메뉴 건너뛰기




Volumn 7, Issue , 2010, Pages

Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection

(23)  Dembek, Claudia J a   Kutscher, Sarah a   Heltai, Silvia b   Allgayer, Simone a,c   Biswas, Priscilla b   Ghezzi, Silvia b   Vicenzi, Elisa b   Hoffmann, Dieter c   Reitmeir, Peter a   Tambussi, Giuseppe b   Bogner, Johannes R d   Lusso, Paolo b   Stellbrink, Hans J e   Santagostino, Elena f   Vollbrecht, Thomas d   Goebel, Frank D d   Protzer, Ulrike a,c   Draenert, Rika d   Tinelli, Marco g   Poli, Guido b,h   more..


Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GAMMA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NEF PROTEIN; TRANSACTIVATOR PROTEIN;

EID: 77954079577     PISSN: 17426405     EISSN: None     Source Type: Journal    
DOI: 10.1186/1742-6405-7-20     Document Type: Article
Times cited : (5)

References (42)
  • 1
    • 0031985775 scopus 로고    scopus 로고
    • Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
    • 109361, 9420212
    • Matano T, Shibata R, Siemon C, Connors M, Lane HC, Martin MA. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J Virol 1998, 72:164-169. 109361, 9420212.
    • (1998) J Virol , vol.72 , pp. 164-169
    • Matano, T.1    Shibata, R.2    Siemon, C.3    Connors, M.4    Lane, H.C.5    Martin, M.A.6
  • 2
    • 0033559648 scopus 로고    scopus 로고
    • Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
    • 10.1084/jem.189.6.991, 2193038, 10075982
    • Jin X, Bauer DE, Tuttleton SE, Lewin S, Gettie A, Blanchard J, Irwin CE, Safrit JT, Mittler J, Weinberger L, et al. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 1999, 189:991-998. 10.1084/jem.189.6.991, 2193038, 10075982.
    • (1999) J Exp Med , vol.189 , pp. 991-998
    • Jin, X.1    Bauer, D.E.2    Tuttleton, S.E.3    Lewin, S.4    Gettie, A.5    Blanchard, J.6    Irwin, C.E.7    Safrit, J.T.8    Mittler, J.9    Weinberger, L.10
  • 4
    • 27144513224 scopus 로고    scopus 로고
    • Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution
    • 10.1128/JVI.79.21.13239-13249.2005, 1262562, 16227247
    • Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'Sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL, et al. Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J Virol 2005, 79:13239-13249. 10.1128/JVI.79.21.13239-13249.2005, 1262562, 16227247.
    • (2005) J Virol , vol.79 , pp. 13239-13249
    • Allen, T.M.1    Altfeld, M.2    Geer, S.C.3    Kalife, E.T.4    Moore, C.5    O'Sullivan, K.M.6    Desouza, I.7    Feeney, M.E.8    Eldridge, R.L.9    Maier, E.L.10
  • 8
    • 0035198096 scopus 로고    scopus 로고
    • Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection
    • 10.1128/JVI.75.24.11983-11991.2001, 116093, 11711588
    • Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, Casazza JP, Koup RA, Picker LJ. Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection. J Virol 2001, 75:11983-11991. 10.1128/JVI.75.24.11983-11991.2001, 116093, 11711588.
    • (2001) J Virol , vol.75 , pp. 11983-11991
    • Betts, M.R.1    Ambrozak, D.R.2    Douek, D.C.3    Bonhoeffer, S.4    Brenchley, J.M.5    Casazza, J.P.6    Koup, R.A.7    Picker, L.J.8
  • 9
    • 1842614416 scopus 로고    scopus 로고
    • Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load
    • 10.1128/JVI.78.7.3233-3243.2004, 371059, 15016844
    • Masemola A, Mashishi T, Khoury G, Mohube P, Mokgotho P, Vardas E, Colvin M, Zijenah L, Katzenstein D, Musonda R, et al. Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load. J Virol 2004, 78:3233-3243. 10.1128/JVI.78.7.3233-3243.2004, 371059, 15016844.
    • (2004) J Virol , vol.78 , pp. 3233-3243
    • Masemola, A.1    Mashishi, T.2    Khoury, G.3    Mohube, P.4    Mokgotho, P.5    Vardas, E.6    Colvin, M.7    Zijenah, L.8    Katzenstein, D.9    Musonda, R.10
  • 11
    • 3543069879 scopus 로고    scopus 로고
    • Seventeen-colour flow cytometry: unravelling the immune system
    • 10.1038/nri1416, 15286731
    • Perfetto SP, Chattopadhyay PK, Roederer M. Seventeen-colour flow cytometry: unravelling the immune system. Nat Rev Immunol 2004, 4:648-655. 10.1038/nri1416, 15286731.
