Acute lymphoid and gastrointestinal toxicity induced by selective p38α map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog

Toxicologic Pathology

Volumn 38, Issue 4, 2010, Pages 606-618

  Morris, Dale L ^a   O'Neil, Shawn P ^a   Devraj, Rajesh V ^a   Portanova, Joseph P ^a   Gilles, Richard W ^a   Gross, Cindy J ^a   Curtiss, Sandra W ^a   Komocsar, Wendy J ^b   Garner, Debra S ^a   Happa, Fernando A ^a   Kraus, Lori J ^a   Nikula, Kristen J ^c   Monahan, Joseph B ^a   Selness, Shaun R ^a   Galluppi, Gerald R ^d   Shevlin, Kimberly M ^a   Kramer, Jeffrey A ^e   Walker, John K ^a   Messing, Dean M ^a   Anderson, David R ^a   Mourey, Robert J ^a   Whiteley, Laurence O ^a   Daniels, John S ^a   Yang, Jerry Z ^a   Rowlands, Philip C ^a   Alden, Carl L ^f   Davis II, John W ^a   Sagartz, John E ^c   more..

^a PFIZER INC   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c Seventh Wave Laboratories   (United States)

^d BIOGEN   (United States)

^e LEXICON PHARMACEUTICALS INC   (United States)

^f MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Dog; Kinase; MK2; P38; Toxicity

Indexed keywords

ALPHA TUBULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; SC 036; UNCLASSIFIED DRUG; MAP-KINASE-ACTIVATED KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CECUM; COLON HEMORRHAGE; CONTROLLED STUDY; DIARRHEA; DOG; ENZYME INHIBITION; FEMALE; FEVER; GASTROINTESTINAL TOXICITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE LYMPHATIC TISSUE; LYMPHADENITIS; LYMPHOID ORGAN; MALE; MESENTERY LYMPH NODE; MOUSE; NECROSIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN; ANIMAL; ANTAGONISTS AND INHIBITORS; B LYMPHOCYTE; CELL CULTURE; CELL PROLIFERATION; CHEMICALLY INDUCED; COLON; CYTOLOGY; DRUG EFFECTS; GASTROINTESTINAL DISEASE; GASTROINTESTINAL HEMORRHAGE; HUMAN; LYMPH NODE; LYMPHATIC SYSTEM DISEASE; MACACA FASCICULARIS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL; T LYMPHOCYTE; TOXICITY; TOXICITY TESTING; WESTERN BLOTTING;

CANIS FAMILIARIS; MACACA FASCICULARIS; RATTUS;

ANIMALS; B-LYMPHOCYTES; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; COLON; DOGS; FEMALE; GASTROINTESTINAL DISEASES; GASTROINTESTINAL HEMORRHAGE; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LINEAR MODELS; LYMPH NODES; LYMPHATIC DISEASES; MACACA FASCICULARIS; MALE; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; T-LYMPHOCYTES; TOXICITY TESTS, ACUTE;

EID: 77953665240     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623310367807     Document Type: Article

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