메뉴 건너뛰기




Volumn 82, Issue 6, 2010, Pages 1139-1150

Transcriptional profiling of luteinizing hormone receptor-deficient mice before and after testosterone treatment provides insight into the hormonal control of postnatal testicular development and Leydig cell differentiation

Author keywords

Early development; Leydig cells; Luteinizing hormone; Spermatid; Spermatogenesis; Testis; Testosterone

Indexed keywords

ANDROGEN; LUTEINIZING HORMONE RECEPTOR; TESTOSTERONE;

EID: 77953814972     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.109.082099     Document Type: Article
Times cited : (27)

References (51)
  • 1
    • 84995867043 scopus 로고
    • The spermatogenic and secretory function of the gonads of hypophysectomised adult rats treated with pituitary FSH and LH
    • Greep RO, Fevold H. The spermatogenic and secretory function of the gonads of hypophysectomised adult rats treated with pituitary FSH and LH. Endocrinology 1937; 21:611-619.
    • (1937) Endocrinology , vol.21 , pp. 611-619
    • Greep, R.O.1    Fevold, H.2
  • 2
    • 0031054284 scopus 로고    scopus 로고
    • Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
    • DOI 10.1038/ng0297-201
    • Kumar TR, Wang Y, Lu N, Matzuk MM. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet 1997; 15:201-204. (Pubitemid 27061644)
    • (1997) Nature Genetics , vol.15 , Issue.2 , pp. 201-204
    • Kumar, T.R.1    Wang, Y.2    Lu, N.3    Matzuk, M.M.4
  • 3
    • 0032506018 scopus 로고    scopus 로고
    • Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
    • Dierich A, Sairam MR, Monaco L, Fimia GM, Gansmuller A, LeMeur M, Sassone-Corsi P. Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A 1998; 95:13612-13617.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13612-13617
    • Dierich, A.1    Sairam, M.R.2    Monaco, L.3    Fimia, G.M.4    Gansmuller, A.5    LeMeur, M.6    Sassone-Corsi, P.7
  • 4
    • 0034457577 scopus 로고    scopus 로고
    • The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction
    • Abel MH, Wootton AN, Wilkins V, Huhtaniemi I, Knight PG, Charlton HM. The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology 2000; 141:1795-1803.
    • (2000) Endocrinology , vol.141 , pp. 1795-1803
    • Abel, M.H.1    Wootton, A.N.2    Wilkins, V.3    Huhtaniemi, I.4    Knight, P.G.5    Charlton, H.M.6
  • 5
    • 0035133266 scopus 로고    scopus 로고
    • Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice
    • Zhang FP, Poutanen M, Wilbertz J, Huhtaniemi I. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol Endocrinol 2001; 15:172-183.
    • (2001) Mol Endocrinol , vol.15 , pp. 172-183
    • Zhang, F.P.1    Poutanen, M.2    Wilbertz, J.3    Huhtaniemi, I.4
  • 6
    • 0035136888 scopus 로고    scopus 로고
    • Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene
    • Lei ZM, Mishra S, Zou W, Xu B, Foltz M, Li X, Rao CV. Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene. Mol Endocrinol 2001; 15:184-200.
    • (2001) Mol Endocrinol , vol.15 , pp. 184-200
    • Lei, Z.M.1    Mishra, S.2    Zou, W.3    Xu, B.4    Foltz, M.5    Li, X.6    Rao, C.V.7
  • 7
    • 0028876068 scopus 로고
    • Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice
    • Singh J, O'Neill C, Handelsman DJ. Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice. Endocrinology 1995; 136:5311-5321.
    • (1995) Endocrinology , vol.136 , pp. 5311-5321
    • Singh, J.1    O'Neill, C.2    Handelsman, D.J.3
  • 8
    • 0346093957 scopus 로고    scopus 로고
    • Luteinizing hormone receptor-mediated effects on initiation of spermatogenesis in gonadotropin-deficient (hpg) mice are replicated by testosterone
    • Spaliviero JA, Jimenez M, Allan CM, Handelsman DJ. Luteinizing hormone receptor-mediated effects on initiation of spermatogenesis in gonadotropin-deficient (hpg) mice are replicated by testosterone. Biol Reprod 2004; 70:32-38.
    • (2004) Biol Reprod , vol.70 , pp. 32-38
    • Spaliviero, J.A.1    Jimenez, M.2    Allan, C.M.3    Handelsman, D.J.4
  • 9
    • 12344262662 scopus 로고    scopus 로고
    • Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice
    • Pakarainen T, Zhang FP, Mäkelä S, Poutanen M, Huhtaniemi I. Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice. Endocrinology 2005; 146:596-606.
    • (2005) Endocrinology , vol.146 , pp. 596-606
    • Pakarainen, T.1    Zhang, F.P.2    Mäkelä, S.3    Poutanen, M.4    Huhtaniemi, I.5
  • 13
    • 0031796489 scopus 로고    scopus 로고
    • Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function
    • DOI 10.1210/en.139.3.1141
    • O'Shaughnessy PJ, Baker P, Sohnius U, Haavisto AM, Charlton HM, Huhtaniemi I. Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function. Endocrinology 1998; 139: 1141-1146. (Pubitemid 28510133)
    • (1998) Endocrinology , vol.139 , Issue.3 , pp. 1141-1146
    • O'Shaughnessy, P.J.1    Baker, P.2    Sohnius, U.3    Haavisto, A.-M.4    Charlton, H.M.5    Huhtaniemi, I.6
  • 14
    • 67349249354 scopus 로고    scopus 로고
    • Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: Data from mutant and genetically modified mice
    • O'Shaughnessy PJ, Morris ID, Huhtaniemi I, Baker PJ, Abel MH. Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice. Mol Cell Endocrinol 2009; 306:2-8.
    • (2009) Mol Cell Endocrinol , vol.306 , pp. 2-8
    • O'Shaughnessy, P.J.1    Morris, I.D.2    Huhtaniemi, I.3    Baker, P.J.4    Abel, M.H.5
  • 15
    • 0026670305 scopus 로고
    • Fetal Leydig cells: Cellular origin, morphology, life span, and special functional features
    • Huhtaniemi I, Pelliniemi LJ. Fetal Leydig cells: cellular origin, morphology, life span, and special functional features. Proc Soc Exp Biol Med 1992; 201:125-140.
    • (1992) Proc Soc Exp Biol Med , vol.201 , pp. 125-140
    • Huhtaniemi, I.1    Pelliniemi, L.J.2
  • 16
    • 0033087599 scopus 로고    scopus 로고
    • Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development
    • Baker PJ, Sha JA, McBride MW, Peng L, Payne AH, O'Shaughnessy PJ. Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development. Eur J Biochem 1999; 260:911-917.
    • (1999) Eur J Biochem , vol.260 , pp. 911-917
    • Baker, P.J.1    Sha, J.A.2    McBride, M.W.3    Peng, L.4    Payne, A.H.5    O'Shaughnessy, P.J.6
  • 17
    • 0036195674 scopus 로고    scopus 로고
    • Changes in Leydig cell gene expression during development in the mouse
    • O'Shaughnessy PJ, Willerton L, Baker PJ. Changes in Leydig cell gene expression during development in the mouse. Biol Reprod 2002; 66:966-975. (Pubitemid 34263116)
    • (2002) Biology of Reproduction , vol.66 , Issue.4 , pp. 966-975
    • O'Shaughnessy, P.J.1    Willerton, L.2    Baker, P.J.3
  • 18
    • 0344823859 scopus 로고    scopus 로고
    • The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis
    • Zhang FP, Pakarainen T, Poutanen M, Toppari J, Huhtaniemi I. The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Proc Natl Acad Sci U S A 2003; 100:13692-13697.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13692-13697
    • Zhang, F.P.1    Pakarainen, T.2    Poutanen, M.3    Toppari, J.4    Huhtaniemi, I.5
  • 19
    • 1442299095 scopus 로고    scopus 로고
    • Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice
    • Zhang FP, Pakarainen T, Zhu F, Poutanen M, Huhtaniemi I. Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice. Endocrinology 2004; 145: 1453-1463.
    • (2004) Endocrinology , vol.145 , pp. 1453-1463
    • Zhang, F.P.1    Pakarainen, T.2    Zhu, F.3    Poutanen, M.4    Huhtaniemi, I.5
  • 22
    • 48449104617 scopus 로고    scopus 로고
    • GOEAST: A web-based software toolkit for gene ontology enrichment analysis
    • Zheng Q, Wang XJ. GOEAST: a web-based software toolkit for gene ontology enrichment analysis. Nucleic Acids Res 2008; 36(Web server issue):W358-363.
    • (2008) Nucleic Acids Res , vol.36 , Issue.WEB SERVER ISSUE
    • Zheng, Q.1    Wang, X.J.2
  • 24
    • 33744809022 scopus 로고    scopus 로고
    • Effects of neonatal exposure to 4-tertoctylphenol, diethylstilbestrol, and flutamide on steroidogenesis in infantile rat testis
    • Mikkilä TF, Toppari J, Paranko J. Effects of neonatal exposure to 4-tertoctylphenol, diethylstilbestrol, and flutamide on steroidogenesis in infantile rat testis. Toxicol Sci 2006; 91:456-466.
    • (2006) Toxicol Sci , vol.91 , pp. 456-466
    • Mikkilä, T.F.1    Toppari, J.2    Paranko, J.3
