FROUNT is a common regulator of CCR2 and CCR5 signaling to control directional migration

Journal of Immunology

Volumn 183, Issue 10, 2009, Pages 6387-6394

  Toda, Etsuko ^a   Terashima, Yuya ^a,b   Sato, Tsuyoshi ^b   Hirose, Kenzo ^a   Kanegasaki, Shiro ^b   Matsushima, Kouji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b ECI Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROTEIN FROUNT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL INFILTRATION; CHEMOTAXIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PSEUDOPODIUM; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ACTINS; AMINO ACID SEQUENCE; CELL LINE, TUMOR; CELL MOVEMENT; CHEMOKINE CCL4; CHEMOTAXIS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PORE COMPLEX PROTEINS; PHYLOGENY; PSEUDOPODIA; RECEPTORS, CCR2; RECEPTORS, CCR5; RNA, SMALL INTERFERING; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 77954224131     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803469     Document Type: Article

References (41)

1. Manes, S., C. Gomez-Mouton, R. A. Lacalle, S. Jimenez-Baranda, E. Mira, and A. C. Martinez. 2005. Mastering time and space: immune cell polarization and chemotaxis. Semin. Immunol. 17: 77-86.
2. Murphy, P. M., M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power. 2000. International union of pharmacology, XXII: Nomenclature for chemokine receptors. Pharmacol. Rev. 52: 145-176.
3. Mellado, M., J. M. Rodriguez-Frade, S. Manes, and A. C. Martinez. 2001. Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation. Annu. Rev. Immunol. 19: 397-421.
4. Srinivasan, S., F. Wang, S. Glavas, A. Ott, F. Hofmann, K. Aktories, D. Kalman, and H. R. Bourne. 2003. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J. Cell Biol. 160: 375-385.
5. Merlot, S., and R. A. Firtel. 2003. Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J. Cell Sci. 116: 3471-3478.
6. Funamoto, S., R. Meili, S. Lee, L. Parry, and R. A. Firtel. 2002. Spatial and temporal regulation of 3-phosphoinositides by PI3-kinase and PTEN mediates chemotaxis. Cell 109: 611-623.
7. Maghazachi, A. A. 2000. Intracellular signaling events at the leading edge of migrating cells. Int. J. Biochem. Cell Biol. 32: 931-943.
8. Parent, C. A., and P. N. Devreotes. 1999. A cell's sense of direction. Science 284: 765-770.
9. Terashima, Y., N. Onai, M. Murai, M. Enomoto, V. Poonpiriya, T. Hamada, K. Motomura, M. Suwa, T. Ezaki, T. Haga, et al. 2005. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. Nat. Immunol. 6: 827-835.
10. Satoh, M., T. Akatsu, Y. Ishkawa, Y. Minami, and M. Nakamura. 2007. A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart. J. Card. Fail. 13: 114-119.
11. Belema-Bedada, F., S. Uchida, A. Martire, S. Kostin, and T. Braun. 2008. Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell 2: 566-575.
12. van Golen, K. L., C. Ying, L. Sequeira, C. W. Dubyk, T. Reisenberger, A. M. Chinnaiyan, K. J. Pienta, and R. D. Loberg. 2008. CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac. J. Cell. Biochem. 104: 1587-1597.
13. Arai, H., F. S. Monteclaro, C. L. Tsou, C. Franci, and I. F. Charo. 1997. Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B: evidence that directed migration does not require rapid modulation of signaling at the receptor level. J. Biol. Chem. 272: 25037-25042.
14. Kraft, K., H. Olbrich, I. Majoul, M. Mack, A. Proudfoot, and M. Oppermann. 2001. Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization. J. Biol. Chem. 276: 34408-34418.
15. Le Gouill, C., J. L. Parent, C. A. Caron, R. Gaudreau, L. Volkov, M. Rola-Pleszczynski, and J. Stankova. 1999. Selective modulation of wild type receptor functions by mutants of G-protein-coupled receptors. J. Biol. Chem. 274: 12548-12554.
16. Samson, M., O. Labbe, C. Mollereau, G. Vassart, and M. Parmentier. 1996. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35: 3362-3367.
17. Raport, C. J., J. Gosling, V. L. Schweickart, P. W. Gray, and I. F. Charo. 1996. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α. J. Biol. Chem. 271: 17161-17166.
