Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 11, 2009, Pages 5080-5088

  Liu, Yongqing ^a,b   Ye, Fei ^b   Li, Qiutang ^a,b   Tamiya, Shigeo ^b   Darling, Douglas S ^a   Kaplan, Henry J ^b   Dean, Douglas C ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; BETA TUBULIN 3; CYCLIN DEPENDENT KINASE INHIBITOR 1; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN; ZINC FINGER E BOX BINDING HOMEODOMAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CONTACT; CELL CULTURE; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE REPRESSION; GENE TARGETING; HETEROZYGOSITY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; PIGMENT EPITHELIUM; PIGMENTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HOMEODOMAIN PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MELANINS; MESODERM; MICE; MICE, INBRED C57BL; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ZINC FINGERS;

EID: 77954040402     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2911     Document Type: Article

References (41)

1. Cheung M, Chaboissier MC, Mynett A, Hisrt E, Shedl A, Briscoe J. The transcriptional control of trunk neural crest induction, survival and delamination. Dev Cell. 2005;8:179-192.
2. Hay ED. An overview of epithelio-mesenchymal transformation. Acta Anat. 1995;154:8-20.
3. Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opion Cell Biol. 2003;15:740-746.
4. Alonso SR, Tracey L, Ortiz P, et al. A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. Cancer Res. 2007;67:3450-3460.
5. Mani S, Guo W, Liao M-J, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133: 704-715.
6. Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer. 2007;7:415-428.
7. Chinnadurai G. CtBP an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell. 2002;9:213-224.
8. Eger A, Aigner K, Sonderegger S, et al. DeltaEf1 is a transcriptional repressor of e-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene. 2005;24:2375-2385.
9. Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol. 2001;13:555-562.
10. Hemavathy K, Ashraf SL, Ip YT. Snail/slug family of repressors, slowly going into the fast lane of development and cancer. Gene. 2005;257:1-12.
11. Singh M, Spoelstra NS, Jean A. et al. ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease. Mod Pathol. 2008;21:912-923.
12. Postigo AA, Dean DC. ZEB represses transcription through interaction with the corepressor CtBP. Proc Natl Acad Sci U S A. 1999;96:6683-6688.
13. Liu Y, El-Naggar S, Darling DS, Higashi Y, Dean DC. Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development. 2008a;135:579-588.
14. Takagi T, Moribe H, Kondoh H, Higashi Y. DeltaEF1: a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development. 1998;125:21-31.
15. Nishimura G, Manabe I, Tsushima K, et al. Delta EF1 regulates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell. 2006;11:93-104.
16. Krafchak CM, Pawar H, Moroi SE, et al. Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. Am J Hum Genet. 2005;77:694-708.
17. Liskova P, Tuft SJ, Gwilliam R, et al. Novel mutations in the ZEB1 gene identified in Czech and British patients with posterior polymorphous corneal dystrophy. Hum Mut. 2007;28:638.
18. Liu Y, Peng X, Tan J, Darling DS, Kaplan HJ, Dean DC. Zeb1 mutant mice as a model of posterior corneal dystrophy. Invest Ophthalmol Vis Sci. 2008b;49:1843-1849.
19. Abe T, Sato M, Tamai M. Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy. Curr Eye Res. 1998;17:1103-1109.
20. Alge CS, Suppmann S, Priglinger SG, et al. Comparative proteome analysis of native differentiated and cultured dedifferentiated human RPE cells. Invest Ophthalmol Vis Sci. 2003;44:3629-3641.
21. Hiscott P, Sheridan C, Magee RM, Grierson I. Matrix and the retinal pigment epithelium in proliferative retinal disease. Prog Retin Eye Res. 1999;18:167-190.
22. Del Priore LV, Hornbeck R, Kaplan HJ, et al. Debridement of the pig retinal pigment epithelium in vivo. Arch Ophthalmol. 1995; 113:939-944.
23. Lee SC, Kwon OW, Seong GJ, Kim SH, Ahn JE, Kay ED. Epitheliomesenchymal transdifferentiation of cultured RPE cells. Ophthalmic Res. 2001;33:80-86.
24. Maher J, Pandolfi PP, Roberts IA. Selection of a highly enriched population of retrovirus-infected human hematopoietic progenitor cells using SNL fibroblasts. Leukemia. 1995;9:29-33.
25. Singer O, Marr RA, Rockenstein E, et al. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci. 2005;8:1343-1349.
26. Tiscornia G, Singer O, Verma IM. Design and cloning of lentiviral vectors expressing small interfering RNAs. Nat Protoc. 2006;1: 234-240.
27. Carreira S, Goodall J, Aksan I, et al. Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature. 2005;433:764-769.
28. Loercher AE, Tank EM, Delston RB, Harbour JW. Mitf links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4a. J Cell Biol. 2005;168:35-45.
29. Horsford DJ, Nguyen MT, Sellar GC, Kothary R, Arnheiter H, McInnes RR. Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development. 2005; 132:177-187.
30. Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development. 2004;131:5139-5152.
31. Lee M, Goodall J, Verastegui C, Ballotti R, Goding CR. Direct regulation of the microphthalmia promoter by sox10 links Waardenburg- Shah syndrome WS4-associated hypopigmentation and deafness to WS2. J Biol Chem. 2000;275:37978-37983.
32. Potterf SB, Furumura M, Dunn KJ, Arnheiter H, Pavan WJ. Transcription factor hierarchy in Waardenburg syndrome: regulation of Mitf expression by Sox10 and Pax3. Hum Genet. 2000;107:1-6.
33. Bharti K, Liu W, Csermely T, Bertuzzi S, Arnheiter H. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development. 2008;135: 1169-1178.
34. Harbour JW, Dean DC. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 2000;14:2393-2409.
35. Lowe SW, Sherr CJ. Tumor suppression by INK4a-Arf, progress and puzzles. Curr Opin Genet Dev. 2003;13:77-83.
36. Maminishkis A, Chen S, Jalickee S, et al. Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue. Invest Ophthalmol Vis Sci. 2006;47:3612-3624.
37. Aksan I, Goding CG. Targeting the microphthalmia basic helixloop- helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo. Mol Cell Biol. 1998;18:6930-6938.
38. Postigo AA, Dean DC. Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors. Proc Natl Acad Sci U S A. 2000;97:6391-6396.
39. Zhang HS, Postigo AP, Dean DC. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGF-beta, and contact inhibition. Cell. 1999;97:53-61.
40. Liu Y, Constatino ME, Montoya-Durango D, Higashi Y, Darling DS, Dean DC. The zinc finger transcription factor, ZFHX1A, is linked to cell proliferation by Rb/E2F1. Biochem J. 2007;408:79-85.
41. Darling D, Stearman RP, Qi Y, Qiu MS, Feller JP. Expression of Zfhep/deltaEf1 protein in palate, neural progenitors and differentiated neurons. Gene Expr Patterns. 2003;3:709-717.