Endothelial progenitor cells as a new cardiovascular risk factor in klinefelter's syndrome

Molecular Human Reproduction

Volumn 16, Issue 6, 2010, Pages 411-417

  Di Mambro, A ^a   Ferlin, A ^a   De Toni, L ^a   Selice, R ^a   Caretta, N ^a   Foresta, C ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cardiovascular diseases; Endothelial progenitor cells; Klinefelter

Indexed keywords

ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

ABDOMINAL OBESITY; ADULT; ANDROGEN THERAPY; ARTICLE; CARDIOVASCULAR RISK; CELL COUNT; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; ESTRADIOL BLOOD LEVEL; FOLLITROPIN BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; HYPOGONADISM; KARYOTYPE 47,XXY; KLINEFELTER SYNDROME; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; RISK FACTOR; SMOKING; STEM CELL; TESTOSTERONE BLOOD LEVEL;

ADULT; ANIMALS; BLOOD CELL COUNT; CARDIOVASCULAR DISEASES; ENDOTHELIAL CELLS; HUMANS; KLINEFELTER SYNDROME; MALE; MODELS, BIOLOGICAL; RISK FACTORS; STEM CELLS;

EID: 77953922281     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gaq015     Document Type: Article

References (52)

1. Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW. Cardiovascular risk factors and venous thromboembolism: A meta-analysis. Circulation 2008;117:93-102.
2. Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, Zeiher AM, Dimmeler S. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003;9:1370-1376.
3. Alexandersen P, Haarbo J, Byrjalsen I, Lawaetz H, Christiansen C. Natural androgens inhibit male atherosclerosis: A study in castrated, cholesterol-fed rabbits. Circ Res 1999;84:813-819.
4. Andersen NH, Bojesen A, Kristensen K, Birkebaek NH, Fedder J, Bennett P, Christiansen JS, Gravholt CH. Left ventricular dysfunction in Klinefelter syndrome is associated to insulin resistance, abdominal adiposity and hypogonadism. Clin Endocrinol (Oxf). 2008;69:785-791.
5. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275:964-967.
6. Assmus B, Urbich C, Aicher A, Hofmann WK, Haendeler J, Rössig L, Spyridopoulos I, Zeiher AM, Dimmeler S. HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ Res 2003;92:1049-1055.
7. Baba K, Yajima M, Carrier S et al. Effect of testosterone on the number of NADPH diaphorase-stained nerve fibres in the rat corpus cavernosum and dorsal nerve. Urology 2000;56:533-538.
8. Bakshi SR, Trivedi PJ, Brahmbhatt MM, Rawal SM, Kakadia PM, Bhatt SS. Aplastic anemia and Klinefelter syndrome. Cancer Genet Cytogenet 2004;154:91-92.
9. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski Ke, Magliano L, Dzekov C et al. Testosterone dose-response relationships in healthy young men. Am J Physiol 2001; 281:1172-1181.
10. Bojesen A, Juul S, Birkebaek N, Gravholt CH. Increased mortality in Klinefelter's syndrome. J Clin Endocrinol Metab 2004;89:3830-3834.
11. Bojesen A, Juul S, Birkebaek N, Gravholt CH. Morbidity in Klinefelter's syndrome: A Danish Register Study based on hospital discharge diagnoses. J Clin Endocrinol Metab 2006a;91:1254-1260.
12. Bojesen A, Kristensen K, Birkbaek NH, Fedder J, Mosekilde L, Bennet P. The Metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism. Diabetes Care 2006b;29:1591-1598.
13. Campbell WA, Price WH. Venous thromboembolic disease in Klinefelter's syndrome. Clin Genet. 1981;19:275-280.
14. Chamness SL, Ricker DD, Crone JK, Dembeck CL, Maguire MP, Burnett AL, Chang TS. The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fertil Steril. 1995; 63:1101-1107.
