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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
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This article describes several novel genetic associations for common diseases in the Wellcome Trust case-control studies
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661-678. This article describes several novel genetic associations for common diseases in the Wellcome Trust case-control studies.
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Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005, 352:1685-1695.
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A common allele on chromosome 9 associated with coronary heart disease
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This is one of the first articles that described association between the chromosome 9p21 region and risk of CAD
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McPherson R, Pertsemlidis A, Kavaslar N, et al.: A common allele on chromosome 9 associated with coronary heart disease. Science 2007, 316:1488-1491. This is one of the first articles that described association between the chromosome 9p21 region and risk of CAD.
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Gudbjartsson, D.F.12
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Palsson, S.19
Einarsdottir, H.20
Gunnarsdottir, S.21
Gylfason, A.22
Vaccarino, V.23
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Reilly, M.P.25
Granger, C.B.26
Austin, H.27
Rader, D.J.28
Shah, S.H.29
Quyyumi, A.A.30
Gulcher, J.R.31
Thorgeirsson, G.32
Thorsteinsdottir, U.33
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Stefansson, K.35
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41649085340
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Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
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Schunkert H, Gotz A, Braund P, et al.: Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation 2008, 117:1675-1684.
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Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p
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Broadbent HM, Peden JF, Lorkowski S, et al.: Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet 2008, 17:806-814.
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The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
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Helgadottir A, Thorleifsson G, Magnusson KP, et al.: The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008, 40:217-224.
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Jarinova O, Stewart AF, Roberts R, et al.: Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler Thromb Vasc Biol 2009, 29:1671-1677.
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Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants
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Folkersen L, Kyriakou T, Goel A, et al.: Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants. PLoS One 2009, 4:e7677.
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Samani NJ, Erdmann J, Hall AS, et al.: Genomewide association analysis of coronary artery disease. N Engl J Med 2007, 357:443-453. This article reported on new loci with a robust association with CAD. (Pubitemid 47204873)
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New England Journal of Medicine
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Mayer, B.6
Dixon, R.J.7
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Braund, P.9
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Konig, I.R.12
Stevens, S.E.13
Szymczak, S.14
Tregouet, D.-A.15
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Pahlke, F.17
Pollard, H.18
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Cambien, F.20
Fischer, M.21
Ouwehand, W.22
Blankenberg, S.23
Balmforth, A.J.24
Baessler, A.25
Ball, S.G.26
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Braenne, I.28
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Deloukas, P.30
Tobin, M.D.31
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Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
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The article describes the largest GWA study of premature MI to date, in which eight different loci for susceptibility to MI were robustly associated
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Kathiresan S, Voight BF, Purcell S, et al.: Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009, 41:334-341. The article describes the largest GWA study of premature MI to date, in which eight different loci for susceptibility to MI were robustly associated.
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Nat Genet
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Kathiresan, S.1
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Common variants at 30 loci contribute to polygenic dyslipidemia
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The article describes the identification of many common loci for plasma LDL cholesterol, HDL cholesterol, and triglyceride concentrations, all of which are pathophysiologically important factors in atherothrombosis
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Kathiresan S, Willer CJ, Peloso GM, et al.: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009:41:56-65. The article describes the identification of many common loci for plasma LDL cholesterol, HDL cholesterol, and triglyceride concentrations, all of which are pathophysiologically important factors in atherothrombosis.
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Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
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Tregouet DA, Konig IR, Erdmann J, et al.: Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet 2009, 41:283-285.
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Genetic variants associated with Lp(a) lipoprotein level and coronary disease
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Clarke R, Peden JF, Hopewell JC, et al.: Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med 2009, 361:2518-2528. This is the first study to demonstrate a causal association between lipoprotein(a) and risk of atherothrombosis.
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Clarke, R.1
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New susceptibility locus for coronary artery disease on chromosome 3q22.3
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Erdmann J, Grosshennig A, Braund PS, et al.: New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 2009, 41:280-282. The article describes the identification of a novel CAD susceptibility locus on 3q22, where MRAS is the nearest gene.
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Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet 2008, 82:1185-1192.
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Gudbjartsson DF, Bjornsdottir US, Halapi E, et al.: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009, 41:342-347. This article is the first to describe association between a non-synonymous SNP in the SH2B3 gene and risk of MI.
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This is the first article to identify common loci for blood pressure, one of the established risk factors for atherothrombosis
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Newton-Cheh C, Johnson T, Gateva V, et al.: Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009, 41:666-676. This is the first article to identify common loci for blood pressure, one of the established risk factors for atherothrombosis.
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Tregouet DA, Heath S, Saut N, et al.: Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood 2009, 113:5298-5303. This is the only article reporting results from a genome-wide association study of VTE.
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