-
1
-
-
77953664988
-
Effect of raltegravir (RAL) on the pharmacokinetics (PK) of oral contraceptives
-
[abstract]. abstract A-1425. 2007
-
Anderson MS, Wenning LA, Moreau A, et al. 2007, Effect of raltegravir (RAL) on the pharmacokinetics (PK) of oral contraceptives [abstract]. 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 17-20 September 2007, Chicago, IL, USA abstract A-1425. 2007.
-
(2007)
47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 17-20 September 2007, Chicago, IL, USA
-
-
Anderson, M.S.1
Wenning, L.A.2
Moreau, A.3
-
2
-
-
34248177765
-
Results of BENCHMRK-1, a Phase III study evaluating the efficacy and safety of MK-0518, a Novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
-
[abstract]. abstract 105aLB
-
Cooper DA, Gatell J, Rockstroh J, et al. 2007. Results of BENCHMRK-1, a Phase III study evaluating the efficacy and safety of MK-0518, a Novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus [abstract]. 14th Conf Retro Opportun Infect Los Angeles abstract 105aLB.
-
(2007)
14th Conf Retro Opportun Infect Los Angeles
-
-
Cooper, D.A.1
Gatell, J.2
Rockstroh, J.3
-
3
-
-
47949114939
-
Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
-
Cooper DA, Steigbigel RT, Gatell JM, et al. 2008. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med, 359:355-365
-
(2008)
N Engl J Med
, vol.359
, pp. 355-365
-
-
Cooper, D.A.1
Steigbigel, R.T.2
Gatell, J.M.3
-
4
-
-
0035968306
-
HIV Integrase, a Brief Overview from Chemistry to Therapeutics
-
DOI 10.1074/jbc.R100027200
-
Craigie R. 2001. HIV integrase, a brief overview from chemistry to therapeutics. J Biol Chem, 276:23213-23216 (Pubitemid 37410700)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.26
, pp. 23213-23216
-
-
Craigie, R.1
-
5
-
-
70350152660
-
First report of raltegravir (RAL, MK-0518) use after virologic rebound on elvitegravir (EVT, GS 9137)
-
[abstract]. Abstract TUPEB032. 2007
-
DeJesus E, Cohen C, Elion R, et al. 2007. First report of raltegravir (RAL, MK-0518) use after virologic rebound on elvitegravir (EVT, GS 9137) [abstract]. 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Sydney, Australia, 22-25, July 2007; Abstract TUPEB032. 2007.
-
(2007)
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Sydney, Australia, 22-25, July 2007
-
-
DeJesus, E.1
Cohen, C.2
Elion, R.3
-
6
-
-
24344490276
-
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6] naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells
-
Embrey MW, Wai JS, Funk TW, et al. 2005. A series of 5-(5,6)- dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells. Bioorg Med Chem Lett, 15:4550-4554
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 4550-4554
-
-
Embrey, M.W.1
Wai, J.S.2
Funk, T.W.3
-
7
-
-
12944270496
-
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
-
Espeseth AS, Felock P, Wolfe A, et al. 2000. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase. Proc Natl Acad Sci U S A, 97:11244-11249
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 11244-11249
-
-
Espeseth, A.S.1
Felock, P.2
Wolfe, A.3
-
8
-
-
70350466247
-
Resistance mutations in HIV-1 integrase selected with raltegravir or elvitegravir confer reduced susceptibility to a diverse panel of integrase inhibitors
-
[abstract]. abstract no. 2008
-
Goethals O, Clayton R, Wagemans E, et al. 2008. Resistance mutations in HIV-1 integrase selected with raltegravir or elvitegravir confer reduced susceptibility to a diverse panel of integrase inhibitors [abstract]. XVII International HIV Drug Resistance Workshop June 10-14, 2008 Sitges, Spain abstract no. 2008.
