Inhibitory effect of Total Flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons

Neuroscience Research

Volumn 55, Issue 2, 2006, Pages 142-145

  Cheng, Xin Ping ^a   Qin, Song ^a   Dong, Liu Yi ^b   Zhou, Jiang Ning ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Hippocampal neurons; NMDA receptor; Total Flavone of Abelmoschus manihot L. Medic (TFA); Whole cell patch clamp technique

Indexed keywords

FLAVONE; HERBACEOUS AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TOTAL FLAVONE OF ABELMOSCHUS MANIHOT; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR STIMULATING AGENT; FLAVONOID; N METHYLASPARTIC ACID;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG MECHANISM; HIPPOCAMPUS; INTRACELLULAR SPACE; MEMBRANE CURRENT; NERVE CELL; NERVE CELL MEMBRANE; NEUROPROTECTION; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; WHOLE CELL; ANIMAL; CELL CULTURE; CELL MEMBRANE POTENTIAL; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; ELECTROSTIMULATION; METHODOLOGY; NERVE CELL INHIBITION; OKRA; PHYSIOLOGY; RADIATION EXPOSURE; WISTAR RAT;

ABELMOSCHUS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; EXCITATORY AMINO ACID AGONISTS; FLAVONOIDS; HIPPOCAMPUS; MEMBRANE POTENTIALS; N-METHYLASPARTATE; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 33746681384     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2006.02.011     Document Type: Article

References (14)

1. Coyle J.T., and Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262 5134 (1993) 689-695
2. Fan L., Dong L.Y., Jiang Q., Cen D.Y., Chen Z.W., and Ma C.G. Anti-inflammatory and antipyretic effects of TFA. Acta Universitatis Medicinalis Anhui 38 1 (2003) 25-27
3. Fan L., Dong L.Y., Chen Z.W., Cen D.Y., Jiang Q., and Ma C.G. Analgesic effect of Total Flavone of Abelmoschl manihot L. medic. Pharmacol. Clin. Chin. Mater. Med. 19 1 (2003) 12-14
4. Guo Y., and Chen Z.W. Protective effect of Abelmischl manihot L. medic against cerebral ischemia-reperfusion injury. Chin. Pharmacol. Bull. 18 6 (2002) 692-695
5. Gao S., Fan L., Dong L.Y., Zhao W.Z., and Chen Z.W. Effect of TFA on cell apoptosis in MCAO rats. Chin. Pharmacol. Bull. 19 6 (2003) 704-707
6. Gao S., Fan L., Dong L.Y., Cen D.Y., Jiang Q., Fang M., and Chen Z.W. Protection effects of the total flavone from Abelmoschus manihot L. medic on acute incompletely cerebral ischemia in rats. Chin. J. Clin. Pharmacol. Ther. 8 2 (2003) 167-169
7. Kim S., Ahn K., Oh T.H., Nah S.Y., and Rhim H. Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem. Biophys. Res. Commun. 296 2 (2002) 247-254
8. Li Q.L., Chen Z.W., and Ma C.G. Protective effects and mechanism of total flavone of the flowers of Abelmoschl on the injury of myocardial ischemia. Chin. Pharmacol. Bull. 17 4 (2001) 466-468
9. Pringle A.K., Iannotti F., Wilde G.J.C., Chad J.E., Seeley P.J., and Sundstrom L.E. Neuroprotection by both NMDA and non-NMDA receptor antagonists in vitro ischemia. Brain Res. 755 1 (1997) 36-46
10. Sattler R., and Tymianski M. Molecular mechanisms of calcium-dependent excitotoxicity. J. Mol. Med. 78 1 (2000) 3-13
11. Wang X.R., Wang Z.Q., and Li Y. Studies on the chemical constituents of Abelmoschus manihot L. Medic. Acta Bot. Sin. 23 3 (1981) 222-227
12. Wang X.R., Zhou Z.H., Du A.Q., and Huang Z.M. Studies on the flavonol constituents of Abelmoschus manihot L. Medic. Chin. J. Nat. Med. 2 2 (2004) 91-93
13. t3 (1999) 701-711
14. Ye J.H., Schaefer R., Wu W.H., Liu P.L., Zbuzek V.K., and Mcardle J.J. Inhibitory effect of ondansetron on glycine response of dissociated rat hippocampal neurons. J. Pharmacol. Exp. Ther. 290 1 (1999) 104-111