1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: Novel and selective 5-HT(2C) receptor inverse agonists with potential as antidepressant/anxiolytic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 16, 2000, Pages 1863-1866

  Bromidge, Steven M ^a   Dabbs, Steven ^a   Davies, Susannah ^a   Duckworth, D Malcolm ^a   Forbes, Ian T ^a   Jones, Graham E ^a   Jones, Jerome ^a   King, Frank D ^a   Saunders, Damian V ^a   Blackburn, Thomas P ^a   Holland, Vicky ^a   Kennett, Guy A ^a   Lightowler, Sean ^a   Middlemiss, Derek N ^a   Riley, Graham J ^a   Trail, Brenda ^a   Wood, Martyn D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (CARBAMOYL) INDOLINE DERIVATIVE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; SEROTONIN 2 RECEPTOR; SEROTONIN 2B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; NONHUMAN; RAT; RECEPTOR AFFINITY; SEROTONINERGIC SYSTEM; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMINOPYRIDINES; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; DRUG DESIGN; HUMANS; INDOLES; KINETICS; MOLECULAR STRUCTURE; MOTOR ACTIVITY; RATS; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0034698890     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00364-4     Document Type: Article

References (11)