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Volumn 13, Issue 4, 2008, Pages 390-402

Chemotherapy in elderly patients with colorectal cancer

Author keywords

Chemotherapy; Colorectal; Geriatric assessment; Irinotecan; Targeted therapy

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PLACEBO; UFT;

EID: 43549126000     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2007-0043     Document Type: Review
Times cited : (85)

References (80)
  • 2
    • 33748669385 scopus 로고    scopus 로고
    • Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer
    • Goldberg RM, Tabah-Fisch I, Bleiberg H et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol 2006;24:4085-4091.
    • (2006) J Clin Oncol , vol.24 , pp. 4085-4091
    • Goldberg, R.M.1    Tabah-Fisch, I.2    Bleiberg, H.3
  • 3
    • 34848926565 scopus 로고
    • Ries LAG, Harkins D, Krapcho M et al, eds, Bethesda, MD:, Available at, Accessed September 27, 2006. 2003
    • Ries LAG, Harkins D, Krapcho M et al., eds. Contents of the SEER Cancer Statistics Review, 1975-2003. Bethesda, MD: National Cancer Institute, 2003. Available at http://seer.cancer.gov/csr/1975_2003/. Accessed September 27, 2006.
    • (1975) Contents of the SEER Cancer Statistics Review
  • 4
    • 0037093947 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S cancer burden
    • Edwards BK, Howe HL, Ries LA et al. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S cancer burden. Cancer 2002;94:2766-2792.
    • (2002) Cancer , vol.94 , pp. 2766-2792
    • Edwards, B.K.1    Howe, H.L.2    Ries, L.A.3
  • 6
    • 43549086294 scopus 로고    scopus 로고
    • Life Expectancy by Selected Ages Since 1946: Females. Paris, France: Institut National D'tudes Démographiques, 2007. Available at http://www.ined.fr/fichier/t_telechargement/11151/ telechargement_fichier_fr_telechargement_fichier_fr_sd2004_t69esp_fm.1.xls. Accessed December 12, 2007.
    • Life Expectancy by Selected Ages Since 1946: Females. Paris, France: Institut National D'tudes Démographiques, 2007. Available at http://www.ined.fr/fichier/t_telechargement/11151/ telechargement_fichier_fr_telechargement_fichier_fr_sd2004_t69esp_fm.1.xls. Accessed December 12, 2007.
  • 7
    • 43549107809 scopus 로고    scopus 로고
    • Life Expectancy by Selected Ages Since 1946: Males. Paris, France: Institut National D'tudes Démographiques, 2007. Available at http://www.ined.fr/fichier/t_telechargement/11152/ telechargement_fichier_fr_telechargement_fichier_fr_sd2004_t69esp_fm.1.xls. Accessed December 12, 2007.
    • Life Expectancy by Selected Ages Since 1946: Males. Paris, France: Institut National D'tudes Démographiques, 2007. Available at http://www.ined.fr/fichier/t_telechargement/11152/ telechargement_fichier_fr_telechargement_fichier_fr_sd2004_t69esp_fm.1.xls. Accessed December 12, 2007.
  • 8
    • 26244449765 scopus 로고    scopus 로고
    • Improvement in colorectal cancer survival: A population-based study
    • Mitry E, Bouvier AM, Esteve J et al. Improvement in colorectal cancer survival: A population-based study. Eur J Cancer 2005;41:2297-2303.
    • (2005) Eur J Cancer , vol.41 , pp. 2297-2303
    • Mitry, E.1    Bouvier, A.M.2    Esteve, J.3
  • 9
    • 34548250015 scopus 로고    scopus 로고
    • Recent major progress in long-term cancer patient survival disclosed by modeled period analysis
    • Brenner H, Gondos A, Arndt V. Recent major progress in long-term cancer patient survival disclosed by modeled period analysis. J Clin Oncol 2007;25:3274-3280.
    • (2007) J Clin Oncol , vol.25 , pp. 3274-3280
    • Brenner, H.1    Gondos, A.2    Arndt, V.3
  • 10
    • 0038662715 scopus 로고    scopus 로고
    • Participation of patients 65 years of age or older in cancer clinical trials
    • Lewis JH, Kilgore ML, Goldman DP et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol 2003;21:1383-1389.
