-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74-108.
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
-
3
-
-
0036894435
-
Modifiable risk factors for colon cancer
-
Giovannucci E. Modifiable risk factors for colon cancer. Gastroenterol Clin North Am. 2002;31:925-943.
-
(2002)
Gastroenterol Clin North Am
, vol.31
, pp. 925-943
-
-
Giovannucci, E.1
-
4
-
-
0003699111
-
-
National Center for Health Statistics. Edition Available at:
-
National Center for Health Statistics. In Health, United States, Edition Available at: http://www.cdc.gov/nchs/data/hus/hus06.pdf. 2006.
-
(2006)
Health, United States
-
-
-
5
-
-
43549126000
-
Chemotherapy in elderly patients with colorectal cancer
-
Kohne CH, Folprecht G, Goldberg RM, et al. Chemotherapy in elderly patients with colorectal cancer. Oncologist. 2008;13:390-402.
-
(2008)
Oncologist
, vol.13
, pp. 390-402
-
-
Ch, K.1
Folprecht, G.2
Goldberg, R.M.3
-
6
-
-
0035846327
-
Older age-not a barrier to cancer treatment
-
Muss HB. Older age-not a barrier to cancer treatment. N Engl J Med. 2001;345:1127-1128.
-
(2001)
N Engl J Med
, vol.345
, pp. 1127-1128
-
-
Muss, H.B.1
-
7
-
-
58949089717
-
Treatment of the elderly colorectal cancer patient: SIOG expert recommendations
-
Papamichael D, Audisio R, Horiot JC, et al. Treatment of the elderly colorectal cancer patient: SIOG expert recommendations. Ann Oncol. 2009; 20:5-16.
-
(2009)
Ann Oncol
, vol.20
, pp. 5-16
-
-
Papamichael, D.1
Audisio, R.2
Horiot, J.C.3
-
9
-
-
84857652236
-
-
Available at
-
EUROSTAT. Population and social conditions. Available at: http://epp. eurostat.ec.europa.eu/cache/ITY-OFFPUB/KS-QA-09-047/EN/KS-QA-09- 047-EN.PDF. 2009.
-
(2009)
Population and Social Conditions
-
-
-
11
-
-
16244392389
-
Never too old? Age should not be a barrier to enrollment in cancer clinical trials
-
Aapro MS, Kohne CH, Cohen HJ, et al. Never too old? Age should not be a barrier to enrollment in cancer clinical trials. Oncologist. 2005;10:198-204.
-
(2005)
Oncologist
, vol.10
, pp. 198-204
-
-
Aapro, M.S.1
Ch, K.2
Cohen, H.J.3
-
12
-
-
77953625878
-
Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy
-
Kopetz S, Chang GJ, Overman MJ, et al. Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol. 2009;26:26.
-
(2009)
J Clin Oncol
, vol.26
, pp. 26
-
-
Kopetz, S.1
Chang, G.J.2
Overman, M.J.3
-
13
-
-
35648981122
-
Actual 10-year survival after resection of colorectal liver metastases defines cure
-
Tomlinson JS, Jarnagin WR, DeMatteo RP, et al. Actual 10-year survival after resection of colorectal liver metastases defines cure. J Clin Oncol. 2007;25:4575-4580.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4575-4580
-
-
Tomlinson, J.S.1
Jarnagin, W.R.2
Dematteo, R.P.3
-
14
-
-
35948978607
-
Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma
-
Wong RK, Tandan V, De Silva S, et al. Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma. Cochrane Database Syst Rev. 2007;18:CD002102.
-
(2007)
Cochrane Database Syst Rev
, vol.18
-
-
Wong, R.K.1
Tandan, V.2
De Silva, S.3
-
15
-
-
67650315187
-
Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial
-
Andre T, Boni C, Navarro M, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol. 2009;27:3109-3116.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3109-3116
-
-
Andre, T.1
Boni, C.2
Navarro, M.3
-
16
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
17
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
-
Tournigand C, Andre T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol. 2004;22:229-237.
-
(2004)
J Clin Oncol
, vol.22
, pp. 229-237
-
-
Tournigand, C.1
Andre, T.2
Achille, E.3
-
18
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360: 1408-1417.
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Ch, K.2
Hitre, E.3
-
19
-
-
36048960109
-
Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
-
Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol. 2007;25:4779-4786.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4779-4786
-
-
Fuchs, C.S.1
Marshall, J.2
Mitchell, E.3
-
20
-
-
40749149728
-
Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): A randomised controlled trial
-
Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371:1007-1016.
-
(2008)
Lancet
, vol.371
, pp. 1007-1016
-
-
Nordlinger, B.1
Sorbye, H.2
Glimelius, B.3
-
21
-
-
4644320061
-
Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: A model to predict long-term survival
-
discussion 657-1648
-
Adam R, Delvart V, Pascal G, et al. Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann Surg. 2004;240:644-657; discussion 657-1648
-
(2004)
Ann Surg
, vol.240
, pp. 644-657
-
-
Adam, R.1
Delvart, V.2
Pascal, G.3
-
22
-
-
64649092523
-
Patients with initially unresectable colorectal liver metastases: Is there a possibility of cure?
-
Adam R, Wicherts DA, de Haas RJ, et al. Patients with initially unresectable colorectal liver metastases: is there a possibility of cure? J Clin Oncol. 2009;10:1829-1835.
-
(2009)
J Clin Oncol
, vol.10
, pp. 1829-1835
-
-
Adam, R.1
Wicherts, D.A.2
De Haas, R.J.3
-
23
-
-
78149404942
-
Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: The CELIM randomised phase 2 trial
-
Folprecht G, Gruenberger T, Bechstein WO, et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol. 2009;24:24.
-
(2009)
Lancet Oncol
, vol.24
, pp. 24
-
-
Folprecht, G.1
Gruenberger, T.2
Bechstein, W.O.3
-
24
-
-
0033619959
-
Underrepresentation of patients 65 years of age or older in cancer-treatment trials
-
Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999;341: 2061-2067.
-
(1999)
N Engl J Med
, vol.341
, pp. 2061-2067
-
-
Hutchins, L.F.1
Unger, J.M.2
Crowley, J.J.3
-
25
-
-
2642573558
-
Participation in cancer clinical trials: Race-, sex-, and age-based disparities
-
Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA. 2004;291:2720-2726.
-
(2004)
JAMA
, vol.291
, pp. 2720-2726
-
-
Murthy, V.H.1
Krumholz, H.M.2
Gross, C.P.3
-
26
-
-
34247135456
-
Treatment tolerance and efficacy in geriatric oncology: A systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups
-
Kumar A, Soares HP, Balducci L, et al. Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups. J Clin Oncol. 2007;25:1272-1276.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1272-1276
-
-
Kumar, A.1
Soares, H.P.2
Balducci, L.3
-
27
-
-
0038662715
-
Participation of patients 65 years of age or older in cancer clinical trials
-
Lewis JH, Kilgore ML, Goldman DP, et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol. 2003;21:1383-1389.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1383-1389
-
-
Lewis, J.H.1
Kilgore, M.L.2
Goldman, D.P.3
-
28
-
-
20044370090
-
Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity
-
Lemmens VE, van Halteren AH, Janssen-Heijnen ML, et al. Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity. Ann Oncol. 2005;16:767-772.
-
(2005)
Ann Oncol
, vol.16
, pp. 767-772
-
-
Lemmens, V.E.1
Van Halteren, A.H.2
Janssen-Heijnen, M.L.3
-
29
-
-
33846939792
-
Survival after hepatic resection in metastatic colorectal cancer: A population-based study
-
Cummings LC, Payes JD, Cooper GS. Survival after hepatic resection in metastatic colorectal cancer: a population-based study. Cancer. 2007;109: 718-726.
