Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship

Analytica Chimica Acta

Volumn 673, Issue 1, 2010, Pages 40-46

  Völgyi, Gergely ^a   Baka, Edit ^a   Box, Karl J ^b   Comer, John E A ^b   Takács Novák, Krisztina ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b Sirius Analytical Instruments Ltd   (United Kingdom)

Author keywords

Henderson Hasselbalch relationship; Intrinsic solubility; Ionizable drugs; PH dependent solubility; Shake flask method

Indexed keywords

AQUEOUS SOLUBILITY; COMMON ION EFFECT; EQUILIBRIUM SOLUBILITIES; FUMARATES; HH EQUATION; INTRINSIC SOLUBILITIES; IONIZABLE DRUGS; ORGANIC BASIS; PH CONTROL; PH-DEPENDENT; PROMETHAZINE; SALT COMPOSITION; SALT SOLUBILITY; SHAKE-FLASK METHOD; SOLUBILITY DATA; SOLUBILITY MEASUREMENT; WEAK BASIS;

PREDICTIVE CONTROL SYSTEMS; SOLUBILITY;

PH EFFECTS;

DESVENLAFAXINE; PAPAVERINE; PROMETHAZINE; PROPAFENONE; QUETIAPINE; TICLOPIDINE; DRUG; ION;

ACCURACY; ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; CHEMICAL COMPOSITION; CHEMICAL PARAMETERS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG SOLUBILITY; DRUG STRUCTURE; EQUILIBRIUM CONSTANT; HENDERSON HASSALBACH EQUATION; PH; POTENTIOMETRY; PRIORITY JOURNAL; SHAKE FLASK METHOD; STRUCTURE ANALYSIS; VALIDITY; CHEMISTRY; SOLUBILITY;

HYDROGEN-ION CONCENTRATION; IONS; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 77954214687     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2010.05.022     Document Type: Article

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