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Volumn 70, Issue 10, 2010, Pages 1231-1243

Microbicides in the prevention of HIV infection: Current status and future directions

Author keywords

biopolymers; C31G; carbomer polymer gel; HIV 1 entry inhibitors; HIV infections; maraviroc; nonoxinol 9; PC 515; prevention; PRO 2000; raltegravir; research and development; surfactants; tenofovir; therapeutic use

Indexed keywords

4 BENZOYL 1 [(4 METHOXY 1H PYRROLO[2,3 B]PYRIDIN 3 YL)OXOACETYL] 2 METHYLPIPERAZINE; ACIDFORM; ANTIRETROVIRUS AGENT; BMS 599793; CARBOPOL 974P; CARRAGEENAN; CELLULOSE SULFATE; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CYANOVIRIN N; DAPIVIRINE; ELVITEGRAVIR; ENFUVIRTIDE; HI 280; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IBALIZUMAB; INTEGRASE INHIBITOR; MARAVIROC; MIC 150; MICROBICIDE; MIV 150; MONOCLONAL ANTIBODY; N [4 CHLORO 3 (3 METHYL 2 BUTENYLOXY)PHENYL] 2 METHYL 3 FURANCARBOTHIOAMIDE; NONOXINOL 9; POLYANION; PRO 2000; PROTEINASE INHIBITOR; RALTEGRAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAVVY; SURFACTANT; TENOFOVIR; TENOFOVIR DISOPROXIL; TIFUVIRTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIVAGEL; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; NEW DRUG;

EID: 77953841413     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/10898650-000000000-00000     Document Type: Review
Times cited : (28)

References (88)
  • 1
    • 0019873358 scopus 로고
    • Pneumocystis pneumonia: Los Angeles
    • Centers for Disease Control
    • Centers for Disease Control. Pneumocystis pneumonia: Los Angeles. MMWR Morb Mortal Wkly Rep 1981; 30: 250-252
    • (1981) MMWR Morb Mortal Wkly Rep , vol.30 , pp. 250-252
  • 2
    • 0019872049 scopus 로고
    • Kaposi's sarcoma and Pneu-mocystis pneumonia among homosexual men: New York City and California
    • Centers for Disease Control
    • Centers for Disease Control. Kaposi's sarcoma and Pneu-mocystis pneumonia among homosexual men: New York City and California. MMWR Morb Mortal Wkly Rep 1981; 30: 306-308
    • (1981) MMWR Morb Mortal Wkly Rep , vol.30 , pp. 306-308
  • 3
    • 0025804107 scopus 로고
    • LAV revisited: Origins of the early HIV-1 isolates from Institute Pasteur
    • Wain-Hobson S, VartanianJ, Henry M, et al. LAV revisited: origins of the early HIV-1 isolates from Institute Pasteur. Science 1991; 252: 961-965
    • (1991) Science , vol.252 , pp. 961-965
    • Wain-Hobson, S.1    Vartanianj Henry, M.2
  • 4
    • 0003547733 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS (UNAIDS)
    • Geneva: UNAIDS Dec
    • Joint United Nations Programme on HIV/AIDS (UNAIDS). AIDS epidemic update. Geneva: UNAIDS 2009 Dec
    • (2009) AIDS Epidemic Update
  • 5
    • 70349969929 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS (UN-AIDS)
    • Geneva: UNAIDS Aug
    • Joint United Nations Programme on HIV/AIDS (UN-AIDS). Report on the Global AIDS epidemic. Geneva: UNAIDS 2008 Aug
    • (2008) Report on the Global AIDS Epidemic
  • 6
    • 0030773675 scopus 로고    scopus 로고
    • AIDS in women in the United States: Recent trends
    • Wortley RM, Fleming PL. AIDS in women in the United States: recent trends. JAMA 1997; 278 (11): 911-916
    • (1997) JAMA , vol.278 , Issue.11 , pp. 911-916
    • Wortley, R.M.1    Fleming, P.L.2
  • 7
    • 0027910513 scopus 로고
    • Update: Barrier protection against HIV infection and other sexually transmitted diseases
    • Centers for Disease Control
    • Centers for Disease Control. Update: barrier protection against HIV infection and other sexually transmitted diseases. MMWR Morb Mortal Wkly Rep 1993; 42: 589-597
    • (1993) MMWR Morb Mortal Wkly Rep , vol.42 , pp. 589-597
  • 8
    • 4244122383 scopus 로고
    • Vaginal microbicides for prevent-ing sexual transmission of HIV
    • Stone AB, Hitchcock PJ. Vaginal microbicides for prevent-ing sexual transmission of HIV. AIDS 1994; 8: S285-93
    • (1994) AIDS , vol.8
    • Stone, A.B.1    Hitchcock, P.J.2
  • 9
    • 0028219733 scopus 로고
    • Challenges for the development of female-controlled vaginal microbicides
    • Elias CJ, Heise LL. Challenges for the development of female-controlled vaginal microbicides. AIDS 1994; 8 (1): 1-9
