메뉴 건너뛰기




Volumn 12, Issue 3, 2010, Pages 159-166

Genetics of atherothrombosis and thrombophilia

Author keywords

Atherosclerosis; Atherothrombosis; CAD; Coronary artery disease; Genetics; Genome wide association; Heritability; Linkage; Myocardial infarction; Polymorphism; Quantitative trait; Single nucleotide polymorphism; SNP; Thrombophilia; Venous thromboembolism; VTE

Indexed keywords

ATHEROTHROMBOSIS; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; CORONARY ARTERY THROMBOSIS; DISEASE COURSE; DISEASE PREDISPOSITION; GENETIC ASSOCIATION; GENETICS; HEART INFARCTION; HERITABILITY; HUMAN; PATHOPHYSIOLOGY; REVIEW; THROMBOPHILIA; VENOUS THROMBOEMBOLISM; ATHEROSCLEROSIS; COMPLICATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HUMAN GENOME; MYOCARDIAL INFARCTION; PROGNOSIS; RISK FACTOR; STROKE; THROMBOEMBOLISM;

EID: 77953544760     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11883-010-0101-z     Document Type: Review
Times cited : (14)

References (50)
  • 1
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • This article describes several novel genetic associations for common diseases in the Wellcome Trust case-control studies
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661-678. This article describes several novel genetic associations for common diseases in the Wellcome Trust case-control studies.
    • (2007) Nature , vol.447 , pp. 661-678
  • 2
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff LA, Sethupathy P, Junkins HA, et al.: Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 2009, 106:9362-9367.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 3
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005, 352:1685-1695.
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 5
    • 70450189795 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis: From pathophysiology to practice
    • Libby P, Ridker PM, Hansson GK: Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009, 54:2129-2138.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 2129-2138
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 6
    • 34249996115 scopus 로고    scopus 로고
    • A common allele on chromosome 9 associated with coronary heart disease
    • This is one of the first articles that described association between the chromosome 9p21 region and risk of CAD
    • McPherson R, Pertsemlidis A, Kavaslar N, et al.: A common allele on chromosome 9 associated with coronary heart disease. Science 2007, 316:1488-1491. This is one of the first articles that described association between the chromosome 9p21 region and risk of CAD.
    • (2007) Science , vol.316 , pp. 1488-1491
    • McPherson, R.1    Pertsemlidis, A.2    Kavaslar, N.3
  • 8
    • 41649085340 scopus 로고    scopus 로고
    • Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    • Schunkert H, Gotz A, Braund P, et al.: Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation 2008, 117:1675-1684.
    • (2008) Circulation , vol.117 , pp. 1675-1684
    • Schunkert, H.1    Gotz, A.2    Braund, P.3
  • 9
    • 40549109924 scopus 로고    scopus 로고
    • Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p
    • Broadbent HM, Peden JF, Lorkowski S, et al.: Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet 2008, 17:806-814.
    • (2008) Hum Mol Genet , vol.17 , pp. 806-814
    • Broadbent, H.M.1    Peden, J.F.2    Lorkowski, S.3
  • 10
    • 38649091662 scopus 로고    scopus 로고
    • The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    • Helgadottir A, Thorleifsson G, Magnusson KP, et al.: The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008, 40:217-224.
    • (2008) Nat Genet , vol.40 , pp. 217-224
    • Helgadottir, A.1    Thorleifsson, G.2    Magnusson, K.P.3
  • 11
    • 70349569056 scopus 로고    scopus 로고
    • Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus
    • Jarinova O, Stewart AF, Roberts R, et al.: Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler Thromb Vasc Biol 2009, 29:1671-1677.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1671-1677
    • Jarinova, O.1    Stewart, A.F.2    Roberts, R.3
  • 12
    • 70449555143 scopus 로고    scopus 로고
    • Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants
    • Folkersen L, Kyriakou T, Goel A, et al.: Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants. PLoS One 2009, 4:e7677.
    • (2009) PLoS One , vol.4
    • Folkersen, L.1    Kyriakou, T.2    Goel, A.3
  • 14
    • 70749096913 scopus 로고    scopus 로고
    • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    • The article describes the largest GWA study of premature MI to date, in which eight different loci for susceptibility to MI were robustly associated
