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Volumn 583, Issue 2, 2007, Pages 418-428
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Potentiometric and spectrophotometric pKa determination of water-insoluble compounds: Validation study in a new cosolvent system
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Author keywords
Cosolvent procedure; Methanol dioxane acetonitrile water (MDM); pKa; Validation
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Indexed keywords
DISSOCIATION;
MIXTURES;
POTENTIOMETERS (RESISTORS);
SOLUBILITY;
SPECTROPHOTOMETRY;
TITRATION;
COSOLVENT PROCEDURE;
DRUG RESEARCH;
METHANOL/DIOXANE/ACETONITRILE-WATER (MDM);
SINGLE POINT ESTIMATION;
ORGANIC SOLVENTS;
ACETONITRILE;
ACETYLSALICYLIC ACID;
AMINOPHENAZONE;
AMODIAQUINE;
AMPICILLIN;
ATENOLOL;
BENZOCAINE;
BUSPIRONE;
CEFALEXIN;
CHLORPROMAZINE;
CHLORTALIDONE;
CIPROFLOXACIN;
CLIOQUINOL;
CODEINE;
DIAZEPAM;
DIOXANE;
DIPHENOXYLATE;
EPHEDRINE;
FUROSEMIDE;
HALOPERIDOL;
HYDROCHLOROTHIAZIDE;
IBUPROFEN;
KETAMINE;
MESALAZINE;
METHANOL;
MEXILETINE;
SELEGILINE;
SOLVENT;
UNINDEXED DRUG;
VERAPAMIL;
WATER;
AQUEOUS SOLUTION;
ARTICLE;
CALCULATION;
DIELECTRIC CONSTANT;
DISSOCIATION CONSTANT;
ELECTRODE;
MEASUREMENT;
PKA;
POTENTIOMETRY;
PRIORITY JOURNAL;
SOLUBILITY;
SPECTROPHOTOMETRY;
TITRIMETRY;
VALIDATION PROCESS;
YASUDA SHEDLOVSKY PLOT;
CHEMISTRY;
METHODOLOGY;
PH;
ULTRAVIOLET SPECTROPHOTOMETRY;
VALIDATION STUDY;
CHEMISTRY, ANALYTICAL;
HYDROGEN-ION CONCENTRATION;
POTENTIOMETRY;
SOLUBILITY;
SOLVENTS;
SPECTROPHOTOMETRY, ULTRAVIOLET;
WATER;
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EID: 33846126544
PISSN: 00032670
EISSN: None
Source Type: Journal
DOI: 10.1016/j.aca.2006.10.015 Document Type: Article |
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Times cited : (148)
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References (16)
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