Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: Involvement of IL-10 and prostaglandins

Journal of Immunology

Volumn 183, Issue 10, 2009, Pages 6778-6787

  Thivierge, Maryse ^a   Stankova, Jana ^a   Rola Pleszczynski, Marek ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; DECTIN 1; INTERLEUKIN 10; LEUKOTRIENE D4; LEUKOTRIENE RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; PEPTIDOLEUKOTRIENE RECEPTOR 1; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG; ZYMOSAN;

ARTICLE; CALCIUM MOBILIZATION; CELL DIFFERENTIATION; CELL MATURATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 77954233609     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901800     Document Type: Article

References (59)

1. Steinman, R. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9: 271-296.
2. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
3. Hart, D. N. 1997. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 90: 3245-3287.
4. Mellman, I., and R. M. Steinman. 2001. Dendritic cells: specialized and regulated antigen processing machines. Cell 106: 255-258.
5. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182: 389-400.
6. Takeda, K., and S. Akira. 2005. Toll-like receptors in innate immunity. Int. Immunol. 17: 1-14.
7. Medzhitov, R., P. Preston-Hurlburt, and C. A. Janeway, Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
8. Takeuchi, O., and S. Akira. 2001. Toll-like receptors: their physiological role and signal transduction system. Int. Immunopharmacol. 1: 625-635.
9. Schwandner, R., R. Dziarski, H. Wesche, M. Rothe, and C. J. Kirschning. 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by tolllike receptor 2. J. Biol. Chem. 274: 17406-17409.
10. Takeuchi, O., S. Sato, T. Horiuchi, K. Hoshino, K. Takeda, Z. Dong, R. L. Modlin, and S. Akira. 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169: 10-14. (Pubitemid 34686113)
11. Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413: 732-738.
12. Poltorak, A., X. He, I. Smirnova, M. Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088.
13. Hayashi, F., K. D. Smith, A. Ozinsky, T. R. Hawn, E. C. Yi, D. R. Goodlett, J. K. Eng, S. Akira, D. M. Underhill, and A. Aderem. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410: 1099-1103.
14. Jurk, M., F. Heil, J. Vollmer, C. Schetter, A. M. Krieg, H. Wagner, G. Lipford, and S. Bauer. 2002. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3: 499.
15. Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745.
16. Thoma-Uszynski, S., S. Stenger, O. Takeuchi, M. T. Ochoa, M. Engele, P. A. Sieling, P. F. Barnes, M. Rollinghoff, P. L. Bolcskei, M. Wagner, et al. 2001. Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 291: 1544-1547.
17. Medzhitov, R. 2001. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1: 135-145.
18. Pasare, C., and R. Medzhitov. 2004. Toll-like receptors: linking innate and adaptive immunity. Microbes Infect. 6: 1382-1387.
19. Brink, C., S. E. Dahlen, J. Drazen, J. F. Evans, D. W. Hay, S. Nicosia, C. N. Serhan, T. Shimizu, and T. Yokomizo. 2003. International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors. Pharmacol. Rev. 55: 195-227.
20. Heise, C. E., B. F. O'Dowd, D. J. Figueroa, N. Sawyer, T. Nguyen, D. S. Im, R. Stocco, J. N. Bellefeuille, M. Abramovitz, R. Cheng, et al. 2000. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275: 30531-30536.
21. Lynch, K. R., G. P. O'Neill, Q. Liu, D. S. Im, N. Sawyer, K. M. Metters, N. Coulombe, M. Abramovitz, D. J. Figueroa, Z. Zeng, et al. 1999. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399: 789-793.