    • (2004) Nat Rev Immunol , vol.4 , pp. 648-655
    • Perfetto, S.P.1    Chattopadhyay, P.K.2    Roederer, M.3
  • 12
    • 33745091465 scopus 로고    scopus 로고
    • Functional signatures of protective antiviral T-cell immunity in human virus infections
    • 10.1111/j.0105-2896.2006.00395.x, 16824132
    • Harari A, Dutoit V, Cellerai C, Bart PA, Du Pasquier RA, Pantaleo G. Functional signatures of protective antiviral T-cell immunity in human virus infections. Immunol Rev 2006, 211:236-254. 10.1111/j.0105-2896.2006.00395.x, 16824132.
    • (2006) Immunol Rev , vol.211 , pp. 236-254
    • Harari, A.1    Dutoit, V.2    Cellerai, C.3    Bart, P.A.4    Du Pasquier, R.A.5    Pantaleo, G.6
  • 14
    • 55949104717 scopus 로고    scopus 로고
    • Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection
    • 10.1371/journal.pone.0000321, 1824710, 17389912
    • Addo MM, Draenert R, Rathod A, Verrill CL, Davis BT, Gandhi RT, Robbins GK, Basgoz NO, Stone DR, Cohen DE, et al. Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection. PLoS ONE 2007, 2:e321. 10.1371/journal.pone.0000321, 1824710, 17389912.
    • (2007) PLoS ONE , vol.2
    • Addo, M.M.1    Draenert, R.2    Rathod, A.3    Verrill, C.L.4    Davis, B.T.5    Gandhi, R.T.6    Robbins, G.K.7    Basgoz, N.O.8    Stone, D.R.9    Cohen, D.E.10
  • 15
    • 34249824297 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point
    • 10.1128/JVI.00045-07, 1900265, 17376902
    • Northfield JW, Loo CP, Barbour JD, Spotts G, Hecht FM, Klenerman P, Nixon DF, Michaelsson J. Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point. J Virol 2007, 81:5759-5765. 10.1128/JVI.00045-07, 1900265, 17376902.
    • (2007) J Virol , vol.81 , pp. 5759-5765
    • Northfield, J.W.1    Loo, C.P.2    Barbour, J.D.3    Spotts, G.4    Hecht, F.M.5    Klenerman, P.6    Nixon, D.F.7    Michaelsson, J.8
  • 16
    • 41149160165 scopus 로고    scopus 로고
    • Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy
    • 10.1128/JVI.02383-07, 2268491, 18199637
    • Rehr M, Cahenzli J, Haas A, Price DA, Gostick E, Huber M, Karrer U, Oxenius A. Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. J Virol 2008, 82:3391-3404. 10.1128/JVI.02383-07, 2268491, 18199637.
    • (2008) J Virol , vol.82 , pp. 3391-3404
    • Rehr, M.1    Cahenzli, J.2    Haas, A.3    Price, D.A.4    Gostick, E.5    Huber, M.6    Karrer, U.7    Oxenius, A.8
  • 18
  • 20
    • 34250636765 scopus 로고    scopus 로고
    • Live-cell assay to detect antigen-specific CD4+ T-cell responses by CD154 expression
    • 10.1038/nprot.2006.1, 17406204
    • Chattopadhyay PK, Yu J, Roederer M. Live-cell assay to detect antigen-specific CD4+ T-cell responses by CD154 expression. Nat Protoc 2006, 1:1-6. 10.1038/nprot.2006.1, 17406204.
    • (2006) Nat Protoc , vol.1 , pp. 1-6
    • Chattopadhyay, P.K.1    Yu, J.2    Roederer, M.3
  • 21
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • 10.1146/annurev.immunol.16.1.111, 9597126
    • Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998, 16:111-135. 10.1146/annurev.immunol.16.1.111, 9597126.
    • (1998) Annu Rev Immunol , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 22
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • 10.1038/44385, 10537110
    • Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999, 401:708-712. 10.1038/44385, 10537110.
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 25
    • 44449096577 scopus 로고    scopus 로고
    • Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
    • 10.1371/journal.pmed.0050100, 2365971,2365971, 18462013
    • Streeck H, Brumme ZL, Anastario M, Cohen KW, Jolin JS, Meier A, Brumme CJ, Rosenberg ES, Alter G, Allen TM, et al. Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med 2008, 5:e100. 10.1371/journal.pmed.0050100, 2365971,2365971, 18462013.