    • (1994) AIDS , vol.8 , Issue.1 , pp. 1-9
    • Elias, C.J.1    Heise, L.L.2
  • 10
    • 0029806126 scopus 로고    scopus 로고
    • Female-controlled methods to prevent sexual transmission of HIV
    • Elias CJ, Coggins C. Female-controlled methods to prevent sexual transmission of HIV. AIDS 1996; 10: S43-51
    • (1996) AIDS , vol.10
    • Elias, C.J.1    Coggins, C.2
  • 11
    • 77953847552 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS (UN-AIDS)
    • Geneva: UNAIDS Dec
    • Joint United Nations Programme on HIV/AIDS (UN-AIDS). AIDS epidemic update. Special report on HIV prevention. Geneva: UNAIDS, 2005 Dec
    • (2005) AIDS Epidemic Update. Special Report on HIV Prevention
  • 12
    • 33846704291 scopus 로고    scopus 로고
    • Beyond slogans: Lessons from Uganda's experi-ence with ABC and HIV/AIDS
    • Cohen SA. Beyond slogans: lessons from Uganda's experi-ence with ABC and HIV/AIDS. Guttmacher Rep Public Policy 2003; 6 (5): 1-3
    • (2003) Guttmacher Rep Public Policy , vol.6 , Issue.5 , pp. 1-3
    • Cohen, S.A.1
  • 13
    • 57349086059 scopus 로고    scopus 로고
    • Circumcision: A surgical strategy for HIV prevention in Africa
    • Katz IT, Wright AA. Circumcision: a surgical strategy for HIV prevention in Africa. N Engl J Med 2008; 359 (23): 2412-2415
    • (2008) N Engl J Med , vol.359 , Issue.23 , pp. 2412-2415
    • Katz, I.T.1    Wright, A.A.2
  • 14
    • 68449100510 scopus 로고    scopus 로고
    • How reliable is an undetectable viral load?
    • Combescure C, Vallier N, Ledergerber B, et al. How reliable is an undetectable viral load? HIV Med 2009; 10 (8): 470-476
    • (2009) HIV Med , vol.10 , Issue.8 , pp. 470-476
    • Combescure, C.1    Vallier, N.2    Ledergerber, B.3
  • 15
    • 0345569681 scopus 로고    scopus 로고
    • Inhibiting HIV-1 sexual transmis-sion
    • Shattock RA, Moore JP. Inhibiting HIV-1 sexual transmis-sion. Nat Rev Microbiol 2003; 1: 25-34
    • (2003) Nat Rev Microbiol , vol.1 , pp. 25-34
    • Shattock, R.A.1    Moore, J.P.2
  • 16
    • 24144438231 scopus 로고    scopus 로고
    • Candidate sulfo-nated and sulfated topical microbicides: Comparison of antihuman immunodeficiency virus activities and mechanisms of action
    • Scordi-Bello IA, Mosoian A, He C, et al. Candidate sulfo-nated and sulfated topical microbicides: comparison of antihuman immunodeficiency virus activities and mechanisms of action. Antimicrob Agents Chemother 2005; 49 (9): 3607-3615
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.9 , pp. 3607-3615
    • Scordi-Bello, I.A.1    Mosoian, A.2    He, C.3
  • 17
    • 21744462601 scopus 로고    scopus 로고
    • Intravaginal and intrarectal microbicides to prevent HIV infection
    • Balzarini J, Van Damme L. Intravaginal and intrarectal microbicides to prevent HIV infection. CMAJ 2005; 172 (4): 461-464
    • (2005) CMAJ , vol.172 , Issue.4 , pp. 461-464
    • Balzarini, J.1    Van Damme, L.2
  • 18
    • 0037190597 scopus 로고    scopus 로고
    • Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: A randomised, controlled trial
    • Van Damme L, Ramjee G, Alary M, et al. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised, controlled trial. Lancet 2002; 360: 962-964
    • (2002) Lancet , vol.360 , pp. 962-964
    • Van Damme, L.1    Ramjee, G.2    Alary, M.3
  • 19
    • 0026684234 scopus 로고
    • Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes
    • Kreiss J, Ngugi E, Holmes K, et al. Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes. JAMA 1992; 268 (4): 477-482
    • (1992) JAMA , vol.268 , Issue.4 , pp. 477-482
    • Kreiss, J.1    Ngugi, E.2    Holmes, K.3
  • 20
    • 0032552228 scopus 로고    scopus 로고
    • A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases
    • Roddy RE, Zekeng L, Ryan KA, et al. A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases. N Engl J Med 1998; 339 (8): 504-510
    • (1998) N Engl J Med , vol.339 , Issue.8 , pp. 504-510
    • Roddy, R.E.1    Zekeng, L.2    Ryan, K.A.3
  • 21
    • 31944439679 scopus 로고    scopus 로고
    • In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: A retrospective analysis of results from five laboratories
