C-Methylflavonoids isolated from callistemon lanceolatus protect pc12 cells against a-induced toxicity

Planta Medica

Volumn 76, Issue 9, 2010, Pages 863-868

  Park, So Young ^a   Lim, Ji Youn ^a   Jeong, Wonsik ^b   Hong, Seong Su ^b   Yang, Young Taek ^c   Hwang, Bang Yeon ^d   Lee, Dongho ^b  

^a Korea University College of Medicine   (South Korea)

^b Korea University   (South Korea)

^c Jeju Special Self Governing Province Agricultural Research   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

4,5dihydroxy6, 8dimethyl7methoxyflavanone; amyloid; apoptosis; C methylflavonoids; Callistemon lanceolatus; Myrtaceae; PC12 cells

Indexed keywords

4',5 DIHYDROXY 6,8 DIMETHYL 7 METHOXYFLAVANONE; 8 DEMETHYL EUCALYPTIN; AMYLOID BETA PROTEIN; C METHYLFLAVONOID; CALLISTEMON LANCEOLATUS EXTRACT; CASPASE 3; EUCALYPTIN; FLAVONOID; NEUROPROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; QUERCETIN; SIDEROXYLIN; SYZALTERIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CALLISTEMON LANCEOLATUS; CELL DEATH; CELL STRAIN; DRUG STRUCTURE; ENZYME ACTIVATION; FRACTIONATION; MYRTACEAE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PURIFICATION; RAT; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CASPASE 3; FLAVONOIDS; MYRTACEAE; NEUROPROTECTIVE AGENTS; PC12 CELLS; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS;

CALLISTEMON LANCEOLATUS; MYRTACEAE;

EID: 77953819386     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1240801     Document Type: Article

References (34)

