Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1β activity

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 20607-20614

  Roell, Marina K ^a   Issafras, Hassan ^a   Bauer, Robert J ^a,b   Michelson, Kristen S ^a   Mendoza, Nerissa ^a   Vanegas, Sandra I ^a   Gross, Lisa M ^a   Larsen, Paul D ^a   Bedinger, Daniel H ^a   Bohmann, David J ^a   Nonet, Genevieve H ^a   Liu, Naichi ^a   Lee, Steve R ^a   Handa, Masahisa ^a   Kantak, Seema S ^a   Horwitz, Arnold H ^a   Hunter, John J ^a   Owyang, Alexander M ^a   Mirza, Amer M ^a   Corbin, John A ^a   White, Mark L ^a   more..

^a XOMA Corporation   (United States)

^b ICON Development Solutions   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR SIGNALING; CONTEXT DEPENDENT; CYTOKINES; EFFECTIVE DOSE; HIGH ACTIVITY; IN-VITRO; INTERLEUKIN-1; KINETIC APPROACH; LIGAND BINDING; POTENT INHIBITOR; REGULATORY MECHANISM; REGULATORY PROTEIN; SIGNALING PATHWAYS; SIGNALING RECEPTOR; THERAPEUTIC ANTIBODIES; THERAPEUTIC USE;

MONOCLONAL ANTIBODIES;

SIGNALING;

INTERLEUKIN 1BETA; INTERLEUKIN 1BETA ANTIBODY; MONOCLONAL ANTIBODY XOMA 052; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; LIGAND BINDING; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANTIBODIES, MONOCLONAL; BIOENGINEERING; FIBROBLASTS; HELA CELLS; HOMEOSTASIS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-1BETA; KIDNEY; KINETICS; LIGANDS; LUCIFERASES; LUNG; NF-KAPPA B; PHOSPHOPROTEINS; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 77954224428     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.115790     Document Type: Article

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