    • Beer BE, Doncel GF, Krebs FC, et al. In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories. Antimicrob Agents Chemother 2006; 50 (2): 713-723
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.2 , pp. 713-723
    • Beer, B.E.1    Doncel, G.F.2    Krebs, F.C.3
  • 22
    • 41849087248 scopus 로고    scopus 로고
    • SAVVY vaginal gel (C31G) for prevention of HIV infection: A randomized controlled trial in Nigeria
    • Feldblum PJ, Adeiga A, Bakare R, et al. SAVVY vaginal gel (C31G) for prevention of HIV infection: a randomized controlled trial in Nigeria. PLoS One 2008; 3 (1): e1474
    • (2008) PLoS One , vol.3 , Issue.1
    • Feldblum, P.J.1    Adeiga, A.2    Bakare, R.3
  • 23
    • 44349126694 scopus 로고    scopus 로고
    • SAVVY® (C31G) gel for prevention of HIV infection in women: A phase 3, double-blind, randomized, placebo-controlled trial in Ghana
    • Peterson L, Nanda K, Opoku BK, et al. SAVVY® (C31G) gel for prevention of HIV infection in women: a phase 3, double-blind, randomized, placebo-controlled trial in Ghana. PLoS One 2007; 2 (12): e1312
    • (2007) PLoS One , vol.2 , Issue.12
    • Peterson, L.1    Nanda, K.2    Opoku, B.K.3
  • 24
    • 57049091723 scopus 로고    scopus 로고
    • Efficacy of Carraguard for prevention of HIV infection in women in South Africa: A randomised, double-blind, placebo-controlled trial
    • Skoler-Karpoff S, Ramjee G, Ahmed K, et al. Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 372 (9654): 1977-1987
    • (2008) Lancet , vol.372 , Issue.9654 , pp. 1977-1987
    • Skoler-Karpoff, S.1    Ramjee, G.2    Ahmed, K.3
  • 25
    • 68049133613 scopus 로고    scopus 로고
    • Safety and effectiveness of vaginal microbicides BufferGel and 0.5% PRO 2000/5 gel for the prevention of HIV infection in women: Results of the HPTN 035 trial [abstract no. 48LB]
    • Feb Montreal (QC)
    • Abdool Karim S, Coletti A, Richardson B, et al. Safety and effectiveness of vaginal microbicides BufferGel and 0.5% PRO 2000/5 gel for the prevention of HIV infection in women: results of the HPTN 035 trial [abstract no. 48LB]. 16th Conference on Retroviruses and Opportunistic Infections; 2009 Feb 8-11; Montreal (QC)
    • (2009) 16th Conference on Retroviruses and Opportunistic Infections , pp. 8-11
    • Abdool Karim, S.1    Coletti, A.2    Richardson, B.3
  • 26
    • 77953617087 scopus 로고    scopus 로고
    • Medical Research Council proven ineffective [online] [Accessed 2009 Dec 17]
    • Medical Research Council. HIV 'prevention' gel PRO 2000 proven ineffective [online]. Available from URL: http://www.mrc.ac.uk/Newspublications/ News/MRC006553 [Accessed 2009 Dec 17]
    • (2000) HIV 'Prevention' Gel PRO
  • 27
    • 48249154985 scopus 로고    scopus 로고
    • Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission
    • Van Damme L, Govinden R, Mirembe FM, et al. Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission. N Engl J Med 2008; 359 (5): 463-472
    • (2008) N Engl J Med , vol.359 , Issue.5 , pp. 463-472
    • Van Damme, L.1    Govinden, R.2    Mirembe, F.M.3
  • 28
    • 38949198100 scopus 로고    scopus 로고
    • VivaGel (SPL7013 Gel): A candidate dendrimer-microbicide for the prevention of HIV and HSV infection
    • Rupp R, Rosenthal SL, Stanberry LR. VivaGel (SPL7013 Gel): a candidate dendrimer-microbicide for the prevention of HIV and HSV infection. Int J Nanomedicine 2007; 2 (4): 561-566
    • (2007) Int J Nanomedicine , vol.2 , Issue.4 , pp. 561-566
    • Rupp, R.1    Rosenthal, S.L.2    Stanberry, L.R.3
  • 29
    • 36349021921 scopus 로고    scopus 로고
    • Phase i safety trial of two vaginal microbicide gels (Acidform or Buffer-Gel) used with a diaphragm compared to KY jelly used with a diaphragm
    • Williams DL, Newman DR, Ballagh SA, et al. Phase I safety trial of two vaginal microbicide gels (Acidform or Buffer-Gel) used with a diaphragm compared to KY jelly used with a diaphragm. Sex Transm Dis 2007; 34 (12): 977-984
    • (2007) Sex Transm Dis , vol.34 , Issue.12 , pp. 977-984
    • Williams, D.L.1    Newman, D.R.2    Ballagh, S.A.3
  • 30
    • 0007110406 scopus 로고    scopus 로고
    • Page CP, Curtis MJ, Sutter MC, et al., editors. London: Mosby
    • Page CP, Curtis MJ, Sutter MC, et al., editors. Integrated pharmacology. London: Mosby, 1997.
