Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Sobrino, Agua ^a   Mata, Manuel ^b   Laguna Fernandez, Andrés ^a   Novella, Susana ^a,c   Oviedo, Pilar J ^a   García Pérez, Miguel Angel ^a   Tarín, Juan J ^c   Cano, Antonio ^c   Hermenegildo, Carlos ^a,c  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

7 DEHYDROCHOLESTEROL REDUCTASE; ACTIN; CYCLOOXYGENASE 1; DIMETHYLARGININASE; DIMETHYLARGININASE 2; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; INTEGRIN; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NOTCH RECEPTOR; OXIDOREDUCTASE; PENTOSE PHOSPHATE; PHOSPHOLIPASE A2 GROUP IV; PROSTACYCLIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; DNA MICROARRAY; DRUG MECHANISM; ENDOTHELIUM CELL; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE INDUCTION; GENE REGULATORY NETWORK; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; HUMAN CELL; METABOLIC REGULATION; NERVE FIBER GROWTH; NUCLEOTIDE SEQUENCE; PROSTAGLANDIN SYNTHESIS; PROTEIN CONTENT; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; UNINDEXED SEQUENCE; VASODILATATION;

AMIDOHYDROLASES; CELLS, CULTURED; CLUSTER ANALYSIS; CYCLOOXYGENASE 1; ENDOTHELIAL CELLS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; METABOLIC NETWORKS AND PATHWAYS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; UMBILICAL VEINS; VASODILATION;

EID: 77954072402     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008242     Document Type: Article

References (45)

