Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease

International Journal of Obesity

Volumn 30, Issue 2, 2006, Pages 209-213

  Porreca, E ^a   Di Febbo, C ^a   Pintor, S ^a   Baccante, G ^a   Gatta, V ^a   Moretta, V ^a   Di Nisio, M ^a   Palka, C ^b   Cuccurullo, F ^a   Stuppia, L ^a,c  

^a UNIVERSITY OF CHIETI   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c CNR   (Italy)

Author keywords

Cardiovascular risk; LEP gene; Leptin; Polymorphism

Indexed keywords

LEPTIN; MICROSATELLITE DNA;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; DNA POLYMORPHISM; FEMALE; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NUCLEIC ACID ANALYSIS; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; SMOKING; UNIVARIATE ANALYSIS;

3' UNTRANSLATED REGIONS; AGE FACTORS; AGED; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; DIABETES MELLITUS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; LEPTIN; LOGISTIC MODELS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; POLYMORPHISM, GENETIC; SEX FACTORS; SMOKING;

EID: 32544434818     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803150     Document Type: Article

References (20)

1. Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 1999; 130: 671-680.
2. Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbidy obesity. Nat Genet 1998; 18: 213-215.
3. Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F et al. Phenotipic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. PNAS 2004; 101: 4531-4536.
4. Shintani M, Ikegami H, Yamato E, Kawaguchi Y, Fujisawa T, Nakagawa Y et al. A novel microsatellite polymorphism in the human OB gene: a highly polymorphic marker for linkage analysis. Diabetologia 1996; 39: 1398-1401.
5. Shintani M, Ikegami H, Fujisawa T, Kawaguchi Y, Ohishi M, Katsuya T et al. Leptin gene polymorphism is associated with hypertension independent of obesity. J Clin Endocrinol Metab 2002; 87: 2909-2912.
6. Onions KL, Hunt SC, Rutkowski MP, Klanke CA, Ru Su Y, Reif M et al. Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. Hypertension 1998; 31: 1230-1234.
7. Duggirala R, Stern MP, Mitchell BD, Reinhart LJ, Shipman PA, Uresandi OC et al. Quantitative variation in obesity-related trait and insulin precursors linked to the OB gene region on human chromosome 7. Am J Human Genet 1996; 59: 694-703.
8. Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A et al. Plasma leptin and the risk of cardiovascular disease in West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 2001; 104: 3052-3056.
9. Soderberg S, Ahren B, Jansson JH, Johnson O, Hallmans G, Asplund K et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med 1999; 246: 409-418.
10. Soderberg S, Stegmayr B, Ahlbeck-Glader C, Slunga-Birgander L, AhrOlson T. High leptin levels are associated with stroke. Cerebrovasc Dis 2003; 15: 63-66.
11. Oksanen L, Ohman M, Heiman M, Kainulainen K, Kaprio J, Mustajoki P et al. Markers for the gene ob and serum leptin levels in human morbid obesity. Hum Genet 1997; 99: 559-564.
12. Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P. Stroke. Lancet 2003; 362: 1211-1224.
13. Lupker RV, Apple FS, Christenson RH, Crow RS, Fortmann SP, Goff D et al. Case definitions for acute coronary heart disease in epidemiology and clinical Research Studies. Circulation 2003; 108: 2543-2549.
14. Eckel RH, Krauss RM, for the AHA Nutrition Committee. American Heart Association call to action: obesity as a major risk factor for coronary heart disease. Circulation 1998; 97: 2099-2100.
15. Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497.
16. Thompson WD. Statistical analysis of case-control studies. Epidemiol Rev 1994; 16: 33-50.
17. Li WD, Li D, Wang S, Zhang S, Zhao H, Price RA. Linkage and linkage disequilibrium mapping of genes influencing human obesity in chromosome region 7q22.1-7q35. Diabetes 2003; 52: 1557-1561.
18. Jiang Y, Jiang Y, Wilk JB, Borecki I, Williamson S, DeStefano AL et al. Common Variants in the 5′ Region of the Leptin Gene Are Associated with Body Mass Index in Men from the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet 2004; 75: 220-230.
19. Gaukrodger N, Mayosi BM, Imrie H, Avery P, Baker M, Connell JM et al. A rare variant of the leptin gene has large effects on blood pressure and carotid intima-medial thickness: a study of 1428 individuals in 248 families. J Med Genet 2005; 42: 474-478.
20. Wallerstedt SM, Eriksson AL, Niklason A, Ohlsson C, Hedner T. Serum leptin and myocardial infarction in hypertension. Blood Pressure 2004; 13: 243-246.