The sheep Ig variable region repertoire consists of a single VH family

Journal of Immunology

Volumn 156, Issue 6, 1996, Pages 2163-2170

  Dufour, Vinciane ^a,b   Malinge, Sophie ^a   Nau, François ^a  

^a CNRS   (France)

^b IBMIG Institut de Biologie Moleculaire et dIngenierie Genetique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIODIVERSITY; DNA LIBRARY; GENE ISOLATION; GENE SEQUENCE; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; RESTRICTION FRAGMENT; SHEEP;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; BLOTTING, SOUTHERN; DNA; GENE EXPRESSION REGULATION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PSEUDOGENES; SHEEP; SPLEEN;

EID: 0029922831     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575.
2. Alt, F W., K. Blackwell, and G. D. Yancopoulos. 1987. Development of the primary antibody repertoire. Science 238:1079.
3. Desiderio, S V., G. D. Yancopoulos, M. Paskind, E Thomas, M A Boss, N. Landau, F. W. Alt, and D. Baltimore. 1984. Insertion of N regions into heavy chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature 331:627.
4. Lebecque, S. G., and P. J Gearhart. 1990 Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is ∼1 kb from V(D)J gene J Exp. Med. 172:1717.
5. H genes. Cell 27.573.
6. Reynaud, C.-A., B. Bertocci, A. Dahan, and J. C. Weill. 1994. Formation of the B-cell repertoire: ontogenesis, regulation of Ig gene rearrangement, and diversification by gene conversion. Adv. Immunol. 57:353.
7. H gene of the chicken with a high incidence in the D region. Cell 59:171.
8. Becker, R. S., and K. L. Knight. 1990. Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits Cell 6:987
9. H gene usage and generation of antibody diversity in rabbit Annu Rev. Immunol. 10:593.
10. H diversification by gene conversion-like and hypermutation mechanisms Immunity 1:647.
11. Xu, B., and E. Selsing 1994. Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene. Science 265:1590
12. Sanz, I. 1991. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J. Immunol 147:1720
13. Rathbun, G., J. Herman, G Yancopoulos, and F. W. Alt. 1989. Organization and expression of the mammalian heavy-chain variable-region locus. In Immunoglobulin Genes. T. Honjo, F. W. Alt, and T. H. Rabbitts, eds. Academic Press, Inc., London, p. 63
14. H repertoire. Immunol. Today 16:237.
15. H gene families J. Immunol. 147:3215.
16. Roman, T., and J. Charlemagne. 1994. The immunoglobulin repertoire of the rainbow trout (Oncorhynchus mykiss): definition of nine Igh-V families. Immunogenetics 40.210
17. Ghaffari, S. H., and C J. Lobb. 1991. Heavy chain variable region gene families evolved early in phylogeny: Ig complexity in fish. J. Immunol. 146:1037
18. H sequences in the channel catfish Eur. J. Immunogenet. 18:393.
19. H chromosomal region J. Immunol. 140:1651.
20. HIII. J. Immunol. 153:5618
21. H segmental elements during vertebrate evolution. Nature 320:546.
22. H gene loci in a primitive vertebrate. EMBO J. 7:3413.
23. Hinds-Frey, K. R., H. Nishikata, R. T. Litman, and G. W. Litman. 1993. Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity J Exp. Med. 178:815.
24. Reynaud, C.-A., C. R Mackay, R. G. Muller, and J. C. Weill. 1991. Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep deal Peyer's patches. Cell 64:995.
25. Reynolds, J D., and B. Morris 1983 The evolution and involution of sheep Peyer's patches in fetal and postnatal sheep Eur J. Immunol 13.627.
26. Reynolds, J. D. 1986. Evidence of extensive lymphocyte death in sheep Peyer's patches. I. A comparison of lymphocyte production and export. J. Immunol. 136: 2005.
27. Reynaud, C.-A., C. Garcia, W. R. Hein, and J. C. Weill. 1995. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80:115.
28. Patri, S., and F. Nau 1992. Isolation and sequence of a cDNA coding for the immunoglobulin μ chain of the sheep. Mol. Immunol. 29:829.
29. Foley, R. C., and K. J. Beh. 1989. Isolation and sequence of sheep Ig H and L chain cDNA J. Immunol. 142:706
30. Patri, S. 1992. Étude des gènes codant pour les chaînes lourdes d'immunoglobulines de mouton. Doctoral dissertation. University of Poitiers, Poitiers, France.
31. Clarkson, C A., D. Beale, J. W. Coadwell, and D. B. A. Symons. 1993. Sequence of ovine Ig γ2 constant region heavy chain cDNA and molecular modelling of ruminant IgG isotypes. Mol Immunol. 30:1195.
32. Engwerda, C R., R A Sandeman, S J. Stuart, and M. Sandeman. 1992. Isolation and sequence of sheep immunoglobulin E heavy-chain complementary DNA. Vet. Immunol. Immunopathol. 34:115.
33. Davis, L. G., M. D Dibner, and J. F. Battey. 1986. DNA preparation from cultured cells and tissue In Basic Methods in Molecular Biology. Elsevier Science Publishing Co , New York, p. 47.
34. Cogne, M., P. Aucouturier, A. Brizard, B. Dreyfus, F Duarte, and J. L Preud'homme 1993. Complete variable region deletion in a μ heavy chain disease protein (ROUL). Correlation with light chain secretion. Leuk. Res. 17:S27.
35. Sanger, F., S Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors Proc. Natl. Acad. Sci USA 74:5463.
36. Chirgwin, J. M., A E. Przybyla, R. J MacDonald, and W J. Rutter 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
37. Devereux, J., P Haeberli, and O. Smithies. 1984 A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12.387.
38. Kabat, E. A , T. T Wu, H M Perry, K. S Gottesman, and C. Foeller 1991. Sequences of Proteins of Immunological Interest, 5th ed. National Institutes of Health, Bethesda.
39. Brodeur, P. H , and R. Riblet. 1984. The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes compose seven families of homologous genes. Eur. J. Immunol. 14.922
40. Jackson, T., B. A. Morris, and P. G. Sanders 1992. Nucleotide sequences and expression of cDNAs for a bovine anti-testosterone monoclonal IgG1 antibody. Mol Immunol 29.667.
41. Navarro, P. A , D. P Barbis, D. F Antczak, and J. E. Butler. 1994. The complete cDNA and deduced amino acid sequence of equine IgE. Mol. Immunol. 32:1.
42. Wellman, A. A., and C. F. Meares 1990 Sequences of the Lym-1 antibody heavy and light chain variable regions. Nucleic Acids Res. 18:5281
43. Milili, M , F. Le Deist, G. De Saint-Basile, A Fisher, M Fougereau, and C. Schiff 1993. Bone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire. J Clin. Invest 91: 1616.
44. Wu, T. T., and E. A Kabat. 1970. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J. Exp Med. 132.211.
45. Armour, K L., P. R Tempest, P. H. Fawcett, M. L. Fernie, S. I. King, P. White, G. Taylor, and W J. Harris. 1994. Sequences of heavy and light chain variable regions from four bovine immunoglobulins. Mol. Immunol 31:1369.
46. Tutter, A., and R. Riblet. 1989. Conservation of an immunoglobutin variable-region gene family indicates a specific, noncoding function. Proc Natl. Acad. Sci. USA 86.7460.