Staphylococcus aureus stimulates neutrophil targeting chemokine expression in keratinocytes through an autocrine IL-1α signaling loop

Journal of Investigative Dermatology

Volumn 130, Issue 7, 2010, Pages 1866-1876

  Olaru, Florina ^a   Jensen, Liselotte E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOTEICHOIC ACID; MESSENGER RNA; NEUTRALIZING ANTIBODY; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR 2;

ARTICLE; BACTERIAL CELL WALL; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INNATE IMMUNITY; KERATINOCYTE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; STAPHYLOCOCCUS AUREUS;

ANTIBODIES, NEUTRALIZING; AUTOCRINE COMMUNICATION; CELL WALL; CELLS, CULTURED; CHEMOKINE CXCL1; CHEMOKINE CXCL2; CHEMOTAXIS, LEUKOCYTE; HUMANS; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; INTERLEUKIN-8; KERATINOCYTES; LIPOPOLYSACCHARIDES; NEUTROPHILS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDOGLYCAN; RECEPTORS, INTERLEUKIN-1; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS AUREUS; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2;

EID: 77953622206     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.37     Document Type: Article

References (30)

1. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801
2. Boraschi D, Tagliabue A (2006) The Interleukin-1 receptor family. Vitam Horm 74:229-254
3. DeLeo FR, Diep BA, Otto M (2009) Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin North Am 23:17-34
4. Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27:519-550
5. Fournier B, Philpott DJ (2005) Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev 18:521-540
6. Franchi L, Eigenbrod T, Munoz-Planillo R et al. (2009) The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 10:241-247
7. Gonzalez-Zorn B, Senna JPM, Fiette L et al. (2005) Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice. Infect Immun 73:1847-1851
8. Hashimoto M, Tawaratsumida K, Kariya H et al. (2006) Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components. Int Immunol 18:355-362
9. Horng T, Barton GM, Flavell RA et al. (2002) The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420:329-333
10. Ishii KJ, Koyama S, Nakagawa A et al. (2008) Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe 3:352-363
11. Jensen LE, Whitehead AS (2003a) Pellino2 activates the mitogen activated protein kinase pathway. FEBS Lett 545:199-202
12. Jensen LE, Whitehead AS (2003b) Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. J Immunol 171:1500-1506
13. Kraus D, Peschel A (2008) Staphylococcus aureus evasion of innate antimicrobial defense. Future Microbiol 3:437-451
14. Kristian SA, Lauth X, Nizet V et al. (2003) Alanylation of teichoic acids protects Staphylococcus aureus against Toll-like receptor 2-dependent host defense in a mouse tissue cage infection model. J Infect Dis 188:414-423
15. Lebre MC, van der Aar AMG, van Baarsen L et al. (2006) Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 127:331-341
16. Mempel M, Voelcker V, Kollisch G et al. (2003) Toll-like receptor expression in human keratinocytes: nuclear factor kB controlled gene activation by Staphylococcus aureus is Toll-like receptor 2 but not Toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol 121:1389-1396
17. Menzies BE, Kenoyer A (2006) Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human b-defensin 3 in skin keratinocytes. Infect Immun 74:6847-6854
18. Miller LS, O'Connell RM, Gutierrez MA et al. (2006) MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity 24:79-91
19. Miller LS, Pietras EM, Uricchio LH et al. (2007) Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol 179:6933-6942
20. Mölne L, Verdrengh M, Tarkowski A (2000) Role of neutrophil leukocytes in cutaneous infection caused by Staphylococcus aureus. Infect Immun 68:6162-6167
21. Morrison DK, Davis RJ (2003) Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 19:91-118
22. O'Neill LAJ (2008) The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol Rev 226:10-18
23. Rooijakkers SH, van Kessel KP, van Strijp JA (2005) Staphylococcal innate immune evasion. Trends Microbiol 13:596-601
24. Sanmiguel JC, Olaru F, Li J et al. (2009) Interleukin-1 regulates keratinocyte expression of T cell targeting chemokines through interleukin-1 receptor associated kinase-1 (IRAK1) dependent and independent pathways. Cell Signal 21:685-694
25. Sasaki T, Kano R, Sato H et al. (2003) Effects of staphylococci on cytokine production from human keratinocytes. Br J Dermatol 148:46-50
26. Takeuchi O, Hoshino K, Akira S (2000) Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 165:5392-5396
27. Takeuchi O, Hoshino K, Kawai T et al. (1999) Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11:443-451
28. van Belkum A (2006) Staphylococcal colonization and infection: homeostasis versus disbalance of human (innate) immunity and bacterial virulence. Curr Opin Infect Dis 19:339-344
29. Verdrengh M, Tarkowski A (1997) Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus. Infect Immun 65:2517-2521
30. Yamamoto M, Sato S, Hemmi H et al. (2002) Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420:324-329