  • 25
    • 0035992521 scopus 로고    scopus 로고
    • Identification of testis development and spermatogenesis-related genes in human and mouse testes using cDNA arrays
    • Sha J, Zhou Z, Li J, Yin L, Yang H, Hu G, Luo M, Chan HC, Zhou K. Identification of testis development and spermatogenesis-related genes in human and mouse testes using cDNA arrays. Mol Hum Reprod 2002; 8: 511-517.
    • (2002) Mol Hum Reprod , vol.8 , pp. 511-517
    • Sha, J.1    Zhou, Z.2    Li, J.3    Yin, L.4    Yang, H.5    Hu, G.6    Luo, M.7    Chan, H.C.8    Zhou, K.9
  • 26
    • 0142091380 scopus 로고    scopus 로고
    • A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets
    • Schultz N, Hamra FK, Garbers DL. A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets. Proc Natl Acad Sci U S A 2003; 100:12201-12206.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12201-12206
    • Schultz, N.1    Hamra, F.K.2    Garbers, D.L.3
  • 27
    • 0942298000 scopus 로고    scopus 로고
    • Stagespecific and tissue-specific expression characteristics of differentially expressed genes during mouse spermatogenesis
    • Guo R, Yu Z, Guan J, Ge Y, Ma J, Li S, Wang S, Xue S, Han D. Stagespecific and tissue-specific expression characteristics of differentially expressed genes during mouse spermatogenesis. Mol Reprod Dev 2004; 67:264-272.
    • (2004) Mol Reprod Dev , vol.67 , pp. 264-272
    • Guo, R.1    Yu, Z.2    Guan, J.3    Ge, Y.4    Ma, J.5    Li, S.6    Wang, S.7    Xue, S.8    Han, D.9
  • 31
    • 2642558614 scopus 로고    scopus 로고
    • The mouse X chromosome is enriched for sex-biased genes not subject to selection by meiotic sex chromosome inactivation
    • Khil PP, Smirnova NA, Romanienko PJ, Camerini-Otero RD. The mouse X chromosome is enriched for sex-biased genes not subject to selection by meiotic sex chromosome inactivation. Nat Genet 2004; 36:642-646.
    • (2004) Nat Genet , vol.36 , pp. 642-646
    • Khil, P.P.1    Smirnova, N.A.2    Romanienko, P.J.3    Camerini-Otero, R.D.4
  • 32
    • 0242384961 scopus 로고    scopus 로고
    • Feasibility of global gene expression analysis in testicular biopsies from infertile men
    • Fox MS, Ares VX, Turek PJ, Haqq C, Reijo Pera RA. Feasibility of global gene expression analysis in testicular biopsies from infertile men. Mol Reprod Dev 2003; 66:403-421.
    • (2003) Mol Reprod Dev , vol.66 , pp. 403-421
    • Fox, M.S.1    Ares, V.X.2    Turek, P.J.3    Haqq, C.4    Reijo Pera, R.A.5
  • 33
    • 33845629456 scopus 로고    scopus 로고
    • A new paradigm for profiling testicular gene expression during normal and disturbed human spermatogenesis
    • Feig C, Kirchhoff C, Ivell R, Naether O, Schulze W, Spiess AN. A new paradigm for profiling testicular gene expression during normal and disturbed human spermatogenesis. Mol Hum Reprod 2007; 13:33-43.
    • (2007) Mol Hum Reprod , vol.13 , pp. 33-43
    • Feig, C.1    Kirchhoff, C.2    Ivell, R.3    Naether, O.4    Schulze, W.5    Spiess, A.N.6
  • 35
  • 36
    • 34250823708 scopus 로고    scopus 로고
    • Altered expression of genes involved in regulation of vitamin a metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive Tfm mouse testis
    • O'Shaughnessy PJ, Abel M, Charlton HM, Hu B, Johnston H, Baker PJ. Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive Tfm mouse testis. Endocrinology 2007; 148:2914-2924.
    • (2007) Endocrinology , vol.148 , pp. 2914-2924
    • O'Shaughnessy, P.J.1    Abel, M.2    Charlton, H.M.3    Hu, B.4    Johnston, H.5    Baker, P.J.6
  • 37
    • 34247846135 scopus 로고    scopus 로고
    • Transcriptional profiling of androgen receptor (AR) mutants suggests instructive and permissive roles of AR signaling in germ cell development
    • Eacker SM, Shima JE, Connolly CM, Sharma M, Holdcraft RW, Griswold MD, Braun RE. Transcriptional profiling of androgen receptor (AR) mutants suggests instructive and permissive roles of AR signaling in germ cell development. Mol Endocrinol 2007; 21:895-907.
    • (2007) Mol Endocrinol , vol.21 , pp. 895-907
    • Eacker, S.M.1    Shima, J.E.2    Connolly, C.M.3    Sharma, M.4    Holdcraft, R.W.5    Griswold, M.D.6    Braun, R.E.7
  • 39
