Different effects of optical isomers of the 5-HT1A receptor antagonist pyrapyridolol against postischemic guinea-pig myocardial dysfunction and apoptosis through the mitochondrial permeability transition pore

European Journal of Pharmacology

Volumn 534, Issue 1-3, 2006, Pages 165-177

  Huang, Lei ^a   Hotta, Yoshihiro ^b   Miyazeki, Kunihiro ^b   Ishikawa, Naohisa ^b   Miki, Yasuyoshi ^c   Sugimoto, Yumi ^d   Yamada, Jun ^d   Nakano, Akinobu ^e   Nishiwaki, Kimitoshi ^a   Shimada, Yasuhiro ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KINKI UNIVERSITY   (Japan)

^d KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^e SHIMANE UNIVERSITY   (Japan)

Author keywords

5 HT1A receptor antagonist; Apoptosis; Langendorff heart; Mitochondrial KATP channel; MPTP (mitochondrial permeability transition pore); Spectroscopy

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATASE (POTASSIUM); CALCIUM ION; CASPASE 3; CYCLOSPORIN A; DIAZOXIDE; PYRAPYRIDOLOL; SEROTONIN 1A ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; GUINEA PIG; HEART MITOCHONDRION; HEART MUSCLE INJURY; MALE; MYOCARDIAL DISEASE; NICK END LABELING; NONHUMAN; PH; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STEREOISOMERISM;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CALCIUM; CARBAZOLES; FREE RADICAL SCAVENGERS; GUINEA PIGS; HEART; ION CHANNELS; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRIC OXIDE; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN; SEROTONIN ANTAGONISTS; STEREOISOMERISM; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 33644883311     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.01.040     Document Type: Article

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