Acetaminophen-glutathione conjugate formation in a coupled cytochrome P-450-glutathione S-transferase assay system mediated by subcellular preparations from adult and weanling rat tissues

Toxicology in Vitro

Volumn 16, Issue 6, 2002, Pages 637-641

  Allameh, A ^a   Alikhani, N ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

Adult; Cytosol; Glutathione conjugation; Microsome; Paracetamol; Weanling rat

Indexed keywords

BUTYLATED HYDROXYANISOLE; CYTOCHROME P450; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PARACETAMOL; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONJUGATION; CONTROLLED STUDY; CYTOSOLIC FRACTION; DIET; ENZYME ACTIVITY; ENZYME RECONSTITUTION; KIDNEY; LIVER; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; RAT; WEANING; AGE; ANIMAL; CHEMISTRY; CULTURE TECHNIQUE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; NEWBORN; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALIA;

ACETAMINOPHEN; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; GLUTATHIONE TRANSFERASE; KIDNEY; LIVER; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 0036890530     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(02)00087-5     Document Type: Article

References (28)

1. Allameh A., Farahani M., Zarghi A. Kinetic studies of aflatoxin B1-glutathione conjugate formation in liver and kidneys of adult and weanling rats. Mechanisms of Ageing and Development. 115:2000;73-83.
2. Allameh A., Nikseresht M., Kheyrdoosh F. Role of cytosolic glutathione S-transferases in protection against acetaminophen-induced lipid peroxidation in weanling rats. Medical Journal of Iran. 13:1999;213-217.
3. Allameh A., Vansoun E., Zarghi A. Role of glutathione conjugation in protection of weanling rat liver against acetaminophen-induced hepatotoxicity. Mechanisms of Ageing and Development. 95:1997;71-79.
4. Allameh A., Amini A., Farzami B., 1994. Differences in the activities and subunits of glutathione S-transferases in newborn and adult rat livers. Proceedings of the 16th International congress of Biochemistry and Molecular Biology, New Delhi, India.
5. Behroozikha M., Saidee M., Allameh A. Comparison of aflatoxin B1-DNA binding and glutathione conjugation by liver preparations from rats of different ages. Cancer Letters. 66:1989;69-76.
6. Bessems J.G.M., Vermeulen P.E. Paracetamol (acetaminophen)-induced toxicity. Molecular and biochemical mechanisms, analogues and protective approaches Critical Reviews in Toxicology. 31:2001;55-138.
7. Boyer T.D., Rouffs L.J. Acetaminophen-induced hepatic necrosis and renal failure. Journal of the American Medical Association. 218:1971;440-441.
8. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry. 72:1976;248-254.
9. Coles B., Wilson I., Wardman P., Hinson J.A., Nelson S.D., Ketterer B. The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione. a stopped-flowkinetic study Archives of Biochemistry and Biophysics. 264:1988;253-260.
10. Commandeur J.N.M., Stijntjes G.J., Vermeulen N.P.E. Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics. Pharmacology Review. 47:1995;271-330.
11. Dalhoff K., Laursen H., Banger K., Poulsen H.E., Anderson M.E., Grunnet N., Tygstrup N. Autoprotection in acetaminophen intoxication in rats. The role of liver regeneration Pharmacology and Toxicology. 88:2001;135-141.
12. Dutton G.J. Biochemical development of the fetus and neonate. Jones C.T. Drug Metabolism and Development. 1982;69 Elsevier, Amsterdam.
13. Fischer L.J., Green M.D., Harman A.W. Studies on the fate of the glutathione and cystein conjugates of acetaminophen in mice. Drug Metabolism and Disposition. 13:1985;121-126.
14. Gregus Z., Madhu C., Klassen C.D. Species variation in toxication and detoxication of acetaminophen in vivo. a comparative study of biliary and urinary excretion of acetaminophen metabolites Journal of Pharmacology and Experimental Therapy. 244:1988;91-99.
15. Grafstrom K., Ormstad P., Moldeus P., Orrenius S. Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine. Biochemical Pharmacology. 28:1979;3573-3579.
16. Green M.D., Shires T.K., Fischer L.J. Hepatotoxicity of acetaminophen in neonatal and young rats. I. Age-related changes in susceptibility. Toxicology and Applied Pharmacology. 74:1981;116-124.
17. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation Journal of Biological Chemistry. 25:1974;7130-7139.
18. Hart J.G., Timbrell J.A. The effect of age on paracetamol hepatotoxicity in mice. Biochemical Pharmacology. 28:1979;3015-3017.
19. Holtzman J.L. The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen. Drug Metabolism Reviews. 27:1995;227-297.
20. Jollow D.J., Mitchell J.R., Potter W.Z., Davies D.C., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. Journal of Pharmacology and Experimental Therapy. 187:1973;195-202.
21. Kleinman J.G., Breitenfiels R.V., Roth D.A. Acute renal failure associated with acetaminophen ingestion. report of a case and review of the literature Clinical Nephrology. 14:1980;201-205.
22. Meredith T.J., Newman B., Goulding R. Paracetamol poisoning in children. British Medical Journal. 2:1978;478-479.
23. Mitchell D.J., Jollow W.Z., Potter J.R., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. Journal of Pharmacology and Experimental Therapy. 187:1973;211-217.
24. Peterson R.G., Rumack B.H. Age as a variable in acetaminophen overdose. Archives of Internal Medicine. 141:1981;390-393.
25. Potter W.Z., Thorgeirsson S.A., Jollow D.J., Mitchell J.R. Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. Pharmacology. 12:1974;129-143.
26. Wendel A., Cikryt P. Binding of paracetamol metabolites to mouse liver glutathione S-transferases. Research Communications in Chemical Pathology and Pharmacology. 33:1981;463-473.
27. Wong L.T., Whitehouse L.W., Solomonraj G.P. Pathways of disposition of acetaminophen conjugates in mouse. Toxicology Letters. 91:1981;145-151.
28. Yonamine M., Aniya Y., Yokomakura T., Koyama T., Nagamine T., Nakanishi H. Acetaminophen-drived activation of liver microsomal glutathione S-transferase of rats. Japanese Journal of Pharmacology. 72:1996;175-181.