    • (2003) J Clin Oncol , vol.21 , pp. 1383-1389
    • Lewis, J.H.1    Kilgore, M.L.2    Goldman, D.P.3
  • 11
    • 0037022820 scopus 로고    scopus 로고
    • Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with nodepositive colon cancer
    • Sundararajan V, Mitra N, Jacobson JS et al. Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with nodepositive colon cancer. Ann Intern Med 2002;136:349-357.
    • (2002) Ann Intern Med , vol.136 , pp. 349-357
    • Sundararajan, V.1    Mitra, N.2    Jacobson, J.S.3
  • 12
    • 0036498881 scopus 로고    scopus 로고
    • Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer
    • Potosky AL, Harlan LC, Kaplan RS et al. Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer. J Clin Oncol 2002;20:1192-1202.
    • (2002) J Clin Oncol , vol.20 , pp. 1192-1202
    • Potosky, A.L.1    Harlan, L.C.2    Kaplan, R.S.3
  • 13
    • 20044370090 scopus 로고    scopus 로고
    • Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity
    • Lemmens VEPP, van Halteren AH, Janssen-Heijnen MLG et al. Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity. Ann Oncol 2005;16:767-772.
    • (2005) Ann Oncol , vol.16 , pp. 767-772
    • Lemmens, V.E.P.P.1    van Halteren, A.H.2    Janssen-Heijnen, M.L.G.3
  • 14
    • 4644288273 scopus 로고    scopus 로고
    • Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: A pooled analysis of clinical trials
    • Folprecht G, Cunningham D, Ross P et al. Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: A pooled analysis of clinical trials. Ann Oncol 2004;15:1330-1338.
    • (2004) Ann Oncol , vol.15 , pp. 1330-1338
    • Folprecht, G.1    Cunningham, D.2    Ross, P.3
  • 15
    • 0035846320 scopus 로고    scopus 로고
    • Apooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients
    • Sargent DJ, Goldberg RM, Jacobson SD et al.Apooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001;345:1091-1097.
    • (2001) N Engl J Med , vol.345 , pp. 1091-1097
    • Sargent, D.J.1    Goldberg, R.M.2    Jacobson, S.D.3
  • 16
    • 0032792959 scopus 로고    scopus 로고
    • Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
    • Popescu RA, Norman A, Ross PJ et al. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 1999;17:2412-2418.
    • (1999) J Clin Oncol , vol.17 , pp. 2412-2418
    • Popescu, R.A.1    Norman, A.2    Ross, P.J.3
  • 17
    • 0033920730 scopus 로고    scopus 로고
    • Management of cancer in the older person: A practical approach
    • Balducci L, Extermann M. Management of cancer in the older person: A practical approach. The Oncologist 2000;5:224-237.
    • (2000) The Oncologist , vol.5 , pp. 224-237
    • Balducci, L.1    Extermann, M.2
  • 18
    • 0033961487 scopus 로고    scopus 로고
    • Cancer in the frail patient. A coming epidemic
    • Balducci L, Stanta G. Cancer in the frail patient. A coming epidemic. Hematol Oncol Clin North Am 2000;14:235-250.
    • (2000) Hematol Oncol Clin North Am , vol.14 , pp. 235-250
    • Balducci, L.1    Stanta, G.2
  • 19
    • 0032160550 scopus 로고    scopus 로고
    • Money, medicine, and Methuselah
    • Cassel CK. Money, medicine, and Methuselah. Mt Sinai J Med 1998;65:237-245.
    • (1998) Mt Sinai J Med , vol.65 , pp. 237-245
    • Cassel, C.K.1
  • 20
    • 0033008996 scopus 로고    scopus 로고
    • Toward an understanding of frailty
    • Hamerman D. Toward an understanding of frailty. Ann Intern Med 1999;130:945-950.
    • (1999) Ann Intern Med , vol.130 , pp. 945-950
    • Hamerman, D.1
  • 21
    • 0032941990 scopus 로고    scopus 로고
    • Disease, disability, and age in cognitively intact seniors: Results from the Canadian Study of Health and Aging
    • Hogan DB, Ebly EM, Fung TS. Disease, disability, and age in cognitively intact seniors: Results from the Canadian Study of Health and Aging. J Gerontol A Biol Sci Med Sci 1999;54:M77-M82.
