6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases (Proceedings of the National Academy of Sciences of the United States of America (2008) 105 (2773-2778) Doi: 10.1073/pnas.0708281105);6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 8, 2008, Pages 2773-2778

  Wood, Edgar R ^a   Shewchuk, Lisa M ^a   Ellis, Byron ^a   Brignola, Perry ^a   Brashear, Ronald L ^a   Caferro, Thomas R ^a   Dickerson, Scott H ^a   Dickson, Hamilton D ^a   Donaldson, Kelly H ^a   Gaul, Michael ^a   Griffin, Robert J ^a   Hassell, Anne M ^a   Keith, Barry ^a   Mullin, Robert ^a   Petrov, Kimberly G ^a   Reno, Michael J ^a   Rusnak, David W ^a   Tadepalli, Sarva M ^a   Ulrich, John C ^a   Wagner, Craig D ^a   Vanderwall, Dana E ^a   Waterson, Alex G ^a   Williams, Jon D ^a   White, Wendy L ^a   Uehling, David E ^a   more..

^a GLAXOSMITHKLINE   (United States)

Author keywords

Alkylation; Enzyme; Inhibitors; Irreversible; Thiol

Indexed keywords

6 ETHYNYLTHIENO[2,3 D]PYRIMIDIN 4 ANILINE; 6 ETHYNYLTHIENO[3,2 D]PYRIMIDIN 4 ANILINE; ANILINE DERIVATIVE; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; THIOL DERIVATIVE; ALKYNE; DRUG DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; ISATIN; PROPARGYLIC SULFONE; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; THIENOPYRIMIDINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN FAMILY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANIMAL; CELL PROLIFERATION; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; FEMALE; METABOLISM; MOUSE; MOUSE MUTANT;

ALKYNES; ANILINE COMPOUNDS; ANIMALS; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ISATIN; MASS SPECTROMETRY; MICE; MICE, SCID; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 42949149763     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802448105     Document Type: Erratum

References (17)