    • (1997) Integrated Pharmacology
  • 31
    • 0032842752 scopus 로고    scopus 로고
    • Phase 1 trial of nonoxynol-9 film among sex workers in South Africa
    • Rustomjee R, Abdool Karim Q, Abdool Karim SS, et al. Phase 1 trial of nonoxynol-9 film among sex workers in South Africa. AIDS 1999; 13 (12): 1511-1515
    • (1999) AIDS , vol.13 , Issue.12 , pp. 1511-1515
    • Rustomjee, R.1    Abdool Karim, Q.2    Abdool Karim, S.S.3
  • 32
    • 0036981913 scopus 로고    scopus 로고
    • Nonoxynol-9 for preventing vaginal acquisition of sexually transmitted infections by women from men
    • Wilkinson D, Ramjee G, Tholandi M, et al. Nonoxynol-9 for preventing vaginal acquisition of sexually transmitted infections by women from men. Cochrane Database Syst Rev 2002; (4): CD003939
    • (2002) Cochrane Database Syst Rev , vol.4
    • Wilkinson, D.1    Ramjee, G.2    Tholandi, M.3
  • 33
    • 48249121565 scopus 로고    scopus 로고
    • Whither or wither mi-crobicides?
    • Grant RM, Hamer D, Hope T, et al. Whither or wither mi-crobicides? Science 2008; 321: 532-534
    • (2008) Science , vol.321 , pp. 532-534
    • Grant, R.M.1    Hamer, D.2    Hope, T.3
  • 34
    • 33750012577 scopus 로고    scopus 로고
    • Intravaginal ring delivery of the reverse transcriptase inhibitor TMC120 as an HIV microbicide
    • Woolfson A, Malcolm R, Morrow R, et al. Intravaginal ring delivery of the reverse transcriptase inhibitor TMC120 as an HIV microbicide. Int J Pharm 2006; 325 (1-2): 82-89
    • (2006) Int J Pharm , vol.325 , Issue.1-2 , pp. 82-89
    • Woolfson, A.1    Malcolm, R.2    Morrow, R.3
  • 35
    • 0141703204 scopus 로고    scopus 로고
    • A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding
    • Lin P-F, Blair W, Wang T, et al. A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding. Proc Natl Acad Sci USA 2003; 100 (19): 11013-11018
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.19 , pp. 11013-11018
    • Lin, P.-F.1    Blair, W.2    Wang, T.3
  • 36
    • 27744571425 scopus 로고    scopus 로고
    • Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion
    • Veazey RS, Klasse PJ, Schader SM, et al. Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion. Nature 2005; 438 (7064): 99-102
    • (2005) Nature , vol.438 , Issue.7064 , pp. 99-102
    • Veazey, R.S.1    Klasse, P.J.2    Schader, S.M.3
  • 37
    • 0035112229 scopus 로고    scopus 로고
    • Cyanovirin-N, a potent human immunodeficiency virus-inactivating protein, blocks both CD4-dependent and CD4-independent binding of soluble gp120 (sgp120) to target cells, inhibits sCD4-induced binding of sgp120 to cell-associated CXCR4, and dissociates bound sgp120 from target cells
    • Mori T, Boyd MR. Cyanovirin-N, a potent human immunodeficiency virus-inactivating protein, blocks both CD4-dependent and CD4-independent binding of soluble gp120 (sgp120) to target cells, inhibits sCD4-induced binding of sgp120 to cell-associated CXCR4, and dissociates bound sgp120 from target cells. Antimicrob Agents Chemother 2001; 45 (3): 664-672
    • (2001) Antimicrob Agents Chemother , vol.45 , Issue.3 , pp. 664-672
    • Mori, T.1    Boyd, M.R.2
  • 38
    • 33749532310 scopus 로고    scopus 로고
    • Engineered vaginal Lactobacillus for mucosal delivery of the HIV inhibitor
    • Liu X, Lagenaur LA, Simpson DA, et al. Engineered vaginal Lactobacillus for mucosal delivery of the HIV inhibitor, Cyanovirin-N. Antimicrob Agents Chemother 2006; 50 (10): 3250-3259
    • (2006) Cyanovirin-N. Antimicrob Agents Chemother , vol.50 , Issue.10 , pp. 3250-3259
    • Liu, X.1    Lagenaur, L.A.2    Simpson, D.A.3
  • 40
    • 59749089619 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults
    • Jacobson JM, Kuritzkes DR, Godofsky E, et al. Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults. Antimicrob Agents Chemother 2009; 53 (2): 450-457
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.2 , pp. 450-457
    • Jacobson, J.M.1    Kuritzkes, D.R.2    Godofsky, E.3
  • 41
    • 84923476082 scopus 로고    scopus 로고
    • A phase 2b, randomized, double-blinded, 48-week, multicenter, dose-response study of ibalizumab plus an optimized background regimen in treatment-experienced patients infected with HIV-1 [Clin-icalTrials.gov identifier NCT00784147]
    • US National Institutes of Health [online] [Accessed 2009 Oct 5]
    • US National Institutes of Health. A phase 2b, randomized, double-blinded, 48-week, multicenter, dose-response study of ibalizumab plus an optimized background regimen in treatment-experienced patients infected with HIV-1 [Clin-icalTrials.gov identifier NCT00784147]. US National Institutes of Health, ClinicalTrials.gov [online]. Available from URL: http://clinicaltrials.gov [Accessed 2009 Oct 5]