    • (1999) J Gerontol A Biol Sci Med Sci , vol.54
    • Hogan, D.B.1    Ebly, E.M.2    Fung, T.S.3
  • 22
    • 0032985575 scopus 로고    scopus 로고
    • A brief clinical instrument to classify frailty in elderly people
    • Rockwood K, Stadnyk K, MacKnight C et al. A brief clinical instrument to classify frailty in elderly people. Lancet 1999;353:205-206.
    • (1999) Lancet , vol.353 , pp. 205-206
    • Rockwood, K.1    Stadnyk, K.2    MacKnight, C.3
  • 23
    • 20644437768 scopus 로고    scopus 로고
    • Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors study
    • Sastre J, Marcuello E, Masutti B et al. Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors study. J Clin Oncol 2005;23:3545-3551.
    • (2005) J Clin Oncol , vol.23 , pp. 3545-3551
    • Sastre, J.1    Marcuello, E.2    Masutti, B.3
  • 24
    • 0141465154 scopus 로고    scopus 로고
    • Are older French patients as willing as older American patients to undertake chemotherapy?
    • Extermann M, Albrand G, Chen H et al. Are older French patients as willing as older American patients to undertake chemotherapy? J Clin Oncol 2003;21:3214-3219.
    • (2003) J Clin Oncol , vol.21 , pp. 3214-3219
    • Extermann, M.1    Albrand, G.2    Chen, H.3
  • 25
    • 4143089333 scopus 로고    scopus 로고
    • Predictive factors of survival in patients with advanced colorectal cancer: An individual data analysis of 602 patients included in irinotecan phase III trials
    • Mitry E, Douillard JY, Van Cutsem E et al. Predictive factors of survival in patients with advanced colorectal cancer: An individual data analysis of 602 patients included in irinotecan phase III trials. Ann Oncol 2004;15:1013-1017.
    • (2004) Ann Oncol , vol.15 , pp. 1013-1017
    • Mitry, E.1    Douillard, J.Y.2    Van Cutsem, E.3
  • 26
    • 14644429819 scopus 로고    scopus 로고
    • 5-Fluorouracil-based chemotherapy for advanced colorectal cancer in elderly patients: A North Central Cancer Treatment Group study
    • D'Andre S, Sargent DJ, Cha SS et al. 5-Fluorouracil-based chemotherapy for advanced colorectal cancer in elderly patients: A North Central Cancer Treatment Group study. Clin Colorectal Cancer 2005;4:325-331.
    • (2005) Clin Colorectal Cancer , vol.4 , pp. 325-331
    • D'Andre, S.1    Sargent, D.J.2    Cha, S.S.3
  • 27
    • 30744468361 scopus 로고    scopus 로고
    • Geriatric assessment with focus on instrument selectivity for outcomes
    • Extermann M. Geriatric assessment with focus on instrument selectivity for outcomes. Cancer J 2005;11:474-480.
    • (2005) Cancer J , vol.11 , pp. 474-480
    • Extermann, M.1
  • 28
    • 0023092594 scopus 로고
    • A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
    • Charlson ME, Pompei P, Ales KL et al. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987;40:373-383.
    • (1987) J Chronic Dis , vol.40 , pp. 373-383
    • Charlson, M.E.1    Pompei, P.2    Ales, K.L.3
  • 29
    • 0242408138 scopus 로고    scopus 로고
    • Oxaliplatin- or irinotecan-based chemotherapy for metastatic colorectal cancer in the elderly
    • Aparicio T, Desrame J, Lecomte T et al. Oxaliplatin- or irinotecan-based chemotherapy for metastatic colorectal cancer in the elderly. Br J Cancer 2003;89:1439-1444.
    • (2003) Br J Cancer , vol.89 , pp. 1439-1444
    • Aparicio, T.1    Desrame, J.2    Lecomte, T.3
  • 30
    • 0036100183 scopus 로고    scopus 로고
    • A case for geriatric oncology
    • Repetto L, Balducci L. A case for geriatric oncology. Lancet Oncol 2002;3:289-297.
    • (2002) Lancet Oncol , vol.3 , pp. 289-297
    • Repetto, L.1    Balducci, L.2
  • 31
    • 0025312606 scopus 로고
    • Attitudes to chemotherapy: Comparing views of patients with cancer with those of doctors, nurses, and general public
    • Slevin ML, Stubbs L, Plant HJ et al. Attitudes to chemotherapy: Comparing views of patients with cancer with those of doctors, nurses, and general public. BMJ 1990;300:1458-1460.