-
(2007)
Cancer
, vol.109
, pp. 718-726
-
-
Cummings, L.C.1
Payes, J.D.2
Cooper, G.S.3
-
30
-
-
0036498881
-
Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer
-
Potosky AL, Harlan LC, Kaplan RS, et al. Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer. J Clin Oncol. 2002;20:1192-1202.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1192-1202
-
-
Potosky, A.L.1
Harlan, L.C.2
Kaplan, R.S.3
-
31
-
-
50649115456
-
Population-based analysis of patients with advanced colorectal cancer: The impact of age on treatment and outcomes
-
ASCO Annual Meeting Proceedings
-
Ho C, O'Reilly S, Ng K, et al. Population-based analysis of patients with advanced colorectal cancer: the impact of age on treatment and outcomes. ASCO Annual Meeting Proceedings. J Clin Oncol. 2005;23:abstract 3614.
-
(2005)
J Clin Oncol
, vol.23
-
-
Ho, C.1
O'Reilly, S.2
Ng, K.3
-
32
-
-
60849123935
-
Evidence for cure by adjuvant therapy in colon cancer: Observations based on individual patient data from 20,898 patients on 18 randomized trials
-
Sargent D, Sobrero A, Grothey A, et al. Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol. 2009;27:872-877.
-
(2009)
J Clin Oncol
, vol.27
, pp. 872-877
-
-
Sargent, D.1
Sobrero, A.2
Grothey, A.3
-
33
-
-
33644834827
-
Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: Individual patient data from 20,898 patients on 18 randomized trials
-
Sargent DJ, Wieand HS, Haller DG, et al. Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol. 2005;23:8664-8670.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8664-8670
-
-
Sargent, D.J.1
Wieand, H.S.2
Haller, D.G.3
-
34
-
-
22844443043
-
Systemic therapy for metastatic colorectal cancer: Current options, current evidence
-
Kelly H, Goldberg RM. Systemic therapy for metastatic colorectal cancer: current options, current evidence. J Clin Oncol. 2005;23:4553-4560.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4553-4560
-
-
Kelly, H.1
Goldberg, R.M.2
-
35
-
-
4444249171
-
An overview of 48 elderly-specific clinical trials of systemic chemotherapy for advanced non-small cell lung cancer
-
Hotta K, Ueoka H, Kiura K, et al. An overview of 48 elderly-specific clinical trials of systemic chemotherapy for advanced non-small cell lung cancer. Lung Cancer. 2004;46:61-76.
-
(2004)
Lung Cancer
, vol.46
, pp. 61-76
-
-
Hotta, K.1
Ueoka, H.2
Kiura, K.3
-
36
-
-
30744434127
-
Physiologic aspects of aging: Impact on cancer management and decision making, part I
-
Sawhney R, Sehl M, Naeim A. Physiologic aspects of aging: impact on cancer management and decision making, part I. Cancer J. 2005;11:449-460. (Pubitemid 43097072)
-
(2005)
Cancer Journal
, vol.11
, Issue.6
, pp. 449-460
-
-
Sawhney, R.1
Sehl, M.2
Naeim, A.3
-
37
-
-
30744449760
-
Physiologic aspects of aging: Impact on cancer management and decision making, part II
-
Sehl M, Sawhney R, Naeim A. Physiologic aspects of aging: impact on cancer management and decision making, part II. Cancer J. 2005;11:461-473. (Pubitemid 43097073)
-
(2005)
Cancer Journal
, vol.11
, Issue.6
, pp. 461-473
-
-
Sehl, M.1
Sawhney, R.2
Naeim, A.3
-
38
-
-
33846553130
-
Pharmacokinetics of chemotherapy in the older patient
-
Hurria A, Lichtman SM. Pharmacokinetics of chemotherapy in the older patient. Cancer Control. 2007;14:32-43.
-
(2007)
Cancer Control
, vol.14
, pp. 32-43
-
-
Hurria, A.1
Lichtman, S.M.2
-
39
-
-
33244481095
-
A retrospective study of coagulation abnormalities in patients receiving concomitant capecitabine and warfarin
-
Shah HR, Ledbetter L, Diasio R, et al. A retrospective study of coagulation abnormalities in patients receiving concomitant capecitabine and warfarin. Clin Colorectal Cancer. 2006;5:354-358.
-
(2006)
Clin Colorectal Cancer
, vol.5
, pp. 354-358
-
-
Shah, H.R.1
Ledbetter, L.2
Diasio, R.3
-
40
-
-
79960213013
-
Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: The BEAT study
-
Van Cutsem E, Rivera F, Berry S, et al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol. 2009;30:30.
-
(2009)
Ann Oncol
, vol.30
, pp. 30
-
-
Van Cutsem, E.1
Rivera, F.2
Berry, S.3
-
41
-
-
0035849151
-
A reevaluation of the duration of survival after the onset of dementia
-
Wolfson C, Wolfson DB, Asgharian M, et al. A reevaluation of the duration of survival after the onset of dementia. N Engl J Med. 2001;344:1111-1116.
-
(2001)
N Engl J Med
, vol.344
, pp. 1111-1116
-
-
Wolfson, C.1
Wolfson, D.B.2
Asgharian, M.3
-
42
-
-
27644431794
-
A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function
-
Jansen CE, Miaskowski C, Dodd M, et al. A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function. Cancer. 2005;104:2222-2233.
-
(2005)
Cancer
, vol.104
, pp. 2222-2233
-
-
Jansen, C.E.1
Miaskowski, C.2
Dodd, M.3
-
43
-
-
32844473064
-
Therapy insight: Therapeutic challenges in the treatment of elderly cancer patients
-
Lichtman SM. Therapy insight: therapeutic challenges in the treatment of elderly cancer patients. Nat Clin Pract Oncol. 2006;3:86-93.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 86-93
-
-
Lichtman, S.M.1
-
44
-
-
0031901577
-
Comorbidity and functional status are independent in older cancer patients
-
Extermann M, Overcash J, Lyman GH, et al. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol. 1998;16:1582-1587.
-
(1998)
J Clin Oncol
, vol.16
, pp. 1582-1587
-
-
Extermann, M.1
Overcash, J.2
Lyman, G.H.3
-
45
-
-
0037149714
-
A controlled trial of inpatient and outpatient geriatric evaluation and management
-
DOI 10.1056/NEJMsa010285
-
Cohen HJ, Feussner JR, Weinberger M, et al. A controlled trial of inpatient and outpatient geriatric evaluation and management. N Engl J Med. 2002; 346:905-912. (Pubitemid 34984640)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.12
, pp. 905-912
-
-
Cohen, H.J.1
Feussner, J.R.2
Weinberger, M.3
Carnes, M.4
Hamdy, R.C.5
Hsieh, F.6
Phibbs, C.7
Courtney, D.8
Lyles, K.W.9
May, C.10
McMurtry, C.11
Pennypacker, L.12
Smith, D.M.13
Ainslie, N.14
Hornick, T.15
Brodkin, K.16
Lavori, P.17
-
46
-
-
33745854156
-
Vulnerability in the elderly: Frailty
-
Slaets JP. Vulnerability in the elderly: frailty. Med Clin North Am. 2006; 90:593-601.
-
(2006)
Med Clin North Am
, vol.90
, pp. 593-601
-
-
Slaets, J.P.1
-
47
-
-
33751564529
-
We need a geriatric assessment for oncologists
-
Hurria A. We need a geriatric assessment for oncologists. Nat Clin Pract Oncol. 2006;3:642-643.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 642-643
-
-
Hurria, A.1
-
48
-
-
27244441470
-
Developing a cancer-specific geriatric assessment: A feasibility study
-
Hurria A, Gupta S, Zauderer M, et al. Developing a cancer-specific geriatric assessment: a feasibility study. Cancer. 2005;104:1998-2005.