22. Sarau, H. M., R. S. Ames, J. Chambers, C. Ellis, N. Elshourbagy, J. J. Foley, D. B. Schmidt, R. M. Muccitelli, O. Jenkins, P. R. Murdock, et al. 1999. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol. Pharmacol. 56: 657-663.
23. Figueroa, D. J., R. M. Breyer, S. K. Defoe, S. Kargman, B. L. Daugherty, K. Waldburger, Q. Liu, M. Clements, Z. Zeng, G. P. O'Neill, et al. 2001. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. Am. J. Respir. Crit. Care Med. 163: 226-233.
24. Robbiani, D. F., R. A. Finch, D. Jager, W. A. Muller, A. C. Sartorelli, and G. J. Randolph. 2000. The leukotriene C4 transporter MRP1 regulates CCL19 (MIP-3β, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 103: 757-768.
25. Machida, I., H. Matsuse, Y. Kondo, T. Kawano, S. Saeki, S. Tomari, Y. Obase, C. Fukushima, and S. Kohno. 2004. Cysteinyl leukotrienes regulate dendritic cell functions in a murine model of asthma. J. Immunol. 172: 1833-1838.
26. + hematopoietic progenitors and in lymphoid organs. Blood 96: 3857-3865.
27. Spanbroek, R., H. J. Stark, U. Janssen-Timmen, S. Kraft, M. Hildner, T. Andl, F. X. Bosch, N. E. Fusenig, T. Bieber, O. Radmark, et al. 1998. 5-Lipoxygenase expression in Langerhans cells of normal human epidermis. Proc. Natl. Acad. Sci. USA 95: 663-668.
28. Okunishi, K., M. Dohi, K. Nakagome, R. Tanaka, and K. Yamamoto. 2004. A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung. J. Immunol. 173: 6393-6402. (Pubitemid 39487799)
29. Parameswaran, K., H. Liang, A. Fanat, R. Watson, D. P. Snider, and P. M. O'Byrne. 2004. Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma. J. Allergy Clin. Immunol. 114: 73-79.
30. Jozefowski, S., R. Biedron, M. Bobek, and J. Marcinkiewicz. 2005. Leukotrienes modulate cytokine release from dendritic cells. Immunology 116: 418-428.
31. Thivierge, M., J. Stankova, and M. Rola-Pleszczynski. 2006. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. J. Allergy Clin. Immunol. 117: 1155-1162.
32. Underhill, D. M., A. Ozinsky, A. M. Hajjar, A. Stevens, C. B. Wilson, M. Bassetti, and A. Aderem. 1999. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401: 811-815.
33. Underhill, D. M., and A. Ozinsky. 2002. Phagocytosis of microbes: complexity in action. Annu. Rev. Immunol. 20: 825-852.
34. Brown, G. D., P. R. Taylor, D. M. Reid, J. A. Willment, D. L. Williams, L. Martinez-Pomares, S. Y. Wong, and S. Gordon. 2002. Dectin-1 is a major β-glucan receptor on macrophages. J. Exp. Med. 196: 407-412.
35. Gantner, B. N., R. M. Simmons, S. J. Canavera, S. Akira, and D. M. Underhill. 2003. Collaborative induction of inflammatory responses by dectin-1 and Tolllike receptor 2. J. Exp. Med. 197: 1107-1117.
36. Harizi, H., and N. Gualde. 2006. Pivotal role of PGE2 and IL-10 in the crossregulation of dendritic cell-derived inflammatory mediators. Cell Mol. Immunol. 3: 271-277.
37. Sallusto, F., and A. Lanzavecchia. 2000. Understanding dendritic cell and Tlymphocyte traffic through the analysis of chemokine receptor expression. Immunol. Rev. 177: 134-140.
38. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4: 499-511.
39. Kaisho, T., and S. Akira. 2006. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117: 979-988.
40. Aicher, A., G. L. Shu, D. Magaletti, T. Mulvania, A. Pezzutto, A. Craxton, and E. A. Clark. 1999. Differential role for p38 mitogen-activated protein kinase in regulating CD40-induced gene expression in dendritic cells and B cells. J. Immunol. 163: 5786-5795.
41. Arrighi, J. F., M. Rebsamen, F. Rousset, V. Kindler, and C. Hauser. 2001. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers. J. Immunol. 166: 3837-3845.
