of subcutaneous release of norgestromed from hydrophilic implant. J. Pharm. Sci., 1976, 65(4), 481-492.
22. 22. Chien, Y.W. and Lambert, H.J., Controlled release from polymeric devices: technique for rapid in vitro release studies. J. Pharm. Sci., 1974, 63(3), 365-369.
23. 23. Chien, Y.W. and Lambert, H.J., Controlled drug release from polymeric devices. II. Differentiation between partition-controlled and matrix-controlled drug release mechanisms. J. Pharm. Sci., 1974, 63(4), 515-519.
24. 24. Desai, J., Simonelli, A.P. and Higuchi, W.I., Investigation of factors influencing release of solid drug dispersed in inert matrices I. J. Pharm. Sci., 1965, 54(10), 1469-1474.
25. 25. Desai, J. and Higuchi, W.I., Investigation of factors influencing release of solid drug dispersed in inert matrices II. J. Pharm. Sci., 1966, 55(11), 1224-1229.