-
(2005)
Cancer
, vol.104
, pp. 1998-2005
-
-
Hurria, A.1
Gupta, S.2
Zauderer, M.3
-
49
-
-
34848822879
-
Identifying vulnerable older adults with cancer: Integrating geriatric assessment into oncology practice
-
Hurria A, Lichtman SM, Gardes J, et al. Identifying vulnerable older adults with cancer: integrating geriatric assessment into oncology practice. J Am Geriatr Soc. 2007;55:1604-1608.
-
(2007)
J Am Geriatr Soc
, vol.55
, pp. 1604-1608
-
-
Hurria, A.1
Lichtman, S.M.2
Gardes, J.3
-
50
-
-
0031019918
-
Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly highdose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French intergroup study
-
de Gramont A, Bosset JF, Milan C, et al. Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly highdose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study. J Clin Oncol. 1997; 15:808-815.
-
(1997)
J Clin Oncol
, vol.15
, pp. 808-815
-
-
De Gramont, A.1
Bosset, J.F.2
Milan, C.3
-
51
-
-
4644252335
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated metaanalysis
-
Thirion P, Michiels S, Pignon JP, et al. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated metaanalysis. J Clin Oncol. 2004;22:3766-3775.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3766-3775
-
-
Thirion, P.1
Michiels, S.2
Pignon, J.P.3
-
52
-
-
0037022820
-
Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer
-
Sundararajan V, Mitra N, Jacobson JS, et al. Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer. Ann Intern Med. 2002;136:349-357.
-
(2002)
Ann Intern Med
, vol.136
, pp. 349-357
-
-
Sundararajan, V.1
Mitra, N.2
Jacobson, J.S.3
-
53
-
-
28844482345
-
Adjuvant chemotherapy for stage III colon cancer: Implications of race/ethnicity, age, and differentiation
-
Jessup JM, Stewart A, Greene FL, et al. Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. Jama. 2005;294:2703-2711.
-
(2005)
Jama
, vol.294
, pp. 2703-2711
-
-
Jessup, J.M.1
Stewart, A.2
Greene, F.L.3
-
54
-
-
50249128823
-
Adjuvant treatments do not alter the quality of life in elderly patients with colorectal cancer: A populationbased study
-
Bouvier AM, Jooste V, Bonnetain F, et al. Adjuvant treatments do not alter the quality of life in elderly patients with colorectal cancer: a populationbased study. Cancer. 2008;113:879-886.
-
(2008)
Cancer
, vol.113
, pp. 879-886
-
-
Bouvier, A.M.1
Jooste, V.2
Bonnetain, F.3
-
55
-
-
33644846283
-
Phase III study of fluorouracil, leucovorin, and levamisole in high-risk stage II and III colon cancer: Final report of Intergroup 0089
-
Haller DG, Catalano PJ, Macdonald JS, et al. Phase III study of fluorouracil, leucovorin, and levamisole in high-risk stage II and III colon cancer: final report of Intergroup 0089. J Clin Oncol. 2005;23:8671-8678.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8671-8678
-
-
Haller, D.G.1
Catalano, P.J.2
MacDonald, J.S.3
-
56
-
-
0035846320
-
A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients
-
Sargent DJ, Goldberg RM, Jacobson SD, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med. 2001;345:1091-1097.
-
(2001)
N Engl J Med
, vol.345
, pp. 1091-1097
-
-
Sargent, D.J.1
Goldberg, R.M.2
Jacobson, S.D.3
-
57
-
-
36849064682
-
Adjuvant chemotherapy versus observation in patients with colorectal cancer: A randomised study
-
Quasar Collaborative G, Gray R, Barnwell J, et al. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet. 2007;370:2020-2029.
-
(2007)
Lancet
, vol.370
, pp. 2020-2029
-
-
Quasar, C.G.1
Gray, R.2
Barnwell, J.3
-
58
-
-
21244497388
-
Capecitabine as adjuvant treatment for stage III colon cancer
-
Twelves C, Wong A, Nowacki MP, et al. Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med. 2005;352:2696-2704.
-
(2005)
N Engl J Med
, vol.352
, pp. 2696-2704
-
-
Twelves, C.1
Wong, A.2
Nowacki, M.P.3
-
59
-
-
58049219396
-
Capecitabine versus 5-FU/LV in stage III colon cancer: Updated 5-year efficacy data from X-ACT trial and preliminary analysis of relationship between hand-foot syndrome (HFS) and efficacy
-
Presented at Orlando FL
-
Twelves C, Scheithauer W, McKendrick J, et al. Capecitabine versus 5-FU/LV in stage III colon cancer: updated 5-year efficacy data from X-ACT trial and preliminary analysis of relationship between hand-foot syndrome (HFS) and efficacy. Presented at Gastrointestinal Cancers Symposium. Orlando, FL; 2010:Abstract 274.
-
(2010)
Gastrointestinal Cancers Symposium
-
-
Twelves, C.1
Scheithauer, W.2
McKendrick, J.3
-
60
-
-
9144238357
-
Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: Safety results of a randomized phase III trial
-
Scheithauer W, McKendrick J, Begbie S, et al. Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial. Ann Oncol. 2003;14:1735-1743.
-
(2003)
Ann Oncol
, vol.14
, pp. 1735-1743
-
-
Scheithauer, W.1
McKendrick, J.2
Begbie, S.3
-
61
-
-
34548159442
-
Renal insufficiency in elderly cancer patients: International Society of Geriatric Oncology clinical practice recommendations
-
DOI 10.1093/annonc/mdm011
-
Launay-Vacher V, Chatelut E, Lichtman SM, et al. Renal insufficiency in elderly cancer patients: International Society of Geriatric Oncology clinical practice recommendations. Ann Oncol. 2007;18:1314-1321. (Pubitemid 47305003)
-
(2007)
Annals of Oncology
, vol.18
, Issue.8
, pp. 1314-1321
-
-
Launay-Vacher, V.1
Chatelut, E.2
Lichtman, S.M.3
Wildiers, H.4
Steer, C.5
Aapro, M.6
-
62
-
-
33645729838
-
An observational study examining the impact of capecitabine on warfarin antithrombotic activity and bleeding complications
-
Yood MU, Quesenberry CP Jr, Alford SH, et al. An observational study examining the impact of capecitabine on warfarin antithrombotic activity and bleeding complications. Curr Med Res Opin. 2006;22:307-314.
-
(2006)
Curr Med Res Opin
, vol.22
, pp. 307-314
-
-
Yood, M.U.1
Quesenberry Jr., C.P.2
Alford, S.H.3
-
63
-
-
71749084894
-
Chemotherapy options and outcomes in older adult patients with colorectal cancer
-
Saif MW, Lichtman SM. Chemotherapy options and outcomes in older adult patients with colorectal cancer. Crit Rev Oncol Hematol. 2009;72:155-169.
-
(2009)
Crit Rev Oncol Hematol
, vol.72
, pp. 155-169
-
-
Saif, M.W.1
Lichtman, S.M.2
-
64
-
-
65649108950
-
Adjuvant chemotherapy in older women with early-stage breast cancer
-
Muss HB, Berry DA, Cirrincione CT, et al. Adjuvant chemotherapy in older women with early-stage breast cancer. N Engl J Med. 2009;360:2055-2065.
-
(2009)
N Engl J Med
, vol.360
, pp. 2055-2065
-
-
Muss, H.B.1
Berry, D.A.2
Cirrincione, C.T.3
-
65
-
-
58149097469
-
Anticancer drug therapy in the older cancer patient: Pharmacology and polypharmacy
-
Lichtman SM, Boparai MK. Anticancer drug therapy in the older cancer patient: pharmacology and polypharmacy. Curr Treat Options Oncol. 2008; 9:191-203.