    • US National Institutes of Health, ClinicalTrials.gov
  • 42
    • 0037651593 scopus 로고    scopus 로고
    • HIV-1 coreceptor usage, transmission, and disease progression
    • Philpott SM. HIV-1 coreceptor usage, transmission, and disease progression. Curr HIV Res 2003; 1 (2): 217-227
    • (2003) Curr HIV Res , vol.1 , Issue.2 , pp. 217-227
    • Philpott, S.M.1
  • 43
    • 48549106475 scopus 로고    scopus 로고
    • Maraviroc: A CCR5-receptor antagonist for the treatment of HIV-1 infection
    • Lieberman-Blum SS, Fung HB, Bandres JC. Maraviroc: a CCR5-receptor antagonist for the treatment of HIV-1 infection. Clin Ther 2008; 30 (7): 1228-1250
    • (2008) Clin Ther , vol.30 , Issue.7 , pp. 1228-1250
    • Lieberman-Blum, S.S.1    Fung, H.B.2    Bandres, J.C.3
  • 44
    • 65549149201 scopus 로고    scopus 로고
    • Topically applied re-combinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge
    • Veazey RS, Ling B, Green LC, et al. Topically applied re-combinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge. J Infect Dis 2009; 199: 1525-1527
    • (2009) J Infect Dis , vol.199 , pp. 1525-1527
    • Veazey, R.S.1    Ling, B.2    Green, L.C.3
  • 45
    • 1842502994 scopus 로고    scopus 로고
    • Enfuvirtide: A fusion inhibitor for the treatment of HIV infection
    • Funf HB, Guo Y. Enfuvirtide: A fusion inhibitor for the treatment of HIV infection. Clin Ther 2004; 26 (3): 352-378
    • (2004) Clin Ther , vol.26 , Issue.3 , pp. 352-378
    • Funf, H.B.1    Guo, Y.2
  • 46
    • 48749094276 scopus 로고    scopus 로고
    • Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249
    • Veazey RS, Ketas TA, Klasse PJ, et al. Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249. Proc Natl Acad Sci USA 2008; 105 (30): 10531-10536
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.30 , pp. 10531-10536
    • Veazey, R.S.1    Ketas, T.A.2    Klasse, P.J.3
  • 47
    • 65249085618 scopus 로고    scopus 로고
    • Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency
    • Ingallinella P, Bianchi E, Ladwa NA, et al. Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency. Proc Natl Acad Sci USA 2009; 106 (14): 5801-5806
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.14 , pp. 5801-5806
    • Ingallinella, P.1    Bianchi, E.2    Ladwa, N.A.3
  • 49
    • 13644260559 scopus 로고    scopus 로고
    • Teno-fovir disoproxil fumarate: A review of its use in the management of HIV infection
    • Lyseng-Williamson KA, Reynolds NA, Plosker GL. Teno-fovir disoproxil fumarate: a review of its use in the management of HIV infection. Drugs 2005; 65 (3): 413-432
    • (2005) Drugs , vol.65 , Issue.3 , pp. 413-432
    • Lyseng-Williamson, K.A.1    Reynolds, N.A.2    Plosker, G.L.3
  • 50
    • 49349112505 scopus 로고    scopus 로고
    • Biomedical interventions to prevent HIV infection: Evidence, challenges, and way forward
    • Padian NS, Buve A, Balkus J, et al. Biomedical interventions to prevent HIV infection: evidence, challenges, and way forward. Lancet 2008; 372 (9638): 585-599
    • (2008) Lancet , vol.372 , Issue.9638 , pp. 585-599
    • Padian, N.S.1    Buve, A.2    Balkus, J.3
  • 51
    • 34247202070 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro
    • Grobler JA, Dornadula G, Rice MR, et al. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem 2007; 282 (11): 8005-8010
    • (2007) J Biol Chem , vol.282 , Issue.11 , pp. 8005-8010
    • Grobler, J.A.1    Dornadula, G.2    Rice, M.R.3
  • 53
  • 54
    • 0347992022 scopus 로고    scopus 로고
    • In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides
    • Van Herrewege Y, Michiels J, Van Roey J, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemo-ther 2004; 48: 337-339
    • (2004) Antimicrob Agents Chemo-ther , vol.48 , pp. 337-339
    • Van Herrewege, Y.1    Michiels, J.2    Van Roey, J.3
  • 55
    • 32644438459 scopus 로고    scopus 로고
    • Dawn of non-nucleoside inhibitor-based anti-HIV microbicides
    • D'Cruz OJ, Uckun FM. Dawn of non-nucleoside inhibitor-based anti-HIV microbicides. J Antimicrob Chemother 2006; 57 (3): 411-423
    • (2006) J Antimicrob Chemother , vol.57 , Issue.3 , pp. 411-423
    • D'Cruz, O.J.1    Uckun, F.M.2
  • 56
    • 0037317788 scopus 로고    scopus 로고
    • HIV-1 integrase in-hibitors that block HIV-1 replication in infected cells: Planning synthetic derivatives from natural products
    • Di Santo R, Costi R, Artico M, et al. HIV-1 integrase in-hibitors that block HIV-1 replication in infected cells: planning synthetic derivatives from natural products. Pure Appl Chem 2003; 75 (2-3): 195-206