15. De Pergola G, De Mitrio V, Sciaraffia M, Pannacciulli N, Minenna A, Giorgino F, Petronelli M, Laudadio E, Giorgino R. Lower androgenicity is associated with higher plasma levels of prothrombotic factors irrespective of age, obesity, body fat distribution, and related metabolic parameters in men. Metabolism 1997;46:1287-1293.
16. Dimmeler S, Zeiher AM. Vascular repair by circulating endothelial progenitor cells: The missing link in atherosclerosis? J Mol Med 2004; 82:671-677.
17. Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, Rütten H, Fichtlscherer S, Martin H, Zeiher AM. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 2001;108:391-397.
18. Dockery F, Bulpitt CJ, Donaldson M, Fernandez S, Rajkumar C. The relationship between androgens and arterial stiffness in older men. J Am Geriatr Soc 2003;51:627-1632.
19. Fadini GP, Agostini C, Sartore S, Avogaro A. Endothelial progenitor cells in the natural history of atherosclerosis. Atherosclerosis 2007;194:46-54.
20. Fadini GP, Baesso I, Albiero M, Sartore S, Agostini C, Avogaro A. Technical notes on endothelial progenitor cells: Ways to escape from the knowledge plateau. Atherosclerosis 2008;97:496-503.
21. Foresta C, Caretta N, Lana A, Cabrelle A, Palù G, Ferlin A. Circulating endothelial progenitor cells in subjects with erectile dysfunction. Int J Impot Res 2005;17:288-290.
22. Foresta C, Caretta N, Lana A, De Toni L, Biagioli A, Ferlin A, Garolla A. Reduced number of circulating endothelial progenitor cells in hypogonadal men. J Clin Endocrinol Metab 2006a;91:4599-4602.
23. Foresta C, Ferlin A, De Toni L, Lana A, Vinanzi C, Galan A, Caretta N. Circulating endothelial progenitor cells and endothelial function after chronic Tadalafil treatment in subjects with erectile dysfunction. Int J Impot Res 2006b;18:484-488.
24. Foresta C, Caretta N, Lana A, De Toni L, Biagioli A, Vinanzi C, Ferlin A. Relationship between vascular damage degrees and endothelial progenitor cells in patient with erectile dysfunction: Effect of Vardenafil and PDE5 expression in bone marrow. Eur Urol 2007;51:1411-1419.
25. Foresta C, Zuccarello D, De Toni L, Garolla A, Caretta N, Ferlin A. Androgens stimulate endothelial progenitor cells through an androgen receptor-mediated pathway. Clin Endocrinol (Oxf). 2008;68:284-289.
26. Foresta C, Di Mambro A, Caretta N, De Toni L, Zuccarello D, Ferlin A. Effect of vardenafil on endothelial progenitor cells in hypogonadotrophic hypogonadal patients: Role of testosterone treatment. Clin Endocrinol (Oxf) 2009;71:412-416.
27. Fricke GR, Mattern HJ, Schweikert HU, Schwanitz G. Klinefelter's syndrome and mitral valve prolapse an echocardiographic study in twenty-two patients. Biomed Pharmacother 1984;38:88-97.
28. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593-600.
29. Kapoor D, Aldred H, Clark S, Channer KS, Jones TH. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: Correlations with bioavailable testosterone and visceral adiposity. Diabetes Care 2007;30:911-917.
30. Khaw Kt, Dowsett M, Folkerd E, Bingham S, Wareham N, Lben R, Welh A, Day N. Endogenous testosterone and mortality due to all causes, cardiovascular disease, n cancer in men: European Prospective Investigation In Cancer in Norfolk (EPIC- Norfolk) Prospective Population Study. Circulation 2007;116:2694-2701.
31. Laaksonen DE, Niskanen L, Punnonen K, Nyyssönen K, Tuomainen TP, Valkonen VP, Salonen R, Salonen JT. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004;27:1036-1041.
