Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive lyme arthritis

Arthritis and Rheumatism

Volumn 62, Issue 7, 2010, Pages 2127-2137

  Shen, Shiqian ^a   Shin, Junghee J ^a   Strle, Klemen ^a   McHugh, Gail ^a   Li, Xin ^a   Glickstein, Lisa J ^a   Drouin, Elise E ^a   Steere, Allen C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; DOXYCYCLINE; GAMMA INTERFERON; METHOTREXATE; TRANSCRIPTION FACTOR FOXP3;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; BORRELIA BURGDORFERI; CD4 LYMPHOCYTE COUNT; CD4[+] T LYMPHOCYTE; CLINICAL ARTICLE; DISEASE DURATION; DRUG RESPONSE; FEMALE; HUMAN; HUMAN CELL; LYME DISEASE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SYNOVECTOMY; SYNOVIAL FLUID; SYNOVITIS; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TREATMENT RESPONSE;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; ARTHRITIS, INFECTIOUS; BORRELIA BURGDORFERI; CD4 LYMPHOCYTE COUNT; CELL PROLIFERATION; CHILD; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; LYME DISEASE; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; SYNOVIAL FLUID; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 77954235937     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27468     Document Type: Article

References (44)

1. Steere AC. Lyme disease. N Engl J Med 2001;345:115-25.
2. Steere AC, Angelis SM. Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis [review]. Arthritis Rheum 2006;54:3079-86.
3. Jones KL, McHugh GA, Glickstein LJ, Steere AC. Analysis of Borrelia burgdorferi genotypes in patients with Lyme arthritis: high frequency of ribosomal RNA intergenic spacer type 1 strains in antibiotic-refractory arthritis. Arthritis Rheum 2009;60:2174-82.
4. Kannian P, Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC. Decline in the frequencies of Borrelia burgdorferi OspA161-175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory Lyme arthritis. J Immunol 2007;179:6336-42.
5. Kannian P, McHugh G, Johnson BJ, Bacon RM, Glickstein LJ, Steere AC. Antibody responses to Borrelia burgdorferi in patients with antibiotic- refractory, antibiotic-responsive, or non-antibiotic-treated Lyme arthritis. Arthritis Rheum 2007;56:4216-25. (Pubitemid 350262350)
6. Steere AC, Duray PH, Butcher EC. Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis: comparison with rheumatoid synovium and tonsillar lymphoid tissue. Arthritis Rheum 1988;31:487-95.
7. Akin E, Aversa J, Steere AC. Expression of adhesion molecules in synovia of patients with treatment-resistant Lyme arthritis. Infect Immun 2001;69:1774-80. (Pubitemid 32187637)
8. Steere AC, Klitz W, Drouin EE, Falk BA, Kwok WW, Nepom GT, et al. Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide. J Exp Med 2006;203:961-71.
9. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
10. Weyand CM, Hicok KC, Conn DL, Goronzy JJ. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 1992;117:801-6.
11. Yudoh K, Matsuno H, Nakazawa F, Yonezawa T, Kimura T. Reduced expression of the regulatory CD4+ T cell subset is related to Th1/Th2 balance and disease severity in rheumatoid arthritis. Arthritis Rheum 2000;43:617-27. (Pubitemid 30394954)
12. Canete JD, Martinez SE, Farres J, Sanmarti R, Blay M, Gomez A, et al. Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon γ is highly expressed in synovium of rheumatoid arthritis compared with seronegative spondyloarthropathies. Ann Rheum Dis 2000;59:263-8. (Pubitemid 30305567)
13. Yssel H, Shanafelt MC, Soderberg C, Schneider PV, Anzola J, Peltz G. Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J Exp Med 1991;174:593-601.
14. Gross DM, Steere AC, Huber BT. T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis. J Immunol 1998;160:1022-8.