-
(2008)
XVII International HIV Drug Resistance Workshop June 10-14, 2008 Sitges, Spain
-
-
Goethals, O.1
Clayton, R.2
Wagemans, E.3
-
9
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
DOI 10.1016/S0140-6736(07)60597-2, PII S0140673607605972
-
Grinsztejn B, Nguyen BY, Katlama C, et al. 2007. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet, 369:1261-1269 (Pubitemid 46553846)
-
(2007)
Lancet
, vol.369
, Issue.9569
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.-Y.2
Katlama, C.3
Gatell, J.M.4
Lazzarin, A.5
Vittecoq, D.6
Gonzalez, C.J.7
Chen, J.8
Harvey, C.M.9
Isaacs, R.D.10
-
10
-
-
63649139412
-
Exacerbation of depression associated with starting raltegravir: A report of four cases
-
Harris M, Larsen G, Montaner JS. 2008a. Exacerbation of depression associated with starting raltegravir: a report of four cases. AIDS, 22:1890-1892
-
(2008)
AIDS
, vol.22
, pp. 1890-1892
-
-
Harris, M.1
Larsen, G.2
Montaner, J.S.3
-
11
-
-
50949112147
-
Outcomes of multidrug-resistant patients switched from enfuvirtide to raltegravir within a virologically suppressive regimen
-
Harris M, Larsen G, Montaner JS. 2008b. Outcomes of multidrug-resistant patients switched from enfuvirtide to raltegravir within a virologically suppressive regimen. Aids, 22:1224-1226
-
(2008)
Aids
, vol.22
, pp. 1224-1226
-
-
Harris, M.1
Larsen, G.2
Montaner, J.S.3
-
12
-
-
0032922813
-
Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites
-
Hazuda D, Blau CU, Felock P, et al. 1999. Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites. Antivir Chem Chemother, 10:63-70. (Pubitemid 29158682)
-
(1999)
Antiviral Chemistry and Chemotherapy
, vol.10
, Issue.2
, pp. 63-70
-
-
Hazuda, D.1
Blau, C.U.2
Felock, P.3
Hastings, J.4
Pramanik, B.5
Wolfe, A.6
Bushman, F.7
Farnet, C.8
Goetz, M.9
Williams, M.10
Silverman, K.11
Lingham, R.12
Singh, S.13
-
13
-
-
37249065868
-
Resistance to the HIV-integrase inhibitor raltegravir: Analysis of Protocol 005, a Phase 2 study in patients with triple-class resistant HIV-1 infection
-
[abstract]. abstract no.8
-
Hazuda D, Miller MD, Nguyen BY, et al. 2007. Resistance to the HIV-integrase inhibitor raltegravir: analysis of Protocol 005, a Phase 2 study in patients with triple-class resistant HIV-1 infection [abstract]. Antivir Ther, abstract no.8[12], S10.
-
(2007)
Antivir Ther
, Issue.12
-
-
Hazuda, D.1
Miller, M.D.2
Nguyen, B.Y.3
-
14
-
-
3843108916
-
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
-
Hazuda DJ, Anthony NJ, Gomez RP, et al. 2004. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc Natl Acad Sci U S A, 101:11233-11238
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 11233-11238
-
-
Hazuda, D.J.1
Anthony, N.J.2
Gomez, R.P.3
-
15
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
DOI 10.1126/science.287.5453.646
-
Hazuda DJ, Felock P, Witmer M, et al. 2000. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science, 287:646-650 (Pubitemid 30070911)
-
(2000)
Science
, vol.287
, Issue.5453
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
Espeseth, A.7
Gabryelski, L.8
Schleif, W.9
Blau, C.10
Miller, M.D.11
-
16
-
-
38349182976
-
Lack of a pharmacokinetic effect of raltegravir on midazolam: In vitro/in vivo correlation
-
Iwamoto M, Kassahun K, Troyer MD, et al. 2008a. Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation. J Clin Pharmacol, 48:209-214
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 209-214
-
-
Iwamoto, M.1
Kassahun, K.2
Troyer, M.D.3
-
17
-
-
70349527751
-
Rifampin (RIF) modestly reduces plasma levels of MK-0518
-
[abstract]. abstract
-
Iwamoto M, Wenning LA, Liou SY, et al. 2006a. Rifampin (RIF) modestly reduces plasma levels of MK-0518 [abstract]. 8th international congress on drug therapy in HIV infection, Glasgow, United Kingdom, November 12-16, 2006; abstract P299.
-
(2006)
8th International Congress on Drug Therapy in HIV Infection, Glasgow, United Kingdom, November 12-16, 2006
, pp. 299
-
-
Iwamoto, M.1
Wenning, L.A.2
Liou, S.Y.3
-
18
-
-
77953659589
-
Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PK) of MK-0518
-
[abstract]. abstract A-373
-
Iwamoto M, Wenning LA, Petry AS, et al. 2006b. Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PK) of MK-0518 [abstract]. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 27-30, 2006; San Francisco, USA abstract A-373.
