The ternary complex of PrnB (the second enzyme in the pyrrolnitrin biosynthesis pathway), tryptophan, and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 21126-21133

  Zhu, Xiaofeng ^a   Van Pée, Karl Heinz ^b   Naismith, James H ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL COMPOUNDS; BINARY COMPLEXES; BIOSYNTHESIS PATHWAYS; CARBOXYLATE GROUPS; CYANIDE COMPLEXES; D-TRYPTOPHAN; DIOXYGENASES; IN-VITRO; IN-VIVO; INDOLE RINGS; ISOTHERMAL TITRATION CALORIMETRY; L-TRYPTOPHAN; TERNARY COMPLEX;

AMIDES; AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLATION; CONFORMATIONS; CYANIDES; ENZYMES; HEMOGLOBIN; OXYGEN; PORPHYRINS; SUBSTRATES;

CHLORINE COMPOUNDS;

AMIDE; CARBOXYLIC ACID; CYANIDE; INDOLEAMINE 2,3 DIOXYGENASE; PYRROLNITRIN; PYRROLNITRIN A; PYRROLNITRIN B; PYRROLNITRIN C; PYRROLNITRIN D; SERINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PSEUDOMONAS;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; BINDING SITES; CALORIMETRY; CYANIDES; DNA PRIMERS; EMERICELLA; FUNGAL PROTEINS; HEME; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; TRYPTOPHAN; TRYPTOPHAN OXYGENASE;

BURKHOLDERIA PYRROCINIA;

EID: 77954221788     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.120485     Document Type: Article

References (30)

1. van Pée, K. H., and Ligon, J. M. (2000) Nat. Prod. Rep. 17, 157-164
2. Arima, K., Imanaka, H., Kousaka, M., Fukuda, A., and Tamura, G. (1964) Agric. Biol. Chem. 28, 575-576
3. Hammer, P. E., Hill, D. S., Lam, S. T., Van Pée, K. H., and Ligon, J. M. (1997) Appl. Environ. Microbiol. 63, 2147-2154
4. Kirner, S., Hammer, P. E., Hill, D. S., Altmann, A., Fischer, I., Weislo, L. J., Lanahan, M., van Pée, K. H., and Ligon, J. M. (1998) J. Bacteriol. 180, 1939-1943
5. Hammer, P. E., Burd, W., Hill, D. S., Ligon, J. M., and van Pée, K. H. (1999) FEMS Microbiol. Lett. 180, 39-44
6. Hohaus, K., Altmann, A., Burd, W., Fischer, I., Hammer, P. E., Hill, D. S., Ligon, J. M., and van Pee, K. H. (1997) Angew Chem. Int. Ed. Engl. 36, 2012-2013
7. Dong, C., Flecks, S., Unversucht, S., Haupt, C., van Pée, K. H., and Naismith, J. H. (2005) Science 309, 2216-2219
8. Yeh, E., Cole, L. J., Barr, E. W., Bollinger, J. M., Jr., Ballou, D. P., and Walsh, C. T. (2006) Biochemistry 45, 7904-7912
9. Yeh, E., Blasiak, L. C., Koglin, A., Drennan, C. L., and Walsh, C. T. (2007) Biochemistry 46, 1284-1292
10. Zhu, X., De Laurentis, W., Leang, K., Herrmann, J., Ihlefeld, K., van Pée, K. H., and Naismith, J. H. (2009) J. Mol. Biol. 391, 74-85
11. Flecks, S., Patallo, E. P., Zhu, X., Ernyei, A. J., Seifert, G., Schneider, A., Dong, C., Naismith, J. H., and van Pée, K. H. (2008) Angew Chem. Int. Ed. Engl. 47, 9533-9536
12. Lee, J. K., Ang, E. L., and Zhao, H. M. (2006) J. Bacteriol. 188, 6179-6183
13. De Laurentis, W., Khim, L., Anderson, J. L., Adam, A., Johnson, K. A., Phillips, R. S., Chapman, S. K., van Pee, K. H., and Naismith, J. H. (2007) Biochemistry 46, 12393-12404
14. Sugimoto, H., Oda, S., Otsuki, T., Hino, T., Yoshida, T., and Shiro, Y. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 2611-2616
15. Forouhar, F., Anderson, J. L., Mowat, C. G., Vorobiev, S. M., Hussain, A., Abashidze, M., Bruckmann, C., Thackray, S. J., Seetharaman, J., Tucker, T., Xiao, R., Ma, L. C., Zhao, L., Acton, T. B., Montelione, G. T., Chapman, S. K., and Tong, L. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 473-478
16. Thackray, S. J., Mowat, C. G., and Chapman, S. K. (2008) Biochem. Soc. Trans. 36, 1120-1123
17. Chauhan, N., Thackray, S. J., Rafice, S. A., Eaton, G., Lee, M., Efimov, I., Basran, J., Jenkins, P. R., Mowat, C. G., Chapman, S. K., and Raven, E. L. (2009) J. Am. Chem. Soc. 131, 4186-4187
18. Chung, L. W., Li, X., Sugimoto, H., Shiro, Y., and Morokuma, K. (2008) J. Am. Chem. Soc. 130, 12299-12309
19. Lewis-Ballester, A., Batabyal, D., Egawa, T., Lu, C., Lin, Y., Marti, M. A., Capece, L., Estrin, D. A., and Yeh, S. R. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 17371-17376
20. De Laurentis, W., Leang, K., Hahn, K., Podemski, B., Adam, A., Kroschwald, S., Carter, L. G., van Pee, K. H., and Naismith, J. H. (2006) Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62, 1134-1137
21. Littlejohn, T. K., Takikawa, O., Skylas, D., Jamie, J. F., Walker, M. J., and Truscott, R. J. (2000) Protein Expr. Purif. 19, 22-29
22. Otwinowski, Z., and Minor, W. (1997) in Methods in Enzymology (Carter, C., Jr., and Sweet, R. M., eds) pp. 307-326, Academic Press, London
23. Murshudov, G. N., Vagin, A. A., Lebedev, A., Wilson, K. S., and Dodson, E. J. (1999) Acta Crystallogr. D. Biol. Crystallogr. 55, 247-255
24. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D. Biol. Crystallogr. 60, 2126-2132
25. Davis, I. W., Leaver-Fay, A., Chen, V. B., Block, J. N., Kapral, G. J., Wang, X., Murray, L. W., Arendall, W. B., 3rd, Snoeyink, J., Richardson, J. S., and Richardson, D. C. (2007) Nucleic Acids Res. 35, W375-W383
26. Bolognesi, M., Rosano, C., Losso, R., Borassi, A., Rizzi, M., Wittenberg, J. B., Boffi, A., and Ascenzi, P. (1999) Biophys. J. 77, 1093-1099
27. Sugishima, M., Sakamoto, H., Noguchi, M., and Fukuyama, K. (2003) Biochemistry 42, 9898-9905
28. Chang, C. J., Floss, H. G., Hook, D. J., Mabe, J. A., Manni, P. E., Martin, L. L., Schröder, K., and Shieh, T. L. (1981) J. Antibiot. 34, 555-566
29. Davydov, R. M., Chauhan, N., Thackray, S. J., Anderson, J. L., Papadopoulou, N. D., Mowat, C. G., Chapman, S. K., Raven, E. L., and Hoffman, B. M. (2010) J. Am. Chem. Soc. 132, 5494-5500
30. Schüttelkopf, A. W., and van Aalten, D. M. (2004) Acta Crystallogr.DBiol. Crystallogr. 60, 1355-1363