    • 77951919535 scopus 로고    scopus 로고
    • Early effects of Sertoli cell-selective androgen receptor ablation on testicular gene expression
    • 2010 (in press). Published online ahead of print 12 April DOI 10.1111/j.1365-2605.2009.00964.x
    • Willems A, De Gendt K, Allemeersch J, Smith LB, Welsh M, Swinnen JV, Verhoeven G. Early effects of Sertoli cell-selective androgen receptor ablation on testicular gene expression. Int J Androl 2010; (in press). Published online ahead of print 12 April 2009: DOI 10.1111/j.1365-2605.2009.00964.x.
    • (2009) Int J Androl
    • Willems, A.1    De Gendt, K.2    Allemeersch, J.3    Smith, L.B.4    Welsh, M.5    Swinnen, J.V.6    Verhoeven, G.7
  • 41
    • 0037073756 scopus 로고    scopus 로고
    • Pem homeobox gene regulatory sequences that direct androgen-dependent developmentally regulated gene expression in different subregions of the epididymis
    • Rao MK, Wayne CM, Wilkinson MF. Pem homeobox gene regulatory sequences that direct androgen-dependent developmentally regulated gene expression in different subregions of the epididymis. J Biol Chem 2002; 277:48771-48778.
    • (2002) J Biol Chem , vol.277 , pp. 48771-48778
    • Rao, M.K.1    Wayne, C.M.2    Wilkinson, M.F.3
  • 42
    • 41149133270 scopus 로고    scopus 로고
    • GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells
    • Bhardwaj A, Rao MK, Kaur R, Buttigieg MR, Wilkinson MF. GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells. Mol Cell Biol 2008; 28:2138-2153.
    • (2008) Mol Cell Biol , vol.28 , pp. 2138-2153
    • Bhardwaj, A.1    Rao, M.K.2    Kaur, R.3    Buttigieg, M.R.4    Wilkinson, M.F.5
  • 43
    • 26444438115 scopus 로고    scopus 로고
    • LMCD1/dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding
    • Rath N, Wang Z, Lu MM, Morrisey EE. LMCD1/dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. Mol Cell Biol 2005; 25:8864-8873.
    • (2005) Mol Cell Biol , vol.25 , pp. 8864-8873
    • Rath, N.1    Wang, Z.2    Lu, M.M.3    Morrisey, E.E.4
  • 46
    • 49649116952 scopus 로고    scopus 로고
    • Lysophospholipid signaling in the function and pathology of the reproductive system
    • Ye X. Lysophospholipid signaling in the function and pathology of the reproductive system. Hum Reprod Update 2008; 14:519-536.
    • (2008) Hum Reprod Update , vol.14 , pp. 519-536
    • Ye, X.1
  • 47
    • 0036712830 scopus 로고    scopus 로고
    • Failure of normal adult Leydig cell development in androgen-receptor- deficient mice
    • O'Shaughnessy PJ, Johnston H, Willerton L, Baker PJ. Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. J Cell Sci 2002; 115:3491-3496. (Pubitemid 34994038)
    • (2002) Journal of Cell Science , vol.115 , Issue.17 , pp. 3491-3496
    • O'Shaughnessy, P.J.1    Johnston, H.2    Willerton, L.3    Baker, P.J.4
  • 49
    • 0025333015 scopus 로고
    • Differentiation of Leydig cell precursors in vitro: A role for androgen
    • Hardy MP, Kelce WR, Klinefelter GR, Ewing LL. Differentiation of Leydig cell precursors in vitro: a role for androgen. Endocrinology 1990; 127:488-490.
    • (1990) Endocrinology , vol.127 , pp. 488-490
    • Hardy, M.P.1    Kelce, W.R.2    Klinefelter, G.R.3    Ewing, L.L.4
  • 50
    • 0038732329 scopus 로고    scopus 로고
    • Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions
    • Gye MC, Ohsako S. Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions. Toxicol Lett 2003; 143:217-222.
    • (2003) Toxicol Lett , vol.143 , pp. 217-222
    • Gye, M.C.1    Ohsako, S.2
  • 51
    • 0035143818 scopus 로고    scopus 로고
    • Mesenchymal cell precursors of peritubular smooth muscle cells of the mouse testis can be identified by the presence of the p75 neurotrophin receptor
    • Campagnolo L, Russo MA, Puglianiello A, Favale A, Siracusa G. Mesenchymal cell precursors of peritubular smooth muscle cells of the mouse testis can be identified by the presence of the p75 neurotrophin receptor. Biol Reprod 2001; 64:464-472. (Pubitemid 32109734)
    • (2001) Biology of Reproduction , vol.64 , Issue.2 , pp. 464-472
    • Campagnolo, L.1    Russo, M.A.2    Puglianiello, A.3    Favale, A.4    Siracusa, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.