1. Selkoe D J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol 1998 8 447-453
2. Pike C J., Walencewicz A J., Glabe C G., Cotman C W. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 1991 563 311-314
3. Cummings J L., Vinters H V., Cole G M., Khachaturian Z S. Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 1998 51 S2-S17
4. Pasinetti G M., Aisen P S. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 1998 87 319-324
5. Winstein C J., Bentzen K R., Boyd L, Schneider L S. Does the cholinesterase inhibitor, donepezil, benefit both declarative and non-declarative processes in mild to moderate Alzheimer's disease? Curr Alzheimer Res 2007 4 273-276
6. Gauthier S, Emre M, Farlow M R., Bullock R, Grossberg G T., Potkin S G. Strategies for continued successful treatment of Alzheimer's disease: switching cholinesterase inhibitors. Curr Med Res Opin 2003 19 707-714
7. Mahmoud I I., Moharram F A., Marzouk M S., Linscheid M W., Saleh M I. Polyphenolic constituents of Callistemon lanceolatus leaves. Pharmazie 2002 57 494-496
8. Jeong W, Hong S S., Kim N, Yang Y T., Shin Y S., Lee C, Hwang B Y., Lee D. Bioactive triterpenoids from Callistemon lanceolatus. Arch Pharm Res 2009 32 845-849
9. Kim H S., Sul D, Lim J Y., Lee D, Joo S S., Hwang K W., Park S Y. Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation. Biosci Biotechnol Biochem 2009 73 1685-1689
10. Park S Y., Kim H S., Hong S S., Sul D, Hwang K W., Lee D. The neuroprotective effects of traditional oriental herbal medicines against beta-amyloid-induced toxicity. Pharm Biol 2009 47 976-981
11. Fallarini S, Miglio G, Paoletti T, Minassi A, Amoruso A, Bardelli C, Brunelleschi S, Lombardi G. Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. Br J Pharmacol 2009 157 1072-1084
12. Wollenweber E, Wehde R, Dorr M, Lang G, Stevens J F. C-Methyl-flavonoids from the leaf waxes of some Myrtaceae. Phytochemistry 2000 55 965-970
13. Huq F, Misra L N. An alkenol and C-methylated flavones from Callistemon lanceolatus leaves. Planta Med 1997 63 369-370
14. Hillis W E., Isoi K. Variation in the chemical composition of Eucalyptus sideroxylon. Phytochemistry 1965 4 541-550
15. Youssef D T. A., Ramadan M A., Khalifa A A. Acetophenones, a chalcone, a chromone and flavonoids from Pancratium maritimum. Phytochemistry 1998 49 2579-2583
16. Op de Beck P, Dijoux M G., Cartier G, Mariotte A M. Quercitrin 3-sulphate from leaves of Leea guinensis. Phytochemistry 1998 47 1171-1173
17. Babajide O J., Babajide O O., Daramola A O., Mabusela W T. Flavonols and an oxychromonol from Piliostigma reticulatum. Phytochemistry 2008 69 2245-2250
18. Jung M J., Choi J H., Chung H Y., Jung J H., Choi J S. A new C-methylated flavonoid glycoside from Pinus densiflora. Fitoterapia 2001 72 943-945
19. Basnet P, Kadota S, Hase K, Namba T. Five new C-methyl flavonoids, the potent aldose reductase inhibitors from Matteuccia orientalis Trev. Chem Pharm Bull 1995 43 1558-1564
20. Kadota S, Basnet P, Hase K, Namba T. Matteuorienate A and B, two new and potent aldose reductase inhibitors from Matteuccia orientalis (Hook.) Trev. Chem Pharm Bull 1994 42 1712-1714
21. Harborne J B., Greenham J, Williams C A., Eagles J, Markham K R. Ten isoprenylated and C-methylated flavonoids from the leaves of three Vellozia species. Phytochemistry 1993 34 219-226
22. Hwang B Y., Roberts S K., Chadwick L R., Wu C D., Kinghorn A D. Antimicrobial constituents from goldenseal (the rhizomes of Hydrastis canadensis) against selected oral pathogens. Planta Med 2003 69 623-627
23. Yan S D., Zhu H, Fu J, Yan S F., Roher A, Tourtellotte W W., Rajavashisth T, Chen X, Godman G C., Stern D, Schmidt A M. Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc Natl Acad Sci USA 1997 94 5296-5301
24. Lorenzo A, Yankner B A. Amyloid fibril toxicity in Alzheimer's disease and diabetes. Ann NY Acad Sci 1996 777 89-95
25. Tohda C, Matsumoto N, Zou K, Meselhy M R., Komatsu K. Abeta(2535)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology 2004 29 860-868
26. Bruggisser R, von Daeniken K, Jundt G, Schaffner W, Tullberg-Reinert H. Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay. Planta Med 2002 68 445-448
27. Selkoe D J. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann NY Acad Sci 2000 924 17-25
28. Su J H., Zhao M, Anderson A J., Srinivasan A, Cotman C W. Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. Brain Res 2001 898 350-357
29. Ye J, Meng X, Yan C, Wang C. Effect of purple sweet potato anthocyanins on beta-amyloid-mediated PC-12 cells death by inhibition of oxidative stress. Neurochem Res 2009
30. Kim H J., Lee K W., Lee H J. Protective effects of piceatannol against beta-amyloid-induced neuronal cell death. Ann NY Acad Sci 2007 1095 473-482
31. Adams J M., Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998 281 1322-1326
32. Yuyama K, Yamamoto H, Nishizaki I, Kato T, Sora I, Yamamoto T. Caspase-independent cell death by low concentrations of nitric oxide in PC12 cells: involvement of cytochrome C oxidase inhibition and the production of reactive oxygen species in mitochondria. J Neurosci Res 2003 73 351-363
33. Zhang H Y., Liu Y H., Wang H Q., Xu J H., Hu H T. Puerarin protects PC12 cells against beta-amyloid-induced cell injury. Cell Biol Int 2008 32 1230-1237
34. Kim H S., Lim J Y., Sul D, Hwang B Y., Won T J., Hwang K W., Park S Y. Neuroprotective effects of the new diterpene, CBNU06 against beta-amyloid-induced toxicity through the inhibition of NF-kappaB signaling pathway in PC12 cells. Eur J Pharmacol 2009 622 25-31