18. Dawson, T. C., M. A. Beck, W. A. Kuziel, F. Henderson, and N. Maeda. 2000. Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am. J. Pathol. 156: 1951-1959.
19. Tacke, F., D. Alvarez, T. J. Kaplan, C. Jakubzick, R. Spanbroek, J. Llodra, A. Garin, J. Liu, M. Mack, N. van Rooijen, et al. 2007. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J. Clin. Invest. 117: 185-194.
20. Mellado, M., J. M. Rodriguez-Frade, A. J. Vila-Coro, S. Fernandez, A. Martin de Ana, D. R. Jones, J. L. Toran, and A. C. Martinez. 2001. Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J. 20: 2497-2507.
21. Shirane, D., K. Sugao, S. Namiki, M. Tanabe, M. Iino, and K. Hirose. 2004. Enzymatic production of RNAi libraries from cDNAs. Nat. Genet. 36: 190-196.
22. Kanegasaki, S., Y. Nomura, N. Nitta, S. Akiyama, T. Tamatani, Y. Goshoh, T. Yoshida, T. Sato, and Y. Kikuchi. 2003. A novel optical assay system for the quantitative measurement of chemotaxis. J. Immunol. Methods 282: 1-11.
23. Nitta, N., T. Tsuchiya, A. Yamauchi, T. Tamatani, and S. Kanegasaki. 2007. Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device: TAXIScan. J. Immunol. Methods 320: 155-163.
24. Nieto, M., J. M. Frade, D. Sancho, M. Mellado, A. C. Martinez, and F. Sanchez-Madrid. 1997. Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis. J. Exp. Med. 186: 153-158.
25. van Buul, J. D., C. Voermans, J. van Gelderen, E. C. Anthony, C. E. van der Schoot, and P. L. Hordijk. 2003. Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4. J. Biol. Chem. 278: 30302-30310.
26. Petrie, R. J., A. D. Doyle, and K. M. Yamada. 2009. Random versus directionally persistent cell migration. Nat. Rev. Mol. Cell Biol. 10: 538-549.
27. Andrew, N., and R. H. Insall. 2007. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat. Cell Biol. 9: 193-200.
28. Arrieumerlou, C., and T. Meyer. 2005. A local coupling model and compass parameter for eukaryotic chemotaxis. Dev. Cell 8: 215-227.
29. Comer, F. I., and C. A. Parent. 2002. PI3-kinases and PTEN: how opposites chemoattract. Cell 109: 541-544.
30. Kimmel, A. R., and C. A. Parent. 2003. The signal to move: D. discoideum go orienteering. Science 300: 1525-1527.
31. Meili, R., and R. A. Firtel. 2003. Two poles and a compass. Cell 114: 153-156.
32. Sasaki, A. T., C. Chun, K. Takeda, and R. A. Firtel. 2004. Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J. Cell Biol. 167: 505-518.
33. Vicente-Manzanares, M., A. Cruz-Adalia, N. B. Martin-Cofreces, J. R. Cabrero, M. Dosil, B. Alvarado-Sanchez, X. R. Bustelo, and F. Sanchez-Madrid. 2005. Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav. Blood 105: 3026-3034.
34. Sai, J., G. Walker, J. Wikswo, and A. Richmond. 2006. The IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells. J. Biol. Chem. 281: 35931-35941.
35. Mueller, S. G., J. R. White, W. P. Schraw, V. Lam, and A. Richmond. 1997. Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. J. Biol. Chem. 272: 8207-8214.
36. Sabroe, I., A. Jorritsma, V. E. Stubbs, G. Xanthou, L. A. Jopling, P. D. Ponath, T. J. Williams, P. M. Murphy, and J. E. Pease. 2005. The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner. Eur. J. Immunol. 35: 1301-1310.
37. Otero, C., P. S. Eisele, K. Schaeuble, M. Groettrup, and D. F. Legler. 2008. Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis. J. Cell Sci. 121: 2759-2767.
38. Sawanobori, Y., S. Ueha, M. Kurachi, T. Shimaoka, J. E. Talmadge, J. Abe, Y. Shono, M. Kitabatake, K. Kakimi, N. Mukaida, and K. Matsushima. 2008. Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood 111: 5457-5466.
39. Boring, L., J. Gosling, S. W. Chensue, S. L. Kunkel, R. V. Farese, Jr., H. E. Broxmeyer, and I. F. Charo. 1997. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100: 2552-2561.
40. Kurihara, T., G. Warr, J. Loy, and R. Bravo. 1997. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J. Exp. Med. 186: 1757-1762.
41. Kuziel, W. A., S. J. Morgan, T. C. Dawson, S. Griffin, O. Smithies, K. Ley, and N. Maeda. 1997. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc. Natl. Acad. Sci. USA 94: 12053-12058.