    • (1990) BMJ , vol.300 , pp. 1458-1460
    • Slevin, M.L.1    Stubbs, L.2    Plant, H.J.3
  • 32
    • 0028967128 scopus 로고
    • Patient preferences for treatment of metastatic breast cancer: A study of women with early-stage breast cancer
    • McQuellon RP, Muss HB, Hoffman SL et al. Patient preferences for treatment of metastatic breast cancer: A study of women with early-stage breast cancer. J Clin Oncol 1995;13:858-868.
    • (1995) J Clin Oncol , vol.13 , pp. 858-868
    • McQuellon, R.P.1    Muss, H.B.2    Hoffman, S.L.3
  • 33
    • 33745928751 scopus 로고    scopus 로고
    • Management of advanced colorectal cancer: State of the art
    • Saunders M, Iveson T. Management of advanced colorectal cancer: State of the art. Br J Cancer 2006;95:131-138.
    • (2006) Br J Cancer , vol.95 , pp. 131-138
    • Saunders, M.1    Iveson, T.2
  • 34
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C, Andre T, Achille E et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study. J Clin Oncol 2004;22:229-237.
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3
  • 35
    • 24644432555 scopus 로고    scopus 로고
    • Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986
    • Köhne CH, van Cutsem E, Wils J et al. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. J Clin Oncol 2005;23:4856-4865.
    • (2005) J Clin Oncol , vol.23 , pp. 4856-4865
    • Köhne, C.H.1    van Cutsem, E.2    Wils, J.3
  • 36
    • 6444225487 scopus 로고    scopus 로고
    • A review of oxaliplatin and its clinical use in colorectal cancer
    • Grothey A, Goldberg RM. A review of oxaliplatin and its clinical use in colorectal cancer. Expert Opin Pharmacother 2004;5:2159-2170.
    • (2004) Expert Opin Pharmacother , vol.5 , pp. 2159-2170
    • Grothey, A.1    Goldberg, R.M.2
  • 37
    • 36048960109 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C study
    • Fuchs CS, Marshall J, Mitchell E et al. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C study. J Clin Oncol 2007;25:4779-4786.
    • (2007) J Clin Oncol , vol.25 , pp. 4779-4786
    • Fuchs, C.S.1    Marshall, J.2    Mitchell, E.3
  • 38
    • 43549108664 scopus 로고    scopus 로고
    • Safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in mCRC patients >65 years compared with those ≤65: The BICC-C study
    • Barrueco J, Marshall J, Mitchell E et al. Safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in mCRC patients >65 years compared with those ≤65: The BICC-C study. Proc Am Soc Clin Oncol 2007;25:4076.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 4076
    • Barrueco, J.1    Marshall, J.2    Mitchell, E.3
  • 39
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000;18:2938-2947.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 40
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial. Lancet 2000;355:1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 41
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz LB, Cox JV, Blanke C et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 2000;343:905-914.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 42
    • 2642529751 scopus 로고    scopus 로고
    • Is age a prognostic factor of toxicity and efficacy in patients (pts) with metastatic colorectal cancer (MCRC) receiving irinotecan in combination with 5FU/folinic acid (FA)
    • Rougier P, Mitry E, Cunningham D et al. Is age a prognostic factor of toxicity and efficacy in patients (pts) with metastatic colorectal cancer (MCRC) receiving irinotecan in combination with 5FU/folinic acid (FA). Proc Am Soc Clin Oncol 2003;22:1072.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 1072
    • Rougier, P.1    Mitry, E.2    Cunningham, D.3
  • 43
    • 33846042717 scopus 로고    scopus 로고
    • Comparison of the tolerance and efficacy of LV5FU2-CPT11 and FOLFIRI regimens in front-line treatment of advanced colorectal cancer - a pooled analysis of 254 patients included in 2 randomised trials
    • Mitry E, Tournigand C, André T et al. Comparison of the tolerance and efficacy of LV5FU2-CPT11 and FOLFIRI regimens in front-line treatment of advanced colorectal cancer - a pooled analysis of 254 patients included in 2 randomised trials. Proc Am Soc Clin Oncol 2004;22:3576.