42. Dillon, S., S. Agrawal, K. Banerjee, J. Letterio, T. L. Denning, K. Oswald-Richter, D. J. Kasprowicz, K. Kellar, J. Pare, T. van Dyke, et al. 2006. Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigenpresenting cells and immunological tolerance. J. Clin. Invest. 116: 916-928.
43. Spanbroek, R., M. Hildner, A. Kohler, A. Muller, F. Zintl, H. Kuhn, O. Radmark, B. Samuelsson, and A. J. Habenicht. 2001. IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression. Proc. Natl. Acad. Sci. USA 98: 5152-5157.
44. Woszczek, G., L. Y. Chen, S. Nagineni, and J. H. Shelhamer. 2008. IL-10 inhibits cysteinyl leukotriene-induced activation of human monocytes and monocyte-derived dendritic cells. J. Immunol. 180: 7597-7603.
45. Corinti, S., C. Albanesi, A. la Sala, S. Pastore, and G. Girolomoni. 2001. Regulatory activity of autocrine IL-10 on dendritic cell functions. J. Immunol. 166: 4312-4318. (Pubitemid 32233711)
46. Re, F., and J. L. Strominger. 2004. IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells. J. Immunol. 173: 7548-7555. (Pubitemid 39628196)
47. Samarasinghe, R., P. Tailor, T. Tamura, T. Kaisho, S. Akira, and K. Ozato. 2006. Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling. J. Interferon Cytokine Res. 26: 893-900.
48. Peguet-Navarro, J., C. Moulon, C. Caux, C. Dalbiez-Gauthier, J. Banchereau, and D. Schmitt. 1994. Interleukin-10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells. Eur. J. Immunol. 24: 884-891.
49. 2 that contributes to the immunomodulation induced by antigen-presenting cells. Cell Immunol. 209: 19-28.
50. Harizi, H., M. Juzan, V. Pitard, J. F. Moreau, and N. Gualde. 2002. Cyclooxygenase- 2-issued prostaglandin E2 enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J. Immunol. 168: 2255-2263.
51. Kambayashi, T., R. P. Wallin, and H. G. Ljunggren. 2001. cAMP-elevating agents suppress dendritic cell function. J. Leukocyte Biol. 70: 903-910. (Pubitemid 33151129)
52. Harizi, H., M. Juzan, J. F. Moreau, and N. Gualde. 2003. Prostaglandins inhibit 5-lipoxygenase-activating protein expression and leukotriene B4 production from dendritic cells via an IL-10-dependent mechanism. J. Immunol. 170: 139-146.
53. Harizi, H., and G. Norbert. 2004. Inhibition of IL-6, TNF-α, and cyclooxygenase-2 protein expression by prostaglandin E2-induced IL-10 in bone marrowderived dendritic cells. Cell Immunol. 228: 99-109.
54. Wang, P., P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah. 1995. Interleukin (IL)-10 inhibits nuclear factor κB (NF κB) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J. Biol. Chem. 270: 9558-9563.
55. Driessler, F., K. Venstrom, R. Sabat, K. Asadullah, and A. J. Schottelius. 2004. Molecular mechanisms of interleukin-10-mediated inhibition of NF-κB activity: a role for p50. Clin. Exp. Immunol. 135: 64-73.
56. Murray, P. J. 2005. The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc. Natl. Acad. Sci. USA 102: 8686-8691.
57. Park, J. M., F. R. Greten, A. Wong, R. J. Westrick, J. S. Arthur, K. Otsu, A. Hoffmann, M. Montminy, and M. Karin. 2005. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis-CREB and NF-κB as key regulators. Immunity 23: 319-329.
58. Dillon, S., A. Agrawal, T. Van Dyke, G. Landreth, L. McCauley, A. Koh, C. Maliszewski, S. Akira, and B. Pulendran. 2004. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J. Immunol. 172: 4733-4743.
59. Rogers, N. C., E. C. Slack, A. D. Edwards, M. A. Nolte, O. Schulz, E. Schweighoffer, D. L. Williams, S. Gordon, V. L. Tybulewicz, G. D. Brown, and C. Reis e Sousa. 2005. Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22: 507-517.