LMCD1/dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding

Molecular and Cellular Biology

Volumn 25, Issue 20, 2005, Pages 8864-8873

  Rath, Nibedita ^a   Wang, Zhishan ^a   Lu, Min Min ^a   Morrisey, Edward E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; PROTEIN ISL 1; PROTEIN LIN11; PROTEIN MEC 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DYXIN; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR LMCD1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; GEL MOBILITY SHIFT ASSAY; GENE REPRESSION; HEART MUSCLE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RESPIRATORY EPITHELIUM; VASCULAR SMOOTH MUSCLE; ZINC FINGER MOTIF;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; DNA; FETAL HEART; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LUNG; MICE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 26444438115     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.20.8864-8873.2005     Document Type: Article

References (47)

1. Akazawa, H., S. Kudoh, N. Mochizuki, N. Takekoshi, H. Takano, T. Nagai, and I. Komuro. 2004. A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. J. Cell Biol. 164:395-405.
2. Anguita, E., J. Hughes, C. Heyworth, G. A. Blobel, W. G. Wood, and D. R. Higgs. 2004. Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J. 23:2841-2852.
3. Aronheim, A., E. Zandi, H. Hennemann, S. J. Elledge, and M. Karin. 1997. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol. Cell. Biol. 17:3094-3102.
4. Bekman, E., and D. Henrique. 2002. Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene. Mech. Dev. 119(Suppl. 1):S77-S81.
5. Bespalova, I. N., and M. Burmeister. 2000. Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse. Genomics 63:69-74.
6. Bruno, M. D., T. R. Korfhagen, C. Liu, E. E. Morrisey, and J. A. Whitsett. 2000. GATA-6 activates transcription of surfactant protein A. J. Biol. Chem. 275:1043-1049.
7. Chang, D. F., N. S. Belaguli, D. Iyer, W. B. Roberts, S. P. Wu, X. R. Dong, J. G. Marx, M. S. Moore, M. C. Beckerle, M. W. Majesky, and R. J. Schwartz. 2003. Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev. Cell 4:107-118.
8. Deconinck, A. E., P. E. Mead, S. G. Tevosian, J. D. Crispino, S. G. Katz, L. I. Zon, and S. H. Orkin. 2000. FOG acts as a repressor of red blood cell development in Xenopus. Development 127:2031-2040.
9. Durocher, D., F. Charron, R. Warren, R. J. Schwartz, and M. Nemer. 1997. The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 16:5687-5696.
10. Gubb, D., C. Green, D. Huen, D. Coulson, G. Johnson, D. Tree, S. Collier, and J. Roote. 1999. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Genes Dev. 13:2315-2327.
11. Hall, R. A. 2004. Studying protein-protein interactions via blot overlay or Far Western blot. Methods Mol. Biol. 261:167-174.
12. Kanungo, J., S. J. Pratt, H. Marie, and G. D. Longmore. 2000. Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions. Mol. Biol. Cell 11:3299-3313.
13. Kuo, C. T., E. E. Morrisey, R. Anandappa, K. Sigrist, M. M. Lu, M. S. Parmacek, C. Soudais, and J. M. Leiden. 1997. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11:1048-1060.
14. Li, S., J. Weidenfeld, and E. E. Morrisey. 2004. Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol. Cell. Biol. 24:809-822.
15. Lin, A. C., A. E. Roche, J. Wilk, and E. C. Svensson. 2004. The N termini of friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors. J. Biol. Chem. 279:55017-55023.
16. Liu, C., S. W. Glasser, H. Wan, and J. A. Whitsett. 2002. GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J. Biol. Chem. 277:4519-4525.
17. Liu, C., M. Ikegami, M. T. Stahlman, C. R. Dey, and J. A. Whitsett. 2003. Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:L1246-L1254.
18. Liu, C., E. E. Morrisey, and J. A. Whitsett. 2002. GATA-6 is required for maturation of the lung in late gestation. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L468-L475.
19. Lu, M. M., S. Li, H. Yang, and E. E. Morrisey. 2002. Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues. Mech. Dev. 119(Suppl. 1):S197-S202.
20. Lu, M. M., H. Yang, L. Zhang, W. Shu, D. G. Blair, and E. E. Morrisey. 2001. The bone morphogenic protein antagonist gremlin regulates proximal-distal patterning of the lung. Dev. Dyn. 222:667-680.
21. Molkentin, J. D. 2000. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. J. Biol. Chem. 275:38949-38952.