    • (2008) PLoS Med , vol.5
    • Streeck, H.1    Brumme, Z.L.2    Anastario, M.3    Cohen, K.W.4    Jolin, J.S.5    Meier, A.6    Brumme, C.J.7    Rosenberg, E.S.8    Alter, G.9    Allen, T.M.10
  • 27
    • 34547643061 scopus 로고    scopus 로고
    • Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1
    • 10.1371/journal.ppat.0030094, 1904471,1904471, 17616974
    • Brumme ZL, Brumme CJ, Heckerman D, Korber BT, Daniels M, Carlson J, Kadie C, Bhattacharya T, Chui C, Szinger J, et al. Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. PLoS Pathog 2007, 3:e94. 10.1371/journal.ppat.0030094, 1904471,1904471, 17616974.
    • (2007) PLoS Pathog , vol.3
    • Brumme, Z.L.1    Brumme, C.J.2    Heckerman, D.3    Korber, B.T.4    Daniels, M.5    Carlson, J.6    Kadie, C.7    Bhattacharya, T.8    Chui, C.9    Szinger, J.10
  • 28
    • 0028866238 scopus 로고
    • Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques
    • 10.1038/nm1195-1167, 7584989
    • Gallimore A, Cranage M, Cook N, Almond N, Bootman J, Rud E, Silvera P, Dennis M, Corcoran T, Stott J, et al. Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques. Nat Med 1995, 1:1167-1173. 10.1038/nm1195-1167, 7584989.
    • (1995) Nat Med , vol.1 , pp. 1167-1173
    • Gallimore, A.1    Cranage, M.2    Cook, N.3    Almond, N.4    Bootman, J.5    Rud, E.6    Silvera, P.7    Dennis, M.8    Corcoran, T.9    Stott, J.10
  • 29
    • 0038806352 scopus 로고    scopus 로고
    • Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences
    • 10.1128/JVI.77.13.7330-7340.2003, 164796, 12805431
    • Altfeld M, Addo MM, Shankarappa R, Lee PK, Allen TM, Yu XG, Rathod A, Harlow J, O'Sullivan K, Johnston MN, et al. Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences. J Virol 2003, 77:7330-7340. 10.1128/JVI.77.13.7330-7340.2003, 164796, 12805431.
    • (2003) J Virol , vol.77 , pp. 7330-7340
    • Altfeld, M.1    Addo, M.M.2    Shankarappa, R.3    Lee, P.K.4    Allen, T.M.5    Yu, X.G.6    Rathod, A.7    Harlow, J.8    O'Sullivan, K.9    Johnston, M.N.10
  • 30
    • 25144449263 scopus 로고    scopus 로고
    • CD4+ T-cell depletion in HIV infection: killed by friendly fire?
    • 10.1007/s11904-996-0004-3, 16091244
    • Moanna A, Dunham R, Paiardini M, Silvestri G. CD4+ T-cell depletion in HIV infection: killed by friendly fire?. Curr HIV/AIDS Rep 2005, 2:16-23. 10.1007/s11904-996-0004-3, 16091244.
    • (2005) Curr HIV/AIDS Rep , vol.2 , pp. 16-23
    • Moanna, A.1    Dunham, R.2    Paiardini, M.3    Silvestri, G.4
  • 31
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • 10.1086/314660, 10068581
    • Giorgi JV, Hultin LE, McKeating JA, Johnson TD, Owens B, Jacobson LP, Shih R, Lewis J, Wiley DJ, Phair JP, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999, 179:859-870. 10.1086/314660, 10068581.
    • (1999) J Infect Dis , vol.179 , pp. 859-870
    • Giorgi, J.V.1    Hultin, L.E.2    McKeating, J.A.3    Johnson, T.D.4    Owens, B.5    Jacobson, L.P.6    Shih, R.7    Lewis, J.8    Wiley, D.J.9    Phair, J.P.10
  • 32
    • 0030668834 scopus 로고    scopus 로고
    • Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression
    • Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, Giorgi JV. Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 1997, 16:83-92.
    • (1997) J Acquir Immune Defic Syndr Hum Retrovirol , vol.16 , pp. 83-92
    • Liu, Z.1    Cumberland, W.G.2    Hultin, L.E.3    Prince, H.E.4    Detels, R.5    Giorgi, J.V.6
  • 33
    • 67650924875 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells
    • 10.1128/JVI.00182-09, 2708622, 19458000
    • Streeck H, Jolin JS, Qi Y, Yassine-Diab B, Johnson RC, Kwon DS, Addo MM, Brumme C, Routy JP, Little S, et al. Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells. J Virol 2009, 83:7641-7648. 10.1128/JVI.00182-09, 2708622, 19458000.