    • (2004) Proc Am Soc Clin Oncol , vol.22 , pp. 3576
    • Mitry, E.1    Tournigand, C.2    André, T.3
  • 44
    • 29144469349 scopus 로고    scopus 로고
    • Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: A phase II trial
    • Souglakos J, Pallis A, Kakolyris S et al. Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: A phase II trial. Oncology 2005;69:384-390.
    • (2005) Oncology , vol.69 , pp. 384-390
    • Souglakos, J.1    Pallis, A.2    Kakolyris, S.3
  • 45
    • 33751073739 scopus 로고    scopus 로고
    • Irinotecan in first line therapy of elderly and non-elderly patients with metastatic colorectal cancer: Meta-analysis of three trials investigating 5-FU and irinotecan
    • Folprecht G, Rougier P, Saltz L et al. Irinotecan in first line therapy of elderly and non-elderly patients with metastatic colorectal cancer: Meta-analysis of three trials investigating 5-FU and irinotecan. Proc Am Soc Clin Oncol 2006;24:3578.
    • (2006) Proc Am Soc Clin Oncol , vol.24 , pp. 3578
    • Folprecht, G.1    Rougier, P.2    Saltz, L.3
  • 46
    • 0032585232 scopus 로고    scopus 로고
    • Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
    • Cunningham D, Pyrhonen S, James RD et al. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 1998;352:1413-1418.
    • (1998) Lancet , vol.352 , pp. 1413-1418
    • Cunningham, D.1    Pyrhonen, S.2    James, R.D.3
  • 47
    • 0032585197 scopus 로고    scopus 로고
    • Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
    • Rougier P, Van Cutsem E, Bajetta E et al. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 1998;352:1407-1412.
    • (1998) Lancet , vol.352 , pp. 1407-1412
    • Rougier, P.1    Van Cutsem, E.2    Bajetta, E.3
  • 48
    • 7944223833 scopus 로고    scopus 로고
    • Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy
    • Chau I, Norman AR, Cunningham D et al. Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Br J Cancer 2004;91:1453-1458.
    • (2004) Br J Cancer , vol.91 , pp. 1453-1458
    • Chau, I.1    Norman, A.R.2    Cunningham, D.3
  • 49
    • 0042478012 scopus 로고    scopus 로고
    • Influence of age on the pharmacokinetics of irinotecan (CPT-11) and its metabolites, SN-38 and SN-38 glucuronide (SN-38G), in patients with previously treated colorectal cancer
    • Schaaf L, Ichpurani N, Elfring G et al. Influence of age on the pharmacokinetics of irinotecan (CPT-11) and its metabolites, SN-38 and SN-38 glucuronide (SN-38G), in patients with previously treated colorectal cancer Proc Am Soc Clin Oncol 1997;15:708.
    • (1997) Proc Am Soc Clin Oncol , vol.15 , pp. 708
    • Schaaf, L.1    Ichpurani, N.2    Elfring, G.3
  • 50
    • 43549091212 scopus 로고    scopus 로고
    • Camptosar® (irinotecan hydrochloride injection) Prescribing Information. New York: Pharmacia & Upjohn Co, revised June 2006.
    • Camptosar® (irinotecan hydrochloride injection) Prescribing Information. New York: Pharmacia & Upjohn Co, revised June 2006.
  • 51
    • 9144256327 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863
    • Venook AP, Enders Klein C, Fleming G et al. A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863. Ann Oncol 2003;14:1783-1790.
    • (2003) Ann Oncol , vol.14 , pp. 1783-1790
    • Venook, A.P.1    Enders Klein, C.2    Fleming, G.3
  • 52
    • 33745725765 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of intravenous irinotecan in refractory solid tumor patients with hepatic dysfunction
    • Schaaf LJ, Hammond LA, Tipping SJ et al. Phase I and pharmacokinetic study of intravenous irinotecan in refractory solid tumor patients with hepatic dysfunction. Clin Cancer Res 2006;12:3782-3791.
    • (2006) Clin Cancer Res , vol.12 , pp. 3782-3791
    • Schaaf, L.J.1    Hammond, L.A.2    Tipping, S.J.3
  • 53
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracilleucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM et al. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracilleucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004;22:1209-1214.
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3
  • 54
    • 0010521320 scopus 로고    scopus 로고
    • Oxaliplatin/5 FU/LV is feasible, safe and active in elderly colorectal cancer (CRC) patients
    • Tabah-Fisch I, Maindrault-Goebel F, Benavides M et al. Oxaliplatin/5 FU/LV is feasible, safe and active in elderly colorectal cancer (CRC) patients. Proc Am Soc Clin Oncol 2002;21:556.
