Mechanism of activation of the double-stranded-RNA-dependent protein kinase PKR: Role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2)

European Journal of Biochemistry

Volumn 268, Issue 13, 2001, Pages 3674-3684

  Vattem, Krishna M ^a   Staschke, Kirk A ^a   Wek, Ronald C ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Dimerization; eIF2; PKR; Protein kinases; Ribosome targeting

Indexed keywords

ALANINE; ASPARTIC ACID; GLUTAMIC ACID; HYBRID PROTEIN; INITIATION FACTOR 2; PROTEIN KINASE; PROTEIN KINASE R; RAS PROTEIN; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CELLULAR DISTRIBUTION; CHIMERA; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; MOLECULAR INTERACTION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RIBOSOME;

ANIMALS; DIMERIZATION; EIF-2 KINASE; ENZYME ACTIVATION; EUKARYOTIC INITIATION FACTOR-2; GLUTATHIONE TRANSFERASE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RECOMBINANT FUSION PROTEINS; RIBOSOMES; RNA, DOUBLE-STRANDED; RNA, VIRAL; SACCHAROMYCES CEREVISIAE; SCHISTOSOMA JAPONICUM; SEQUENCE DELETION;

EID: 0034825325     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02273.x     Document Type: Article

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