    • Kathiresan S, Voight BF, Purcell S, et al.: Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009, 41:334-341. The article describes the largest GWA study of premature MI to date, in which eight different loci for susceptibility to MI were robustly associated.
    • (2009) Nat Genet , vol.41 , pp. 334-341
    • Kathiresan, S.1    Voight, B.F.2    Purcell, S.3
  • 15
    • 0033605593 scopus 로고    scopus 로고
    • Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase
    • Nielsen MS, Jacobsen C, Olivecrona G, Gliemann J, Petersen CM. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem 1999, 274:8832-8836.
    • (1999) J Biol Chem , vol.274 , pp. 8832-8836
    • Nielsen, M.S.1    Jacobsen, C.2    Olivecrona, G.3    Gliemann, J.4    Petersen, C.M.5
  • 16
    • 58149163149 scopus 로고    scopus 로고
    • Common variants at 30 loci contribute to polygenic dyslipidemia
    • The article describes the identification of many common loci for plasma LDL cholesterol, HDL cholesterol, and triglyceride concentrations, all of which are pathophysiologically important factors in atherothrombosis
    • Kathiresan S, Willer CJ, Peloso GM, et al.: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009:41:56-65. The article describes the identification of many common loci for plasma LDL cholesterol, HDL cholesterol, and triglyceride concentrations, all of which are pathophysiologically important factors in atherothrombosis.
    • (2009) Nat Genet , vol.41 , pp. 56-65
    • Kathiresan, S.1    Willer, C.J.2    Peloso, G.M.3
  • 17
    • 73649141739 scopus 로고    scopus 로고
    • Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease
    • Linsel-Nitschke P, Heeren J, Aherrahrou Z, et al.: Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Atherosclerosis 2009, 208:183-189.
    • (2009) Atherosclerosis , vol.208 , pp. 183-189
    • Linsel-Nitschke, P.1    Heeren, J.2    Aherrahrou, Z.3
  • 18
    • 70449368195 scopus 로고    scopus 로고
    • The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis
    • Mousavi SA, Berge KE, Leren TP: The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis. J Intern Med 2009, 266:507-519.
    • (2009) J Intern Med , vol.266 , pp. 507-519
    • Mousavi, S.A.1    Berge, K.E.2    Leren, T.P.3
  • 19
    • 0041743167 scopus 로고    scopus 로고
    • Monogenic hypercholesterolemia: New insights in pathogenesis and treatment
    • Rader DJ, Cohen J, Hobbs HH: Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest 2003, 111:1795-1803.
    • (2003) J Clin Invest , vol.111 , pp. 1795-1803
    • Rader, D.J.1    Cohen, J.2    Hobbs, H.H.3
  • 20
    • 61349137526 scopus 로고    scopus 로고
    • Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
    • Tregouet DA, Konig IR, Erdmann J, et al.: Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet 2009, 41:283-285.
    • (2009) Nat Genet , vol.41 , pp. 283-285
    • Tregouet, D.A.1    Konig, I.R.2    Erdmann, J.3
  • 21
    • 73549097512 scopus 로고    scopus 로고
    • Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    • This is the first study to demonstrate a causal association between lipoprotein(a) and risk of atherothrombosis
    • Clarke R, Peden JF, Hopewell JC, et al.: Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med 2009, 361:2518-2528. This is the first study to demonstrate a causal association between lipoprotein(a) and risk of atherothrombosis.
    • (2009) N Engl J Med , vol.361 , pp. 2518-2528
    • Clarke, R.1    Peden, J.F.2    Hopewell, J.C.3
  • 22
    • 67651210632 scopus 로고    scopus 로고
    • Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality
    • Erqou S, Kaptoge S, Perry PL, et al.: Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA 2009, 302:412-423.
    • (2009) JAMA , vol.302 , pp. 412-423
    • Erqou, S.1    Kaptoge, S.2    Perry, P.L.3
  • 23
    • 2942630927 scopus 로고    scopus 로고
    • Characterization and expression pattern of the novel MIA homolog TANGO
    • Bosserhoff AK, Moser M, Buettner R: Characterization and expression pattern of the novel MIA homolog TANGO. Gene Expr Patterns 2004, 4:473-479.
    • (2004) Gene Expr Patterns , vol.4 , pp. 473-479
    • Bosserhoff, A.K.1    Moser, M.2    Buettner, R.3
  • 24
    • 23744467924 scopus 로고    scopus 로고
    • Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation
    • Holzel M, Rohrmoser M, Schlee M, et al.: Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. J Cell Biol 2005, 170:367-378.
    • (2005) J Cell Biol , vol.170 , pp. 367-378
    • Holzel, M.1    Rohrmoser, M.2    Schlee, M.3
  • 25
    • 2342617354 scopus 로고    scopus 로고
    • Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins
    • Allen PB, Greenfield AT, Svenningsson P, et al.: Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Proc Natl Acad Sci U S A 2004, 101:7187-7192.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7187-7192
