Effect of chloride ion on dissolution of different salt forms of haloperidol, a model basic drug

Journal of Pharmaceutical Sciences

Volumn 94, Issue 10, 2005, Pages 2224-2231

  Li, Shoufeng ^a   Doyle, Pamela ^b   Metz, Stephanie ^a   Royce, Alan E ^a   Serajuddin, Abu T M ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b LONG ISLAND UNIVERSITY   (United States)

Author keywords

Basic drug; Chloride ion; Dissolution rate; Haloperidol; Powder dissolution; Salt selection

Indexed keywords

CHLORIDE; CHLORIDE ION; HALOPERIDOL; HYDROCHLORIC ACID; MESYLIC ACID; PHOSPHATE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG DOSAGE FORM; DRUG SOLUBILITY; INFRARED SPECTROSCOPY; KINETICS; PH; PKA; POWDER; X RAY POWDER DIFFRACTION;

EID: 23844475290     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20440     Document Type: Article

References (13)

1. Higuchi W, Parrot EL, Wurster DE, Higuchi T. 1958. Investigation of drug release from solids II: theoretical and experimental study of influences of bases and buffers on rates of dissolution of acidic solids. J Am Pharm Assoc 47:376-383.
2. Mooney KG, Mintun MA, Himmelstein KJ, Stella VJ. 1981. Dissolution kinetics of carboxylic acids I: effect of pH under unbuffered conditions. J Pharm Sci 70:13-22.
3. Serajuddin ATM, Jarowski CI. 1985. Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical bases and their hydrochloride salts. I. Phenazopyridine. J Pharm Sci 74:142-147.
4. Serajuddin ATM, Jarowski C. 1985. Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical acids and sodium salts. II: salicylic acid, theophylline, and benzoic acid. J Pharm Sci 74:148-154.
5. Ozturk SS, Palsson BO, Dressman JB. 1988. Dissolution of ionizable drugs in buffered and unbuffered solutions. Pharm Res 5:272-282.
6. Pudipeddi M, Serajuddin ATM, Grant DJW, Stahl PH. 2001. Solubility and dissolution of weak acids, bases, and salts. In: Stahl PH, Wermuth CG, editors. Handbook of pharmaceutical salts-properties, selection, and use. Zurich: Verlag Helvetica Chimica Acta, pp 19-39.
7. Lindahl A, Ungell AL, Lennernas H. 1997. Characterization of fluids from the stomach and proximal jejunum in men and women. Pharm Res 14:497-502.
8. Dressman JB, Reppas C. 2000. In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs. Eur J Pharm Sci 11(Suppl 2):S73-S80.
9. Lin SL, Lachman L, Schwartz CJ, Huebner CF. 1972. Preformulation investigation I: relation of salt forms and biological activity of an experimental antihypertensive. J Pharm Sci 61:1418-1422.
10. Li S, Wong SM, Sethia S, Almoazen H, Joshi YM, Serajuddin ATM. 2005. Investigation of solubility and dissolution of a free base and two different salt forms as a function of pH. Pharm Res 22:628-635.
11. Horter D, Dressman JB. 2001. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv Drug Delivery Rev 46:75-87.
12. Bakatselou V, Oppenheim RC, Dressman JB. 1991. Solubilization and wetting effects of bile salts on the dissolution of steroids. Pharm Res 8:1461-1469.
13. Pharmacopeial Forum, Vol. 24, No. 1, 1998, pp 5436-5437.