Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze

European Journal of Pharmacology

Volumn 473, Issue 2-3, 2003, Pages 153-161

  Zanoveli, Janaina M ^a   Nogueira, Regina L ^b,c   Zangrossi Jr , Hélio ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b ESTÁCIO DE SÁ UNIVERSITY   (Brazil)

^c UNIVERSITY OF RIBEIRÃO PRETO   (Brazil)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); Anxiety; Dorsal; Elevated; Panic; Periaqueductal gray; T maze

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; ANXIOLYTIC AGENT; BRAIN RECEPTOR; PIPERAZINE; SEROTONIN; SEROTONIN AGONIST;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BRAIN; BRAIN REGION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG SCREENING; ESCAPE BEHAVIOR; EXPERIMENTAL TEST; INJECTION; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; OBSERVATION; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0041743267     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01970-8     Document Type: Article

References (42)

1. Amano K., Tanikawa T., Iseki H., Kawabatabe H., Notani M., Kawamura H., Kitamura K. Single neuron analysis of the human midbrain tegmentum. Rostral mesencephalic reticulotomy for pain relief. Appl. Neurophysiol. 41(1-4):1978;66-78.
2. Bandler R., Shipley M.T. Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? Trends Neurosci. 17(9):1994;379-389.
3. Beckett S., Marsden C.A. Computer analysis and quantification of periaqueductal grey-induced defence behaviour. J. Neurosci. Methods. 58(1-2):1995;157-161.
4. 1 receptor agonists administered into the periaqueductal gray. Psychopharmacology. 108:1992;110-114.
5. Beckett S.R.G., Marshall P.W., Marsden C.A. Intra-periaqueductal grey administration of mCPP potentiates a chemically-induced defence response. Br. J. Pharmacol. 107:1992;8P. (suppl.).
6. Blanchard D.C., Griebel G., Blanchard R.J. Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic. Neurosci. Biobehav. Rev. 25(3):2001;205-218.
7. Bourin M., Baker G.B., Bradwejn J. Neurobiology of panic disorder. J. Psychosom. Res. 44(1):1998;163-180.
8. Brandão M.L., Lopez-Garcia J.A., Graeff F.G., Roberts M.H. Electrophysiological evidence for excitatory 5-HT2 and depressant 5-HT1A receptors on neurones of the rat midbrain tectum. Brain Res. 556(2):1991;259-266.
9. 2A receptors in rats. Psychopharmacology. 155(2):2001;154-162.
10. Charney D.S., Woods S.W., Goodman W.K., Henninger G.R. Serotonin function in anxiety: II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects. Psychopharmacology. 92(1):1987;14-24.
11. Deakin J.F.W., Graeff F.G. 5-HT and mechanisms of defence. J. Psychopharmacol. 5:1991;305-315.
12. 1B binding sites. Naunyn-Schmiedeberg's Arch. Pharmacol. 332(1):1986;1-7.
13. Graeff F.G. Brain defense systems and anxiety. Roth M., Burrows G.D., Noyes R. Handbook of Anxiety. The Neurobiology of Anxiety. vol. 3:1990;307-354 Elsevier, Amsterdam.
14. Graeff F.G. Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals. Braz. J. Med. Biol. Res. 27(4):1994;11-29.
15. Graeff F.G., Zangrossi H. Jr. Animal models of anxiety disorders. D'Haenen H., den Boer J.A., Westenberg H., Willner P. Textbook of Biological Psychiatry. 2002;879-893 Wiley, London.
16. Graeff F.G., Viana M.B., Tomaz C. The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam. Braz. J. Med. Biol. Res. 26(1):1993;67-70.
17. Graeff F.G., Netto C.F., Zangrossi H. Jr. The elevated T-maze as an experimental model of anxiety. Neurosci. Biobehav. Rev. 23(2):1998;237-246.
18. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol. Ther. 65(3):1995;319-395.
19. Griffiths J.L., Lovick T.A. Co-localization of 5-HT(2A)-receptor- and GABA-immunoreactivity in neurones in the periaqueductal grey matter of the rat. Neurosci. Lett. 326(3):2002;151-154.
20. Hoyer D. Functional correlates of serotonin 5-HT1 recognition sites. J. Recept. Res. 8(1-4):1988;59-81.
21. Jacob C.A., Cabral A.H., Almeida L.P., Magierek V., Ramos P.L., Zanoveli J.M., Landeira-Fernandez J., Zangrossi H. Jr., Nogueira R.L. Chronic imipramine enhances 5-HT(1A) and 5-HT(2) receptors-mediated inhibition of panic-like behavior in the rat dorsal periaqueductal gray. Pharmacol. Biochem. Behav. 72(4):2002;761-766.
22. 1C) receptors on periaqueductal gray aversion. Eur. J. Pharmacol. 161(2-3):1989;219-221.
23. Jenck F., Moreau J.L., Martin J.R. Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity. Psychiatry Res. 57(2):1995;181-191.
24. 1C receptors. Br. J. Pharmacol. 94(1):1988;137-147.
25. 1C antagonists. Eur. J. Pharmacol. 164(3):1989;445-454.
26. Lovick T.A. Panic disorder - a malfunction of multiple transmitter control systems within the midbrain periaqueductal gray matter. Neuroscientist. 6:2000;48-59.
27. 1A-receptor-mediated inhibition of panic-like behaviours. Psychopharmacology. 131(4):1997;321-328.
28. Nashold B.S. Jr., Wilson W.P., Slaughter D.G. Sensations evoked by stimulation in the midbrain of man. J. Neurosurg. 30(1):1969;14-24.
29. Nogueira R.L., Graeff F.G. 5-HT mediation of the antiaversive effect of isamoltane injected into the dorsal periaqueductal grey. Behav. Pharmacol. 2(1):1991;73-77.
30. Nogueira R.L., Graeff F.G. Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray aversion. Pharmacol. Biochem. Behav. 52(1):1995;1-6.
31. Olds M.E., Olds J. Approach-escape interactions in rat brain. Am. J. Physiol. 203:1962;803-810.
32. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, New York.
33. Pazos A., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain: I. Serotonin-1 receptors. Brain Res. 346:1985;205-230.
34. Pazos A., Cortés R., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain: II. Serotonin-2 receptors. Brain Res. 346:1985;231-249.
35. Poltronieri S., Zangrossi H. Jr., Viana M.B. Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. Behav. Brain Res. 142:2003;125-133.
36. Schenberg L.C., Bittencourt A.S., Sudre E.C., Vargas L.C. Modeling panic attacks. Neurosci. Biobehav. Rev. 25(7-8):2001;647-659.
37. Schütz M.T., Aguiar J.C., Graeff F.G. Anti-aversive role of serotonin in the dorsal periaqueductal grey matter. Psychopharmacology. 85(3):1985;340-345.
38. Sena L.M., Bueno C., Pobbe R.L.H., Andrade T.G.C.S., Zangrossi H. Jr., Viana M.B. The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats. Behav. Brain Res. 2003;. (in press).
39. Teixeira R.C., Zangrossi H. Jr., Graeff F.G. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol. Biochem. Behav. 65(4):2000;571-576.
40. Tilakaratne N., Friedman E. Genomic responses to 5-HT1A or 5-HT2A/2C receptor activation is differentially regulated in four regions of rat brain. Eur. J. Pharmacol. 307(2):1996;211-217.
41. Viana M.B., Tomaz C., Graeff F.G. The elevated T-maze: a new animal model of anxiety and memory. Pharmacol. Biochem. Behav. 49(3):1994;549-554.
42. Zangrossi H. Jr., Graeff F.G. Behavioral validation of the elevated T-maze, a new model of anxiety. Brain Res. Bull. 44(1):1997;1-5.