1. Mendelsohn ME, Karas RH (2005) Molecular and cellular basis of cardiovascular gender differences. Science 308: 1583-1587.
2. Barrett-Connor E, Grady D (1998) Hormone replacement therapy, heart disease, and other considerations. Annu Rev Pub Health 19: 55-72.
3. Hulley S, Grady D, Bush T, Furberg C, Herrington D, et al. (1998) Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 280: 605-613.
4. Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, et al. (2002) Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA 288: 49-57.
5. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, et al. (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288: 321-333.
6. Turgeon JL, Carr MC, Maki PM, Mendelsohn ME, Wise PM (2006) Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies. Endocr Rev 27: 575-605.
7. Ross R (1999) Atherosclerosis: an inflammatory disease. N Engl J Med 340: 115-126.
8. Mendelsohn ME (2000) Mechanisms of estrogen action in the cardiovascular system. J Steroid Biochem Mol Biol 74: 337-343.
9. Mendelsohn ME (2002) Protective effects of estrogen on the cardiovascular system. Am J Cardiol 89: 12E-18E.
10. Trevino V, Falciani F, Barrera-Saldana HA (2007) DNA microarrays: a powerful genomic tool for biomedical and clinical research. Mol Med 13: 527-541.
11. Archacki SR, Wang QK (2006) Microarray analysis of cardiovascular diseases. Methods Mol Med 129: 1-13.
12. Hiltunen MO, Tuomisto TT, Niemi M, Bräsen JH, Rissanen TT, et al. (2002) Changes in gene expression in atherosclerotic plaques analyzed using DNA array. Atherosclerosis 165: 23-32.
13. Graham D, McBride MW, Gaasenbeek M, Gilday K, Beattie E, et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: congenic analysis. Hypertension 50: 1134-1141.
14. Hermenegildo C, Oviedo PJ, Garcia-Perez MA, Tarin JJ, Cano A (2005) Effects of phytoestrogens genistein and daidzein on prostacyclin production by human endothelial cells. J Pharmacol Exp Ther 315: 722-728.
15. Li C, Hung Wong W (2001) Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biology 2: research0032.
16. Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucl Acids Res 30: 207-210.
17. Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucl Acids Res 30: e36.
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 196: 265-275.
19. Monsalve E, Oviedo PJ, Garcia-Perez MA, Tarin JJ, Cano A, et al. (2007) Estradiol counteracts oxidized LDL-induced asymmetric dimethylarginine production by cultured human endothelial cells. Cardiovasc Res 73: 66-72.
20. Vallance P, Leiper J (2004) Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 24: 1023-1030.
21. Leong KG, Karsan A (2006) Recent insights into the role of Notch signaling in tumorigenesis. Blood 107: 2223-2233.
22. Uyttendaele H, Ho J, Rossant J, Kitajewski J (2001) Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. PNAS 98: 5643-5648.
23. Lindner V, Booth C, Prudovsky I, Small D, Maciag T, et al. (2001) Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Am J Pathol 159: 875-883.
24. Soares R, Balogh G, Guo S, Gartner F, Russo J, et al. (2004) Evidence for the Notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol 18: 2333-2343.
25. Cid M, Esparza J, Schnaper H, Juan M, Yague J, et al. (1999) Estradiol enhances endothelial cell interactions with extracellular matrix proteins via an increase in integrin expression and function. Angiogenesis 3: 271-280.
26. Thomas M, Bader C, Monet JD (1990) Sex steroid hormone modulation of NADPH pathways in MCF-7 cells. Cancer Res 50: 1195-1200.
27. Forbes NS, Meadows AL, Clark DS, Blanch HW (2006) Estradiol stimulates the biosynthetic pathways of breast cancer cells: Detection by metabolic flux analysis. Metabolic Engineering 8: 639-652.
28. Soares R, Guo S, Gärtner F, Schmitt F, Russo J (2003) 17b-Estradiol-mediated vessel assembly and stabilization in tumor angiogenesis requires TGFb and EGFR crosstalk. Angiogenesis 6: 271-281.
29. Gourdy P, Schambourg A, Filipe C, Douin-Echinard V, Garmy-Susini B, et al. (2007) Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 27: 2214-2221.
30. Djurovic S, Os I, Hofstad AE, Abdelnoor M, Westheim A, et al. (2000) Increased plasma concentrations of TGF-beta1 after hormone replacement therapy. J Int Med 247: 279-285.
31. Toth B, Scholz C, Saadat G, Geller A, Schulze S, et al. (2008) Estrogen receptor modulators and estrogen receptor beta immunolabelling in human umbilical vein endothelial cells. Acta Histochemica; doi:10.1016/j.acthis.2008.05.006.
32. Wagner AH, Schroeter MR, Hecker M (2001) 17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J 15: 2121-2130.
33. Oviedo PJ, Hermenegildo C, Tarin JJ, Cano A (2007) Raloxifene increases proliferation of human endothelial cells in association with increased gene expression of cyclins A and B1. Fertil Steril 88: 326-332.
34. Harris HA (2007) Estrogen Receptor-{beta}: Recent Lessons from in Vivo Studies. Mol Endocrinol 21: 1-13.
35. Kolf-Clauw M, Chevy F, Wolf C, Siliart B, Citadelle D, et al. (1996) Inhibition of 7-dehydrocholesterol reductase by the teratogen AY9944: a rat model for Smith-Lemli-Opitz syndrome. Teratology 54: 115-125.
36. Witsch-Baumgartner M, Loffler J, Utermann G (2001) Mutations in the human DHCR7 gene. Hum Mutat 17: 172-182.
37. Monroe DG, Secreto FJ, Subramaniam M, Getz BJ, Khosla S, et al. (2005) Estrogen Receptor {alpha} and {beta} Heterodimers Exert Unique Effects on Estrogen-and Tamoxifen-Dependent Gene Expression in Human U2OS Osteosarcoma Cells. Mol Endocrinol 19: 1555-1568.
38. Smith WL, DeWitt DL, Garavito RM (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69: 145-182.
39. Jun SS, Chen Z, Pace MC, Shaul PW (1998) Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium. J Clin Invest 102: 176-183.
40. Hermenegildo C, Oviedo PJ, Cano A (2006) Cyclooxygenases regulation by estradiol on endothelium. Curr Pharm Des 12: 205-215.
41. Rupnow HL, Phernetton TM, Modrick ML, Wiltbank MC, Bird IM, et al. (2002) Endothelial vasodilator production by uterine and systemic arteries. VIII. Estrogen and progesterone effects on cPLA2, COX-1, and PGIS protein expression. Biol Reprod 66: 468-474.
42. Farina MG, Billi S, Leguizamon G, Weissmann C, Guadagnoli T, et al. (2007) Secretory and cytosolic phospholipase A2 activities and expression are regulated by oxytocin and estradiol during labor. Reproduction 134: 355-364.
43. Hermenegildo C, Garcia-Martinez MC, Tarin JJ, Cano A (2002) Estradiol reduces F2alpha -isoprostane production in cultured human endothelial cells. Am J Physiol Heart Circ Physiol 283: H2644-H2649.
44. Cicatiello L, Scafoglio C, Altucci L, Cancemi M, Natoli G, et al. (2004) A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome. J Mol Endocrinol 32: 719-775.
45. Stevenson JC (2007) HRT and the primary prevention of cardiovascular disease. Maturitas 57: 31-34.