-
(2008)
Curr Treat Options Oncol
, vol.9
, pp. 191-203
-
-
Lichtman, S.M.1
Boparai, M.K.2
-
66
-
-
21744460230
-
Benefits and drawbacks of the use of oral fluoropyrimidines as single-agent therapy in advanced colorectal cancer
-
Cassidy J. Benefits and drawbacks of the use of oral fluoropyrimidines as single-agent therapy in advanced colorectal cancer. Clin Colorectal Cancer. 2005;5(suppl 1):S47-S50.
-
(2005)
Clin Colorectal Cancer
, vol.5
, Issue.SUPPL. 1
-
-
Cassidy, J.1
-
67
-
-
2542615200
-
Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
-
Andre T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350: 2343-2351.
-
(2004)
N Engl J Med
, vol.350
, pp. 2343-2351
-
-
Andre, T.1
Boni, C.2
Mounedji-Boudiaf, L.3
-
68
-
-
33748669385
-
Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer
-
Goldberg RM, Tabah-Fisch I, Bleiberg H, et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol. 2006;24: 4085-4091.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4085-4091
-
-
Goldberg, R.M.1
Tabah-Fisch, I.2
Bleiberg, H.3
-
69
-
-
33847722573
-
Phase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancer: A planned safety analysis in 1,864 patients
-
Schmoll HJ, Cartwright T, Tabernero J, et al. Phase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancer: a planned safety analysis in 1,864 patients. J Clin Oncol. 2007;25:102-109.
-
(2007)
J Clin Oncol
, vol.25
, pp. 102-109
-
-
Schmoll, H.J.1
Cartwright, T.2
Tabernero, J.3
-
70
-
-
84975315529
-
Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3
-
Van Cutsem E, Labianca R, Bodoky G, et al. Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3. J Clin Oncol. 2009;18:18.
-
(2009)
J Clin Oncol
, vol.18
, pp. 18
-
-
Van Cutsem, E.1
Labianca, R.2
Bodoky, G.3
-
71
-
-
63549145899
-
A phase III randomised trial of LV5FU2 + irinotecan versus LV5FU2 alone in adjuvant high-risk colon cancer (FNCLCC Accord02/FFCD9802)
-
Ychou M, Raoul JL, Douillard JY, et al. A phase III randomised trial of LV5FU2 + irinotecan versus LV5FU2 alone in adjuvant high-risk colon cancer (FNCLCC Accord02/FFCD9802). Ann Oncol. 2009;20:674-680.
-
(2009)
Ann Oncol
, vol.20
, pp. 674-680
-
-
Ychou, M.1
Raoul, J.L.2
Douillard, J.Y.3
-
72
-
-
34548160680
-
Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: Results of CALGB 89803
-
Saltz LB, Niedzwiecki D, Hollis D, et al. Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803. J Clin Oncol. 2007;25:3456-3461.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3456-3461
-
-
Saltz, L.B.1
Niedzwiecki, D.2
Hollis, D.3
-
73
-
-
70350177864
-
Impact of older age on the efficacy of newer adjuvant therapies in>12,500 patients (pts) with stage II/III colon cancer: Findings from the ACCENT Database
-
Presented at Orlando, FL
-
Jackson McCleary NA, Meyerhardt J, Green E, et al. Impact of older age on the efficacy of newer adjuvant therapies in>12,500 patients (pts) with stage II/III colon cancer: findings from the ACCENT Database. Presented at American Society of Clinical Oncology Annual Meeting; Orlando, FL; 2009. Abstract 4010.
-
(2009)
American Society of Clinical Oncology Annual Meeting
-
-
Jackson McCleary, N.A.1
Meyerhardt, J.2
Green, E.3
-
74
-
-
66149147757
-
Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer
-
Allegra CJ, Yothers G, O'Connell MJ, et al. Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J Clin Oncol. 2009;27:3385-3390.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3385-3390
-
-
Allegra, C.J.1
Yothers, G.2
O'Connell, M.J.3
-
75
-
-
4644288273
-
Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: A pooled analysis of clinical trials
-
Folprecht G, Cunningham D, Ross P, et al. Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol. 2004;15:1330-1338.
-
(2004)
Ann Oncol
, vol.15
, pp. 1330-1338
-
-
Folprecht, G.1
Cunningham, D.2
Ross, P.3
-
76
-
-
0032792959
-
Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
-
Popescu RA, Norman A, Ross PJ, et al. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol. 1999;17: 2412-2418.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2412-2418
-
-
Popescu, R.A.1
Norman, A.2
Ross, P.J.3
-
77
-
-
0036235128
-
First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
-
Cassidy J, Twelves C, Van Cutsem E, et al. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol. 2002;13:566-575.
-
(2002)
Ann Oncol
, vol.13
, pp. 566-575
-
-
Cassidy, J.1
Twelves, C.2
Van Cutsem, E.3
-
78
-
-
21144452813
-
Capecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: An oncopaz cooperative group study
-
Feliu J, Escudero P, Llosa F, et al. Capecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: an oncopaz cooperative group study. J Clin Oncol. 2005;23:3104-3111.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3104-3111
-
-
Feliu, J.1
Escudero, P.2
Llosa, F.3
-
79
-
-
7944223833
-
Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy
-
Chau I, Norman AR, Cunningham D, et al. Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Br J Cancer. 2004;91:1453-1458.
-
(2004)
Br J Cancer
, vol.91
, pp. 1453-1458
-
-
Chau, I.1
Norman, A.R.2
Cunningham, D.3
-
80
-
-
0034712536
-
Irinotecan combined with fluorouracil compared with fluorouracil alone. As first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
-
Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone. As first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet. 2000; 355:1041-1047.
-
(2000)
Lancet
, vol.355
, pp. 1041-1047
-
-
Douillard, J.Y.1
Cunningham, D.2
Roth, A.D.3
-
81
-
-
24644432555
-
Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer
-
European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986
-
Kohne CH, Van Cutsem E, Wils J, et al. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. J Clin Oncol. 2005;23:4856-4865.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4856-4865
-
-
Ch, K.1
Van Cutsem, E.2
Wils, J.3
-
82
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
-
Irinotecan Study Group
-
Saltz LB, Cox JV, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med. 2000;343:905-914.
-
(2000)
N Engl J Med
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
-
83
-
-
41149180580
-
Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: Combined analysis of 2,691 patients in randomized controlled trials
-
Folprecht G, Seymour MT, Saltz L, et al. Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691 patients in randomized controlled trials. J Clin Oncol. 2008;26:1443-1451.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1443-1451
-
-
Folprecht, G.1
Seymour, M.T.2
Saltz, L.3
-
84
-
-
4143089333
-
Predictive factors of survival in patients with advanced colorectal cancer: An individual data analysis of 602 patients included in irinotecan phase III trials
-
Mitry E, Douillard JY, Van Cutsem E, et al. Predictive factors of survival in patients with advanced colorectal cancer: an individual data analysis of 602 patients included in irinotecan phase III trials. Ann Oncol. 2004;15:1013-1017.
-
(2004)
Ann Oncol
, vol.15
, pp. 1013-1017
-
-
Mitry, E.1
Douillard, J.Y.2
Van Cutsem, E.3
-
85
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
De Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2000;18:2938-2947.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2938-2947
-
-
De Gramont, A.1
Figer, A.2
Seymour, M.3
-
86
-
-
25444442283
-
High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer
-
Mattioli R, Massacesi C, Recchia F, et al. High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer. Ann Oncol. 2005;16:1147-1151.
