Cell-free synthesis and functional characterization of sphingolipid synthases from parasitic trypanosomatid protozoa

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 20580-20587

  Sevova, Elitza S ^a   Goren, Michael A ^b   Schwartz, Kevin J ^a   Hsu, Fong Fu ^c   Turk, John ^c   Fox, Brian G ^b   Bangs, James D ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUREOBASIDIN; BIFUNCTIONAL; CELL-FREE; CELLULAR ACTIVITIES; END-PRODUCTS; ENZYME SYSTEMS; ETHANOLAMINES; FUNCTIONAL ANNOTATION; FUNCTIONAL CHARACTERIZATION; GENE FAMILIES; GENES ENCODING; INTEGRAL MEMBRANE PROTEINS; ORTHOLOGS; POLYTOPIC MEMBRANE PROTEINS; POTENT INHIBITOR; POTENTIAL DRUG; PROTOZOAN PARASITES; RAPID OPTIMIZATION; REACTION CONDITIONS; SINGLE RESIDUE; SITE-SPECIFIC MUTAGENESIS; SPHINGOLIPIDS; SYNTHASES; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ALCOHOLS; BIOLOGICAL MEMBRANES; ENZYMES; GENES; PROTOZOA; SUGARS; SYNTHESIS (CHEMICAL);

AMIDES;

AUREOBASIDIN A; CERAMIDE DERIVATIVE; ETHANOLAMINE PHOSPHORYLCERAMIDE; INOSITOL PHOSPHORYLCERAMIDE; INOSITOL PHOSPHORYLCERAMIDE SYNTHASE; LIPOSOME; MEMBRANE PROTEIN; SPHINGOLIPID SYNTHASE; SPHINGOLIPID SYNTHASE 1; SPHINGOLIPID SYNTHASE 2; SPHINGOLIPID SYNTHASE 3; SPHINGOLIPID SYNTHASE 4; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CELL FREE SYSTEM; CLADISTICS; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SYNTHESIS; GENETIC DISTANCE; IN VITRO STUDY; MOLECULAR PHYLOGENY; MULTIGENE FAMILY; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS; SPHEROPLAST; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

3' UNTRANSLATED REGIONS; ANIMALS; CELL-FREE SYSTEM; CERAMIDES; CLONING, MOLECULAR; GENOME; HUMANS; LIPOSOMES; MUTAGENESIS, SITE-DIRECTED; OPEN READING FRAMES; SACCHAROMYCES CEREVISIAE; SPHEROPLASTS; SPHINGOLIPIDS; TRANSCRIPTION, GENETIC; TRYPANOSOMA; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS;

HEXAPODA; PROTOZOA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 77954240918     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.127662     Document Type: Article

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