    • Allen, P.B.1    Greenfield, A.T.2    Svenningsson, P.3
  • 26
    • 0033964318 scopus 로고    scopus 로고
    • The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques
    • Abi-Younes S, Sauty A, Mach F, et al.: The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques. Circ Res 2000, 86:131-138.
    • (2000) Circ Res , vol.86 , pp. 131-138
    • Abi-Younes, S.1    Sauty, A.2    Mach, F.3
  • 28
    • 63349086636 scopus 로고    scopus 로고
    • Expression of stromal-cellderived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells
    • Stellos K, Bigalke B, Langer H, et al.: Expression of stromal-cellderived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. Eur Heart J 2009, 30:584-593.
    • (2009) Eur Heart J , vol.30 , pp. 584-593
    • Stellos, K.1    Bigalke, B.2    Langer, H.3
  • 29
    • 0033574273 scopus 로고    scopus 로고
    • MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
    • Abbott GW, Sesti F, Splawski I, et al.: MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 1999, 97:175-187.
    • (1999) Cell , vol.97 , pp. 175-187
    • Abbott, G.W.1    Sesti, F.2    Splawski, I.3
  • 30
    • 61349177857 scopus 로고    scopus 로고
    • New susceptibility locus for coronary artery disease on chromosome 3q22.3
    • The article describes the identification of a novel CAD susceptibility locus on 3q22, where MRAS is the nearest gene
    • Erdmann J, Grosshennig A, Braund PS, et al.: New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 2009, 41:280-282. The article describes the identification of a novel CAD susceptibility locus on 3q22, where MRAS is the nearest gene.
    • (2009) Nat Genet , vol.41 , pp. 280-282
    • Erdmann, J.1    Grosshennig, A.2    Braund, P.S.3
  • 31
    • 67649961412 scopus 로고    scopus 로고
    • Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    • Elliott P, Chambers JC, Zhang W, et al.: Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 2009, 302:37-48.
    • (2009) JAMA , vol.302 , pp. 37-48
    • Elliott, P.1    Chambers, J.C.2    Zhang, W.3
  • 32
    • 42749092252 scopus 로고    scopus 로고
    • Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women's genome health study
    • Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet 2008, 82:1185-1192.
    • (2008) Am J Hum Genet , vol.82 , pp. 1185-1192
  • 33
    • 61349089164 scopus 로고    scopus 로고
    • Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    • This article is the first to describe association between a non-synonymous SNP in the SH2B3 gene and risk of MI
    • Gudbjartsson DF, Bjornsdottir US, Halapi E, et al.: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009, 41:342-347. This article is the first to describe association between a non-synonymous SNP in the SH2B3 gene and risk of MI.
    • (2009) Nat Genet , vol.41 , pp. 342-347
    • Gudbjartsson, D.F.1    Bjornsdottir, U.S.2    Halapi, E.3
  • 34
    • 0033637359 scopus 로고    scopus 로고
    • Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins
    • Takaki S, Sauer K, Iritani BM, et al.: Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity 2000, 13:599-609.
    • (2000) Immunity , vol.13 , pp. 599-609
    • Takaki, S.1    Sauer, K.2    Iritani, B.M.3
  • 35
    • 74949127673 scopus 로고    scopus 로고
    • Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
    • Takizawa H, Nishimura S, Takayama N, et al.: Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest 2010, 120:179-190.
    • (2010) J Clin Invest , vol.120 , pp. 179-190
    • Takizawa, H.1    Nishimura, S.2    Takayama, N.3
  • 36
    • 67349085063 scopus 로고    scopus 로고
    • Genome-wide association study identifies eight loci associated with blood pressure
    • This is the first article to identify common loci for blood pressure, one of the established risk factors for atherothrombosis
    • Newton-Cheh C, Johnson T, Gateva V, et al.: Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009, 41:666-676. This is the first article to identify common loci for blood pressure, one of the established risk factors for atherothrombosis.
    • (2009) Nat Genet , vol.41 , pp. 666-676
    • Newton-Cheh, C.1    Johnson, T.2    Gateva, V.3
  • 37
    • 75649103221 scopus 로고    scopus 로고
    • Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families
    • Cooper JD, Walker NM, Smyth DJ, et al.: Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes Immun 2009, 10(Suppl 1):S85-S94.
    • (2009) Genes Immun , vol.10 , Issue.SUPPL. 1
    • Cooper, J.D.1    Walker, N.M.2    Smyth, D.J.3
  • 38
    • 70350003968 scopus 로고    scopus 로고
    • Common and different genetic background for rheumatoid arthritis and celiac disease