-
(2005)
Ann Oncol
, vol.16
, pp. 1147-1151
-
-
Mattioli, R.1
Massacesi, C.2
Recchia, F.3
-
87
-
-
22244477362
-
Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: Final results of the Southern Italy Cooperative Oncology Group trial 0108
-
DOI 10.1002/cncr.21167
-
Comella P, Natale D, Farris A, et al. Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: final results of the Southern Italy Cooperative Oncology Group Trial 0108. Cancer. 2005;104:282-289. (Pubitemid 40993254)
-
(2005)
Cancer
, vol.104
, Issue.2
, pp. 282-289
-
-
Comelia, P.1
Natale, D.2
Farris, A.3
Gambardella, A.4
Maiorino, L.5
Massidda, B.6
Casaretti, R.7
Tafuto, S.8
Lorusso, V.9
Leo, S.10
Cannone, M.11
-
88
-
-
33644839646
-
Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: Post hoc analysis of a large phase II study
-
Twelves CJ, Butts CA, Cassidy J, et al. Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: post hoc analysis of a large phase II study. Clin Colorectal Cancer. 2005;5:101-107.
-
(2005)
Clin Colorectal Cancer
, vol.5
, pp. 101-107
-
-
Twelves, C.J.1
Butts, C.A.2
Cassidy, J.3
-
89
-
-
33644843853
-
OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer-a GERCOR study
-
Tournigand C, Cervantes A, Figer A, et al. OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer-a GERCOR study. J Clin Oncol. 2006;24:394-400.
-
(2006)
J Clin Oncol
, vol.24
, pp. 394-400
-
-
Tournigand, C.1
Cervantes, A.2
Figer, A.3
-
90
-
-
37049022436
-
FOLFOX in patients aged between 76 and 80 years with metastatic colorectal cancer: An exploratory cohort of the OPTIMOX1 study
-
Figer A, Perez-Staub N, Carola E, et al. FOLFOX in patients aged between 76 and 80 years with metastatic colorectal cancer: an exploratory cohort of the OPTIMOX1 study. Cancer. 2007;110:2666-2671.
-
(2007)
Cancer
, vol.110
, pp. 2666-2671
-
-
Figer, A.1
Perez-Staub, N.2
Carola, E.3
-
91
-
-
34848850990
-
Final results of OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC): A GERCOR study
-
Maindrault-Goebel F, Lledo G, Chibaudel B, et al. Final results of OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC): A GERCOR study. J Clin Oncol. 2007;25:abstract 4013.
-
(2007)
J Clin Oncol
, vol.25
-
-
Maindrault-Goebel, F.1
Lledo, G.2
Chibaudel, B.3
-
92
-
-
34447277453
-
Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): A phase III randomised controlled trial
-
Koopman M, Antonini NF, Douma J, et al. Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet. 2007;370:135-142.
-
(2007)
Lancet
, vol.370
, pp. 135-142
-
-
Koopman, M.1
Antonini, N.F.2
Douma, J.3
-
93
-
-
34447255724
-
Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): A randomised controlled trial
-
Seymour MT, Maughan TS, Ledermann JA, et al. Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial. Lancet. 2007;370:143-152.
-
(2007)
Lancet
, vol.370
, pp. 143-152
-
-
Seymour, M.T.1
Maughan, T.S.2
Ledermann, J.A.3
-
94
-
-
84975244847
-
Capecitabine (Cap) and oxaliplatin (Ox) in elderly and/or frail patients with metastatic colorectal cancer: The FOCUS2 trial
-
Presented at Chicago IL
-
Seymour MT, Maughan TS, Wasan HS, et al. Capecitabine (Cap) and oxaliplatin (Ox) in elderly and/or frail patients with metastatic colorectal cancer: The FOCUS2 trial. Presented at American Society of Clinical Oncology Annual Meeting. Chicago, IL; 2007:Abstract 9030.
-
(2007)
American Society of Clinical Oncology Annual Meeting
-
-
Seymour, M.T.1
Maughan, T.S.2
Wasan, H.S.3
-
95
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008;26:2013-2019.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
96
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007;25:1539-1544.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
-
97
-
-
56749169353
-
Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort Study (BRiTE)
-
Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort Study (BRiTE). J Clin Oncol. 2008;26:5326-5334.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5326-5334
-
-
Grothey, A.1
Sugrue, M.M.2
Purdie, D.M.3
-
98
-
-
70349413045
-
Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: The BRiTE observational cohort study
-
Kozloff M, Yood MU, Berlin J, et al. Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: the BRiTE observational cohort study. Oncologist. 2009;14:862-870.
-
(2009)
Oncologist
, vol.14
, pp. 862-870
-
-
Kozloff, M.1
Yood, M.U.2
Berlin, J.3
-
99
-
-
20544478429
-
Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
-
Kabbinavar FF, Schulz J, McCleod M, et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol. 2005;23:3697-3705.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3697-3705
-
-
Kabbinavar, F.F.1
Schulz, J.2
McCleod, M.3
-
100
-
-
84975244913
-
Effect of bevacizumab in older patients with metastatic colorectal cancer: Pooled analysis of four randomized studies
-
Cassidy J, Saltz LB, Giantonio BJ, et al. Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies. J Cancer Res Clin Oncol. 2009;11:11.
-
(2009)
J Cancer Res Clin Oncol
, vol.11
, pp. 11
-
-
Cassidy, J.1
Saltz, L.B.2
Giantonio, B.J.3
-
101
-
-
34548141828
-
Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
-
Scappaticci FA, Skillings JR, Holden SN, et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst. 2007;99:1232-1239.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 1232-1239
-
-
Scappaticci, F.A.1
Skillings, J.R.2
Holden, S.N.3
-
102
-
-
58249088835
-
Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: Pooled analysis of cohorts of older patients from two randomized clinical trials
-
Kabbinavar FF, Hurwitz HI, Yi J, et al. Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: pooled analysis of cohorts of older patients from two randomized clinical trials. J Clin Oncol. 2009;27:199-205.
-
(2009)
J Clin Oncol
, vol.27
, pp. 199-205
-
-
Kabbinavar, F.F.1
Hurwitz, H.I.2
Yi, J.3
-
103
-
-
66149120036
-
Safety and efficacy of first-line bevacizumab and chemotherapy in elderly patients with metastatic colorectal cancer: Results from the BEAT observational cohort study
-
Van Cutsem E, Rivera F, Berry S, et al. Safety and efficacy of first-line bevacizumab and chemotherapy in elderly patients with metastatic colorectal cancer: results from the BEAT observational cohort study. Ann Oncol. 2009;20(suppl 7):1842-11647
-
(2009)
Ann Oncol
, vol.20
, Issue.SUPPL. 7
, pp. 1842-11647
-
-
Van Cutsem, E.1
Rivera, F.2
Berry, S.3
-
104
-
-
50649094504
-
Disparities in the use of chemotherapy and monoclonal antibody therapy for elderly advanced colorectal cancer patients in the community oncology setting
-
McKibbin T, Frei CR, Greene RE, et al. Disparities in the use of chemotherapy and monoclonal antibody therapy for elderly advanced colorectal cancer patients in the community oncology setting. Oncologist. 2008;13: 876-885.
-
(2008)
Oncologist
, vol.13
, pp. 876-885
-
-
McKibbin, T.1
Frei, C.R.2
Greene, R.E.3
-
105
-
-
51649120733
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2008;29:29.
