Effects of multiday exposure to ozone on airway inflammation as determined using sputum induction

Environmental Health Perspectives

Volumn 114, Issue 2, 2006, Pages 209-212

  Ratto, Jeffrey ^a   Wong, Hofer ^a   Liu, Jane ^a   Fahy, John ^a   Boushey, Homer ^a   Solomon, Colin ^a   Balmes, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Airway inflammation; Multiday exposure; Ozone; Proximal airways; Sputum induction

Indexed keywords

OZONE;

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; INFLAMMATION; LUNG FUNCTION TEST; LUNG LAVAGE; MACROPHAGE; MALE; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZATION; RESPIRATORY SYSTEM; RESPIRATORY TRACT DISEASE; SPUTUM ANALYSIS;

ADULT; CROSS-OVER STUDIES; FEMALE; HUMANS; INFLAMMATION; INHALATION EXPOSURE; MACROPHAGES; MALE; NEUTROPHILS; OXIDANTS, PHOTOCHEMICAL; OZONE; RESPIRATORY FUNCTION TESTS; SPUTUM;

EID: 32044466972     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.8341     Document Type: Article

References (26)

1. Alexis N, Hu S, Zeman K, Alter T, Bennet, W. 2001. Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique. Am J Respir Crit Care Med 164:1964-1970.
2. American Thoracic Society. 1987. Standardization of spirometry - 1987 update. Am Rev Respir Dis 126:1285-1298.
3. Aris R, Christian D, Hearne P, Kerr K, Finkbeiner W, Balmes J. 1993. Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy. Am Rev Respir Dis 148:1363-1372.
4. Arjormandi M, Schmidlin I, Girling P, Ferrando R, Balmes J. 2005. Sputum induction and bronchoscopy for assessment of ozone-induced airway inflammation in asthma. Chest 128:416-423.
5. 1 and FVC do not correlate with measures of inflammation. Am J Respir Crit Care Med 153:904-909.
6. Christian D, Chen L, Scannell C, Ferrando R, Welch B, Balmes J. 1998. Ozone-induced inflammation is attenuated with multi-day exposure. Am J Respir Crit Care Med 158:532-537.
7. Devlin R, Folinsbee L, Biscardi F, Hatch G, Becker S, Madden M, et al. 1997. Inflammation and cell damage induced by repeated exposure of humans to ozone. Inhal Toxicol 9:211-235.
8. Duan X, Buckpitt A, Pinkerton K, Ji C, Plopper C. 1996a. Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys. Am J Respir Cell Mol Biol 14:70-75.
9. Duan X, Plopper C, Brennan P, Buckpitt A. 1996b. Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury. J Pharmacol Exp Ther 277:1402-1409.
10. European Communities. 2002. Directive 2002/3/EC of the European Parliament and of the Council of 12 February 2002 Relating to Ozone in Ambient Air. Off J Eur Commun L67:14-30.
11. Fahy J, Liu J, Wong H, Boushey H. 1993. Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis 147:1126-1131.
12. Fahy J, Wong H, Liu J, Boushey H. 1995. Analysis of induced sputum after air and ozone exposures in healthy subjects. Environ Res 70:77-83.
13. Fiala J, Cernikovsky L, Leeuw F, Kurfuerst P. 2003. Air pollution by ozone in summer 2003. Topic Report. European Topic Centre on Air and Climate Change. Copenhagen:European Environmental Agency.
14. Gershman N, Liu H, Wong H, Liu J, Fahy J. 1999. Fractional analysis of sequential induced sputum samples during sputum induction: evidence that different lung compartments are sampled at different time points. J Allergy Clin Immunol 104:322-328.
15. Hackney J, Linn W, Mohler J, Collier C. 1977. Adaptation to short-term respiratory effects of ozone in men exposed repeatedly. J Appl Physiol 43:82-85.
16. Hiltermann T, Stolk J, Hiemstra P, Fokkens P, Rombout P, Sont J, et al. 1995. Effect of ozone exposure on maximal airway narrowing in non-asthmatic and asthmatic subjects, Clin Sci (Lond) 89:619-624.
17. Holz O, Jorres R, Koschyk S, Speckin P, Welker L, Magnussen H. 1998. Changes in sputum composition during sputum induction in healthy and asthmatic subjects. Clin Exp Allergy 28:284-292.
18. Jorres R, Holz O, Zachgo W, Timm P, Koschyk S, Muller B, et al. 2000. The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies. Am J Respir Crit Care Med 161:1855-1861.
19. Kelly C, Fenwick J, Corris P, Fleetwood A, Hendrick D, Walters E. 1988. Fluid dynamics during bronchoalveolar lavage. Am Rev Respir Dis 138:81-84.
20. Koren H, Devlin R, Graham D, Mann R, McGee M, Horstman D, et al. 1989. Ozone-induced inflammation in the lower airways of human subjects. Am Rev Respir Dis 139:407-415.
21. Plopper C, Hatch G, Wong V, Duan X, Weir A, Tarkington B, et al. 1998. Relationship of inhaled ozone concentration to acute tracheobronchial epithelial injury, site-specific ozone dose, and glutathione depletion in rhesus monkeys. Am J Respir Cell Mol Biol 19:387-399.
22. Romieu I, Sienra-Monge J, Ramirez-Aguilar M, Moreno-Macias H, Reyes-Ruiz N, Estela del Rio-Navarro B, et al. 2004. Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax 59:8-10.
23. Schelegle E, Siefkin A, McDonald R. 1991. Time course of ozone-induced neutrophilia in normal humans. Am Rev Respir Dis 143:1353-1358.
24. 3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol 60:1321-1326.
25. U.S. EPA. 2004. EPA Green Book - 8-Hour Ozone Area Standard. Washington, DC:U.S. Environmental Protection Agency.
26. WHO. 2000. Air Quality Guidelines for Europe. World Health Organization Regional Publications, European Ser No 91. Copenhagen:World Health Organization.