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 556
    • Tabah-Fisch, I.1    Maindrault-Goebel, F.2    Benavides, M.3
  • 55
    • 25444443120 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients
    • Rosati G, Cordio S, Tucci A et al. Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients. Oncology 2005;69:122-129.
    • (2005) Oncology , vol.69 , pp. 122-129
    • Rosati, G.1    Cordio, S.2    Tucci, A.3
  • 56
    • 8444224072 scopus 로고    scopus 로고
    • Age-independent benefit of chronotherapy with 5-fluorouracil, leucovorin, and oxaliplatin in patients with metastatic colorectal cancer within multicenter randomized phase III trials
    • Levi F, Zidani R, Focan C et al. Age-independent benefit of chronotherapy with 5-fluorouracil, leucovorin, and oxaliplatin in patients with metastatic colorectal cancer within multicenter randomized phase III trials. Proc Am Soc Clin Oncol 2002;21:1431.
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 1431
    • Levi, F.1    Zidani, R.2    Focan, C.3
  • 57
    • 1842741640 scopus 로고    scopus 로고
    • A study of capecitabine in elderly patients as first line treatment in advanced or metastatic colorectal cancer
    • Escudero P, Verge V, Feliu J et al. A study of capecitabine in elderly patients as first line treatment in advanced or metastatic colorectal cancer. Proc Am Soc Clin Oncol 2003;22:3114.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 3114
    • Escudero, P.1    Verge, V.2    Feliu, J.3
  • 58
    • 43549109677 scopus 로고    scopus 로고
    • A phase II study of capecitabine (X) in elderly patients (p) as 1st line treatment for patients (pts) with advanced of metastatic colorectal cancer (MCRC)
    • Feliú J, Escudero P, Losa F et al. A phase II study of capecitabine (X) in elderly patients (p) as 1st line treatment for patients (pts) with advanced of metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 2004;22:3567.
    • (2004) Proc Am Soc Clin Oncol , vol.22 , pp. 3567
    • Feliú, J.1    Escudero, P.2    Losa, F.3
  • 59
    • 21244497388 scopus 로고    scopus 로고
    • Capecitabine as adjuvant treatment for stage III colon cancer
    • Twelves C, Wong A, Nowacki MP et al. Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med 2005;352:2696-2704.
    • (2005) N Engl J Med , vol.352 , pp. 2696-2704
    • Twelves, C.1    Wong, A.2    Nowacki, M.P.3
  • 60
    • 1842691339 scopus 로고    scopus 로고
    • Capecitabine (C) and irinotecan (I) (CAPIRI): A good combination in elderly patients (pts) with advanced colorectal cancer (ACRC) as first-line chemotherapy (CT). Preliminary results of a phase II trial
    • Bollina R, Beretta G, Toniolo D et al. Capecitabine (C) and irinotecan (I) (CAPIRI): A good combination in elderly patients (pts) with advanced colorectal cancer (ACRC) as first-line chemotherapy (CT). Preliminary results of a phase II trial. Proc Am Soc Clin Oncol 2003;22:1332.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 1332
    • Bollina, R.1    Beretta, G.2    Toniolo, D.3
  • 61
    • 34548310721 scopus 로고    scopus 로고
    • Capecitabine plus irinotecan versus 5-FU/FA/irinotecan ± celecoxib in first line treatment of metastatic colorectal cancer (CRC). Long-term results of the prospective multicenter EORTC phase III study 40015
    • De Grève J, Koehne C, Hartmann J et al. Capecitabine plus irinotecan versus 5-FU/FA/irinotecan ± celecoxib in first line treatment of metastatic colorectal cancer (CRC). Long-term results of the prospective multicenter EORTC phase III study 40015. Proc Am Soc Clin Oncol 2006;24:3577.
    • (2006) Proc Am Soc Clin Oncol , vol.24 , pp. 3577
    • De Grève, J.1    Koehne, C.2    Hartmann, J.3
  • 62
    • 33750909668 scopus 로고    scopus 로고
    • A randomized trial of first-line irinotecan/fluoropyrimidine combinations with or without celecoxib in metastatic colorectal cancer (BICC-C)
    • Fuchs C, Marshall J, Mitchell E et al. A randomized trial of first-line irinotecan/fluoropyrimidine combinations with or without celecoxib in metastatic colorectal cancer (BICC-C). Proc Am Soc Clin Oncol 2006;24:3506.