    • (2009) J Virol , vol.83 , pp. 7641-7648
    • Streeck, H.1    Jolin, J.S.2    Qi, Y.3    Yassine-Diab, B.4    Johnson, R.C.5    Kwon, D.S.6    Addo, M.M.7    Brumme, C.8    Routy, J.P.9    Little, S.10
  • 34
    • 54349092626 scopus 로고    scopus 로고
    • The intracellular detection of MIP-1beta enhances the capacity to detect IFN-gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT
    • 10.1186/1742-6405-5-22, 2569082, 18837993
    • Kutscher S, Dembek CJ, Allgayer S, Heltai S, Stadlbauer B, Biswas P, Nozza S, Tambussi G, Bogner JR, Stellbrink HJ, et al. The intracellular detection of MIP-1beta enhances the capacity to detect IFN-gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT. AIDS Res Ther 2008, 5:22. 10.1186/1742-6405-5-22, 2569082, 18837993.
    • (2008) AIDS Res Ther , vol.5 , pp. 22
    • Kutscher, S.1    Dembek, C.J.2    Allgayer, S.3    Heltai, S.4    Stadlbauer, B.5    Biswas, P.6    Nozza, S.7    Tambussi, G.8    Bogner, J.R.9    Stellbrink, H.J.10
  • 35
    • 0031908542 scopus 로고    scopus 로고
    • Production of beta-chemokines in human immunodeficiency virus (HIV) infection: evidence that high levels of macrophage inflammatory protein-1beta are associated with a decreased risk of HIV disease progression
    • 10.1086/514192, 9466518
    • Ullum H, Cozzi Lepri A, Victor J, Aladdin H, Phillips AN, Gerstoft J, Skinhoj P, Pedersen BK. Production of beta-chemokines in human immunodeficiency virus (HIV) infection: evidence that high levels of macrophage inflammatory protein-1beta are associated with a decreased risk of HIV disease progression. J Infect Dis 1998, 177:331-336. 10.1086/514192, 9466518.
    • (1998) J Infect Dis , vol.177 , pp. 331-336
    • Ullum, H.1    Cozzi Lepri, A.2    Victor, J.3    Aladdin, H.4    Phillips, A.N.5    Gerstoft, J.6    Skinhoj, P.7    Pedersen, B.K.8
  • 36
    • 0029417004 scopus 로고
    • Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    • 10.1126/science.270.5243.1811, 8525373
    • Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995, 270:1811-1815. 10.1126/science.270.5243.1811, 8525373.
    • (1995) Science , vol.270 , pp. 1811-1815
    • Cocchi, F.1    DeVico, A.L.2    Garzino-Demo, A.3    Arya, S.K.4    Gallo, R.C.5    Lusso, P.6
  • 37
    • 33751071052 scopus 로고    scopus 로고
    • Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection
    • 10.1007/s00281-006-0025-4, 16932955
    • Makedonas G, Betts MR. Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection. Springer Semin Immunopathol 2006, 28:209-219. 10.1007/s00281-006-0025-4, 16932955.
    • (2006) Springer Semin Immunopathol , vol.28 , pp. 209-219
    • Makedonas, G.1    Betts, M.R.2
  • 38
    • 0347951395 scopus 로고    scopus 로고
    • Regulation of HIV-1 gene transcription: from lymphocytes to microglial cells
    • 10.1189/jlb.0403180, 12960235
    • Rohr O, Marban C, Aunis D, Schaeffer E. Regulation of HIV-1 gene transcription: from lymphocytes to microglial cells. J Leukoc Biol 2003, 74:736-749. 10.1189/jlb.0403180, 12960235.
    • (2003) J Leukoc Biol , vol.74 , pp. 736-749
    • Rohr, O.1    Marban, C.2    Aunis, D.3    Schaeffer, E.4
  • 39
    • 0026707722 scopus 로고
    • Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells
    • 10.1084/jem.176.3.739, 2119360, 1512539
    • Biswas P, Poli G, Kinter AL, Justement JS, Stanley SK, Maury WJ, Bressler P, Orenstein JM, Fauci AS. Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells. J Exp Med 1992, 176:739-750. 10.1084/jem.176.3.739, 2119360, 1512539.
    • (1992) J Exp Med , vol.176 , pp. 739-750
    • Biswas, P.1    Poli, G.2    Kinter, A.L.3    Justement, J.S.4    Stanley, S.K.5    Maury, W.J.6    Bressler, P.7    Orenstein, J.M.8    Fauci, A.S.9
  • 41
    • 34347232370 scopus 로고    scopus 로고
    • Intracellular cytokine optimization and standard operating procedure
    • 10.1038/nprot.2006.268, 17406442
    • Lamoreaux L, Roederer M, Koup R. Intracellular cytokine optimization and standard operating procedure. Nat Protoc 2006, 1:1507-1516. 10.1038/nprot.2006.268, 17406442.
    • (2006) Nat Protoc , vol.1 , pp. 1507-1516
    • Lamoreaux, L.1    Roederer, M.2    Koup, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.