    • (2003) Pure Appl Chem , vol.75 , Issue.2-3 , pp. 195-206
    • Di Santo, R.1    Costi, R.2    Artico, M.3
  • 57
    • 63549089353 scopus 로고    scopus 로고
    • Raltegravir elvite-gravir and metoogravir: The birth of "me-too" HIV-1 integrase inhibitors [published erratum appears in Retro-virology 2009; 6: 33]
    • Serrao E, Odde S, Ramkumar K, et al. Raltegravir, elvite-gravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors [published erratum appears in Retro-virology 2009; 6: 33]. Retrovirology 2009; 6: 25
    • (2009) Retrovirology , vol.6 , pp. 25
    • Serrao, E.1    Odde, S.2    Ramkumar, K.3
  • 58
    • 0027413508 scopus 로고
    • HIV protease inhibitors: Their anti-HIV activity and potential role in treatment
    • Robins T, Plattner J. HIV protease inhibitors: their anti-HIV activity and potential role in treatment. J Acquir Immune Defic Syndr 1993; 6 (2): 162-170
    • (1993) J Acquir Immune Defic Syndr , vol.6 , Issue.2 , pp. 162-170
    • Robins, T.1    Plattner, J.2
  • 59
    • 25844482131 scopus 로고    scopus 로고
    • Perils at mucosal front lines for HIV and SIV and their hosts
    • Haase AT. Perils at mucosal front lines for HIV and SIV and their hosts. Nat Rev Immunol 2005; 5 (10): 783-792
    • (2005) Nat Rev Immunol , vol.5 , Issue.10 , pp. 783-792
    • Haase, A.T.1
  • 60
    • 14844293119 scopus 로고    scopus 로고
    • Prevention of mother-to-child transmission of HIV in Africa
    • Vermund SH. Prevention of mother-to-child transmission of HIV in Africa. Top HIV Med 2004; 12 (5): 130-134
    • (2004) Top HIV Med , vol.12 , Issue.5 , pp. 130-134
    • Vermund, S.H.1
  • 61
    • 34848892703 scopus 로고    scopus 로고
    • The renaissance of fixed dose combinations: Combivir
    • Portsmouth SD, Scott CJ. The renaissance of fixed dose combinations: Combivir. Ther Clin Risk Manag 2007; 3 (4): 579-583
    • (2007) Ther Clin Risk Manag , vol.3 , Issue.4 , pp. 579-583
    • Portsmouth, S.D.1    Scott, C.J.2
  • 62
    • 12144273186 scopus 로고    scopus 로고
    • The antiretroviral rollout and drug-resistant HIV in Africa: Insights from empirical data and theoretical models
    • Blower S, Bodine E, Kahn J, et al. The antiretroviral rollout and drug-resistant HIV in Africa: insights from empirical data and theoretical models. AIDS 2005; 19 (1): 1-14
    • (2005) AIDS , vol.19 , Issue.1 , pp. 1-14
    • Blower, S.1    Bodine, E.2    Kahn, J.3
  • 63
    • 33747137566 scopus 로고    scopus 로고
    • Is HIV drug resistance a limiting factor in the development of anti-HIV NNRTI and NRTI-based vaginal microbicide strategies?
    • Martinez J, Coplan P, Wainberg MA. Is HIV drug resistance a limiting factor in the development of anti-HIV NNRTI and NRTI-based vaginal microbicide strategies? Antiviral Res 2006; 71 (2-3): 343-350
    • (2006) Antiviral Res , vol.71 , Issue.2-3 , pp. 343-350
    • Martinez, J.1    Coplan, P.2    Wainberg, M.A.3
  • 64
    • 27744534900 scopus 로고    scopus 로고
    • Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings
    • Malcolm RK, Woolfson AD, Toner CF, et al. Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings. J Antimicrob Chemother 2005; 56 (5): 954-956
    • (2005) J Antimicrob Chemother , vol.56 , Issue.5 , pp. 954-956
    • Malcolm, R.K.1    Woolfson, A.D.2    Toner, C.F.3
  • 65
    • 33745189585 scopus 로고    scopus 로고
    • Challenges in microbicide trial design and implementation
    • Van de Wijgert J, Jones H. Challenges in microbicide trial design and implementation. Stud Fam Plann 2006; 37 (2): 123-129
    • (2006) Stud Fam Plann , vol.37 , Issue.2 , pp. 123-129
    • Van De Wijgert, J.1    Jones, H.2
  • 66
    • 65549169986 scopus 로고    scopus 로고
    • The future of HIV micro-bicides: Challenges and opportunities
    • Garg AB, Nuttall J, Romano J. The future of HIV micro-bicides: challenges and opportunities. Antivir Chem Che-mother 2009; 19 (4): 143-150
    • (2009) Antivir Chem Che-mother , vol.19 , Issue.4 , pp. 143-150
    • Garg, A.B.1    Nuttall, J.2    Romano, J.3
  • 67
    • 29744466672 scopus 로고    scopus 로고
    • PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: A double-blind placebo-controlled trial
    • Keller MJ, Zerhouni-Layachi B, Cheshenko N, et al. PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial. J Infect Dis 2006; 193: 27-35
    • (2006) J Infect Dis , vol.193 , pp. 27-35
    • Keller, M.J.1    Zerhouni-Layachi, B.2    Cheshenko, N.3
  • 68
    • 77952530985 scopus 로고    scopus 로고
    • Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: Implications for future microbicide clinical trials
    • Keller MJ, Mesquita PMM, Torres NM, et al. Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials. PLoS One 2010; 5 (1): e8781