    • (2006) Proc Am Soc Clin Oncol , vol.24 , pp. 3506
    • Fuchs, C.1    Marshall, J.2    Mitchell, E.3
  • 63
    • 33644839646 scopus 로고    scopus 로고
    • Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: Post hoc analysis of a large phase II study
    • Twelves CJ, Butts CA, Cassidy J et al. Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: Post hoc analysis of a large phase II study. Clin Colorectal Cancer 2005;5:101-107.
    • (2005) Clin Colorectal Cancer , vol.5 , pp. 101-107
    • Twelves, C.J.1    Butts, C.A.2    Cassidy, J.3
  • 64
    • 22244477362 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: Final results of the Southern Italy Cooperative Oncology Group Trial 0108
    • Comella P, Natale D, Farris A et al. Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: Final results of the Southern Italy Cooperative Oncology Group Trial 0108. Cancer 2005;104:282-289.
    • (2005) Cancer , vol.104 , pp. 282-289
    • Comella, P.1    Natale, D.2    Farris, A.3
  • 65
    • 33645731984 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin) as first-line treatment of elderly patients over 70 years of age with advanced colorectal cancer
    • Feliú J, Salud A, Escudero P et al. XELOX (capecitabine plus oxaliplatin) as first-line treatment of elderly patients over 70 years of age with advanced colorectal cancer. Br J Cancer 2006;94:969-975.
    • (2006) Br J Cancer , vol.94 , pp. 969-975
    • Feliú, J.1    Salud, A.2    Escudero, P.3
  • 66
    • 2942638081 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
    • Cassidy J, Tabernero J, Twelves C et al. XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol 2004;22:2084-2091.
    • (2004) J Clin Oncol , vol.22 , pp. 2084-2091
    • Cassidy, J.1    Tabernero, J.2    Twelves, C.3
  • 67
    • 0036533777 scopus 로고    scopus 로고
    • Phase II study of capecitabine and oxaliplatin in first- and second-line treatment of advanced or metastatic colorectal cancer
    • Borner MM, Dietrich D, Stupp R et al. Phase II study of capecitabine and oxaliplatin in first- and second-line treatment of advanced or metastatic colorectal cancer. J Clin Oncol 2002;20:1759-1766.
    • (2002) J Clin Oncol , vol.20 , pp. 1759-1766
    • Borner, M.M.1    Dietrich, D.2    Stupp, R.3
  • 68
    • 0141725528 scopus 로고    scopus 로고
    • Phase II study of capecitabine and oxaliplatin as first-line treatment in advanced colorectal cancer
    • Zeuli M, Nardoni C, Pino MS et al. Phase II study of capecitabine and oxaliplatin as first-line treatment in advanced colorectal cancer. Ann Oncol 2003;14:1378-1382.
    • (2003) Ann Oncol , vol.14 , pp. 1378-1382
    • Zeuli, M.1    Nardoni, C.2    Pino, M.S.3
  • 69
    • 32244448355 scopus 로고    scopus 로고
    • Benefits and risks of palliative capecitabine based therapy to elderly patients with advanced colorectal cancer: Danish single centre experience
    • Jensen SA, Lønborg JT, Sorensen JB. Benefits and risks of palliative capecitabine based therapy to elderly patients with advanced colorectal cancer: Danish single centre experience. Acta Oncol 2006;45:67-76.
    • (2006) Acta Oncol , vol.45 , pp. 67-76
    • Jensen, S.A.1    Lønborg, J.T.2    Sorensen, J.B.3
  • 70
    • 43549084892 scopus 로고    scopus 로고
    • Capecitabine (Cap) and oxaliplatin (Ox) in elderly and/or frail patients with metastatic colorectal cancer: The FOCUS2 trial
    • Seymour MT, Maughan TS, Wasan HS et al. Capecitabine (Cap) and oxaliplatin (Ox) in elderly and/or frail patients with metastatic colorectal cancer: The FOCUS2 trial. Proc Am Soc Clin Oncol 2007;25:9030.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 9030
    • Seymour, M.T.1    Maughan, T.S.2    Wasan, H.S.3
  • 71
    • 18144368022 scopus 로고    scopus 로고
    • Basel, Switzerland: Roche Pharmaceuticals Inc, revised April
    • Xeloda® (capecitabine tablets) Prescribing Information. Basel, Switzerland: Roche Pharmaceuticals Inc., revised April 2006.