22. Molkentin, J. D., Q. Lin, S. A. Duncan, and E. N. Olson. 1997. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11:1061-1072.
23. Morrisey, E. E., H. S. Ip, M. M. Lu, and M. S. Parmacek. 1996. GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev. Biol. 177:309-322.
24. Morrisey, E. E., H. S. Ip, Z. Tang, M. M. Lu, and M. S. Parmacek. 1997. GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev. Biol. 183:21-36.
25. Nishida, W., M. Nakamura, S. Mori, M. Takahashi, Y. Ohkawa, S. Tadokoro, K. Yoshida, K. Hiwada, K. Hayashi, and K. Sobue. 2002. A triad of serum response factor and the GATA and NK families governs the transcription of smooth and cardiac muscle genes. J. Biol. Chem. 277:7308-7317.
26. Nix, D. A., J. Fradelizi, S. Bockholt, B. Menichi, D. Louvard, E. Friederich, and M. C. Beckerle. 2001. Targeting of zyxin to sites of actin membrane interaction and to the nucleus. J. Biol. Chem. 276:34759-34767.
27. Ohneda, K., and M. Yamamoto. 2002. Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage. Acta Haematol. 108:237-245.
28. Osada, H., G. G. Grutz, H. Axelson, A. Forster, and T. H. Rabbitts. 1997. LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1. Leukemia 11(Suppl. 3):307-312.
29. Pevny, L., M. C. Simon, E. Robertson, W. H. Klein, S. F. Tsai, V. D'Agati, S. H. Orkin, and F. Costantini. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349:257-260.
30. Sepulveda, J. L., N. Belaguli, V. Nigam, C.-Y. Chen, M. Nemer, and R. J. Schwartz. 1998. GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol. Cell. Biol. 18:3405-3415.
31. Shaw-White, J. R., M. D. Bruno, and J. A. Whitsett. 1999. GATA-6 activates transcription of thyroid transcription factor-1. J. Biol. Chem. 274:2658-2664.
32. Shu, W., H. Yang, L. Zhang, M. M. Lu, and E. E. Morrisey. 2001. Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J. Biol. Chem. 276:27488-27497.
33. Sun, X.-H., N. G. Copeland, N. A. Jenkins, and D. Baltimore. 1991. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol. Cell. Biol. 11:5603-5611.
34. Svensson, E. C., G. S. Huggins, F. B. Dardik, C. E. Polk, and J. M. Leiden. 2000. A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription. J. Biol. Chem. 275:20762-20769.
35. Svensson, E. C., R. L. Tufts, C. E. Polk, and J. M. Leiden. 1999. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Proc. Natl. Acad. Sci. USA 96:956-961.
36. Tevosian, S. G., A. E. Deconinck, A. B. Cantor, H. I. Rieff, Y. Fujiwara, G. Corfas, and S. H. Orkin. 1999. FOG-2: a novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc. Natl. Acad. Sci. USA 96:950-955.
37. Wada, H., K. Hasegawa, T. Morimoto, T. Kakita, T. Yanazume, M. Abe, and S. Sasayama. 2002. Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription. J. Cell Biol. 156:983-991.
38. Wada, H., K. Hasegawa, T. Morimoto, T. Kakita, T. Yanazume, and S. Sasayama. 2000. A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene. J. Biol. Chem. 275:25330-25335.
39. Wadman, I. A., H. Osada, G. G. Grutz, A. D. Agulnick, H. Westphal, A. Forster, and T. H. Rabbitts. 1997. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 16:3145-3157.
40. Warburton, D., M. Schwarz, D. Tefft, G. Flores-Delgado, K. D. Anderson, and W. V. Cardoso. 2000. The molecular basis of lung morphogenesis. Mech. Dev. 92:55-81.
41. Watt, A. J., M. A. Battle, J. Li, and S. A. Duncan. 2004. GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc. Natl. Acad. Sci. USA 101:12573-12578.
42. Weidenfeld, J., W. Shu, L. Zhang, S. E. Millar, and E. E. Morrisey. 2002. The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J. Biol. Chem. 277:21061-21070.
43. Weiss, M. J., and S. H. Orkin. 1995. GATA transcription factors: key regulators of hematopoiesis. Exp. Hematol. 23:99-107.
44. Wilson-Rawls, J., J. D. Molkentin, B. L. Black, and E. N. Olson. 1999. Activated notch inhibits myogenic activity of the MADS-box transcription factor myocyte enhancer factor 2C. Mol. Cell. Biol. 19:2853-2862.
45. Yamada, Y., A. J. Warren, C. Dobson, A. Forster, R. PanneII, and T. H. Rabbitts. 1998. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc. Natl. Acad. Sci. USA 95:3890-3895.
46. Yang, H., M. M. Lu, L. Zhang, J. A. Whitsett, and E. E. Morrisey. 2002. GATA6 regulates differentiation of distal lung epithelium. Development 129:2233-2246.
47. Zhou, M., and W. Ouyang. 2003. The function role of GATA-3 in Th1 and Th2 differentiation. Immunol. Res. 28:25-37.