An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis

Hepatobiliary and Pancreatic Diseases International

Volumn 7, Issue 1, 2008, Pages 51-57

  Jiang, Ming De ^a   Zheng, Shu Mei ^a   Xu, Hui ^a   Zeng, Wei Zheng ^a   Zhang, Yong ^a   Sun, Hao Ping ^a   Wang, Yun Xia ^a   Qin, Jian Ping ^a   Wu, Xiao Ling ^a  

^a CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Extracellular signal regulated kinase; Hepatic fibrosis; Hepatic stellate cell

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETALDEHYDE; COLLAGEN TYPE 1; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL STIMULATION; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL STUDY; FLOW CYTOMETRY; GENE EXPRESSION; LIVER FIBROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL;

ACETALDEHYDE; ANIMALS; CELLS, CULTURED; COLLAGEN TYPE I; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; G0 PHASE; G1 PHASE; HEPATOCYTES; LIVER CIRRHOSIS; MAP KINASE SIGNALING SYSTEM; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1;

EID: 39049092643     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Parsons CJ, Takashima M, Rippe RA. Molecular mechanisms of hepatic fibrogenesis. J Gastroenterol Hepatol 2007;22:S79-84.
2. Friedman SL. Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 2004;1:98-105.
3. Kisseleva T, Brenner DA. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol 2007;22:S73-78.
4. Rockey DC. Antifibrotic therapy in chronic liver disease. Clin Gastroenterol Hepatol 2005;3:95-107.
5. Vera M, Nieto N. Hepatic stellate cells and alcoholic liver disease. Rev Esp Enferm Dig 2006;98:674-684.
6. Novitskiy G, Traore K, Wang L, Trush MA, Mezey E. Effects of ethanol and acetaldehyde on reactive oxygen species production in rat hepatic stellate cells. Alcohol Clin Exp Res 2006;30:1429-1435.
7. Siegmund SV, Dooley S, Brenner DA. Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis 2005;23:264-274.
8. Marra F, Delogu W, Petrai I, Pastacaldi S, Bonacchi A, Efsen E, et al. Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2004;287:G18-26.
9. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002;298:1911-1912.
10. Jiang MD, Ma HD, Zhong XF, Xie FW, Zeng WZ. Effects of Erk signal transduction on the cell cycle of rat hepatic stellate cells stimulated by acetaldehyde. Zhonghua Gan Zang Bing Za Zhi 2003;11:650-653.
11. Chen YX, Chen SW, Zhang XR, Liu S, Xie WF, Li S. Inhibition of proliferation of hepatic stellate cells by taurine is mediated via regulating cell cycle proteins. Zhonghua Gan Zang Bing Za Zhi 2005;13:571-574.
12. Hoshino R, Tanimura S, Watanbe K, Kataoka T, Kohno M. Blockade of the extracellular singal-regulated kinase pathway induces marked G1 cell arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27 (Kip 1). Biol Chem 2001; 276:2686-2692.
13. Ussar S, Voss T. MEK1 and MEK2, different regulators of the G1/S transition. J Biol Chem 2004;279:43861-43869.
14. Wang JH, Batey RG, George. Role of ethanol in the regulation of hepatic stellate cell function. World J Gastroenterol 2006;12:6926-6932.
15. Jiang MD, Ma HD, Xie FW, Zhong XF, Zeng WZ, Qin JP, et al. Effects of extracellular signal-regulated kinase on cell cycle and functions of rat cultured hepatic stellate cells stimulated by acetaldehyde. Chin J Dig 2003;23:735-738.
16. Svegliati-Baroni G, Inagaki Y, Rincon-Sanchez AR, Else C, Saccomanno S, Benedetti A, et al. Early response of alpha 2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent. Hepatology 2005;42:343-352.
17. Gonzalo T, Beljaars L, van de Bovenkamp M, Temming K, van Loenen AM, Reker-Smit C, et al. Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells. J Pharmacol Exp Ther 2007;321:856-865.
18. Xu XB, He ZP, Liang ZQ, Leng XS. Obstruction of TGF-beta1 signal transduction by anti-Smad4 gene can therapy experimental liver fibrosis in the rat. Zhonghua Gan Zang Bing Za Zhi 2004;12:263-266.
19. Lee BS, Kim NJ, Jeong HY, Lee HY, Kang DY, Noh SM. Changes in serum cytokine concentration: a morphological study of liver cirrhosis induced by common bile duct ligation in rats. Korean J Intern Med 2003;18:6-12.
20. Tsukada S, Westwick JK, Ikejima K, Sato N, Rippe RA. SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. J Biol Chem 2005;280:10055-10064.
21. Lü XY, Liu Q, Chen YY, Song YH, Lü ZP. Therapeutic effect of Hongbeiyegen on alcohol-induced rat hepatic fibrosis. Nan Fang Yi Ke Da Xue Xue Bao 2007;27:153-155.