HRT and the primary prevention of cardiovascular disease

Maturitas

Volumn 57, Issue 1, 2007, Pages 31-34

  Stevenson, John C ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Age; Coronary heart disease (CHD); Dose; Hormone replacement therapy (HRT); Primary prevention

Indexed keywords

CONJUGATED ESTROGEN; ESTRADIOL; ESTROGEN; GESTAGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEDROXYPROGESTERONE ACETATE;

AGING; ARTICLE; BIOLOGICAL ACTIVITY; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DRUG MECHANISM; HORMONE SUBSTITUTION; HUMAN; HYSTERECTOMY; ISCHEMIC HEART DISEASE; MENOPAUSE; SIDE EFFECT;

AGE FACTORS; AGED; CARDIOVASCULAR DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; MIDDLE AGED; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIALS;

EID: 34247136661     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2007.02.007     Document Type: Article

References (23)

1. Gordon T., Kannel W.B., Hjortland M.C., et al. Menopause and coronary heart disease: the Framingham Study. Ann Intern Med 89 (1978) 157-161
2. Stevenson J.C. Menopausal hormone therapy. In: Wenger N.K., and Collins P. (Eds). Women and heart disease (2005), Taylor and Francis, London 375-390
3. Spencer C.P., Godsland I.F., and Stevenson J.C. Is there a menopausal metabolic syndrome?. Gynaecol Endocrinol 11 (1997) 341-355
4. Grodstein F., Manson J.E., Colditz G.A., Willett W.C., Speizer F.E., and Stampfer M.J. A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med 133 (2000) 933-941
5. Grodstein F., Manson J.E., and Stampfer M.J. Postmenopausal hormone use and secondary prevention of coronary events in the Nurses' Health Study. Ann Intern Med 135 (2001) 1-138
6. Hodis H.N., Mack W.J., Lobo R.A., et al. Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 135 (2001) 939-953
7. Manson J.E., Hsia J., Johnson K.C., et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349 (2003) 523-534
8. Stevenson J.C. The metabolic basis for the effects of HRT on coronary heart disease. Endocrine 24 (2004) 239-244
9. Godsland I.F. Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000. Fertil Steril 75 (2001) 898-915
10. Stevenson J.C. Lipid metabolism. In: Genazzani A.R. (Ed). Hormone replacement therapy and cardiovascular disease (2001), Parthenon Publishing, Carnforth 27-35
11. Crook D., Cust M.P., Gangar K.F., et al. Comparison of transdermal and oral estrogen/progestin hormone replacement therapy: effects on serum lipids and lipoproteins. Am J Obstet Gynecol 166 (1992) 950-955
12. Spencer C.P., Godsland I.F., Cooper A.J., Ross D., Whitehead M.I., and Stevenson J.C. Effects of oral and transdermal 17β-estradiol with cyclical oral norethindrone actetate on insulin sensitivity, secretion, and elimination in postmenopausal women. Metabolism 49 (2000) 742-747
13. Crook D., Godsland I.F., Hull J., and Stevenson J.C. Hormone replacement therapy with dydrogesterone and oestradiol-17β: effects on serum lipoproteins and glucose tolerance. Br J Obstet Gynaecol 104 (1997) 298-304
14. Gambacciani M., Ciaponi M., Cappagli B., et al. Body weight, body fat distribution, and hormonal replacement therapy in early postmenopausal women. J Clin Endocrinol Metab 82 (1997) 414-417
15. Winkler U.H. Menopause, hormone replacement therapy and cardiovascular disease: a review of haemostaseological findings. Fibrinolysis 6 Suppl. 3 (1992) 5-10
16. Stevenson J.C. Cardiovascular effects of estrogens. J Steroid Biochem Mol Biol 74 (2000) 387-393
17. Wingrove C.S., Garr E., Godsland I.F., and Stevenson J.C. 17β-Oestradiol enhances release of matrix metalloproteinase-2 from human vascular smooth muscle cells. Biochim Biophys Acta 1406 (1998) 169-174
18. Prentice R.L., Langer R., Stefanick M.L., et al. Combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the Women's Health Initiative clinical trial. Am J Epidemiol 162 (2005) 404-414
19. Women's Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. J Am Med Assoc 291 (2004) 1701-1712
20. Hsia J., Langer R.D., Manson J.E., et al. Conjugated equine estrogens and coronary heart disease. Arch Intern Med 166 (2006) 357-365
21. Alexandersen P., Tankó L.B., Bagger Y.Z., Qin G., and Christiansen C. The long term impact of 2-3 years of hormone replacement therapy on cardiovascular mortality and atherosclerosis in healthy women. Climacteric 9 (2006) 108-118
22. Mikkola T.S., and Clarkson T.B. Estrogen replacement therapy, atherosclerosis, and vascular function. Cardiovasc Res 53 (2002) 605-619
23. Collins P., Flather M., Lees B., Mister R., Proudler A.J., and Stevenson J.C. Randomized trial of effects of continuous combined HRT on markers of lipids and coagulation in women with acute coronary syndromes: WHISP Pilot Study. Eur Heart J 27 (2006) 2046-2053