-
(2008)
J Clin Oncol
, vol.29
, pp. 29
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
106
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004;351:337-345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
107
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ Sr, et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol. 2004;22:1201-1208.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
-
108
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol. 2007;25:1658-1664.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
109
-
-
77952172619
-
Randomized phase III study of panitumumab (pmab) with FOLFOX4 compared to FOLFOX4 alone as first-line treatment (tx) for metastatic colorectal cancer (mCRC): PRIME trial
-
Presented at Orlando FL
-
Siena S, Cassidy J, Tabernero J, et al. Randomized phase III study of panitumumab (pmab) with FOLFOX4 compared to FOLFOX4 alone as first-line treatment (tx) for metastatic colorectal cancer (mCRC): PRIME trial. Presented at Gastrointestinal Cancers Symposium. Orlando, FL; 2010: Abstract 283.
-
(2010)
Gastrointestinal Cancers Symposium
-
-
Siena, S.1
Cassidy, J.2
Tabernero, J.3
-
110
-
-
77952623225
-
Randomized phase III study of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Patient-reported outcomes (PRO)
-
Presented at Orlando FL
-
Peeters M, Price TJ, Hotko YS, et al. Randomized phase III study of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Patient-reported outcomes (PRO). Presented at Gastrointestinal Cancers Symposium. Orlando, FL; 2010:Abstract 282.
-
(2010)
Gastrointestinal Cancers Symposium
-
-
Peeters, M.1
Price, T.J.2
Hotko, Y.S.3
-
111
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock W, Piessevaux H, De Schutter J, et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol. 2008;19:508-515.
-
(2008)
Ann Oncol
, vol.19
, pp. 508-515
-
-
De Roock, W.1
Piessevaux, H.2
De Schutter, J.3
-
112
-
-
48749126163
-
Cetuximab efficacy and safety in a retrospective cohort of elderly patients with heavily pretreated metastatic colorectal cancer
-
Bouchahda M, Macarulla T, Spano JP, et al. Cetuximab efficacy and safety in a retrospective cohort of elderly patients with heavily pretreated metastatic colorectal cancer. Crit Rev Oncol Hematol. 2008;67:255-262.
-
(2008)
Crit Rev Oncol Hematol
, vol.67
, pp. 255-262
-
-
Bouchahda, M.1
MacArulla, T.2
Spano, J.P.3
-
113
-
-
84975247919
-
First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD)
-
Sastre J, Aranda E, Gravalos C, et al. First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD). Crit Rev Oncol Hematol. 2009;28:28.
-
(2009)
Crit Rev Oncol Hematol
, vol.28
, pp. 28
-
-
Sastre, J.1
Aranda, E.2
Gravalos, C.3
-
114
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2009;27:663-671.
-
(2009)
J Clin Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
115
-
-
73249130298
-
Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: The CELIM randomised phase 2 trial
-
Folprecht G, Gruenberger T, Bechstein WO, et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol. 2010;11:38-47.
-
(2010)
Lancet Oncol
, vol.11
, pp. 38-47
-
-
Folprecht, G.1
Gruenberger, T.2
Bechstein, W.O.3
-
116
-
-
77952172619
-
Randomized phase III study of panitumumab (pmab) with FOLFOX4 compared to FOLFOX4 alone as first-line treatment (tx) for metastatic colorectal cancer (mCRC): PRIME trial
-
Presented at Orlando, FL
-
Siena S, Cassidy J, Tabernero J, et al. Randomized phase III study of panitumumab (pmab) with FOLFOX4 compared to FOLFOX4 alone as first-line treatment (tx) for metastatic colorectal cancer (mCRC): PRIME trial. Presented at American Society of Clinical Oncology-Gastrointestinal Cancer Symposium; Orlando, FL; 2010: Abstract 283.
-
(2010)
American Society of Clinical Oncology-Gastrointestinal Cancer Symposium
-
-
Siena, S.1
Cassidy, J.2
Tabernero, J.3
-
117
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27:672-680.
-
(2009)
J Clin Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
118
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360:563-572.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
119
-
-
2442704240
-
Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ ablation for colorectal liver metastases
-
Abdalla EK, Vauthey JN, Ellis LM, et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ ablation for colorectal liver metastases. Ann Surg. 2004;239:818-827.
-
(2004)
Ann Surg
, vol.239
, pp. 818-827
-
-
Abdalla, E.K.1
Vauthey, J.N.2
Ellis, L.M.3
-
120
-
-
4344615981
-
Five-year survival after resection of hepatic metastases from colorectal cancer in patients screened by positron emission tomography with F-18 fluorodeoxyglucose (FDG-PET)
-
Fernandez FG, Drebin JA, Linehan DC, et al. Five-year survival after resection of hepatic metastases from colorectal cancer in patients screened by positron emission tomography with F-18 fluorodeoxyglucose (FDG-PET). Ann Surg. 2004;240:438-450.
-
(2004)
Ann Surg
, vol.240
, pp. 438-450
-
-
Fernandez, F.G.1
Drebin, J.A.2
Linehan, D.C.3
-
121
-
-
37549016003
-
Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: A multifactorial model of 929 patients
-
Rees M, Tekkis PP, Welsh FK, et al. Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg. 2008;247:125-135.
-
(2008)
Ann Surg
, vol.247
, pp. 125-135
-
-
Rees, M.1
Tekkis, P.P.2
Welsh, F.K.3
-
122
-
-
77952302964
-
The role of adjuvant therapy after resection of colorectal cancer liver metastases
-
In press
-
Power DG, Kemeny NE. The role of adjuvant therapy after resection of colorectal cancer liver metastases. J Clin Oncol. In press.
-
J Clin Oncol
-
-
Power, D.G.1
Kemeny, N.E.2
-
123
-
-
0032791959
-
Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery
-
Giacchetti S, Itzhaki M, Gruia G, et al. Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol. 1999;10:663-669.
-
(1999)
Ann Oncol
, vol.10
, pp. 663-669
-
-
Giacchetti, S.1
Itzhaki, M.2
Gruia, G.3
-
124
-
-
63449116518
-
Long-term outcome of initially unresectable metastatic colorectal cancer patients treated with 5-fluorouracil/ leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) followed by radical surgery of metastases
-
Masi G, Loupakis F, Pollina L, et al. Long-term outcome of initially unresectable metastatic colorectal cancer patients treated with 5-fluorouracil/ leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) followed by radical surgery of metastases. Ann Surg. 2009;249:420-425.
-
(2009)
Ann Surg
, vol.249
, pp. 420-425
-
-
Masi, G.1
Loupakis, F.2
Pollina, L.3
-
125
-
-
0028805061
-
Pancreatic or liver resection for malignancy is safe and effective for the elderly
-
discussion 434-1427
-
Fong Y, Blumgart LH, Fortner JG, et al. Pancreatic or liver resection for malignancy is safe and effective for the elderly. Ann Surg. 1995;222:426- 434; discussion 434-1427
-
(1995)
Ann Surg
, vol.222
, pp. 426-434
-
-
Fong, Y.1
Blumgart, L.H.2
Fortner, J.G.3
-
126
-
-
76649122170
-
Liver resection of colorectal metastases in elderly patients
-
Adam R, Frilling A, Elias D, et al. Liver resection of colorectal metastases in elderly patients. Br J Surg. 2010;97:366-376.
-
(2010)
Br J Surg
, vol.97
, pp. 366-376
-
-
Adam, R.1
Frilling, A.2
Elias, D.3
-
128
-
-
60849091052
-
Survival after hepatic resection of colorectal cancer metastases: A national experience
-
Robertson DJ, Stukel TA, Gottlieb DJ, et al. Survival after hepatic resection of colorectal cancer metastases: a national experience. Cancer. 2009;115: 752-759.
-
(2009)
Cancer
, vol.115
, pp. 752-759
-
-
Robertson, D.J.1
Stukel, T.A.2
Gottlieb, D.J.3
-
129
-
-
77952302964
-
The role of adjuvant therapy after resection of colorectal cancer liver metastases
-
In press
-
Power DG, Kemeny NE. The role of adjuvant therapy after resection of colorectal cancer liver metastases. J Clin Oncol. In press.
