Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults?

Journal of the American Geriatrics Society

Volumn 57, Issue 8, 2009, Pages 1411-1419

  Cawthon, Peggy Mannen ^a   Fox, Kathleen M ^b   Gandra, Shravanthi R ^c   Delmonico, Matthew J ^d   Chiou, Chiun Fang ^c   Anthony, Mary S ^c   Sewall, Ase ^e   Goodpaster, Bret ^f   Satterfield, Suzanne ^g   Cummings, Steven R ^a   Harris, Tamara B ^h  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b Strategic Healthcare Solutions LLC   (United States)

^c AMGEN INC   (United States)

^d UNIVERSITY OF RHODE ISLAND   (United States)

^e Sewall Incorporated   (United States)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^h NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Hospitalization; Lean mass; Muscle fat infiltration; Physical function; Walking speed

Indexed keywords

AGED; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; ELDERLY CARE; FEMALE; FOLLOW UP; GRIP STRENGTH; HOSPITALIZATION; HUMAN; KNEE FUNCTION; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; PHYSICAL CAPACITY; RISK ASSESSMENT; UNITED STATES; WALKING SPEED;

ABSORPTIOMETRY, PHOTON; AGED; AGED, 80 AND OVER; BODY COMPOSITION; FEMALE; GERIATRIC ASSESSMENT; HAND STRENGTH; HOSPITALIZATION; HUMANS; KNEE JOINT; MALE; MEDICARE; MUSCLE STRENGTH; MUSCLE, SKELETAL; POISSON DISTRIBUTION; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; RISK; THIGH; TOMOGRAPHY, X-RAY COMPUTED; TORQUE; UNITED STATES; WALKING;

EID: 68149141186     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2009.02366.x     Document Type: Article

References (28)

1. Janssen I, Shepard DS, Katzmarzyk PT et al. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 2004 52 : 80 85.
2. Graafmans WC, Ooms ME, Hofstee HM et al. Falls in the elderly: A prospective study of risk factors and risk profiles. Am J Epidemiol 1996 143 : 1129 1136.
3. Moreland JD, Richardson JA, Goldsmith CH et al. Muscle weakness and falls in older adults: A systematic review and meta-analysis. J Am Geriatr Soc 2004 52 : 1121 1129.
4. Stevens JA, Olson S. Reducing falls and resulting hip fractures among older women. MMWR Recomm Rep 2000 49 : 3 12.
5. Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988 319 : 1701 1707.
6. Cawthon PM, Fullman RL, Marshall L et al. Physical performance and risk of hip fractures in older men. J Bone Miner Res 2008 23 : 1037 1044.
7. Cummings SR, Nevitt MC, Browner WS et al. Risk factors for hip fracture in white women. N Engl J Med 1995 332 : 767 773.
8. Lewis CE, Ewing SK, Taylor BC et al. Predictors of non-spine fracture in elderly men: The MrOS study. J Bone Miner Res 2007 22 : 211 219.
9. Visser M, Goodpaster BH, Kritchevsky SB et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci 2005 60A : 324 333.
10. Sager MA, Franke T, Inouye SK et al. Functional outcomes of acute medical illness and hospitalization in older persons. Arch Intern Med 1996 156 : 645 652.
11. Penninx BW, Ferrucci L, Leveille SG et al. Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization. J Gerontol A Biol Sci Med Sci 2000 55A : M691 M697.
12. Hirsch CH, Sommers L, Olsen A et al. The natural history of functional morbidity in hospitalized older patients. J Am Geriatr Soc 1990 38 : 1296 1303.
13. Ferrucci L, Guralnik JM, Pahor M et al. Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled. JAMA 1997 277 : 728 734.
14. Gill TM, Allore HG, Holford TR et al. Hospitalization, restricted activity, and the development of disability among older persons. JAMA 2004 292 : 2115 2124.
15. Newman AB, Haggerty CL, Goodpaster B et al. Strength and muscle quality in a well-functioning cohort of older adults: The Health, Aging and Body Composition study. J Am Geriatr Soc 2003 51 : 323 330.
16. Goodpaster BH, Krishnaswami S, Harris TB et al. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 2005 165 : 777 783.
17. Unger RH, Orci L. Lipoapoptosis: Its mechanism and its diseases. Biochim Biophys Acta 2002 1585 : 202 212.
18. Visser M, Deeg DJ, Lips P et al. Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women. J Am Geriatr Soc 2000 48 : 381 386.
19. Harkonen R, Harju R, Alaranta H. Accuracy of the Jamar dynamometer. J Hand Ther 1993 6 : 259 262.
20. Goodpaster BH, Carlson CL, Visser M et al. Attenuation of skeletal muscle and strength in the elderly: The Health ABC study. J Appl Physiol 2001 90 : 2157 2165.
21. Visser M, Kritchevsky SB, Goodpaster BH et al. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: The Health, Aging and Body Composition study. J Am Geriatr Soc 2002 50 : 897 904.
22. Newman AB, Kupelian V, Visser M et al. Sarcopenia: Alternative definitions and associations with lower extremity function. J Am Geriatr Soc 2003 51 : 1602 1609.
23. Byers AL, Allore H, Gill TM et al. Application of negative binomial modeling for discrete outcomes: A case study in aging research. J Clin Epidemiol 2003 56 : 559 564.
24. Goodpaster BH, Kelley DE, Thaete FL et al. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol 2000 89 : 104 110.
25. Goodpaster BH, Park SW, Harris TB et al. The loss of skeletal muscle strength, mass, and quality in older adults: The Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci 2006 61A : 1059 1064.
26. Ferrucci L, Bandinelli S, Benvenuti E et al. Subsystems contributing to the decline in ability to walk: Bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc 2000 48 : 1618 1625.
27. Ferrucci L, Bandinelli S, Cavazzini C et al. Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological disease. Am J Med 2004 116 : 807 815.
28. Cesari M, Kritchevsky SB, Penninx BW et al. Prognostic value of usual gait speed in well-functioning older people-results from the Health, Aging and Body Composition study. J Am Geriatr Soc 2005 53 : 1675 1680.