    • (2010) PLoS One , vol.5 , Issue.1
    • Keller, M.J.1    Pmm, M.2    Torres, N.M.3
  • 69
    • 74249109825 scopus 로고    scopus 로고
    • Strong suppression of HIV-1 infection of colorectal explants following in vivo rectal application of UC781 gel: Anovel endpoint in a phase i trial [abstract no. 1067]
    • Feb Montreal (QC)
    • Elliott J, McGowan I, Adler A, et al. Strong suppression of HIV-1 infection of colorectal explants following in vivo rectal application of UC781 gel: anovel endpoint in a phase I trial [abstract no. 1067]. 16th Conference on Retroviruses and Opportunistic Infections; 2009 Feb 8-11; Montreal (QC)
    • (2009) 16th Conference on Retroviruses and Opportunistic Infections , pp. 8-11
    • Elliott, J.1    McGowan, I.2    Adler, A.3
  • 70
    • 3342875489 scopus 로고    scopus 로고
    • Assay for estab-lishing whether microbicide applicators have been exposed to the vagina
    • Wallace A, Mitchell T, Maguire R, et al. Assay for estab-lishing whether microbicide applicators have been exposed to the vagina. Sex Transm Dis 2004; 31: 465-468
    • (2004) Sex Transm Dis , vol.31 , pp. 465-468
    • Wallace, A.1    Mitchell, T.2    Maguire, R.3
  • 71
    • 34250743515 scopus 로고    scopus 로고
    • Determining the feasibility of utilizing the microbicide applicator compliance assay for use in clinical trials
    • Wallace AR, Teitelbaum A, Wan L, et al. Determining the feasibility of utilizing the microbicide applicator compliance assay for use in clinical trials. Contraception 2007; 76: 53-56
    • (2007) Contraception , vol.76 , pp. 53-56
    • Wallace, A.R.1    Teitelbaum, A.2    Wan, L.3
  • 72
    • 18544395546 scopus 로고    scopus 로고
    • Randomized con-trolled trial of audio computer-assisted self-interviewing: Utility and acceptability in longitudinal studies
    • Metzger DS, Koblin B, Turner C, et al. Randomized con-trolled trial of audio computer-assisted self-interviewing: utility and acceptability in longitudinal studies. Am J Epidemiol 2000; 152 (2): 99-106
    • (2000) Am J Epidemiol , vol.152 , Issue.2 , pp. 99-106
    • Metzger, D.S.1    Koblin, B.2    Turner, C.3
  • 73
    • 69149100237 scopus 로고    scopus 로고
    • Disruption of tight junctions by cellulose sulfate facilitates HIV infection: Model of microbicide safety
    • Mesquita PM, Cheshenko N, Wilson SS, et al. Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety. J Infect Dis 2009; 200 (4): 599-608
    • (2009) J Infect Dis , vol.200 , Issue.4 , pp. 599-608
    • Mesquita, P.M.1    Cheshenko, N.2    Wilson, S.S.3
  • 74
    • 62849100828 scopus 로고    scopus 로고
    • Understanding basic mechanisms and optimizing assays to evaluate the efficacy of vaginal microbicides
    • Keller MJ, Herold BC. Understanding basic mechanisms and optimizing assays to evaluate the efficacy of vaginal microbicides. Sex Transm Dis 2009; 36 (3 Suppl.): S92-5
    • (2009) Sex Transm Dis , vol.36 , Issue.3 SUPPL.
    • Keller, M.J.1    Herold, B.C.2
  • 75
    • 65749114134 scopus 로고    scopus 로고
    • Polyanionic microbicides modify Toll-like receptor-mediated cervi-covaginal immune responses
    • Trifonova RT, Doncel GF, Fichorova RN. Polyanionic microbicides modify Toll-like receptor-mediated cervi-covaginal immune responses. Antimicrob Agents Che-mother 2009; 53 (4): 1490-1500
    • (2009) Antimicrob Agents Che-mother , vol.53 , Issue.4 , pp. 1490-1500
    • Trifonova, R.T.1    Doncel, G.F.2    Fichorova, R.N.3
  • 76
    • 47649123409 scopus 로고    scopus 로고
    • The para-doxical effects of using antiretroviral-based microbicides to control HIV epidemics
    • Wilson DP, Coplan PM, Wainberg MA, et al. The para-doxical effects of using antiretroviral-based microbicides to control HIV epidemics. Proc Natl Acad Sci USA 2008; 105 (28): 9835-9840
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.28 , pp. 9835-9840
    • Wilson, D.P.1    Coplan, P.M.2    Wainberg, M.A.3
  • 77
    • 0345486993 scopus 로고    scopus 로고
    • Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride
    • Miller V, de Bethune M-P, Kober A, et al. Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride. Antimicrob Agents Chemother 1998; 42 (12): 3123-3129 (Pubitemid 28553729)
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , Issue.12 , pp. 3123-3129
    • Miller, V.1    De Bethune, M.-P.2    Kober, A.3    Sturmer, M.4    Hertogs, K.5    Pauwels, R.6    Stoffels, P.7    Staszewski, S.8
  • 78
    • 33847353726 scopus 로고    scopus 로고
    • Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited
    • Orrell C, Harling G, Lawn SD, et al. Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited. Antivir Ther 2007; 12: 83-88
