Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 13, 2010, Pages 4783-4792

  Cummings, David F ^a   Canseco, Diana C ^b   Sheth, Pratikkumar ^d   Johnson, James E ^b   Schetz, John A ^a,c,d  

^a UNIVERSITY OF NORTH TEXAS   (United States)

^b TEXAS WOMAN'S UNIVERSITY   (United States)

^c University of North Texas Health Science Center   (United States)

^d UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

5 HT2C; 5 HT2C receptor selective ligand; 5 Hydroxytryptamine; Aplysinopsin; Natural product analogue; Serotonin receptor

Indexed keywords

2 AMINO 5 (5 BROMO 1H INDOL 3 YLMETHYLENE) 1 METHYL 1,5 DIHYDRO IMIDAZOL 4 ONE; 2 AMINO 5 [(5 CHLORO 1H INDOL 3 YL)METHYLENE] 1 METHYL 1H IMIDAZOL 4(5H) ONE; 2 AMINO 5 [(5 FLUORO 1H INDOL 3 YL)METHYLENE] 1 METHYL 1H IMIDAZOL 4(5H) ONE; 2 AMINO 5 [(5,6 DICHLORO 1H INDOL 3 YL)METHYLENE] 1 METHYL 1H IMIDAZOL 4(5H) ONE; 2 AMINO 5 [(6 CHLORO 1H INDOL 3 YL)METHYLENE] 1 METHYL 1H IMIDAZOL 4(5H) ONE; 2 AMINO 5 [(6 FLUORO 1H INDOL 3 YL)METHYLENE] 1 METHYL 1H IMIDAZOL 4(5H) ONE; 3 ETHYL 2 IMINO 5 [(5 IODO 1H INDOL 3YL)METHYLENE] 1 METHYLIMIDAZOLIDIN 4 ONE; 3 ETHYL 5 [(6 FLUORO 1H INDOL 3 YL)METHYLENE] 2 IMINO 1METHYLIMIDAZOLIDIN 4 ONE; 5 (5 FLUORO 1H INDOL 3 YLMETHYLENE) 2 IMINO 1,3 DIMETHYL IMIDAZOLIDIN 4 ONE; 5 (6 BROMO 1H INDOL 3 YLMETHYLENE) 2 IMINO 1,3 DIMETHYL IMIDAZOLIDIN 4 ONE; 5 [(1H INDOL 3YL)METHYLENE] 2 AMINO 1 METHYL 1H IMIDAZOL 4(5H) ONE; 5 [(1H INDOL 3YL)METHYLENE] 2 IMINO 1,3 DIMETHYLIMIDAZOLIDIN 4 ONE; 5 [(1H INDOL 3YL)METHYLENE] 3 ETHYL 2 IMINO 1 METHYLIMIDAZOLIDIN 4 ONE; 5 [(5 BROMO 1H INDOL 3YL)METHYLENE] 2 IMINO 1,3 DIMETHYLIMIDAZOLIDIN 4 ONE; 5 [(5 BROMO 1H INDOL 3YL)METHYLENE] 3 ETHYL 2 IMINO 1 METHYLIMIDAZOLIDIN 4 ONE; 5 [(5 CHLORO 1H INDOL 3YL)METHYLENE] 2 IMINO 1,3 DIMETHYLIMIDAZOLIDIN 4 ONE; 5 [(5,6 DICHLORO 1H INDOL 3 YL)METHYLENE] 2 IMINO 1,3 DIMETHYLIMIDAZOLIDIN 4 ONE; 5 [(6 BROMO 1H INDOL 3YL)METHYLENE] 3 ETHYL 2 IMINO 1 METHYLIMIDAZOLIDIN 4 ONE; 5 [(6 CHLORO 1H INDOL 3YL)METHYLENE] 2 IMINO 1,3 DIMETHYLIMIDAZOLIDIN 4 ONE; 5 [(6 FLUORO 1H INDOL 3 YL)METHYLENE] 2 IMINO 1,3 DIMETHYLIMIDAZOLIDIN 4 ONE; INDOLE ALKALOID; NATURAL PRODUCT; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING AFFINITY; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; HUMANS; IMIDAZOLIDINES; INDOLES; PORIFERA; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 77954219570     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.017     Document Type: Article

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