32. Laufs U, Werner N, Link A, Endres M, Wassmann S, Jürgens K, Miche E, Böhm M, Nickenig G. Physical training increases endothelial progenitor cells, inhibition of neointima formation, and enhances angiogenesis. Circulation 2004;109:220-226.
33. Loomans CJ, de Koning EJ, Staal FJ, Rookmaaker MB, Verseyden C, de Boer HC, Verhaar MC, Braam B, Rabelink TJ, van Zonneveld AJ. Endothelial progenitor cell dysfunction: A novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004;53:195-199.
34. Lugg Ja, Rajfer J, Gonzalez-Cadavid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxidemediated penile erection in the rat. Endocrinology 1995;136:1495-1501.
35. Oh JY, Barrett-Connor E, Wedick NM, Wingard DL. Endogenous sex hormones and the development of type 2 diabetes in older men and women: The Rancho Bernardo study. Diabetes Care 2000; 25:55-60.
36. Pitteloud N, Hardin M, Dwyer AA, Valassi E, Yialamas M, Elahi D, Hayes FJ. Increasing insulin resistance is associated with a decrease in Leydig cells testosterone secreation in men. J Clin Endocrinol Metab 2005;90:2636-2641.
37. Reilly CM, Zamorano P, Stopper VS, Mills TM. Androgenic regulation of NO availability in rat penile erection. J Androl 1997;18:110-115.
38. Rodriguez A, Muller DC, Metter EJ, Maggio M, Harman SM, Blackman MR, Andres R. Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab. 2007;92:3568-3572.
39. Rosano GM, Leonardo F, Pagnotta P, Pelliccia F, Panina G, Cerquetani E, della Monica PL, Kang SM, Jang Y, Kim JY et al. Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease. Am J Cardiol 1999;89:862-864.
40. Rosendaal FR, Helmerhorst FM, Vandenbroucke JP. Oral contraceptives, hormone replacement therapy and thrombosis. Thromb Haemost 2001;86:112-123.
41. Schmidt-Lucke C, Rössig L, Fichtlscherer S, Vasa M, Britten M, Kämper U, Dimmeler S, Zeiher AM. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: Proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005;111:2981-2987.
42. Selvin E, Feinleib M, Zhang L, Rohrmann S, Rifai N, Nelson WG, Dobs A, Basaria S, Golden SH, Platz EA. Androgens and diabetes in men: Results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care 2007;30:234-238.
43. Shimizu Y, Suzukawa K, Hirano Y, Seki M, Hirayama K, Yoh K, Hirayama A, Yamagata K, Nagase S, Nagasawa T et al. Erythropoietin-resistant anaemia in a predialysis patient with Klinefelter syndrome. Nephrology 2005;10:147-150.
44. Swerdlow AJ, Higgin CD, Schomaker MJ, Wright AF, Jacobs PA. Mortality in patients with Klinefelter's syndrome in Britain: A cohort study. J Clin Endocrinol Metab 2005;90:6516-6522.
45. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001;89:e1-e7.
46. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-3672.
47. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Böhm M, Nickenig G. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med. 2005;353:999-1007.
48. Winkler UH. Effects of androgens on haemostasis. Maturitas 1996; 24:147-155.
49. Yamauchi K. Myelodysplastic syndrome with thrombocytosis in a patient with Klinefelter's syndrome. Acta Haematol 1993;89:43-45.
50. Zhang XH, Morelli A, Luconi M, Vignozzi L, Filippi S, Marini M, Vannelli GB, Mancina R, Forti G, Maggi M. Testosterone regulates PDE5 expression and in vivo responsiveness to Tadalafil in rat corpus cavernosum. Eur Urol 2005;47:409-416.
51. Zitzmann M, Depenbusch M, Gromoll J, Nieschlag E. X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in Klinefelter patients. J Clin Endocrinol Metab 2004;89:6208-6217.
52. Zitzmann M, Faber S, Nieschlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin Endocrinol Metab 2006;91:4335-4343.