Potent inhibitors of the MAP kinase p38

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 23, 1998, Pages 3335-3340

  Henry, James R ^a   Rupert, Kenneth C ^a   Dodd, John H ^a   Turchi, Ignatius J ^a   Wadsworth, Scott A ^a   Cavender, Druie E ^a   Schafer, Peter H ^a   Siekierka, John J ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; DRUG ACTIVITY; DRUG INDICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENTERITIS; HUMAN; HUMAN CELL; INFLAMMATION; RHEUMATOID ARTHRITIS;

EID: 0032401112     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00589-7     Document Type: Article

References (14)

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7. 6) δ 8.58 (2H, d, J = 5.1 Hz), 7.83 (1H, s), 7.71 (1H, d, J = 9.4 Hz), 7.49 (1H, d, J = 9.4Hz), 7.39 (1H, d, J = 8.6 Hz), 7.35 (2H, d, J = 5.1 Hz), 7.09 (1H, t, J = 8.6 Hz), 6.95 (1H, s), 6.78 (1H, d, J = 8.6 Hz), 3.83 (3H, s). mp 271 - 272 °C.
8. 8. A similar series of compounds has appeared in a recent patent. Zablocki, J.A.; Tarlton, E.; Rizzi, J.P.; Mantlo, N.B. WO 98/22457, 1998; Chem. Abstr. 1998, 352830.
9. 2. Supernatants were harvested, diluted 1/5, and assayed for TNF-α by ELISA as described by the manufacturer (Genzyme, Cambridge, MA).
10. 6): δ 11.61 (1H, s), 8.48 (2H, d, J = 7.6 Hz), 7.63 (1H, d, J = 8.6 Hz), 7.42 (2H, m), 7.23 (4H, , 6.36 (1H, d, J = 8.6 Hz), 5.87 (2H, s); mp 274 - 276 °C.
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13. 3 isodensity surface.
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