Novel atypical nucleotide insertions specifically at VH-DH junction generate exceptionally long CDR3H in cattle antibodies

Molecular Immunology

Volumn 47, Issue 11-12, 2010, Pages 2119-2128

  Koti, Madhuri ^a   Kataeva, Galina ^b   Kaushik, Azad Kumar ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Antibody diversity; Bovine DH gene segment; CDR3H

Indexed keywords

AMINO ACID; ANTIBODY; ASPARAGINE; IMMUNOGLOBULIN HEAVY CHAIN; NUCLEOTIDE; PROLINE; PROTEIN CDR3H; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; CATTLE; CODON; CONTROLLED STUDY; DELETION MUTANT; FETUS; GENE CLUSTER; GENE EXPRESSION; GENE INSERTION SEQUENCE; GENE LOCUS; GENETIC CODE; GENETIC CONSERVATION; GENETIC ORGANIZATION; GENETIC POLYMORPHISM; GENETIC RECOMBINATION; GENETIC VARIABILITY; GERM LINE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOMATIC MUTATION; VDJ EXON;

ANIMALS; ANTIBODY DIVERSITY; CATTLE; COMPLEMENTARITY DETERMINING REGIONS; GENE REARRANGEMENT, B-LYMPHOCYTE; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN VARIABLE REGION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

BOS; BOVINAE; GNATHOSTOMATA (VERTEBRATE);

EID: 77953615460     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.02.014     Document Type: Article

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