    • (2006) Prescribing Information
    • Xeloda®1
  • 72
    • 33750167591 scopus 로고    scopus 로고
    • Tolerability of fluoropyrimidines appears to differ by region
    • Haller DG, Cassidy J, Clarke S et al. Tolerability of fluoropyrimidines appears to differ by region. Proc Am Soc Clin Oncol 2006;24:3514.
    • (2006) Proc Am Soc Clin Oncol , vol.24 , pp. 3514
    • Haller, D.G.1    Cassidy, J.2    Clarke, S.3
  • 73
    • 36849089518 scopus 로고    scopus 로고
    • Phase II study of uracil-tegafur with leucovorin in elderly (≥ 75 years old) patients with colorectal cancer: ECOG 1299
    • Hochster HS, Luo W, Popa EC et al. Phase II study of uracil-tegafur with leucovorin in elderly (≥ 75 years old) patients with colorectal cancer: ECOG 1299. J Clin Oncol 2007;25:5397-5402.
    • (2007) J Clin Oncol , vol.25 , pp. 5397-5402
    • Hochster, H.S.1    Luo, W.2    Popa, E.C.3
  • 74
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial. J Clin Oncol 2005;23:3697-3705.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 75
    • 28344438302 scopus 로고    scopus 로고
    • Arterial thromboembolic events (ATEs) in a pooled analysis of 5 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy
    • Skillings JR, Johnson DH, Miller F et al. Arterial thromboembolic events (ATEs) in a pooled analysis of 5 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy. Proc Am Soc Clin Oncol 2005;23:3019.
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 3019
    • Skillings, J.R.1    Johnson, D.H.2    Miller, F.3
  • 77
    • 43549105492 scopus 로고    scopus 로고
    • Cetuximab activity in elderly patients with extensively pretreated metastatic colorectal cancer
    • Presented at the, Barcelona, Spain, June 28-July 1
    • Bouchahda M, Bachet J, Andre T et al. Cetuximab activity in elderly patients with extensively pretreated metastatic colorectal cancer. Presented at the 8th World Congress on Gastrointestinal Cancers, Barcelona, Spain, June 28-July 1, 2006.
    • (2006) 8th World Congress on Gastrointestinal Cancers
    • Bouchahda, M.1    Bachet, J.2    Andre, T.3
  • 78
    • 43549112175 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Geriatric Oncology Consortium/Sanofi Aventis. Phase II study of oxaliplatin, capecitabine, and bevacizumab in the treatment of elderly patients with metastatic colorectal cancer. Available at http://www.clinicaltrials.gov/ct/show/NCT00120172. Accessed October 26, 2006.
    • ClinicalTrials.gov. Geriatric Oncology Consortium/Sanofi Aventis. Phase II study of oxaliplatin, capecitabine, and bevacizumab in the treatment of elderly patients with metastatic colorectal cancer. Available at http://www.clinicaltrials.gov/ct/show/NCT00120172. Accessed October 26, 2006.
  • 79
    • 43549123859 scopus 로고    scopus 로고
    • The impact of age on the overall chemotherapy (chemo) treatment (tx) of advanced (adv) colorectal (CRC) cancer in the community oncology setting (cos)
    • Presented at the, Orlando, FL, January 19-21
    • Koeller J, McKibbin T, Kwan P et al. The impact of age on the overall chemotherapy (chemo) treatment (tx) of advanced (adv) colorectal (CRC) cancer in the community oncology setting (cos). Presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium 2007, Orlando, FL, January 19-21, 2007.
    • (2007) American Society of Clinical Oncology Gastrointestinal Cancers Symposium
    • Koeller, J.1    McKibbin, T.2    Kwan, P.3
  • 80
    • 31444450593 scopus 로고    scopus 로고
    • Advances in the treatment of metastatic colorectal cancer
    • Goldberg RM. Advances in the treatment of metastatic colorectal cancer. The Oncologist 2005;10(suppl 3):40-48.
    • (2005) The Oncologist , vol.10 , Issue.SUPPL. 3 , pp. 40-48
    • Goldberg, R.M.1


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