15. Chen J, Field JA, Glickstein L, Molloy PJ, Huber BT, Steere AC. Association of antibiotic treatment-resistant Lyme arthritis with T cell responses to dominant epitopes of outer surface protein A of Borrelia burgdorferi. Arthritis Rheum 1999;42:1813-22. (Pubitemid 30257744)
16. Arend WP. Physiology of cytokine pathways in rheumatoid arthritis [review]. Arthritis Rheum 2001;45:101-6.
17. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007;7:429-42.
18. Shin JJ, Glickstein LJ, Steere AC. High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory Lyme arthritis. Arthritis Rheum 2007;56:1325-35.
19. Steere AC, Glickstein L. Elucidation of Lyme arthritis. Nat Rev Immunol 2004;4:143-52.
20. Iliopoulou BP, Alroy J, Huber BT. Persistent arthritis in Borrelia burgdorferi-infected HLA-DR4-positive CD28-negative mice post-antibiotic treatment. Arthritis Rheum 2008;58:3892-901.
21. + regulatory T cells. J Immunol 2003;171:3348-52.
22. Iliopoulou BP, Alroy J, Huber BT. CD28 deficiency exacerbates joint inflammation upon Borrelia burgdorferi infection, resulting in the development of chronic Lyme arthritis. J Immunol 2007;179:8076-82.
23. Iliopoulou BP, Guerau-de-Arallano M, Huber BT. HLA-DR alleles determine responsiveness to Borrelia burgdorferi antigens in a mouse model of self-perpetuating arthritis. Arthritis Rheum 2009;60:3831-40.
24. Wharton M, Chorba TL, Vogt RL, Morse DL, Buehler JW. Case definitions for public health surveillance. MMWR Recomm Rep 1990;39:1-43.
25. Nocton JJ, Dressler F, Rutledge BJ, Rys PN, Persing DH, Steere AC. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in joint fluid in patients with Lyme arthritis. N Engl J Med 1994;330:229-34. (Pubitemid 24034134)
26. Steere AC, McHugh G, Damle N, Sikand VK. Prospective study of serologic tests for Lyme disease. Clin Infect Dis 2008;47:188-95.
27. Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, et al. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006;43:1089-134.
28. Glickstein L, Moore B, Bledsoe T, Damle N, Sikand V, Steere AC. Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans. Infect Immun 2003;71:6051-3.
29. Infante-Duarte C, Horton HF, Byrne MC, Kamradt T. Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol 2000;165:6107-15.
30. Codolo G, Amedei A, Steere AC, Papinutto E, Cappon A, Polenghi A, et al. Borrelia burgdorferi NapA-driven Th17 cell inflammation in Lyme arthritis. Arthritis Rheum 2008;58:3609-17.
31. Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 2006;6:329-33.
32. Kang I, Barthold SW, Persing DH, Bockenstedt LK. T helper cell cytokines in the early evolution of murine Lyme arthritis. Infect Immun 1997;65:3107-11.
33. +high regulatory T cell function. J Immunol 2002;169:6210-7.
34. Yang J, Brook MO, Carvalho-Gaspar, Zang J, Ramon HE, Sayegh MH, et al. Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci U S A 2007;104:19954-9.
35. Van Amelsfort JM, Jacobs KM, Bijlsma JW, Lafeber FP, Taams LS. CD4+CD25+ regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004;50:2775-85.
36. + T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 2003;33:215-23.
37. + regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 2004;6:R335-46.
38. + T cells in rheumatic joints. Scand J Immunol 2006;63:444-52.
39. + T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis. Scand J Immunol 2005;62:312-7.
40. + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005;140:360-7.
41. high regulatory T cell population in peripheral blood. Rheumatology (Oxford) 2006;45:1210-7.
42. bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 2004;172:6435-43.
43. Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J Exp Med 2004;200:277-85.
44. Nadkarni S, Mauri C, Ehrenstein MR. Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. J Exp Med 2007;204:33-9.