-
J Clin Oncol
-
-
Power, D.G.1
Kemeny, N.E.2
-
130
-
-
54449087716
-
Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: A pooled analysis of two randomized trials
-
Mitry E, Fields AL, Bleiberg H, et al. Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: a pooled analysis of two randomized trials. J Clin Oncol. 2008;26:4906-4911.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4906-4911
-
-
Mitry, E.1
Fields, A.L.2
Bleiberg, H.3
-
131
-
-
77953646937
-
A randomized phase III study comparing adjuvant 5-fluorouracil/folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer
-
Ychou M, Hohenberger W, Thezenas S, et al. A randomized phase III study comparing adjuvant 5-fluorouracil/folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer. Ann Oncol. 2009;30:30.
-
(2009)
Ann Oncol
, vol.30
, pp. 30
-
-
Ychou, M.1
Hohenberger, W.2
Thezenas, S.3
-
132
-
-
78651054955
-
The blood supply of neoplasms in the liver
-
Breedis C, Young G. The blood supply of neoplasms in the liver. Am J Pathol. 1954;30:969-977.
-
(1954)
Am J Pathol
, vol.30
, pp. 969-977
-
-
Breedis, C.1
Young, G.2
-
133
-
-
0020552807
-
Clinical pharmacology of hepatic arterial chemotherapy
-
Ensminger WD, Gyves JW. Clinical pharmacology of hepatic arterial chemotherapy. Semin Oncol. 1983;10:176-182.
-
(1983)
Semin Oncol
, vol.10
, pp. 176-182
-
-
Ensminger, W.D.1
Gyves, J.W.2
-
134
-
-
77953647359
-
The role of floxuridine in metastatic liver disease
-
Power DG, Kemeny NE. The role of floxuridine in metastatic liver disease. Mol Cancer Ther. 2009;21:21.
-
(2009)
Mol Cancer Ther
, vol.21
, pp. 21
-
-
Power, D.G.1
Kemeny, N.E.2
-
135
-
-
0037087721
-
Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: Surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy- an intergroup study
-
Kemeny MM, Adak S, Gray B, et al. Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy- an intergroup study. J Clin Oncol. 2002;20:1499-1505.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1499-1505
-
-
Kemeny, M.M.1
Adak, S.2
Gray, B.3
-
136
-
-
70249149719
-
Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma
-
Kemeny NE, Melendez FD, Capanu M, et al. Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma. J Clin Oncol. 2009;27:3465-3471.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3465-3471
-
-
Kemeny, N.E.1
Melendez, F.D.2
Capanu, M.3
-
137
-
-
0035873927
-
Phase i study of hepatic arterial infusion of floxuridine and dexamethasone with systemic irinotecan for unresectable hepatic metastases from colorectal cancer
-
Kemeny N, Gonen M, Sullivan D, et al. Phase I study of hepatic arterial infusion of floxuridine and dexamethasone with systemic irinotecan for unresectable hepatic metastases from colorectal cancer. J Clin Oncol. 2001;19:2687-2695.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2687-2695
-
-
Kemeny, N.1
Gonen, M.2
Sullivan, D.3
-
138
-
-
24644484863
-
Phase i trial of systemic oxaliplatin combination chemotherapy with hepatic arterial infusion in patients with unresectable liver metastases from colorectal cancer
-
Kemeny N, Jarnagin W, Paty P, et al. Phase I trial of systemic oxaliplatin combination chemotherapy with hepatic arterial infusion in patients with unresectable liver metastases from colorectal cancer. J Clin Oncol. 2005; 23:4888-4896.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4888-4896
-
-
Kemeny, N.1
Jarnagin, W.2
Paty, P.3
-
139
-
-
13744255337
-
Hepatic arterial infusion after liver resection
-
Kemeny NE, Gonen M. Hepatic arterial infusion after liver resection. N Engl J Med. 2005;352:734-735.
-
(2005)
N Engl J Med
, vol.352
, pp. 734-735
-
-
Kemeny, N.E.1
Gonen, M.2
-
140
-
-
77953962124
-
A randomized phase II study of hepatic arterial infusion and systemic chemotherapy with or without bevacizumab in patients with resected hepatic metastases from colorectal cancer
-
Presented at the Chicago, IL
-
Kemeny NE, Fong Y, Jarnagin WR, et al. A randomized phase II study of hepatic arterial infusion and systemic chemotherapy with or without bevacizumab in patients with resected hepatic metastases from colorectal cancer. Presented at the American Society of Clinical Oncology Annual Meeting; Chicago, IL; 2010. Abstract 3558.
-
(2010)
American Society of Clinical Oncology Annual Meeting
-
-
Kemeny, N.E.1
Fong, Y.2
Jarnagin, W.R.3
-
141
-
-
0031781467
-
Demonstration of hepatic steatosis by computerized tomography in patients receiving 5-fluorouracilbased therapy for advanced colorectal cancer
-
Peppercorn PD, Reznek RH, Wilson P, et al. Demonstration of hepatic steatosis by computerized tomography in patients receiving 5-fluorouracilbased therapy for advanced colorectal cancer. Br J Cancer. 1998;77:2008-2011.
-
(1998)
Br J Cancer
, vol.77
, pp. 2008-2011
-
-
Peppercorn, P.D.1
Reznek, R.H.2
Wilson, P.3
-
142
-
-
0035503151
-
Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
-
Van Cutsem E, Twelves C, Cassidy J, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol. 2001;19:4097-4106.
-
(2001)
J Clin Oncol
, vol.19
, pp. 4097-4106
-
-
Van Cutsem, E.1
Twelves, C.2
Cassidy, J.3
-
143
-
-
34548059736
-
Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function
-
Takimoto CH, Graham MA, Lockwood G, et al. Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function. Clin Cancer Res. 2007;13:4832-4839.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4832-4839
-
-
Ch, T.1
Ma, G.2
Lockwood, G.3
-
144
-
-
75449088980
-
Hepatic toxicities associated with the use of preoperative systemic therapy in patients with metastatic colorectal adenocarcinoma to the liver
-
Cleary JM, Tanabe KT, Lauwers GY, et al. Hepatic toxicities associated with the use of preoperative systemic therapy in patients with metastatic colorectal adenocarcinoma to the liver. Oncologist. 2009;14:1095-1105.
-
(2009)
Oncologist
, vol.14
, pp. 1095-1105
-
-
Cleary, J.M.1
Tanabe, K.T.2
Lauwers, G.Y.3
-
145
-
-
0037364658
-
Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer
-
Fuchs CS, Moore MR, Harker G, et al. Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer. J Clin Oncol. 2003;21:807-814.
-
(2003)
J Clin Oncol
, vol.21
, pp. 807-814
-
-
Fuchs, C.S.1
Moore, M.R.2
Harker, G.3
-
146
-
-
33746805967
-
Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: A North American Intergroup Trial
-
Goldberg RM, Sargent DJ, Morton RF, et al. Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: a North American Intergroup Trial. J Clin Oncol. 2006;24:3347-3353.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3347-3353
-
-
Goldberg, R.M.1
Sargent, D.J.2
Morton, R.F.3
-
147
-
-
33646457231
-
Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases
-
Vauthey JN, Pawlik TM, Ribero D, et al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol. 2006;24:2065-2072.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2065-2072
-
-
Vauthey, J.N.1
Pawlik, T.M.2
Ribero, D.3
-
148
-
-
6044226542
-
Preoperative versus postoperative chemoradiotherapy for rectal cancer
-
Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731-1740.
-
(2004)
N Engl J Med
, vol.351
, pp. 1731-1740
-
-
Sauer, R.1
Becker, H.2
Hohenberger, W.3
-
149
-
-
0035975394
-
Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
-
Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638-646.
