Relationship Between Vascular Damage Degrees and Endothelial Progenitor Cells in Patients with Erectile Dysfunction: Effect of Vardenafil Administration and PDE5 Expression in the Bone Marrow

European Urology

Volumn 51, Issue 5, 2007, Pages 1411-1419

  Foresta, Carlo ^a   Caretta, Nicola ^a   Lana, Andrea ^a   De Toni, Luca ^a   Biagioli, Andrea ^a   Vinanzi, Cinzia ^a   Ferlin, Alberto ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Bone marrow; EPCs; Erectile dysfunction; PDE5; PDE5 inhibitors

Indexed keywords

MESSENGER RNA; PHOSPHODIESTERASE V; PLACEBO; VARDENAFIL;

ADULT; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL INJURY; BONE MARROW; CARDIOVASCULAR RISK; CAROTID ARTERY DISEASE; CELL COUNT; CELL MIGRATION; CELL REGENERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; INTIMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SINGLE DRUG DOSE; STEM CELL; TREATMENT RESPONSE; TUNICA MEDIA;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; BLOOD CELL COUNT; BONE MARROW CELLS; CAROTID ARTERY DISEASES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; IMIDAZOLES; IMPOTENCE; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; STEM CELLS; SULFONES; TRIAZINES; VASODILATOR AGENTS;

EID: 33947198649     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2006.08.052     Document Type: Article

References (33)

1. Feldman H.A., Goldstein I., Hatzichristou D.G., Krane R.J., and McKinlay J.B. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 151 (1994) 54-61
2. Virag R., Bouilly P., and Frydman D. Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet 26 (1985) 181-184
3. Feldman H.A., Johannes C.B., Derby C.A., et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med 30 (2000) 328-338
4. Braun M., Wassmer G., Klotz T., Reifenrath B., Mathers M., and Engelmann U. Epidemiology of erectile dysfunction: results of the 'Cologne Male Survey'. Int J Impot Res 12 (2000) 305-311
5. Verma S., and Anderson T.J. Fundamentals of endothelial function for the clinical cardiologist. Circulation 105 (2002) 546-549
6. Caretta N., Palego P., Ferlin A., et al. Resumption of spontaneous erections in selected patients affected by erectile dysfunction and various degrees of carotid wall alteration: role of tadalafil. Eur Urol 48 (2005) 326-332
7. Wespes E., Amar E., Hatzichristou D., et al. EAU Guidelines on erectile dysfunction: an update. Eur Urol 49 (2006) 806-815
8. Wespes E., Rammal A., and Garbar C. Sildenafil non-responders: haemodynamic and morphometric studies. Eur Urol 48 (2005) 136-139
9. Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
10. Lindner V., Fingerle J., and Reidy M.A. Mouse model of arterial injury. Circ Res 73 (1993) 792-796
11. Dimmeler S., and Zeiher A.M. Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?. J Mol Med 82 (2004) 671-677
12. Werner N., Kosiol S., Schiegl T., et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 353 (2005) 999-1007
13. Aicher A., Heeschen C., Mildner-Rihm C., et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 9 (2003) 1370-1376
14. Vasa M., Fichtlscherer S., Adler K., et al. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 103 (2001) 2885-2890
15. Min T.Q., Zhu C.J., Xiang W.X., Hui Z.J., and Peng S.Y. Improvement in endothelial progenitor cells from peripheral blood by ramipril therapy in patients with stable coronary artery disease. Cardiovasc Drugs Ther 18 (2004) 203-209
16. Laufs U., Werner N., Link A., et al. Physical training increases endothelial progenitor cells, inhibits neointima formation and enhances angiogenesis. Circulation 109 (2004) 220-226
17. Strehlow K., Werner N., Berweiler J., et al. Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation 107 (2003) 3059-3065
18. Foresta C., Caretta N., Lana A., Cabrelle A., Palu G., and Ferlin A. Circulating endothelial progenitor cells in subjects with erectile dysfunction. Int J Impot Res 17 (2005) 288-290
19. Foresta C., Lana A., Cabrelle A., et al. PDE-5 inhibitor, vardenafil, increases circulating progenitor cells in humans. Int J Impot Res 17 (2005) 377-380
20. Foresta C., Ferlin A., De Toni L., et al. Circulating endothelial progenitor cells and endothelial function after chronic tadalafil treatment in subjects with erectile dysfunction. Int J Impot Res 18 (2006) 484-488
21. Munoz M., Bancroft J., and Marshall I. The performance of the RigiScan in the measurement of penile tumescence and rigidity. Int J Impot Res 5 (1993) 69-76
22. Poli A., Tremoli L., Colombo A., Sintori M., Pignoli P., and Paoletti R. Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients: a new for the quantitation and follow-up of preclinical atherosclerosis in living subjects. Atherosclerosis 20 (1988) 253-261
23. Furberg C.D., Byington R.P., and Borhani N.A. Multicenter isradipine diuretic atherosclerosis study (MIDAS). Design features. The Midas Research Group. Am J Med 86 (1989) 37-39
24. Montorsi F., Briganti A., Salonia A., et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 44 (2003) 360-365
25. Scheubel R.J., Silber R.E., Kuss O., Morawietz H., Holtz J., and Simm A. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol 42 (2003) 2073-2080
26. Ponholzer A., Temml C., Obermayr R., Werhberger C., and Madersbacher S. Is erectile dysfunction an indicator for increased risk of coronary heart disease and stroke?. Eur Urol 48 (2005) 512-518
27. Vlachopoulos C., Rokkas K., Ioakeimidis N., et al. Prevalence of asymptomatic coronary artery disease in men with vasculogenic erectile dysfunction: a prospective angiographic study. Eur Urol 48 (2005) 996-1003
28. Roumeguere T., and Schulman C. Relationship between erectile dysfunction and cardiovascular disease. Rev Med Brux 25 (2004) 507-511
29. Chiurlia E., Menozzi M., Ratti C., Romagnoli R., and Modena M.G. Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. J Am Coll Cardiol 46 (2005) 1503-1506
30. Jones R.W., Rees R.W., Minhas S., Ralph D., Persad R.A., and Jeremy J.Y. Oxygen free radicals and the penis. Expert Opin Pharmacother 3 (2002) 889-897
31. Zhu J., Wang X., Chen J., Sun J., and Zhang F. Reduced number and activity of circulating endothelial progenitor cells from patients with hyperhomocysteinemia. Arch Med Res 37 (2006) 484-489
32. Ückert S., Hedlund P., Andersson K.E., Truss M.C., Jonas U., and Stief C.G. Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol 50 (2006) 1194-1207
33. Pilatz A., Schultheiss D., Gabouev A.I., et al. Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering. Eur Urol 47 (2005) 710-719