-
(2006)
46th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 27-30, 2006; San Francisco, USA
-
-
Iwamoto, M.1
Wenning, L.A.2
Petry, A.S.3
-
19
-
-
38349194563
-
Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects
-
Iwamoto M, Wenning LA, Petry AS, et al. 2008b. Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects. Clin Pharmacol Ther, 83:293-299
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 293-299
-
-
Iwamoto, M.1
Wenning, L.A.2
Petry, A.S.3
-
20
-
-
34548065793
-
Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme
-
DOI 10.1124/dmd.107.016196
-
Kassahun K, McIntosh I, Cui D, et al. 2007. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme. Drug Metab Dispos, 35:1657-1663 (Pubitemid 47296061)
-
(2007)
Drug Metabolism and Disposition
, vol.35
, Issue.9
, pp. 1657-1663
-
-
Kassahun, K.1
McIntosh, I.2
Cui, D.3
Hreniuk, D.4
Merschman, S.5
Lasseter, K.6
Azrolan, N.7
Iwamoto, M.8
Wagner, J.A.9
Wenning, L.A.10
-
21
-
-
77953671095
-
Absorption, metabolism and excretion of MK-0518, a potent HIV-1 integrase inhibitor, in healthy male volunteers
-
[abstract]. abstract A-372
-
Kassahun K, McIntosh I, Hreniuk D, et al. Absorption, metabolism and excretion of MK-0518, a potent HIV-1 integrase inhibitor, in healthy male volunteers [abstract]. 46th Interscience Conference on 1 Agents and Chemotherapy; September 27-30, 2006; San Francisco, USA abstract A-372.
-
46th Interscience Conference on 1 Agents and Chemotherapy; September 27-30, 2006; San Francisco, USA
-
-
Kassahun, K.1
McIntosh, I.2
Hreniuk, D.3
-
22
-
-
0026459411
-
Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells
-
Lafemina RL, Schneider CL, Robbins HL, et al. 1992. Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells. J Virol, 66:7414-7419
-
(1992)
J Virol
, vol.66
, pp. 7414-7419
-
-
Lafemina, R.L.1
Schneider, C.L.2
Robbins, H.L.3
-
23
-
-
42049119625
-
Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
-
DOI 10.1128/AAC.01228-07
-
Malet I, Delelis O, Valantin MA, et al. 2008. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob Agents Chemother, 52:1351-1358 (Pubitemid 351521998)
-
(2008)
Antimicrobial Agents and Chemotherapy
, vol.52
, Issue.4
, pp. 1351-1358
-
-
Malet, I.1
Delelis, O.2
Valantin, M.-A.3
Montes, B.4
Soulie, C.5
Wirden, M.6
Tchertanov, L.7
Peytavin, G.8
Reynes, J.9
Mouscadet, J.-F.10
Katlama, C.11
Calvez, V.12
Marcelin, A.-G.13
-
24
-
-
52749095842
-
Sustained antiretroviral efficacy of raltegravir as part of combination ART in treatment-naive HIV-1 infected patients: 96-week data
-
[abstract]. Abstract TUAB0102
-
Markowitz M, Nguyen BY, Gotuzzo E, et al. 2008. Sustained antiretroviral efficacy of raltegravir as part of combination ART in treatment-naive HIV-1 infected patients: 96-week data [abstract]. 17th International AIDS Conference; August 3-8, 2008; Mexico City, Mexico Abstract TUAB0102.
-
(2008)
17th International AIDS Conference; August 3-8, 2008; Mexico City, Mexico
-
-
Markowitz, M.1
Nguyen, B.Y.2
Gotuzzo, E.3
-
25
-
-
34748860363
-
Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
-
DOI 10.1097/QAI.0b013e318157131c, PII 0012633420071001000001
-
Markowitz M, Nguyen BY, Gotuzzo E, et al. 2007. Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr, 46:125-133 (Pubitemid 47482607)
-
(2007)
Journal of Acquired Immune Deficiency Syndromes
, vol.46
, Issue.2
, pp. 125-133
-
-
Markowitz, M.1
Nguyen, B.-Y.2
Gotuzzo, E.3
Mendo, F.4
Ratanasuwan, W.5
Kovacs, C.6
Prada, G.7
Morales-Ramirez, J.O.8
Crumpacker, C.S.9
Isaacs, R.D.10
Gilde, L.R.11
Wan, H.12
Miller, M.D.13
Wenning, L.A.14
Teppler, H.15
Baker, D.16
Bloch, M.17
Bodsworth, N.18
Cooper, D.19
Workman, C.20
Kovacs, C.21
Tsoukas, C.22
Afani, A.23
Perez, J.24
Cortes, J.25
Prada, G.26
Gotuzzo, E.27
Mendo, F.28
Ratanasuwan, W.29
Thitivichianlert, S.30
Brown, S.31
Crumpacker, C.32
Galpin, J.33
Hicks, C.34
Kumar, P.35
Lichtenstein, K.36
Little, S.37
Liporace, R.38
Markowitz, M.39
Morales-Ramirez, J.40
Santana-Bagur, J.41
Schwartz, R.42
Steigbigel, R.43
Tashima, K.44
more..
-
26
-
-
77953669544
-
-
Merck and Co., W. S. N. 0. U. Homepage
-
Merck and Co., W. S. N. 0. U. IsentressTM FDA Briefing Document. Food And Drug Administration Homepage. 2007. www.fda.gov/ohmrs/ dockets/ac/07/briefing/ 2007-4314b1-01-Merck.pdf.