-
(2001)
N Engl J Med
, vol.345
, pp. 638-646
-
-
Kapiteijn, E.1
Marijnen, C.A.2
Nagtegaal, I.D.3
-
150
-
-
43049109578
-
Controversies of total mesorectal excision for rectal cancer in elderly patients
-
Rutten HJ, den Dulk M, Lemmens VE, et al. Controversies of total mesorectal excision for rectal cancer in elderly patients. Lancet Oncol. 2008;9:494-501.
-
(2008)
Lancet Oncol
, vol.9
, pp. 494-501
-
-
Rutten, H.J.1
Den Dulk, M.2
Lemmens, V.E.3
-
151
-
-
0030999255
-
Age is not a limiting factor for radical radiotherapy in pelvic malignancies
-
Pignon T, Horiot JC, Bolla M, et al. Age is not a limiting factor for radical radiotherapy in pelvic malignancies. Radiother Oncol. 1997;42:107-120.
-
(1997)
Radiother Oncol
, vol.42
, pp. 107-120
-
-
Pignon, T.1
Horiot, J.C.2
Bolla, M.3
-
152
-
-
33750511732
-
Elderly patients with rectal cancer have a higher risk of treatment-related complications and a poorer prognosis than younger patients: A population-based study
-
Shahir MA, Lemmens VE, van de Poll-Franse LV, et al. Elderly patients with rectal cancer have a higher risk of treatment-related complications and a poorer prognosis than younger patients: a population-based study. Eur J Cancer. 2006;42:3015-3021.
-
(2006)
Eur J Cancer
, vol.42
, pp. 3015-3021
-
-
Ma, S.1
Lemmens, V.E.2
Van De Poll-Franse, L.V.3
-
153
-
-
39049148628
-
Survival benefits and trends in use of adjuvant therapy among elderly stage II and III rectal cancer patients in the general population
-
Dobie SA, Warren JL, Matthews B, et al. Survival benefits and trends in use of adjuvant therapy among elderly stage II and III rectal cancer patients in the general population. Cancer. 2008;112:789-799.
-
(2008)
Cancer
, vol.112
, pp. 789-799
-
-
Dobie, S.A.1
Warren, J.L.2
Matthews, B.3
-
154
-
-
0036605760
-
Use of adjuvant chemotherapy and radiation therapy for rectal cancer among the elderly: A population- based study
-
Neugut AI, Fleischauer AT, Sundararajan V, et al. Use of adjuvant chemotherapy and radiation therapy for rectal cancer among the elderly: a population- based study. J Clin Oncol. 2002;20:2643-2650.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2643-2650
-
-
Neugut, A.I.1
Fleischauer, A.T.2
Sundararajan, V.3
-
155
-
-
77349110719
-
Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: A phase 2 trial
-
Chua YJ, Barbachano Y, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol. 2010; 11:241-248.
-
(2010)
Lancet Oncol
, vol.11
, pp. 241-248
-
-
Chua, Y.J.1
Barbachano, Y.2
Cunningham, D.3
-
156
-
-
0141465154
-
Are older French patients as willing as older American patients to undertake chemotherapy?
-
Extermann M, Albrand G, Chen H, et al. Are older French patients as willing as older American patients to undertake chemotherapy? J Clin Oncol. 2003;21:3214-3219.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3214-3219
-
-
Extermann, M.1
Albrand, G.2
Chen, H.3
-
157
-
-
33745208641
-
The cancer and leukemia group B cancer in the elderly committee: Addressing a major cancer need
-
Cohen HJ, Muss HB. The cancer and leukemia group B cancer in the elderly committee: addressing a major cancer need. Clin Cancer Res. 2006;12: 3606s-3611s.
-
(2006)
Clin Cancer Res
, vol.12
-
-
Cohen, H.J.1
Muss, H.B.2
-
159
-
-
49249091769
-
Mentoring junior faculty in geriatric oncology: Report from the Cancer and Aging Research Group
-
Hurria A, Balducci L, Naeim A, et al. Mentoring junior faculty in geriatric oncology: report from the Cancer and Aging Research Group. J Clin Oncol. 2008;26:3125-3127.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3125-3127
-
-
Hurria, A.1
Balducci, L.2
Naeim, A.3
-
160
-
-
0025847822
-
Joint NCI-EORTC consensus meeting on neoplasia in the elderly. San
-
Monfardini S, Chabner B. Joint NCI-EORTC consensus meeting on neoplasia in the elderly. San Servolo Island, Venice: October 15-16, 1990. Eur J Cancer. 1991;27:653-654.
-
(1991)
Eur J Cancer
, vol.27
, pp. 653-654
-
-
Monfardini, S.1
Chabner, B.2
-
161
-
-
0034010518
-
Measuring comorbidity in older cancer patients
-
Extermann M. Measuring comorbidity in older cancer patients. Eur J Cancer. 2000;36:453-471.
-
(2000)
Eur J Cancer
, vol.36
, pp. 453-471
-
-
Extermann, M.1
-
162
-
-
34248643709
-
Pre-operative assessment of cancer in the elderly (PACE): A comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery
-
Pope D, Ramesh H, Gennari R, et al. Pre-operative assessment of cancer in the elderly (PACE): a comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery. Surg Oncol. 2006;15:189-197.
-
(2006)
Surg Oncol
, vol.15
, pp. 189-197
-
-
Pope, D.1
Ramesh, H.2
Gennari, R.3
-
163
-
-
1842569206
-
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
-
Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004;22:23-30.
-
(2004)
J Clin Oncol
, vol.22
, pp. 23-30
-
-
Goldberg, R.M.1
Sargent, D.J.2
Morton, R.F.3
-
164
-
-
0037531121
-
Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil- leucovorin: Interim results of a phase III trial
-
Rothenberg ML, Oza AM, Bigelow RH, et al. Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil- leucovorin: interim results of a phase III trial. J Clin Oncol. 2003; 21:2059-2069.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2059-2069
-
-
Rothenberg, M.L.1
Oza, A.M.2
Bigelow, R.H.3
-
165
-
-
0029794696
-
Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy
-
Bismuth H, Adam R, Levi F, et al. Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Ann Surg. 1996;224:509-522.
-
(1996)
Ann Surg
, vol.224
, pp. 509-522
-
-
Bismuth, H.1
Adam, R.2
Levi, F.3
-
166
-
-
2642541197
-
Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients
-
Pozzo C, Basso M, Cassano A, et al. Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients. Ann Oncol. 2004;15:933-939.
-
(2004)
Ann Oncol
, vol.15
, pp. 933-939
-
-
Pozzo, C.1
Basso, M.2
Cassano, A.3
-
167
-
-
33644819672
-
Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: A North Central Cancer Treatment Group phase II study
-
Alberts SR, Horvath WL, Sternfeld WC, et al. Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: A North Central Cancer Treatment Group phase II study. J Clin Oncol. 2005;23:9243-9249.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9243-9249
-
-
Alberts, S.R.1
Horvath, W.L.2
Sternfeld, W.C.3
-
168
-
-
30944445619
-
Treatment with 5-fluorouracil/folinic acid, oxaliplatin, and irinotecan enables surgical resection of metastases in patients with initially unresectable metastatic colorectal cancer
-
Masi G, Cupini S, Marcucci L, et al. Treatment with 5-fluorouracil/ folinic acid, oxaliplatin, and irinotecan enables surgical resection of metastases in patients with initially unresectable metastatic colorectal cancer. Ann Surg Oncol. 2006;13:58-65.
-
(2006)
Ann Surg Oncol
, vol.13
, pp. 58-65
-
-
Masi, G.1
Cupini, S.2
Marcucci, L.3
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