    • (2007) Antivir Ther , vol.12 , pp. 83-88
    • Orrell, C.1    Harling, G.2    Lawn, S.D.3
  • 79
    • 3042674950 scopus 로고    scopus 로고
    • Regulatory chal-lenges in microbicide development
    • Coplan PM, Mitchnick M, Rosenberg ZF. Regulatory chal-lenges in microbicide development. Science 2004; 304: 1911-1912
    • (2004) Science , vol.304 , pp. 1911-1912
    • Coplan, P.M.1    Mitchnick, M.2    Rosenberg, Z.F.3
  • 80
    • 1442340176 scopus 로고    scopus 로고
    • Regulatory pathways for vaccines for developing countries
    • Milstien J, Belgharbi L. Regulatory pathways for vaccines for developing countries. Bull World Health Organ 2004; 82 (2): 128-133
    • (2004) Bull World Health Organ , vol.82 , Issue.2 , pp. 128-133
    • Milstien, J.1    Belgharbi, L.2
  • 81
    • 77953849041 scopus 로고    scopus 로고
    • Guideline on procedural aspects regarding a CHMP scientific opinion in the context of cooperation with the World Health Organisation (WHO) for the evaluation of medicinal products intended exclusively for markets outside the community
    • Committee for Medicinal Products for Human Use (CHMP) London: CHMP
    • Committee for Medicinal Products for Human Use (CHMP). Guideline on procedural aspects regarding a CHMP scientific opinion in the context of cooperation with the World Health Organisation (WHO) for the evaluation of medicinal products intended exclusively for markets outside the community. EMEA/CHMP/5579/04 Rev.1. London: CHMP, 2005
    • (2005) EMEA/CHMP/5579/04 Rev , vol.1
  • 82
    • 57449098157 scopus 로고    scopus 로고
    • Collaborating with traditional healers for HIV prevention and care in sub-Saharan Africa: Suggestions for programme managers and field workers
    • Geneva: World Health Organization
    • Collaborating with traditional healers for HIV prevention and care in sub-Saharan Africa: suggestions for programme managers and field workers. UNAIDS Best Practice Collection. Geneva: World Health Organization, 2006
    • (2006) UNAIDS Best Practice Collection
  • 83
    • 0034007727 scopus 로고    scopus 로고
    • In-travaginal practices, vaginal flora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women
    • van de Wijgert JHHM, Mason PR, Gwanzura L, et al. In-travaginal practices, vaginal flora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women. J Infect Dis 2000; 181: 587-594
    • (2000) J Infect Dis , vol.181 , pp. 587-594
    • Van De Wijgert Jhhm1    Mason, P.R.2    Gwanzura, L.3
  • 84
    • 28044465440 scopus 로고    scopus 로고
    • Intravaginal practices, bac-terial vaginosis, and women's susceptibility to HIV infection: Epidemiological evidence and biological mechanisms
    • Myer L, Kuhn L, Stein Z, et al. Intravaginal practices, bac-terial vaginosis, and women's susceptibility to HIV infection: epidemiological evidence and biological mechanisms. Lancet Infect Dis 2005; 5 (12): 786-794
    • (2005) Lancet Infect Dis , vol.5 , Issue.12 , pp. 786-794
    • Myer, L.1    Kuhn, L.2    Stein, Z.3
  • 85
    • 0032541783 scopus 로고    scopus 로고
    • Concern voiced over "dry sex" practices in South Africa
    • Baleta A. Concern voiced over "dry sex" practices in South Africa. Lancet 1998; 352: 1292
    • (1998) Lancet , vol.352 , pp. 1292
    • Baleta, A.1
  • 86
    • 52649103078 scopus 로고    scopus 로고
    • Cost-effec-tiveness of HIV monitoring strategies in resource-limited settings: A Southern African analysis
    • Bendavid E, Young SD, Katzenstein DA, et al. Cost-effec-tiveness of HIV monitoring strategies in resource-limited settings: a Southern African analysis. Arch Intern Med 2008; 168 (17): 1910-1918
    • (2008) Arch Intern Med , vol.168 , Issue.17 , pp. 1910-1918
    • Bendavid, E.1    Young, S.D.2    Katzenstein, D.A.3
  • 87
    • 17644398728 scopus 로고    scopus 로고
    • Medication use during pregnancy and lactation: An urgent call for public health action
    • Lagoy CT, Joshi N, Cragan JD, et al. Medication use during pregnancy and lactation: an urgent call for public health action. J Womens Health (Larchmt) 2005; 14 (2): 104-109
    • (2005) J Womens Health (Larchmt) , vol.14 , Issue.2 , pp. 104-109
    • Lagoy, C.T.1    Joshi, N.2    Cragan, J.D.3
  • 88
    • 36348951983 scopus 로고    scopus 로고
    • Microbicide research in developing countries: Have we given the ethical concerns due consideration?
    • Moodley K. Microbicide research in developing countries: have we given the ethical concerns due consideration? BMC Med Ethics 2007; 8: 10
    • (2007) BMC Med Ethics , vol.8 , pp. 10
    • Moodley, K.1


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