    • Coenen MJ, Trynka G, Heskamp S, et al.: Common and different genetic background for rheumatoid arthritis and celiac disease. Hum Mol Genet 2009, 18:4195-4203.
    • (2009) Hum Mol Genet , vol.18 , pp. 4195-4203
    • Coenen, M.J.1    Trynka, G.2    Heskamp, S.3
  • 39
    • 33846185489 scopus 로고    scopus 로고
    • Genetics of ischemic stroke
    • Dichgans M: Genetics of ischemic stroke. Lancet Neurol 2007, 6:149-161.
    • (2007) Lancet Neurol , vol.6 , pp. 149-161
    • Dichgans, M.1
  • 40
    • 65949090748 scopus 로고    scopus 로고
    • Genomewide association studies of stroke
    • Ikram MA, Seshadri S, Bis JC, et al.: Genomewide association studies of stroke. N Engl J Med 2009, 360:1718-1728.
    • (2009) N Engl J Med , vol.360 , pp. 1718-1728
    • Ikram, M.A.1    Seshadri, S.2    Bis, J.C.3
  • 41
    • 77449149991 scopus 로고    scopus 로고
    • Genome-wide association studies of MRI-defined brain infarcts: Meta-analysis from the CHARGE Consortium
    • Debette S, Bis JC, Fornage M, et al.: Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke 2010, 41:210-217.
    • (2010) Stroke , vol.41 , pp. 210-217
    • Debette, S.1    Bis, J.C.2    Fornage, M.3
  • 42
    • 67149087360 scopus 로고    scopus 로고
    • Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: Results from a GWAS approach
    • This is the only article reporting results from a genome-wide association study of VTE
    • Tregouet DA, Heath S, Saut N, et al.: Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood 2009, 113:5298-5303. This is the only article reporting results from a genome-wide association study of VTE.
    • (2009) Blood , vol.113 , pp. 5298-5303
    • Tregouet, D.A.1    Heath, S.2    Saut, N.3
  • 43
    • 40949145685 scopus 로고    scopus 로고
    • Gene variants associated with deep vein thrombosis
    • Bezemer ID, Bare LA, Doggen CJ, et al.: Gene variants associated with deep vein thrombosis. JAMA 2008, 299:1306-1314.
    • (2008) JAMA , vol.299 , pp. 1306-1314
    • Bezemer, I.D.1    Bare, L.A.2    Doggen, C.J.3
  • 44
    • 77953544733 scopus 로고    scopus 로고
    • National Human Genome Research Institute: A Catalog of Published Genome-Wide Association Studies. Available at. Accessed February 8, 2010
    • National Human Genome Research Institute: A Catalog of Published Genome-Wide Association Studies. Available at http:// www.genome.gov/gwastudies. Accessed February 8, 2010.
  • 45
    • 73649103089 scopus 로고    scopus 로고
    • Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    • Chasman DI, Paré G, Mora S, et al.: Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet 2009, 5:e1000730.
    • (2009) PLoS Genet , vol.5
    • Chasman, D.I.1    Paré, G.2    Mora, S.3
  • 46
    • 67849121952 scopus 로고    scopus 로고
    • Association of novel genetic loci with circulating fibrinogen levels
    • Abbas Dehghan, Qiong Yang, Annette Peters, et al. Association of novel genetic loci with circulating fibrinogen levels. Circ Cardiovasc Genet 2009, 2:125-133.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 125-133
    • Abbas, D.1    Qiong, Y.2    Annette, P.3
  • 47
    • 77649222029 scopus 로고    scopus 로고
    • Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17,686 women
    • Danik SJ, Pare G, Chasman DI, et al.: Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17,686 women. Circ Cardiovasc Genet 2009, 2:134-141.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 134-141
    • Danik, S.J.1    Pare, G.2    Chasman, D.I.3
  • 48
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • This article reviews newly identified genetic loci implicated in fasting glucose homeostasis
    • Dupuis J, Langenberg C, Prokopenko I, et al: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010, 42:105-116. This article reviews newly identified genetic loci implicated in fasting glucose homeostasis.
    • (2010) Nat Genet , vol.42 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3
  • 49
    • 75749091912 scopus 로고    scopus 로고
    • Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    • This article examines how genetic variation can influence responses to an oral glucose challenge
    • Saxena R, Hivert MF, Langenberg C, et al.: Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010, 42:142-148. This article examines how genetic variation can influence responses to an oral glucose challenge.
    • (2010) Nat Genet , vol.42 , pp. 142-148
    • Saxena, R.1    Hivert, M.F.2    Langenberg, C.3
  • 50
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio TA, Collins FS, Cox NJ, et al. : Finding the missing heritability of complex diseases. Nature 2009, 461:747-753.
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.