-
(2007)
IsentressTM FDA Briefing Document
-
-
-
27
-
-
77953659906
-
-
Merck and Co., W. S. N. 0. U. Homepage
-
Merck and Co., W. S. N. 0. U. IsentressTM Prescribing Information. US Food and Drug Administration Homepage. 2008. www.fda.gov/cder/foi/label/2007/ 0221451b1.pdf.
-
(2008)
IsentressTM Prescribing Information
-
-
-
28
-
-
77953670919
-
Atazanavir modestly increases plasma leves of MK-0518
-
[abstract]. abstract 1985
-
Mistry G, Wenning L, Petry Aet al. 2007. Atazanavir modestly increases plasma leves of MK-0518 [abstract]. 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Sydney, Australia, 22-25, July 2007; abstract 1985.
-
(2007)
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Sydney, Australia, 22-25, July 2007
-
-
Mistry, G.1
Wenning, L.2
Petry, A.3
-
29
-
-
37349120701
-
Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase
-
Murray JM, Emery S, Kelleher AD, et al. 2007.Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase/Aids, 21:2315-2321
-
(2007)
Aids
, vol.21
, pp. 2315-2321
-
-
Murray, J.M.1
Emery, S.2
Kelleher, A.D.3
-
30
-
-
0037130159
-
Structure activity of 3-Aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors
-
DOI 10.1021/jm020037p
-
Pais GC, Zhang X, Marchand C, et al. 2002. Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors. J Med Chem, 45:3184-3194 (Pubitemid 34774270)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.15
, pp. 3184-3194
-
-
Pais, G.C.G.1
Zhang, X.2
Marchand, C.3
Neamati, N.4
Cowansage, K.5
Svarovskaia, E.S.6
Pathak, V.K.7
Tang, Y.8
Nicklaus, M.9
Pommier, Y.10
Burke Jr., T.R.11
-
31
-
-
54549099338
-
HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvite-gravir in vitro
-
on behalf of the French ANRS HIV DOI 10.1093/jac/dkn335
-
Roquebert B, Damond F, Collin G, et al. on behalf of the French ANRS HIV- 2008. HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvite-gravir in vitro. J Antimicrob Chemother, DOI 10.1093/jac/dkn335.
-
(2008)
J Antimicrob Chemother
-
-
Roquebert, B.1
Damond, F.2
Collin, G.3
-
32
-
-
42449150053
-
Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle
-
DOI 10.1073/pnas.0711372105
-
Sedaghat AR, Dinoso JB, Shen L, et al. 2008. Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle. Proc Natl Acad Sci U S A, 105:4832-4837 (Pubitemid 351753832)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.12
, pp. 4832-4837
-
-
Sedaghat, A.R.1
Dinoso, J.B.2
Shen, L.3
Wilke, C.O.4
Siliciano, R.F.5
-
33
-
-
67651113170
-
Results of BENCHMRK-2, a Phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
-
[abstract]. abstract 105bLB
-
Steigbigel R, Kumar P, Eron J, et al. 2007. Results of BENCHMRK-2, a Phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus [abstract]. 14th Conf Retro Opportun Infect Los Angeles abstract 105bLB.
-
(2007)
14th Conf Retro Opportun Infect Los Angeles
-
-
Steigbigel, R.1
Kumar, P.2
Eron, J.3
-
34
-
-
66349126931
-
Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility
-
Epub ahead of print
-
van Baelen K, van Eygen V, Rondelez E, et al. 2008. Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility Aids, Epub ahead of print.
-
(2008)
Aids
-
-
Van Baelen, K.1
Van Eygen, V.2
Rondelez, E.3
-
35
-
-
67651111369
-
Lack of a significant drug interaction between MK-0518 and tenofovir disoproxil fumarate (TDF)
-
[abstract]. abstract A-375
-
Wenning LA, Friedman E, Kost JT, et al. 2006a. Lack of a significant drug interaction between MK-0518 and tenofovir disoproxil fumarate (TDF) [abstract]. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 27-30, 2006; San Francisco, USA abstract A-375.
-
(2006)
46th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 27-30, 2006; San Francisco, USA
-
-
Wenning, L.A.1
Friedman, E.2
Kost, J.T.3
-
36
-
-
67651121226
-
Effect of tipranavir + ritonavir (TPV + RTV) on pharmacokinetics of MK-0518
-
[abstract]. abstract A-374. 2006b
-
Wenning LA, Hanley H, Stone J, et al. 2006b. Effect of tipranavir + ritonavir (TPV + RTV) on pharmacokinetics of MK-0518 [abstract]. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 27-30, 2006; San Francisco, USA abstract A-374. 2006b.
-
(2006)
46th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 27-30, 2006; San Francisco, USA
-
-
Wenning, L.A.1
Hanley, H.2
Stone, J.3
|